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Enzyme Commission (EC): Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <7>
+ 1:   Oxidoreductases [1] <26>(213|314) (212|187|94)
0:   Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate [1.14] <15>(44|52) (44|23|8)
- 1:   With NADH or NADPH as one donor, and incorporation of one atom of oxygen [1.14.13] <255>(14|16) (14|11|5)
- 1:   With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [1.14.14] <172>(11|12) (11|4|1)
- 1:   With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules o [1.14.19] <81>(2|2) (2|0|0)
- 1:   Miscellaneous [1.14.99] <70>(8|7) (8|1|0)
- 1:   With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [1.14.11] <67>(7|11) (7|3|0)
- 1:   With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [1.14.15] <37>(8|6) (8|3|1)
- 1:   With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [1.14.12] <27>(6|6) (6|3|1)
- 1:   With 2-oxoglutarate as one donor, and the other dehydrogenated [1.14.20] <15>(1|1) (1|0|0)
- 1:   With NADH or NADPH as one donor, and the other dehydrogenated [1.14.21] <12>(0|0) (0|0|0)
- 1:   With NADH or NADPH as one donor [1.14.1] <11>(0|0) (0|0|0)
- 1:   With another compound as one donor, and incorporation of one atom of oxygen [1.14.18] <11>(6|4) (6|3|1)
- 1:   With reduced pteridine as one donor, and incorporation of one atom of oxygen [1.14.16] <7>(2|2) (2|1|0)
- 1:   With reduced ascorbate as one donor, and incorporation of one atom of oxygen [1.14.17] <4>(4|3) (4|1|0)
- 1:   With ascorbate as one donor [1.14.2] <2>(0|0) (0|0|0)
- 1:   With reduced pteridine as one donor [1.14.3] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
NTF2-like0Direct
TPR-like0Direct
Clavaminate synthase-like0Direct
Ferritin-like0Direct
PHM/PNGase F0Direct
FAD/NAD(P)-binding domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Bacterial luciferase-like0Direct
ISP domain0Direct
Riboflavin synthase domain-like0Direct
DinB/YfiT-like putative metalloenzymes0Direct
Bet v1-like0Direct
Calponin-homology domain, CH-domain0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
Cytochrome P4500Direct
Globin-like0Direct
ARM repeat0Direct
Di-copper centre-containing domain0Direct
Hemocyanin, N-terminal domain0Direct
EGF/Laminin2.558e-16Direct
FYVE/PHD zinc finger0.000000000000001011Direct
Heme oxygenase-like0.00000000000009382Direct
Dimeric alpha+beta barrel0.0000000000002595Direct
ACT-like0.000000000001067Direct
SMAD/FHA domain0.00000004716Direct
RNI-like0.0000006838Direct
HIT/MYND zinc finger-like0.000009982Direct
NHL repeat0.00001256Direct
C-type lectin-like0.00001954Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0003632Direct
Calcium-dependent phosphotriesterase0.001558Inherited
PDZ domain-like0.001662Inherited
Metallo-hydrolase/oxidoreductase0.01007Inherited
E set domains0.05152Inherited
Acyl-CoA dehydrogenase NM domain-like0.1495Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.2309Inherited
2Fe-2S ferredoxin-like0.3747Inherited
Heme-dependent peroxidases1Inherited
Nucleotide-diphospho-sugar transferases1Inherited
Flavoproteins1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
FAD-linked reductases, C-terminal domain1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Type II Proline 3-hydroxylase (proline oxidase)0Direct
Calponin-homology domain, CH-domain0Direct
Ring hydroxylating beta subunit0Direct
PG130-like0Direct
Clavaminate synthase0Direct
Phenylalanine metabolism regulatory domain0Direct
Ribonucleotide reductase-like0Direct
Eukaryotic type heme oxygenase0Direct
Cytochrome b50Direct
Hemocyanin middle domain0Direct
Bacterial luciferase (alkanal monooxygenase)0Direct
PHBH-like0Direct
Peptidylglycine alpha-hydroxylating monooxygenase, PHM0Direct
Hemocyanin, N-terminal domain0Direct
EGF-type module0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Penicillin synthase-like0Direct
Hypoxia-inducible factor HIF ihhibitor (FIH1)0Direct
AlkB-like0Direct
Ring hydroxylating alpha subunit ISP domain0Direct
PBS lyase HEAT-like repeat0Direct
Arthropod hemocyanin, C-terminal domain0Direct
FAD-linked reductases, N-terminal domain0Direct
Cytochrome P4500Direct
TauD/TfdA-like0Direct
Ssud-like monoxygenases0Direct
PhyH-like0Direct
Asparaginyl hydroxylase-like0Direct
Ring hydroxylating alpha subunit catalytic domain0Direct
Flavohemoglobin, C-terminal domain0Direct
Globins0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0000000000003411Direct
Tetratricopeptide repeat (TPR)0.0000000000003931Direct
NADPH-cytochrome p450 reductase-like0.000000000006117Direct
Cytochrome p450 reductase N-terminal domain-like0.0000000003108Direct
Myeloperoxidase-like0.00000003544Direct
PDZ domain0.00000005702Direct
FHA domain0.00000008391Direct
PHD domain0.000000145Direct
LIM domain0.0000002011Direct
