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Disease Ontology (DO): hypersensitivity reaction type II disease

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   disease [DOID:4] <8>
+ + + 3:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ + 2:   immune system disease [DOID:2914] <4>(39|47) (42|27|16)
+ 1:   hypersensitivity reaction disease [DOID:0060056] <5>(35|46) (37|23|14)
0:   hypersensitivity reaction type II disease [DOID:417] <26>(33|43) (35|23|14)
- 1:   autoimmune disease of endocrine system [DOID:0060005] <3>(3|4) (5|2|0)
- 1:   autoimmune disease of the nervous system [DOID:438] <3>(0|0) (1|0|0)
- 1:   autoimmune disease of blood [DOID:0060050] <2>(3|4) (4|4|4)
- 1:   autoimmune disease of gastrointestinal tract [DOID:0060031] <2>(2|3) (2|0|0)
- 1:   autoimmune disease of skin and connective tissue [DOID:0060039] <2>(10|11) (10|6|3)
- 1:   lupus erythematosus [DOID:8857] <2>(4|8) (5|3|0)
- 1:   alopecia areata [DOID:986] <1>(0|0) (0|0|0)
- 1:   autoimmune disease of urogenital tract [DOID:0060049] <1>(4|2) (4|3|1)
- 1:   rheumatic disease [DOID:1575] <1>(6|10) (7|2|1)
- 1:   CINCA Syndrome [DOID:0090029](0|0) (0|0|0)
- 1:   Goodpasture syndrome [DOID:9808](0|0) (0|0|0)
- 1:   Jaccoud's syndrome [DOID:13080](0|0) (0|0|0)
- 1:   Mikulicz disease [DOID:12900](0|0) (0|0|0)
- 1:   Sjogren's syndrome [DOID:12894](2|3) (2|3|2)
- 1:   Vogt-Koyanagi-Harada disease [DOID:12297](1|0) (1|0|0)
- 1:   Wegener's granulomatosis [DOID:12132](0|0) (0|0|0)
- 1:   antiphospholipid syndrome [DOID:2988](0|0) (0|0|0)
- 1:   autoimmune disease of cardiovascular system [DOID:0060051](0|0) (0|0|0)
- 1:   autoimmune disease of exocrine system [DOID:0060029](0|0) (0|0|0)
- 1:   autoimmune disease of eyes, ear, nose and throat [DOID:0060030](0|0) (0|0|0)
- 1:   autoimmune disease of musculoskeletal system [DOID:0060032](0|0) (0|0|0)
- 1:   autosomal dominant familial periodic fever [DOID:0090018](0|0) (0|0|0)
- 1:   familial Mediterranean fever [DOID:2987](1|0) (1|0|0)
- 1:   rheumatoid lung disease [DOID:849](0|0) (0|0|0)
- 1:   sympathetic ophthalmia [DOID:12029](0|0) (0|0|0)
- 1:   vitiligo [DOID:12306](1|0) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Di-copper centre-containing domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
MHC antigen-recognition domain0.00000002116Direct
TNF receptor-like0.00000008045Direct
Interleukin 8-like chemokines0.00000875Direct
Notch domain0.0001874Direct
Complement control module/SCR domain0.0006462Direct
Integrin beta tail domain0.0008002Direct
Anaphylotoxins (complement system)0.001279Inherited
Transglutaminase, two C-terminal domains0.004164Inherited
Calcium-dependent phosphotriesterase0.004274Inherited
Bcl-2 inhibitors of programmed cell death0.005091Inherited
PGBD-like0.006864Inherited
Growth factor receptor domain0.008881Inherited
Single hybrid motif0.01674Inherited
SMAD MH1 domain0.01674Inherited
Hemopexin-like domain0.0199Inherited
CoA-dependent acyltransferases0.02602Inherited
Cytokine0.04386Inherited
Immunoglobulin0.09692Inherited
Plexin repeat0.1089Inherited
EGF/Laminin0.1466Inherited
TNF-like0.2812Inherited
ABC transporter transmembrane region0.4462Inherited
vWA-like0.4871Inherited
E set domains0.5345Inherited
Cysteine proteinases0.5345Inherited
Integrin domains0.5345Inherited
STAT0.7662Inherited
Transcription factor STAT-4 N-domain0.7662Inherited
4-helical cytokines0.8285Inherited
DEATH domain0.9763Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Serum paraoxonase/arylesterase 1, PON10Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
C1 set domains (antibody constant domain-like)0.00000001975Direct
MHC antigen-recognition domain0.00000001975Direct
TNF receptor-like0.0000009591Direct
Interleukin 8-like chemokines0.000008414Direct
Notch domain0.0001396Direct
Interleukin-1 (IL-1)0.0003004Direct
Complement control module/SCR domain0.0005859Direct
Integrin beta tail domain0.0005992Direct
Integrin beta EGF-like domains0.0005992Direct
C2 set domains0.0007126Direct
Cytochrome p450 reductase N-terminal domain-like0.0009358Direct
Anaphylotoxins (complement system)0.0009358Direct
Netrin-like domain (NTR/C345C module)0.0009358Direct
Long-chain cytokines0.002512Inherited
Transglutaminase N-terminal domain0.003254Inherited
Transglutaminase, two C-terminal domains0.003254Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.003271Inherited
