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Disease Ontology (DO): disease of anatomical entity

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   disease [DOID:4] <8>
0:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
- 1:   gastrointestinal system disease [DOID:77] <14>(33|43) (35|18|5)
- 1:   nervous system disease [DOID:863] <11>(51|61) (54|28|13)
- 1:   urinary system disease [DOID:18] <10>(20|29) (22|11|6)
- 1:   endocrine system disease [DOID:28] <7>(14|16) (15|4|1)
- 1:   hematopoietic system disease [DOID:74] <7>(27|29) (27|15|8)
- 1:   immune system disease [DOID:2914] <4>(39|47) (42|27|16)
- 1:   reproductive system disease [DOID:15] <4>(11|13) (11|7|6)
- 1:   respiratory system disease [DOID:1579] <4>(29|38) (30|14|7)
- 1:   cardiovascular system disease [DOID:1287] <3>(42|53) (42|24|14)
- 1:   integumentary system disease [DOID:16] <3>(30|34) (31|15|6)
- 1:   musculoskeletal system disease [DOID:17] <3>(29|42) (37|17|6)
- 1:   thoracic disease [DOID:0060118] <1>(0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
beta-sandwich domain of Sec23/240Direct
Cu,Zn superoxide dismutase-like0Direct
Indolic compounds 2,3-dioxygenase-like0Direct
TNF receptor-like0Direct
Apolipoprotein A-I0Direct
Serum albumin-like0Direct
Creatinase/prolidase N-terminal domain0Direct
BPTI-like0Direct
Lamin A/C globular tail domain0Direct
Transferrin receptor-like dimerisation domain0Direct
Serine protease inhibitors0Direct
TSP type-3 repeat0Direct
Synuclein0Direct
Leukotriene A4 hydrolase N-terminal domain0Direct
Somatomedin B domain0Direct
Heme-dependent peroxidases0Direct
Anaphylotoxins (complement system)0Direct
Troponin coil-coiled subunits0Direct
Flavoproteins0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
p53 tetramerization domain0Direct
GLA-domain0Direct
Small-conductance potassium channel0Direct
Hairpin loop containing domain-like0Direct
HMA, heavy metal-associated domain0Direct
Chitinase insertion domain0Direct
Cation efflux protein transmembrane domain-like0Direct
Calpain large subunit, middle domain (domain III)0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Integrin beta tail domain0Direct
Fibrinogen coiled-coil and central regions0Direct
PA domain0Direct
Di-copper centre-containing domain0Direct
Plakin repeat0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Insulin-like0Direct
4Fe-4S ferredoxins0Direct
SRF-like0Direct
4-helical cytokines0.00000007235Direct
Interleukin 8-like chemokines0.0000006024Direct
Voltage-gated potassium channels0.000008446Direct
Cystine-knot cytokines0.00006013Direct
Immunoglobulin0.000149Direct
TNF-like0.0002423Direct
EGF/Laminin0.001065Inherited
Integrin domains0.001164Inherited
Toll/Interleukin receptor TIR domain0.001164Inherited
Cytokine0.001327Inherited
Nuclear receptor ligand-binding domain0.001496Inherited
Complement control module/SCR domain0.002053Inherited
Intermediate filament protein, coiled coil region0.002487Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.002941Inherited
Riboflavin synthase domain-like0.002941Inherited
Family A G protein-coupled receptor-like0.003486Inherited
MHC antigen-recognition domain0.003498Inherited
L domain-like0.00364Inherited
Cytochrome P4500.005625Inherited
FnI-like domain0.00627Inherited
Metalloproteases ("zincins"), catalytic domain0.007936Inherited
ABC transporter transmembrane region0.008086Inherited
Trypsin-like serine proteases0.00872Inherited
Aquaporin-like0.01723Inherited
gamma-Crystallin-like0.01723Inherited
Serpins0.01807Inherited
vWA-like0.02151Inherited
Snake toxin-like0.0219Inherited
DEATH domain0.02302Inherited
Integrin alpha N-terminal domain0.02575Inherited
Fibronectin type III0.03212Inherited
Transglutaminase, two C-terminal domains0.04055Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.04055Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.04055Inherited
TSP-1 type 1 repeat0.04607Inherited
Periplasmic binding protein-like II0.05684Inherited
Spectrin repeat0.05983Inherited
Globin-like0.06029Inherited
STAT0.06202Inherited
Multidrug efflux transporter AcrB transmembrane domain0.06202Inherited
SMAD MH1 domain0.06202Inherited
Transcription factor STAT-4 N-domain0.06202Inherited
C-type lectin-like0.06675Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.08552Inherited
Lipoxigenase0.09533Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.09814Inherited
Periplasmic binding protein-like I0.09835Inherited
TIMP-like0.1031Inherited
Growth factor receptor domain0.1059Inherited
Hemopexin-like domain0.1336Inherited
Cupredoxins0.1349Inherited
SEA domain0.1349Inherited
