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Disease Ontology (DO): hematopoietic system disease

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   disease [DOID:4] <8>
+ 1:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
0:   hematopoietic system disease [DOID:74] <7>(27|29) (27|15|8)
- 1:   anemia [DOID:2355] <8>(4|5) (4|2|1)
- 1:   leukocyte disease [DOID:9500] <5>(3|2) (3|0|0)
- 1:   blood coagulation disease [DOID:1247] <4>(16|18) (17|10|6)
- 1:   blood protein disease [DOID:620] <2>(0|0) (0|0|0)
- 1:   blood group incompatibility [DOID:4176] <1>(0|0) (0|0|0)
- 1:   bone marrow disease [DOID:4961] <1>(2|2) (2|0|0)
- 1:   hereditary elliptocytosis [DOID:2373](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
p53 tetramerization domain0Direct
Complement control module/SCR domain0.0000001044Direct
4-helical cytokines0.0000002221Direct
MHC antigen-recognition domain0.00001503Direct
GLA-domain0.00002096Direct
RuvA domain 2-like0.00002274Direct
Trypsin-like serine proteases0.000139Direct
Restriction endonuclease-like0.0002429Direct
Globin-like0.00138Inherited
Hairpin loop containing domain-like0.001685Inherited
Notch domain0.001685Inherited
TNF-like0.009512Inherited
EGF/Laminin0.03217Inherited
SH2 domain0.03907Inherited
Cupredoxins0.04738Inherited
Fibrinogen C-terminal domain-like0.08381Inherited
GST C-terminal domain-like0.08835Inherited
Integrin domains0.1406Inherited
Interleukin 8-like chemokines0.1609Inherited
Serpins0.162Inherited
Cytokine0.2079Inherited
vWA-like0.223Inherited
L domain-like0.2511Inherited
GTPase activation domain, GAP0.364Inherited
Cystine-knot cytokines0.4025Inherited
Thioredoxin-like0.4432Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
p53 tetramerization domain0Direct
p53 DNA-binding domain-like0Direct
Multidomain cupredoxins0Direct
Short-chain cytokines0.00000005242Direct
Complement control module/SCR domain0.00000007488Direct
MHC antigen-recognition domain0.00001072Direct
GLA-domain0.00001429Direct
C1 set domains (antibody constant domain-like)0.00001823Direct
Eukaryotic proteases0.0000377Direct
C2 set domains0.0001382Direct
XPF/Rad1/Mus81 nuclease0.0001766Direct
Globins0.0009647Direct
Notch domain0.001161Inherited
EGF-type module0.004467Inherited
TNF-like0.007357Inherited
Erythroid transcription factor GATA-10.008961Inherited
Kringle modules0.0118Inherited
Interleukin-1 (IL-1)0.02566Inherited
SH2 domain0.03269Inherited
Glutathione S-transferase (GST), C-terminal domain0.06715Inherited
Fibrinogen C-terminal domain-like0.06994Inherited
V set domains (antibody variable domain-like)0.1188Inherited
Serpins0.12Inherited
Integrin domains0.12Inherited
Integrin A (or I) domain0.1379Inherited
Interleukin 8-like chemokines0.1409Inherited
BCR-homology GTPase activation domain (BH-domain)0.154Inherited
Ngr ectodomain-like0.1655Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
p53 tetramerization domain0Direct
Complement control module/SCR domain0.00000005136Direct
4-helical cytokines0.0000001111Direct
MHC antigen-recognition domain0.000008311Direct
GLA-domain0.00001173Direct
RuvA domain 2-like0.00001277Direct
Trypsin-like serine proteases0.00008259Direct
Restriction endonuclease-like0.0001464Direct
Globin-like0.0008774Direct
Hairpin loop containing domain-like0.001081Inherited
Notch domain0.001081Inherited
TNF-like0.006615Inherited
EGF/Laminin0.02398Inherited
SH2 domain0.02929Inherited
Cupredoxins0.03594Inherited
Fibrinogen C-terminal domain-like0.06587Inherited
GST C-terminal domain-like0.06973Inherited
Integrin domains0.1136Inherited
Interleukin 8-like chemokines0.1308Inherited
Serpins0.1317Inherited
Cytokine0.1721Inherited
vWA-like0.1855Inherited
L domain-like0.2105Inherited
GTPase activation domain, GAP0.3132Inherited
Cystine-knot cytokines0.3483Inherited
Thioredoxin-like0.3861Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,50494
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.000000008282Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.000004683Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.00002374Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0008774Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.003889Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.05124Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.06587Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.1062Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2295Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2502Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57630,57196,50494
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0000001127Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0007117Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.008434Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.01626Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.02446Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.09923Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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