Pentraxin (pentaxin)0.003271Inherited
NADPH-cytochrome p450 reductase-like0.003271Inherited
Bcl-2 inhibitors of programmed cell death0.004085Inherited
Growth factor receptor domain0.005034Inherited
MMP N-terminal domain0.005635Inherited
Transglutaminase core0.005763Inherited
SMAD MH1 domain0.01347Inherited
SMAD domain0.01347Inherited
Biotinyl/lipoyl-carrier proteins and domains0.01347Inherited
Matrix metalloproteases, catalytic domain0.01355Inherited
Hemopexin-like domain0.01719Inherited
Platelet-derived growth factor-like0.02139Inherited
Plexin repeat0.09929Inherited
TNF-like0.2284Inherited
EGF-type module0.253Inherited
I set domains0.3092Inherited
ABC transporter transmembrane region0.3847Inherited
Short-chain cytokines0.4272Inherited
Integrin domains0.4724Inherited
Integrin A (or I) domain0.5227Inherited
STAT DNA-binding domain0.7121Inherited
Transcription factor STAT-4 N-domain0.7121Inherited
STAT0.7121Inherited
Ankyrin repeat0.7151Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Di-copper centre-containing domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
MHC antigen-recognition domain0.00000001008Direct
TNF receptor-like0.00000003942Direct
Interleukin 8-like chemokines0.000004796Direct
Notch domain0.0001119Direct
Complement control module/SCR domain0.0003977Direct
Integrin beta tail domain0.0004959Direct
Anaphylotoxins (complement system)0.0008137Direct
Transglutaminase, two C-terminal domains0.002804Inherited
Calcium-dependent phosphotriesterase0.00288Inherited
Bcl-2 inhibitors of programmed cell death0.003449Inherited
PGBD-like0.004721Inherited
Growth factor receptor domain0.006124Inherited
SMAD MH1 domain0.01195Inherited
Single hybrid motif0.01195Inherited
Hemopexin-like domain0.0144Inherited
CoA-dependent acyltransferases0.01913Inherited
Cytokine0.03311Inherited
Immunoglobulin0.07688Inherited
Plexin repeat0.08668Inherited
EGF/Laminin0.1185Inherited
TNF-like0.2379Inherited
ABC transporter transmembrane region0.3887Inherited
vWA-like0.4274Inherited
Integrin domains0.472Inherited
Cysteine proteinases0.472Inherited
E set domains0.472Inherited
Transcription factor STAT-4 N-domain0.6943Inherited
STAT0.6943Inherited
Ankyrin repeat0.7032Inherited
4-helical cytokines0.7561Inherited
Snake toxin-like0.8226Inherited
DEATH domain0.9086Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.00000001291Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00000002368Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0000002459Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0004959Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0005002Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0005816Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0.0008137Direct
    54001,49309
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.002804Inherited
    81296,54001
  • 81296 - E set domains
  • 54001 - Cysteine proteinases
  • 0.002804Inherited
    49309,49309
  • 49309 - Transglutaminase, two C-terminal domains
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.002804Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.004721Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.014Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0144Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0187Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.08848Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3887Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.6943Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.6943Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.6943Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.00001497Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00001497Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0001119Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0004959Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0005268Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0005816Direct
    81296,54001,49309
  • 81296 - E set domains
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.002804Inherited
    54001,49309,49309
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.002804Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.01069Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01244Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.6943Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.6943Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)