Bcl-2 inhibitors of programmed cell death0.1349Inherited
Triple coiled coil domain of C-type lectins0.1453Inherited
RuvA domain 2-like0.1453Inherited
Notch domain0.1453Inherited
Calcium-dependent phosphotriesterase0.1453Inherited
MAPEG domain-like0.1453Inherited
Phospholipase A2, PLA20.1453Inherited
p53-like transcription factors0.1605Inherited
CoA-dependent acyltransferases0.1754Inherited
Kringle-like0.2026Inherited
SH2 domain0.2107Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.2199Inherited
Restriction endonuclease-like0.2199Inherited
ACT-like0.2199Inherited
PRTase-like0.2199Inherited
Thioredoxin-like0.2214Inherited
Fibrinogen C-terminal domain-like0.2334Inherited
YWTD domain0.2347Inherited
Blood coagulation inhibitor (disintegrin)0.2347Inherited
Class II aaRS and biotin synthetases0.2431Inherited
Inhibitor of apoptosis (IAP) repeat0.2435Inherited
Alpha-macroglobulin receptor domain0.2435Inherited
Protein kinase-like (PK-like)0.2802Inherited
RNI-like0.313Inherited
Terpenoid cyclases/Protein prenyltransferases0.3181Inherited
PGBD-like0.3257Inherited
Proton glutamate symport protein0.3332Inherited
Nicotinic receptor ligand binding domain-like0.3681Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3681Inherited
Thyroglobulin type-1 domain0.3927Inherited
Defensin-like0.4114Inherited
Myosin rod fragments0.5089Inherited
Single hybrid motif0.5235Inherited
Nudix0.5235Inherited
Cysteine proteinases0.5536Inherited
Mitochondrial carrier0.558Inherited
MFS general substrate transporter0.5717Inherited
Annexin0.6176Inherited
Plexin repeat0.623Inherited
E set domains0.6436Inherited
SCOP hierarchy in SUPERFAMILY0.6508Inherited
Cadherin-like0.7118Inherited
GST C-terminal domain-like0.7193Inherited
HSP20-like chaperones0.7399Inherited
Homeodomain-like1Inherited
RNA-binding domain, RBD1Inherited
SET domain1Inherited
PH domain-like1Inherited
GTPase activation domain, GAP1Inherited
Nucleotide-diphospho-sugar transferases1Inherited
ARM repeat1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Insulin-like0Direct
Cu,Zn superoxide dismutase-like0Direct
Interferon regulatory factor0Direct
Tissue inhibitor of metalloproteinases, TIMP0Direct
Prokaryotic proteases0Direct
Transferrin receptor-like dimerisation domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Troponin T0Direct
Somatomedin B domain0Direct
Neurotrophin0Direct
Plakin repeat0Direct
gamma-adaptin C-terminal appendage domain-like0Direct
2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain0Direct
Apolipoprotein A-I0Direct
Neutral endopeptidase (neprilysin)0Direct
Transferrin0Direct
Calpain large subunit, middle domain (domain III)0Direct
p53 DNA-binding domain-like0Direct
Anaphylotoxins (complement system)0Direct
TSP type-3 repeat0Direct
Myeloperoxidase-like0Direct
Interleukin 17F, IL-17F0Direct
MHCK/EF2 kinase0Direct
Alkaline phosphatase0Direct
Interleukin-1 (IL-1)0Direct
Retinol binding protein-like0Direct
IP3 receptor type 1 binding core, domain 20Direct
Family 1 of glycosyl hydrolase0Direct
Leukotriene A4 hydrolase catalytic domain0Direct
Pepsin-like0Direct
Short-chain cytokines0Direct
Chitinase insertion domain0Direct
HMA, heavy metal-associated domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0Direct
p53 tetramerization domain0Direct
Cation efflux protein transmembrane domain-like0Direct
GRAM domain0Direct
FolH catalytic domain-like0Direct
Fibrinogen coiled-coil and central regions0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
Multidomain cupredoxins0Direct
Serum albumin-like0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
Small-conductance potassium channel0Direct
Regulator of chromosome condensation RCC10Direct
PA domain0Direct
2'-5'-oligoadenylate synthetase 1, OAS1, second domain0Direct
Netrin-like domain (NTR/C345C module)0Direct
TNF receptor-like0Direct
Synuclein0Direct
SRF-like0Direct
Type II chitinase0Direct
HtrA-like serine proteases0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Integrin beta tail domain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Tetraspanin0Direct
Small Kunitz-type inhibitors & BPTI-like toxins0Direct
NADPH-cytochrome p450 reductase-like0Direct
Pentraxin (pentaxin)0Direct
Lamin A/C globular tail domain0Direct
Integrin beta EGF-like domains0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Extracellular domain of cell surface receptors0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Anti-sigma factor antagonist SpoIIaa0Direct
Thrombospondin C-terminal domain0Direct
GLA-domain0Direct
alpha-catenin/vinculin0Direct
Leukotriene A4 hydrolase N-terminal domain0Direct
