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Enzyme Commission (EC): Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <7>
+ 1:   Oxidoreductases [1] <26>(213|314) (212|187|94)
0:   Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate [1.14] <15>(44|52) (44|23|8)
- 1:   With NADH or NADPH as one donor, and incorporation of one atom of oxygen [1.14.13] <255>(14|16) (14|11|5)
- 1:   With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [1.14.14] <172>(11|12) (11|4|1)
- 1:   With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules o [1.14.19] <81>(2|2) (2|0|0)
- 1:   Miscellaneous [1.14.99] <70>(8|7) (8|1|0)
- 1:   With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [1.14.11] <67>(7|11) (7|3|0)
- 1:   With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [1.14.15] <37>(8|6) (8|3|1)
- 1:   With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [1.14.12] <27>(6|6) (6|3|1)
- 1:   With 2-oxoglutarate as one donor, and the other dehydrogenated [1.14.20] <15>(1|1) (1|0|0)
- 1:   With NADH or NADPH as one donor, and the other dehydrogenated [1.14.21] <12>(0|0) (0|0|0)
- 1:   With NADH or NADPH as one donor [1.14.1] <11>(0|0) (0|0|0)
- 1:   With another compound as one donor, and incorporation of one atom of oxygen [1.14.18] <11>(6|4) (6|3|1)
- 1:   With reduced pteridine as one donor, and incorporation of one atom of oxygen [1.14.16] <7>(2|2) (2|1|0)
- 1:   With reduced ascorbate as one donor, and incorporation of one atom of oxygen [1.14.17] <4>(4|3) (4|1|0)
- 1:   With ascorbate as one donor [1.14.2] <2>(0|0) (0|0|0)
- 1:   With reduced pteridine as one donor [1.14.3] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DinB/YfiT-like putative metalloenzymes0Direct
Cytochrome P4500Direct
FAD/NAD(P)-binding domain0Direct
PHM/PNGase F0Direct
Di-copper centre-containing domain0Direct
Ferritin-like0Direct
Globin-like0Direct
Bacterial luciferase-like0Direct
Riboflavin synthase domain-like0Direct
TPR-like0Direct
ISP domain0Direct
Hemocyanin, N-terminal domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
Calponin-homology domain, CH-domain0Direct
NTF2-like0Direct
Bet v1-like0Direct
Clavaminate synthase-like0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
ARM repeat0Direct
EGF/Laminin5.087e-16Direct
FYVE/PHD zinc finger0.000000000000001511Direct
Heme oxygenase-like0.0000000000001413Direct
Dimeric alpha+beta barrel0.0000000000003427Direct
ACT-like0.000000000001578Direct
SMAD/FHA domain0.00000005518Direct
RNI-like0.0000007857Direct
HIT/MYND zinc finger-like0.00001073Direct
NHL repeat0.00001371Direct
C-type lectin-like0.0000217Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0004507Direct
Calcium-dependent phosphotriesterase0.001666Inherited
PDZ domain-like0.001823Inherited
Metallo-hydrolase/oxidoreductase0.0116Inherited
E set domains0.05758Inherited
Acyl-CoA dehydrogenase NM domain-like0.164Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.2496Inherited
2Fe-2S ferredoxin-like0.4008Inherited
Nucleotide-diphospho-sugar transferases1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
FAD-linked reductases, C-terminal domain1Inherited
Flavoproteins1Inherited
Heme-dependent peroxidases1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Bacterial luciferase (alkanal monooxygenase)0Direct
TauD/TfdA-like0Direct
Clavaminate synthase0Direct
Ribonucleotide reductase-like0Direct
Ring hydroxylating alpha subunit catalytic domain0Direct
Peptidylglycine alpha-hydroxylating monooxygenase, PHM0Direct
Penicillin synthase-like0Direct
Ring hydroxylating beta subunit0Direct
Hypoxia-inducible factor HIF ihhibitor (FIH1)0Direct
Asparaginyl hydroxylase-like0Direct
Flavohemoglobin, C-terminal domain0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
FAD-linked reductases, N-terminal domain0Direct
Calponin-homology domain, CH-domain0Direct
Ring hydroxylating alpha subunit ISP domain0Direct
Hemocyanin middle domain0Direct
PG130-like0Direct
Eukaryotic type heme oxygenase0Direct
Hemocyanin, N-terminal domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
EGF-type module0Direct
Cytochrome b50Direct
PHBH-like0Direct
Globins0Direct
PhyH-like0Direct
PBS lyase HEAT-like repeat0Direct
Phenylalanine metabolism regulatory domain0Direct
Cytochrome P4500Direct
Ssud-like monoxygenases0Direct
AlkB-like0Direct
Type II Proline 3-hydroxylase (proline oxidase)0Direct
Arthropod hemocyanin, C-terminal domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Tetratricopeptide repeat (TPR)0.0000000000005465Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0000000000006295Direct
NADPH-cytochrome p450 reductase-like0.00000000001081Direct
Cytochrome p450 reductase N-terminal domain-like0.0000000005094Direct
Myeloperoxidase-like0.00000004938Direct
PDZ domain0.0000000654Direct
FHA domain0.0000001002Direct
PHD domain0.0000001762Direct
LIM domain0.0000002255Direct
Flavodoxin-related0.000003079Direct
NHL repeat0.000003571Direct
Aromatic dioxygenase reductase-like0.000004844Direct
