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Disease Ontology (DO): nervous system disease

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   disease [DOID:4] <8>
+ 1:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
0:   nervous system disease [DOID:863] <11>(51|61) (54|28|13)
- 1:   central nervous system disease [DOID:331] <16>(33|44) (36|21|9)
- 1:   peripheral nervous system disease [DOID:574] <8>(5|5) (6|4|2)
- 1:   hyperekplexia [DOID:0060695] <3>(0|0) (0|0|0)
- 1:   sensory system disease [DOID:0050155] <2>(16|13) (17|5|2)
- 1:   Gerstmann syndrome [DOID:4969](0|0) (0|0|0)
- 1:   diplegia of upper limb [DOID:862](0|0) (0|0|0)
- 1:   locked-in syndrome [DOID:12697](0|0) (0|0|0)
- 1:   neurogenic arthrogryposis multiplex congenita [DOID:0090124](0|0) (0|0|0)
- 1:   neuroleptic malignant syndrome [DOID:14464](0|0) (0|0|0)
- 1:   spinocerebellar ataxia type 1 with axonal neuropathy [DOID:0090115](0|0) (0|0|0)
- 1:   toxic encephalopathy [DOID:3602](1|1) (1|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Synuclein0Direct
p53 tetramerization domain0Direct
Cu,Zn superoxide dismutase-like0Direct
gamma-Crystallin-like0.00001551Direct
Periplasmic binding protein-like I0.00002636Direct
Periplasmic binding protein-like II0.0001191Direct
Voltage-gated potassium channels0.0001335Direct
Nicotinic receptor ligand binding domain-like0.0007616Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0007616Direct
Inhibitor of apoptosis (IAP) repeat0.007533Inherited
Flavoproteins0.01478Inherited
MHC antigen-recognition domain0.01629Inherited
ACT-like0.01772Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.01772Inherited
Kringle-like0.01928Inherited
HSP20-like chaperones0.04468Inherited
Thioredoxin-like0.05115Inherited
L domain-like0.05437Inherited
Complement control module/SCR domain0.06666Inherited
TIMP-like0.07833Inherited
Class II aaRS and biotin synthetases0.08393Inherited
4-helical cytokines0.09157Inherited
Calcium-dependent phosphotriesterase0.09793Inherited
Cation efflux protein transmembrane domain-like0.09793Inherited
Proton glutamate symport protein0.09793Inherited
Serine protease inhibitors0.09793Inherited
Aquaporin-like0.1056Inherited
ABC transporter transmembrane region0.1071Inherited
TNF-like0.1158Inherited
PGBD-like0.1216Inherited
Nudix0.156Inherited
Mitochondrial carrier0.2138Inherited
YWTD domain0.2681Inherited
SCOP hierarchy in SUPERFAMILY0.3652Inherited
Insulin-like0.3805Inherited
Hemopexin-like domain0.4567Inherited
Immunoglobulin0.4639Inherited
Cytokine0.4928Inherited
Bcl-2 inhibitors of programmed cell death0.5044Inherited
RNI-like0.5466Inherited
Metalloproteases ("zincins"), catalytic domain0.5678Inherited
Fibronectin type III0.5691Inherited
Protein kinase-like (PK-like)0.5783Inherited
Family A G protein-coupled receptor-like0.5999Inherited
Cystine-knot cytokines0.6498Inherited
Riboflavin synthase domain-like0.6875Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.6875Inherited
TNF receptor-like0.8136Inherited
Toll/Interleukin receptor TIR domain0.9126Inherited
Interleukin 8-like chemokines1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
2'-5'-oligoadenylate synthetase 1, OAS1, second domain0Direct
p53 tetramerization domain0Direct
p53 DNA-binding domain-like0Direct
Transferrin0Direct
Multidomain cupredoxins0Direct
Neurotrophin0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Synuclein0Direct
2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Pentraxin (pentaxin)0Direct
Crystallins/Ca-binding development proteins0.00001212Direct
L-arabinose binding protein-like0.00007305Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0007152Direct
Nicotinic receptor ligand binding domain-like0.0007152Direct
C2 set domains0.0007402Direct
Phosphate binding protein-like0.0007782Direct
L domain0.001501Inherited
Inhibitor of apoptosis (IAP) repeat0.005953Inherited
Glutathione peroxidase-like0.006577Inherited
C1 set domains (antibody constant domain-like)0.008057Inherited
Kringle modules0.0121Inherited
MHC antigen-recognition domain0.01255Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.01418Inherited
Phenylalanine metabolism regulatory domain0.01418Inherited
Alpha-macroglobulin receptor domain0.04111Inherited
Complement components0.04111Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.04111Inherited
NADPH-cytochrome p450 reductase-like0.04111Inherited
Long-chain cytokines0.05311Inherited
Complement control module/SCR domain0.05548Inherited
Ngr ectodomain-like0.05548Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.06825Inherited
Cation efflux protein transmembrane domain-like0.07985Inherited
Cytochrome p450 reductase N-terminal domain-like0.07985Inherited
Interleukin 17F, IL-17F0.07985Inherited
Proton glutamate symport protein0.08422Inherited
Aquaporin-like0.08759Inherited
TNF-like0.09808Inherited
MMP N-terminal domain0.1015Inherited