BAFF receptor-like0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Interleukin 8-like chemokines0.0000007824Direct
Toll/Interleukin receptor TIR domain0.0001591Direct
TNF-like0.0002509Direct
Integrin A (or I) domain0.0002509Direct
C1 set domains (antibody constant domain-like)0.0008985Direct
Integrin domains0.001083Inherited
ABC transporter ATPase domain-like0.001195Inherited
Nuclear receptor ligand-binding domain0.001635Inherited
Complement control module/SCR domain0.002232Inherited
Interferons/interleukin-10 (IL-10)0.002576Inherited
Intermediate filament protein, coiled coil region0.002646Inherited
Nuclear receptor0.003039Inherited
MHC antigen-recognition domain0.003541Inherited
Rhodopsin-like0.004116Inherited
Voltage-gated potassium channels0.005966Inherited
Cytochrome P4500.007919Inherited
I set domains0.008001Inherited
Ngr ectodomain-like0.008428Inherited
Long-chain cytokines0.009793Inherited
Crystallins/Ca-binding development proteins0.01496Inherited
Aquaporin-like0.01496Inherited
Tetramerization domain of potassium channels0.01496Inherited
Eukaryotic proteases0.01671Inherited
Glutathione peroxidase-like0.01776Inherited
Transforming growth factor (TGF)-beta0.01965Inherited
Transglutaminase core0.02292Inherited
Serpins0.02389Inherited
Integrin alpha N-terminal domain0.02404Inherited
EGF-type module0.02532Inherited
ABC transporter transmembrane region0.02892Inherited
Transglutaminase N-terminal domain0.03569Inherited
Platelet-derived growth factor-like0.03569Inherited
Transglutaminase, two C-terminal domains0.03569Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.03569Inherited
Fibronectin type III0.04499Inherited
Laminin-type module0.04807Inherited
TSP-1 type 1 repeat0.04851Inherited
SMAD domain0.05511Inherited
SMAD MH1 domain0.05511Inherited
STAT DNA-binding domain0.05511Inherited
Transcription factor STAT-4 N-domain0.05511Inherited
STAT0.05511Inherited
Erythroid transcription factor GATA-10.05511Inherited
Globins0.05529Inherited
Spectrin repeat0.05849Inherited
DEATH domain, DD0.06091Inherited
Growth factor receptor domain0.06768Inherited
Noncollagenous (NC1) domain of collagen IV0.08463Inherited
Animal lipoxigenases0.08463Inherited
Pancreatic lipase, N-terminal domain0.08463Inherited
L domain0.08463Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.09243Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.114Inherited
C2 set domains0.114Inherited
S100 proteins0.1263Inherited
Bcl-2 inhibitors of programmed cell death0.1263Inherited
Notch domain0.1297Inherited
Triple coiled coil domain of C-type lectins0.1297Inherited
Lipoxigenase N-terminal domain0.1297Inherited
Hemopexin-like domain0.1306Inherited
Phosphate binding protein-like0.131Inherited
Forkhead DNA-binding domain0.162Inherited
MIR domain0.1623Inherited
Kringle modules0.1742Inherited
L-arabinose binding protein-like0.1924Inherited
C-type lectin domain0.1989Inherited
DEATH effector domain, DED0.2003Inherited
Exostosin0.2003Inherited
XPF/Rad1/Mus81 nuclease0.2003Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.2003Inherited
Phenylalanine metabolism regulatory domain0.2003Inherited
Blood coagulation inhibitor (disintegrin)0.2264Inherited
YWTD domain0.2264Inherited
Complement components0.2273Inherited
Penta-EF-hand proteins0.2273Inherited
Alpha-macroglobulin receptor domain0.2273Inherited
Inhibitor of apoptosis (IAP) repeat0.2273Inherited
EF-hand modules in multidomain proteins0.2306Inherited
Fibrinogen C-terminal domain-like0.2347Inherited
SH2 domain0.2416Inherited
Myosin rod fragments0.2764Inherited
Matrix metalloproteases, catalytic domain0.3034Inherited
VWC domain0.3067Inherited
Pyrin domain, PYD0.3159Inherited
Proton glutamate symport protein0.3159Inherited
MMP N-terminal domain0.3221Inherited
Protein kinases, catalytic subunit0.3852Inherited
Nicotinic receptor ligand binding domain-like0.3872Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3872Inherited
Thyroglobulin type-1 domain0.3917Inherited
Caspase recruitment domain, CARD0.3917Inherited
Defensin0.3978Inherited
V set domains (antibody variable domain-like)0.4093Inherited
Sir2 family of transcriptional regulators0.4298Inherited
Fibronectin type II module0.4606Inherited
Biotinyl/lipoyl-carrier proteins and domains0.5062Inherited
28-residue LRR0.5093Inherited
Mitochondrial carrier0.5524Inherited
T-box0.6061Inherited
Annexin0.6061Inherited
Motor proteins0.6063Inherited
Glutathione S-transferase (GST), C-terminal domain0.6201Inherited
Plexin repeat0.6288Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.6421Inherited
Calmodulin-like0.6511Inherited
FAD-linked reductases, N-terminal domain0.6733Inherited
