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Disease Ontology (DO): gastrointestinal system disease

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   disease [DOID:4] <8>
+ 1:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
0:   gastrointestinal system disease [DOID:77] <14>(33|43) (35|18|5)
- 1:   intestinal disease [DOID:5295] <32>(11|13) (12|7|2)
- 1:   stomach disease [DOID:76] <11>(3|5) (4|0|0)
- 1:   mouth disease [DOID:403] <10>(13|13) (14|5|2)
- 1:   esophageal disease [DOID:6050] <8>(4|3) (6|3|1)
- 1:   gallbladder disease [DOID:0060262] <7>(2|2) (2|1|0)
- 1:   peptic ulcer disease [DOID:750] <7>(1|2) (1|0|0)
- 1:   diarrhea [DOID:13250] <6>(1|1) (1|1|0)
- 1:   hepatobiliary disease [DOID:3118] <2>(8|11) (8|6|1)
- 1:   gastroenteritis [DOID:2326] <1>(0|0) (0|0|0)
- 1:   peritonitis [DOID:8283] <1>(0|0) (0|0|0)
- 1:   esophageal atresia/tracheoesophageal fistula [DOID:0080171](0|0) (0|0|0)
- 1:   gastroesophageal reflux disease [DOID:8534](0|0) (0|0|0)
- 1:   mucositis [DOID:0080178](0|0) (0|0|0)
- 1:   perinatal necrotizing enterocolitis [DOID:8677](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
PGBD-like0.000006861Direct
4-helical cytokines0.00001272Direct
MHC antigen-recognition domain0.0001805Direct
Hemopexin-like domain0.001635Inherited
Interleukin 8-like chemokines0.001769Inherited
Defensin-like0.002013Inherited
STAT0.002688Inherited
Transcription factor STAT-4 N-domain0.002688Inherited
RNI-like0.003291Inherited
Toll/Interleukin receptor TIR domain0.005071Inherited
Nuclear receptor ligand-binding domain0.007116Inherited
Kringle-like0.007165Inherited
Aquaporin-like0.01019Inherited
p53-like transcription factors0.01041Inherited
DEATH domain0.01189Inherited
Anaphylotoxins (complement system)0.02158Inherited
CoA-dependent acyltransferases0.02476Inherited
Single hybrid motif0.04212Inherited
TIMP-like0.05888Inherited
Alpha-macroglobulin receptor domain0.06046Inherited
Cytokine0.1029Inherited
Terpenoid cyclases/Protein prenyltransferases0.1154Inherited
Insulin-like0.1154Inherited
ABC transporter transmembrane region0.1298Inherited
Heme-dependent peroxidases0.2551Inherited
Metalloproteases ("zincins"), catalytic domain0.2908Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.468Inherited
GST C-terminal domain-like0.4683Inherited
ARM repeat0.5135Inherited
Cystine-knot cytokines0.8014Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Alkaline phosphatase0Direct
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Multidomain cupredoxins0Direct
MMP N-terminal domain0.000006449Direct
Matrix metalloproteases, catalytic domain0.00006466Direct
MHC antigen-recognition domain0.0001528Direct
Short-chain cytokines0.000178Direct
C1 set domains (antibody constant domain-like)0.0002952Direct
Hemopexin-like domain0.00128Inherited
Interleukin 8-like chemokines0.00155Inherited
Defensin0.001644Inherited
STAT DNA-binding domain0.002007Inherited
Transcription factor STAT-4 N-domain0.002007Inherited
STAT0.002007Inherited
TNF receptor-like0.004173Inherited
Toll/Interleukin receptor TIR domain0.004173Inherited
Nuclear receptor ligand-binding domain0.006204Inherited
Nuclear receptor0.007756Inherited
Aquaporin-like0.008097Inherited
V set domains (antibody variable domain-like)0.01126Inherited
C5 cytosine-specific DNA methylase, DCM0.01705Inherited
Anaphylotoxins (complement system)0.01705Inherited
Netrin-like domain (NTR/C345C module)0.01705Inherited
Interleukin-1 (IL-1)0.01925Inherited
Pyrin domain, PYD0.02074Inherited
Interferons/interleukin-10 (IL-10)0.02522Inherited
ABC transporter transmembrane region0.0322Inherited
Biotinyl/lipoyl-carrier proteins and domains0.03666Inherited
Alpha-macroglobulin receptor domain0.05041Inherited
Complement components0.05041Inherited
28-residue LRR0.06306Inherited
Caspase recruitment domain, CARD0.06356Inherited
Long-chain cytokines0.06356Inherited
Insulin-like0.0995Inherited
Integrin A (or I) domain0.1187Inherited
DEATH domain, DD0.1477Inherited
ABC transporter ATPase domain-like0.225Inherited
Myeloperoxidase-like0.2314Inherited
EGF-type module0.3154Inherited
Glutathione S-transferase (GST), C-terminal domain0.4202Inherited
Transforming growth factor (TGF)-beta0.7203Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
PGBD-like0.000003707Direct
4-helical cytokines0.000006979Direct
MHC antigen-recognition domain0.0001071Direct
Hemopexin-like domain0.001047Inherited
Interleukin 8-like chemokines0.001138Inherited
Defensin-like0.001309Inherited
Transcription factor STAT-4 N-domain0.001769Inherited
STAT0.001769Inherited
RNI-like0.002192Inherited
Toll/Interleukin receptor TIR domain0.003435Inherited
Nuclear receptor ligand-binding domain0.004915Inherited
Kringle-like0.004938Inherited
Flavoproteins0.007002Inherited
Aquaporin-like0.007121Inherited
p53-like transcription factors0.007285Inherited
DEATH domain0.008361Inherited
Anaphylotoxins (complement system)0.01567Inherited
CoA-dependent acyltransferases0.01815Inherited
Single hybrid motif0.03171Inherited
TIMP-like0.04523Inherited
Alpha-macroglobulin receptor domain0.04649Inherited
Cytokine0.08192Inherited
Terpenoid cyclases/Protein prenyltransferases0.09221Inherited
Insulin-like0.09221Inherited
ABC transporter transmembrane region0.1045Inherited
Heme-dependent peroxidases0.2144Inherited
Metalloproteases ("zincins"), catalytic domain0.2469Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.4094Inherited
GST C-terminal domain-like0.4096Inherited
ARM repeat0.4525Inherited
Cystine-knot cytokines0.7295Inherited
Thioredoxin-like0.8821Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.000003707Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0002523Direct
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.0008655Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0009346Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.001769Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.001769Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.001769Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.002615Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.007097Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.007285Inherited
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0.01567Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.09803Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1045Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.3532Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.0002412Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.001769Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.001769Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01815Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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