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Disease Ontology (DO): central nervous system disease

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   disease [DOID:4] <8>
+ + 2:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ 1:   nervous system disease [DOID:863] <11>(51|61) (54|28|13)
0:   central nervous system disease [DOID:331] <16>(33|44) (36|21|9)
- 1:   brain disease [DOID:936] <30>(14|18) (15|6|1)
- 1:   neurodegenerative disease [DOID:1289] <21>(24|31) (26|17|7)
- 1:   meningitis [DOID:9471] <6>(3|2) (3|1|1)
- 1:   spinal cord disease [DOID:319] <5>(0|0) (0|0|0)
- 1:   paraplegia [DOID:607] <2>(0|0) (0|0|0)
- 1:   encephalomyelitis [DOID:640] <1>(0|0) (0|0|0)
- 1:   hemiplegia [DOID:10969] <1>(0|0) (0|0|0)
- 1:   epidural abscess [DOID:11387](0|0) (0|0|0)
- 1:   high pressure neurological syndrome [DOID:3230](0|0) (0|0|0)
- 1:   intracranial abscess [DOID:10095](0|0) (0|0|0)
- 1:   meningoencephalitis [DOID:10554](0|0) (0|0|0)
- 1:   neuromyelitis optica [DOID:8869](1|2) (1|1|0)
- 1:   neuronitis [DOID:8117](0|0) (0|0|0)
- 1:   quadriplegia [DOID:12835](0|0) (0|0|0)
- 1:   restless legs syndrome [DOID:0050425](0|0) (0|0|0)
- 1:   subdural empyema [DOID:11389](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Synuclein0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Flavoproteins0.00008324Direct
4-helical cytokines0.004768Inherited
ACT-like0.006422Inherited
Cation efflux protein transmembrane domain-like0.006422Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.006422Inherited
MHC antigen-recognition domain0.01723Inherited
Calcium-dependent phosphotriesterase0.01925Inherited
Immunoglobulin0.03606Inherited
Insulin-like0.03941Inherited
Proton glutamate symport protein0.03941Inherited
Periplasmic binding protein-like II0.04699Inherited
YWTD domain0.05353Inherited
Nudix0.06636Inherited
Riboflavin synthase domain-like0.07227Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.07227Inherited
Kringle-like0.07782Inherited
Family A G protein-coupled receptor-like0.1146Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1261Inherited
Nicotinic receptor ligand binding domain-like0.1261Inherited
Interleukin 8-like chemokines0.1263Inherited
Toll/Interleukin receptor TIR domain0.1435Inherited
TNF receptor-like0.1647Inherited
Periplasmic binding protein-like I0.1801Inherited
Voltage-gated potassium channels0.185Inherited
ABC transporter transmembrane region0.2211Inherited
Inhibitor of apoptosis (IAP) repeat0.3376Inherited
Protein kinase-like (PK-like)0.5042Inherited
Fibronectin type III0.6402Inherited
TNF-like0.7372Inherited
Thioredoxin-like0.7913Inherited
SCOP hierarchy in SUPERFAMILY0.7965Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
2'-5'-oligoadenylate synthetase 1, OAS1, second domain0Direct
Synuclein0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Multidomain cupredoxins0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Pentraxin (pentaxin)0Direct
Transferrin0Direct
2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain0Direct
C2 set domains0.00008477Direct
Long-chain cytokines0.0007445Direct
Kringle modules0.001065Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001217Inherited
NADPH-cytochrome p450 reductase-like0.001217Inherited
Interleukin 17F, IL-17F0.00497Inherited
Cation efflux protein transmembrane domain-like0.00497Inherited
Cytochrome p450 reductase N-terminal domain-like0.00497Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.00497Inherited
Phenylalanine metabolism regulatory domain0.00497Inherited
Tetramerization domain of potassium channels0.0134Inherited
MHC antigen-recognition domain0.01383Inherited
Interleukin-1 (IL-1)0.02089Inherited
Insulin-like0.03328Inherited
Proton glutamate symport protein0.03328Inherited
YWTD domain0.04758Inherited
C1 set domains (antibody constant domain-like)0.05507Inherited
Rhodopsin-like0.07633Inherited
Phosphate binding protein-like0.08478Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1108Inherited
Nicotinic receptor ligand binding domain-like0.1108Inherited
Toll/Interleukin receptor TIR domain0.1109Inherited
Interleukin 8-like chemokines0.123Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1335Inherited
TNF receptor-like0.1421Inherited
V set domains (antibody variable domain-like)0.2Inherited
L-arabinose binding protein-like0.2276Inherited
Glutathione peroxidase-like0.2944Inherited
Inhibitor of apoptosis (IAP) repeat0.3083Inherited
Complement components0.396Inherited
Alpha-macroglobulin receptor domain0.396Inherited
ABC transporter transmembrane region0.4262Inherited
Calmodulin-like0.5066Inherited
ABC transporter ATPase domain-like0.5357Inherited
Fibronectin type III0.6223Inherited
TNF-like0.7119Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Synuclein0Direct
Flavoproteins0.00004863Direct
4-helical cytokines0.003226Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.004397Inherited
ACT-like0.004397Inherited
Cation efflux protein transmembrane domain-like0.004397Inherited
MHC antigen-recognition domain0.01235Inherited
Calcium-dependent phosphotriesterase0.01393Inherited
Immunoglobulin0.02692Inherited
Insulin-like0.02963Inherited
Proton glutamate symport protein0.02963Inherited
Lipoxigenase0.02963Inherited
Periplasmic binding protein-like II0.03564Inherited
YWTD domain0.04085Inherited
Nudix0.05136Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.05629Inherited
Riboflavin synthase domain-like0.05629Inherited
Kringle-like0.06095Inherited
Family A G protein-coupled receptor-like0.09153Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1012Inherited
Nicotinic receptor ligand binding domain-like0.1012Inherited
Interleukin 8-like chemokines0.1014Inherited
Toll/Interleukin receptor TIR domain0.1159Inherited
TNF receptor-like0.1341Inherited
Periplasmic binding protein-like I0.1476Inherited
Voltage-gated potassium channels0.1518Inherited
ABC transporter transmembrane region0.1838Inherited
Inhibitor of apoptosis (IAP) repeat0.2898Inherited
Alpha-macroglobulin receptor domain0.3739Inherited
Protein kinase-like (PK-like)0.4435Inherited
Fibronectin type III0.5714Inherited
TNF-like0.6653Inherited
Thioredoxin-like0.7192Inherited
L domain-like0.7555Inherited
ARM repeat0.8134Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57414,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    53850,53850
  • 53850 - Periplasmic binding protein-like II
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.00006176Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.001033Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.01235Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.01393Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.01393Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.02133Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.02963Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.1012Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.1037Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.1744Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.1824Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1838Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.2898Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.4155Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.762Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    57414,57440,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.004397Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.004397Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.0114Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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