Ankyrin repeat0.68Inherited
Cadherin0.8708Inherited
BCR-homology GTPase activation domain (BH-domain)0.8898Inherited
Phosphotyrosine-binding domain (PTB)0.9686Inherited
SPRY domain0.9977Inherited
Homeodomain1Inherited
Canonical RBD1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Calpain large subunit, middle domain (domain III)0Direct
BPTI-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Transferrin receptor-like dimerisation domain0Direct
Troponin coil-coiled subunits0Direct
TSP type-3 repeat0Direct
PA domain0Direct
Serum albumin-like0Direct
4Fe-4S ferredoxins0Direct
Somatomedin B domain0Direct
Flavoproteins0Direct
Plakin repeat0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Creatinase/prolidase N-terminal domain0Direct
HMA, heavy metal-associated domain0Direct
Small-conductance potassium channel0Direct
Insulin-like0Direct
Anaphylotoxins (complement system)0Direct
Synuclein0Direct
GLA-domain0Direct
Integrin beta tail domain0Direct
Leukotriene A4 hydrolase N-terminal domain0Direct
Hairpin loop containing domain-like0Direct
Cation efflux protein cytoplasmic domain-like0Direct
Cu,Zn superoxide dismutase-like0Direct
Serine protease inhibitors0Direct
Cation efflux protein transmembrane domain-like0Direct
p53 tetramerization domain0Direct
Heme-dependent peroxidases0Direct
Chitinase insertion domain0Direct
Apolipoprotein A-I0Direct
TNF receptor-like0Direct
SRF-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Lamin A/C globular tail domain0Direct
beta-sandwich domain of Sec23/240Direct
Di-copper centre-containing domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Indolic compounds 2,3-dioxygenase-like0Direct
4-helical cytokines0.00000003531Direct
Interleukin 8-like chemokines0.0000003089Direct
Voltage-gated potassium channels0.000004628Direct
Cystine-knot cytokines0.00003501Direct
Immunoglobulin0.00008901Direct
TNF-like0.0001459Direct
EGF/Laminin0.0006722Direct
Integrin domains0.0007391Direct
Toll/Interleukin receptor TIR domain0.0007391Direct
Cytokine0.0008446Direct
Nuclear receptor ligand-binding domain0.0009588Direct
Complement control module/SCR domain0.001337Inherited
Intermediate filament protein, coiled coil region0.001642Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.001946Inherited
Riboflavin synthase domain-like0.001946Inherited
Family A G protein-coupled receptor-like0.002327Inherited
MHC antigen-recognition domain0.002338Inherited
L domain-like0.002435Inherited
Cytochrome P4500.00384Inherited
FnI-like domain0.004292Inherited
Metalloproteases ("zincins"), catalytic domain0.005458Inherited
ABC transporter transmembrane region0.005557Inherited
Trypsin-like serine proteases0.006003Inherited
Aquaporin-like0.01235Inherited
gamma-Crystallin-like0.01235Inherited
Serpins0.013Inherited
vWA-like0.01564Inherited
Snake toxin-like0.01595Inherited
DEATH domain0.01681Inherited
Integrin alpha N-terminal domain0.01894Inherited
Fibronectin type III0.02395Inherited
Transglutaminase, two C-terminal domains0.03045Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.03045Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.03045Inherited
TSP-1 type 1 repeat0.03499Inherited
Periplasmic binding protein-like II0.04354Inherited
Spectrin repeat0.04597Inherited
Globin-like0.04637Inherited
STAT0.04777Inherited
Transcription factor STAT-4 N-domain0.04777Inherited
SMAD MH1 domain0.04777Inherited
Multidrug efflux transporter AcrB transmembrane domain0.04777Inherited
C-type lectin-like0.05166Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.06729Inherited
Lipoxigenase0.07548Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.07787Inherited
Periplasmic binding protein-like I0.07805Inherited
TIMP-like0.08215Inherited
Growth factor receptor domain0.08439Inherited
Hemopexin-like domain0.1077Inherited
Bcl-2 inhibitors of programmed cell death0.1088Inherited
SEA domain0.1088Inherited
Cupredoxins0.1088Inherited
RuvA domain 2-like0.1175Inherited
Phospholipase A2, PLA20.1175Inherited
Triple coiled coil domain of C-type lectins0.1175Inherited
Calcium-dependent phosphotriesterase0.1175Inherited
MAPEG domain-like0.1175Inherited
Notch domain0.1175Inherited
p53-like transcription factors0.1305Inherited
CoA-dependent acyltransferases0.1435Inherited
MIR domain0.1435Inherited
Kringle-like0.1675Inherited
SH2 domain0.1746Inherited
Restriction endonuclease-like0.1828Inherited
ACT-like0.1828Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.1828Inherited
PRTase-like0.1828Inherited
Thioredoxin-like0.184Inherited
Fibrinogen C-terminal domain-like0.1947Inherited
YWTD domain0.1958Inherited