Sulfatase-modifying factor-like0.000004844Direct
FAD/NAD-linked reductases, N-terminal and central domains0.005231Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.02064Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.3276Inherited
E-set domains of sugar-utilizing enzymes0.3611Inherited
2Fe-2S ferredoxin domains from multidomain proteins0.7717Inherited
Tandem AAA-ATPase domain1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
ARM repeat0Direct
Riboflavin synthase domain-like0Direct
Hemocyanin, N-terminal domain0Direct
Cytochrome P4500Direct
Clavaminate synthase-like0Direct
Bet v1-like0Direct
Calponin-homology domain, CH-domain0Direct
DinB/YfiT-like putative metalloenzymes0Direct
Globin-like0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
TPR-like0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
Ferritin-like0Direct
ISP domain0Direct
Bacterial luciferase-like0Direct
FAD/NAD(P)-binding domain0Direct
PHM/PNGase F0Direct
Di-copper centre-containing domain0Direct
NTF2-like0Direct
EGF/Laminin3.541e-16Direct
FYVE/PHD zinc finger0.000000000000001057Direct
Heme oxygenase-like0.0000000000001004Direct
Dimeric alpha+beta barrel0.0000000000002449Direct
ACT-like0.000000000001137Direct
SMAD/FHA domain0.00000004211Direct
RNI-like0.0000006121Direct
HIT/MYND zinc finger-like0.000008509Direct
NHL repeat0.0000109Direct
C-type lectin-like0.0000173Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0003686Direct
Calcium-dependent phosphotriesterase0.001383Inherited
PDZ domain-like0.001517Inherited
Metallo-hydrolase/oxidoreductase0.009855Inherited
E set domains0.04995Inherited
Acyl-CoA dehydrogenase NM domain-like0.1449Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.223Inherited
2Fe-2S ferredoxin-like0.3635Inherited
Nucleotide-diphospho-sugar transferases1Inherited
Flavoproteins1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
Heme-dependent peroxidases1Inherited
FAD-linked reductases, C-terminal domain1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50022,55961
  • 50022 - ISP domain
  • 55961 - Bet v1-like
  • 0Direct
    47576,57716
  • 47576 - Calponin-homology domain, CH-domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    48056,81296
  • 48056 - Di-copper centre-containing domain
  • 81296 - E set domains
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    51905,47576
  • 51905 - FAD/NAD(P)-binding domain
  • 47576 - Calponin-homology domain, CH-domain
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    48050,48056
  • 48050 - Hemocyanin, N-terminal domain
  • 48056 - Di-copper centre-containing domain
  • 0Direct
    46458,63380
  • 46458 - Globin-like
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    56512,52218
  • 56512 - Nitric oxide (NO) synthase oxygenase domain
  • 52218 - Flavoproteins
  • 0Direct
    50022,56281
  • 50022 - ISP domain
  • 56281 - Metallo-hydrolase/oxidoreductase
  • 0Direct
    57196,48113
  • 57196 - EGF/Laminin
  • 48113 - Heme-dependent peroxidases
  • 0Direct
    49742,49742
  • 49742 - PHM/PNGase F
  • 49742 - PHM/PNGase F
  • 0Direct
    48264,52218
  • 48264 - Cytochrome P450
  • 52218 - Flavoproteins
  • 0Direct
    48452,51197
  • 48452 - TPR-like
  • 51197 - Clavaminate synthase-like
  • 0Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 5.307e-16Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.00000000008836Direct
    52343,54292
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 54292 - 2Fe-2S ferredoxin-like
  • 0.000000002854Direct
    54292,63380
  • 54292 - 2Fe-2S ferredoxin-like
  • 63380 - Riboflavin synthase domain-like
  • 0.00005274Direct
    52218,63380
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0.00377Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.2149Inherited
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.9904Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48264,52218,63380
  • 48264 - Cytochrome P450
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    47576,57716,57716
  • 47576 - Calponin-homology domain, CH-domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    51905,47576,57716
  • 51905 - FAD/NAD(P)-binding domain
  • 47576 - Calponin-homology domain, CH-domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    56512,52218,63380
  • 56512 - Nitric oxide (NO) synthase oxygenase domain
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    48050,48056,81296
  • 48050 - Hemocyanin, N-terminal domain
  • 48056 - Di-copper centre-containing domain
  • 81296 - E set domains
  • 0Direct
    46458,63380,52343
  • 46458 - Globin-like
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    63380,52343,54292
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 54292 - 2Fe-2S ferredoxin-like
  • 0.000000002854Direct
    54292,63380,52343
  • 54292 - 2Fe-2S ferredoxin-like
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.00005274Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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