Matrix metalloproteases, catalytic domain0.1116Inherited
Mitochondrial carrier0.1976Inherited
Motor proteins0.2359Inherited
YWTD domain0.2361Inherited
Tetramerization domain of potassium channels0.2361Inherited
ABC transporter ATPase domain-like0.2593Inherited
ABC transporter transmembrane region0.3235Inherited
Insulin-like0.3432Inherited
Interleukin-1 (IL-1)0.3436Inherited
Hemopexin-like domain0.4217Inherited
Bcl-2 inhibitors of programmed cell death0.4668Inherited
V set domains (antibody variable domain-like)0.4682Inherited
Calmodulin-like0.4835Inherited
Fibronectin type III0.5427Inherited
TNF receptor-like0.5745Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.5824Inherited
Rhodopsin-like0.6342Inherited
Transforming growth factor (TGF)-beta0.8355Inherited
Toll/Interleukin receptor TIR domain0.8873Inherited
Interleukin 8-like chemokines1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Synuclein0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cu,Zn superoxide dismutase-like0Direct
p53 tetramerization domain0Direct
gamma-Crystallin-like0.000008619Direct
Periplasmic binding protein-like I0.00001497Direct
Periplasmic binding protein-like II0.00007052Direct
Voltage-gated potassium channels0.00007952Direct
Nicotinic receptor ligand binding domain-like0.0004721Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0004721Direct
Inhibitor of apoptosis (IAP) repeat0.005192Inherited
Flavoproteins0.01049Inherited
MHC antigen-recognition domain0.01162Inherited
ACT-like0.01273Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.01273Inherited
Kringle-like0.01395Inherited
HSP20-like chaperones0.03375Inherited
Thioredoxin-like0.03891Inherited
Alpha-macroglobulin receptor domain0.03962Inherited
L domain-like0.04159Inherited
Complement control module/SCR domain0.05161Inherited
TIMP-like0.06142Inherited
Class II aaRS and biotin synthetases0.06596Inherited
4-helical cytokines0.07234Inherited
Serine protease inhibitors0.07768Inherited
Proton glutamate symport protein0.07768Inherited
Cation efflux protein transmembrane domain-like0.07768Inherited
Calcium-dependent phosphotriesterase0.07768Inherited
Aquaporin-like0.08416Inherited
ABC transporter transmembrane region0.08524Inherited
TNF-like0.09257Inherited
PGBD-like0.09743Inherited
Nudix0.1265Inherited
Mitochondrial carrier0.1774Inherited
Lipoxigenase0.1952Inherited
YWTD domain0.2262Inherited
Insulin-like0.3281Inherited
Hemopexin-like domain0.3984Inherited
Immunoglobulin0.4051Inherited
Cytokine0.4329Inherited
Bcl-2 inhibitors of programmed cell death0.4437Inherited
RNI-like0.484Inherited
Trypsin-like serine proteases0.4973Inherited
Metalloproteases ("zincins"), catalytic domain0.5033Inherited
Fibronectin type III0.5047Inherited
Protein kinase-like (PK-like)0.5133Inherited
Family A G protein-coupled receptor-like0.5337Inherited
Cystine-knot cytokines0.58Inherited
Riboflavin synthase domain-like0.6168Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.6168Inherited
TNF receptor-like0.7413Inherited
Toll/Interleukin receptor TIR domain0.8422Inherited
Interleukin 8-like chemokines0.9811Inherited
ARM repeat0.9814Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    53850,53850
  • 53850 - Periplasmic binding protein-like II
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    57414,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.0004721Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001283Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.001283Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.005287Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.006271Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.02119Inherited
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.03962Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.07768Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.07768Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08524Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.09743Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.1594Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.1952Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.3073Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.3394Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.4437Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.6386Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8887Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57414,57440,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001283Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.01273Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.01273Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.01273Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.08848Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.2311Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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