Blood coagulation inhibitor (disintegrin)0.1958Inherited
Class II aaRS and biotin synthetases0.2033Inherited
Alpha-macroglobulin receptor domain0.2036Inherited
Inhibitor of apoptosis (IAP) repeat0.2036Inherited
Protein kinase-like (PK-like)0.2371Inherited
RNI-like0.2673Inherited
Terpenoid cyclases/Protein prenyltransferases0.272Inherited
PGBD-like0.2789Inherited
Proton glutamate symport protein0.2859Inherited
Nicotinic receptor ligand binding domain-like0.3175Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3175Inherited
Thyroglobulin type-1 domain0.3394Inherited
Defensin-like0.3564Inherited
Myosin rod fragments0.448Inherited
Single hybrid motif0.4615Inherited
Nudix0.4615Inherited
Cysteine proteinases0.4904Inherited
Mitochondrial carrier0.4944Inherited
MFS general substrate transporter0.5068Inherited
Ankyrin repeat0.5442Inherited
Annexin0.5501Inherited
Plexin repeat0.5551Inherited
E set domains0.5748Inherited
EF-hand0.6165Inherited
Cadherin-like0.6401Inherited
GST C-terminal domain-like0.6474Inherited
HSP20-like chaperones0.668Inherited
Calponin-homology domain, CH-domain0.8605Inherited
Nucleotide-diphospho-sugar transferases0.9398Inherited
RNA-binding domain, RBD0.9903Inherited
GTPase activation domain, GAP0.9978Inherited
HLH, helix-loop-helix DNA-binding domain0.9987Inherited
Homeodomain-like1Inherited
SET domain1Inherited
ARM repeat1Inherited
PH domain-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57362,57362
  • 57362 - BPTI-like
  • 57362 - BPTI-like
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0Direct
    90188,90188
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0Direct
    103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    57184,100895
  • 57184 - Growth factor receptor domain
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    57889,49562
  • 57889 - Cysteine-rich domain
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    52540,-7
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • -7 - CATH
  • 0Direct
    51445,51445
  • 51445 - (Trans)glycosidases
  • 51445 - (Trans)glycosidases
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    49758,47473
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0Direct
    57196,50494
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    50494,50156
  • 50494 - Trypsin-like serine proteases
  • 50156 - PDZ domain-like
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    49265,56112
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    53187,47672
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    63737,55486
  • 63737 - Leukotriene A4 hydrolase N-terminal domain
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    102712,-7
  • 102712 - JAB1/MPN domain
  • -7 - CATH
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    57196,57535
  • 57196 - EGF/Laminin
  • 57535 - Complement control module/SCR domain
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    57414,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 0Direct
    52025,53187
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    53850,53850
  • 53850 - Periplasmic binding protein-like II
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    103647,49899
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    51445,54556
  • 51445 - (Trans)glycosidases
  • 54556 - Chitinase insertion domain
  • 0Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    81324,81327
  • 81324 - Voltage-gated potassium channels
  • 81327 - Small-conductance potassium channel
  • 0Direct
    90188,53649
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0003555Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0007681Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.00148Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.002574Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.004198Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.004781Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.005557Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.006279Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.006279Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.01417Inherited
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.0193Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0193Inherited
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.03045Inherited
    81296,54001
  • 81296 - E set domains
  • 54001 - Cysteine proteinases
  • 0.03045Inherited
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.03045Inherited
    54001,49309
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.03045Inherited
    49309,49309
  • 49309 - Transglutaminase, two C-terminal domains
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.03045Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.04597Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.04777Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.04777Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.04777Inherited
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.04777Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.04777Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.04777Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.04777Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.06013Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.06013Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.07548Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.07548Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.07548Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.08064Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.08328Inherited
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0.1175Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.1175Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.1175Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.1175Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.1947Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.1958Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.2384Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.2384Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.2789Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.3175Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.3394Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.4033Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.4121Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.4132Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.448Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.4507Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.5545Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.7911Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    48726,49265,56112
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57889,57889,49562
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    49265,48726,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    52025,53187,47672
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    90188,90188,53649
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    53300,53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0Direct
    103647,103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0Direct
    103647,103647,49899
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0Direct
    57630,57196,50494
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    57414,57440,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0Direct
    100895,100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    48552,48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0001831Direct
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.006279Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.01417Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01511Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0193Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.02103Inherited
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.03045Inherited
    81296,54001,49309
  • 81296 - E set domains
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.03045Inherited
    54001,49309,49309
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.03045Inherited
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.03127Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.03877Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.04637Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.04777Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.04777Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.06013Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.07548Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1113Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1142Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.1828Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.1828Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.1828Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.3729Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.4944Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.7911Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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