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Disease Ontology (DO): brain disease

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   disease [DOID:4] <8>
+ + + 3:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ + 2:   nervous system disease [DOID:863] <11>(51|61) (54|28|13)
+ 1:   central nervous system disease [DOID:331] <16>(33|44) (36|21|9)
0:   brain disease [DOID:936] <30>(14|18) (15|6|1)
- 1:   movement disease [DOID:480] <8>(0|0) (1|0|0)
- 1:   prion disease [DOID:649] <8>(0|0) (0|0|0)
- 1:   complex cortical dysplasia with other brain malformations [DOID:0090131] <7>(0|0) (0|0|0)
- 1:   epilepsy [DOID:1826] <7>(5|7) (5|2|0)
- 1:   cerebral degeneration [DOID:1443] <6>(2|2) (2|3|1)
- 1:   encephalitis [DOID:9588] <6>(0|0) (0|0|0)
- 1:   cerebral palsy [DOID:1969] <4>(0|0) (0|0|0)
- 1:   basal ganglia disease [DOID:679] <3>(0|0) (0|0|0)
- 1:   cerebellar disease [DOID:2786] <2>(0|0) (0|0|0)
- 1:   intracranial hypertension [DOID:9428] <2>(0|0) (0|0|0)
- 1:   migraine [DOID:6364] <2>(5|5) (5|0|0)
- 1:   encephalomalacia [DOID:2034] <1>(0|0) (0|0|0)
- 1:   hepatic encephalopathy [DOID:13413] <1>(0|0) (0|0|0)
- 1:   hypothalamic disease [DOID:1931] <1>(0|0) (0|0|0)
- 1:   COL4A1-related familial vascular leukoencephalopathy [DOID:0090125](0|0) (0|0|0)
- 1:   Wernicke encephalopathy [DOID:2384](0|0) (0|0|0)
- 1:   akinetic mutism [DOID:4267](0|0) (0|0|0)
- 1:   brain compression [DOID:11457](0|0) (0|0|0)
- 1:   brain edema [DOID:4724](0|0) (0|0|0)
- 1:   central nervous system origin vertigo [DOID:2479](0|0) (0|0|0)
- 1:   cerebritis [DOID:3431](0|0) (0|0|0)
- 1:   cortical dysplasia-focal epilepsy syndrome [DOID:0090130](0|0) (0|0|0)
- 1:   diabetic encephalopathy [DOID:0050850](0|0) (0|0|0)
- 1:   hypoglycemic coma [DOID:1607](0|0) (0|0|0)
- 1:   intracranial hypotension [DOID:4723](0|0) (0|0|0)
- 1:   kernicterus [DOID:2382](0|0) (0|0|0)
- 1:   olfactory nerve disease [DOID:367](0|0) (0|0|0)
- 1:   porencephaly [DOID:0060263](0|0) (0|0|0)
- 1:   pseudobulbar palsy [DOID:12680](0|0) (0|0|0)
- 1:   thalamic disease [DOID:4662](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Voltage-gated potassium channels0.00002964Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.0002238Direct
ACT-like0.0002238Direct
ABC transporter transmembrane region0.0004921Direct
Neurotransmitter-gated ion-channel transmembrane pore0.001353Inherited
Nicotinic receptor ligand binding domain-like0.001353Inherited
Periplasmic binding protein-like I0.01874Inherited
Family A G protein-coupled receptor-like0.07195Inherited
Periplasmic binding protein-like II0.0916Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1507Inherited
Riboflavin synthase domain-like0.1507Inherited
Flavoproteins0.2614Inherited
Kringle-like0.4432Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Multidomain cupredoxins0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.0001632Direct
Phenylalanine metabolism regulatory domain0.0001632Direct
Cytochrome p450 reductase N-terminal domain-like0.0001632Direct
Interleukin-1 (IL-1)0.0004285Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0009132Direct
Nicotinic receptor ligand binding domain-like0.0009132Direct
ABC transporter transmembrane region0.00934Inherited
ABC transporter ATPase domain-like0.01281Inherited
Calmodulin-like0.02149Inherited
Phosphate binding protein-like0.0388Inherited
L-arabinose binding protein-like0.04352Inherited
NADPH-cytochrome p450 reductase-like0.04623Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.04623Inherited
Rhodopsin-like0.06876Inherited
Tetramerization domain of potassium channels0.1249Inherited
Kringle modules0.4522Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Voltage-gated potassium channels0.00001687Direct
ACT-like0.0001343Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.0001343Direct
ABC transporter transmembrane region0.0003006Direct
Nicotinic receptor ligand binding domain-like0.0008612Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0008612Direct
Periplasmic binding protein-like I0.01352Inherited
Family A G protein-coupled receptor-like0.05604Inherited
Periplasmic binding protein-like II0.07238Inherited
Riboflavin synthase domain-like0.122Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.122Inherited
L domain-like0.2174Inherited
Flavoproteins0.22Inherited
Kringle-like0.3861Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0003006Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.0008612Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0.04522Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.2063Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.3247Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.22Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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