Flavodoxin-related0.00000271Direct
NHL repeat0.00000319Direct
Sulfatase-modifying factor-like0.000004186Direct
Aromatic dioxygenase reductase-like0.000004186Direct
FAD/NAD-linked reductases, N-terminal and central domains0.0035Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.01769Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.3073Inherited
E-set domains of sugar-utilizing enzymes0.3449Inherited
2Fe-2S ferredoxin domains from multidomain proteins0.7481Inherited
Tandem AAA-ATPase domain1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
ARM repeat0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
TPR-like0Direct
FAD/NAD(P)-binding domain0Direct
NTF2-like0Direct
ISP domain0Direct
PHM/PNGase F0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
Calponin-homology domain, CH-domain0Direct
Di-copper centre-containing domain0Direct
Hemocyanin, N-terminal domain0Direct
Bacterial luciferase-like0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Cytochrome P4500Direct
Ferritin-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Bet v1-like0Direct
Riboflavin synthase domain-like0Direct
Clavaminate synthase-like0Direct
Globin-like0Direct
DinB/YfiT-like putative metalloenzymes0Direct
EGF/Laminin1.776e-16Direct
FYVE/PHD zinc finger7.055e-16Direct
Heme oxygenase-like0.00000000000006663Direct
Dimeric alpha+beta barrel0.0000000000001853Direct
ACT-like0.0000000000007676Direct
SMAD/FHA domain0.00000003597Direct
RNI-like0.0000005324Direct
HIT/MYND zinc finger-like0.000007909Direct
NHL repeat0.000009969Direct
C-type lectin-like0.00001558Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0002964Direct
Calcium-dependent phosphotriesterase0.001293Inherited
PDZ domain-like0.001381Inherited
Metallo-hydrolase/oxidoreductase0.008536Inherited
E set domains0.04457Inherited
Acyl-CoA dehydrogenase NM domain-like0.1317Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.2058Inherited
2Fe-2S ferredoxin-like0.3394Inherited
Flavoproteins1Inherited
Nucleotide-diphospho-sugar transferases1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
FAD-linked reductases, C-terminal domain1Inherited
Heme-dependent peroxidases1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48452,51197
  • 48452 - TPR-like
  • 51197 - Clavaminate synthase-like
  • 0Direct
    51905,47576
  • 51905 - FAD/NAD(P)-binding domain
  • 47576 - Calponin-homology domain, CH-domain
  • 0Direct
    48056,81296
  • 48056 - Di-copper centre-containing domain
  • 81296 - E set domains
  • 0Direct
    47576,57716
  • 47576 - Calponin-homology domain, CH-domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    50022,55961
  • 50022 - ISP domain
  • 55961 - Bet v1-like
  • 0Direct
    50022,56281
  • 50022 - ISP domain
  • 56281 - Metallo-hydrolase/oxidoreductase
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    49742,49742
  • 49742 - PHM/PNGase F
  • 49742 - PHM/PNGase F
  • 0Direct
    56512,52218
  • 56512 - Nitric oxide (NO) synthase oxygenase domain
  • 52218 - Flavoproteins
  • 0Direct
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    46458,63380
  • 46458 - Globin-like
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    48264,52218
  • 48264 - Cytochrome P450
  • 52218 - Flavoproteins
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    57196,48113
  • 57196 - EGF/Laminin
  • 48113 - Heme-dependent peroxidases
  • 0Direct
    48050,48056
  • 48050 - Hemocyanin, N-terminal domain
  • 48056 - Di-copper centre-containing domain
  • 0Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 3.539e-16Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.00000000004585Direct
    52343,54292
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 54292 - 2Fe-2S ferredoxin-like
  • 0.000000002508Direct
    54292,63380
  • 54292 - 2Fe-2S ferredoxin-like
  • 63380 - Riboflavin synthase domain-like
  • 0.00004692Direct
    52218,63380
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0.003214Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.198Inherited
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.9788Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48264,52218,63380
  • 48264 - Cytochrome P450
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    47576,57716,57716
  • 47576 - Calponin-homology domain, CH-domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    56512,52218,63380
  • 56512 - Nitric oxide (NO) synthase oxygenase domain
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    46458,63380,52343
  • 46458 - Globin-like
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    51905,47576,57716
  • 51905 - FAD/NAD(P)-binding domain
  • 47576 - Calponin-homology domain, CH-domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    48050,48056,81296
  • 48050 - Hemocyanin, N-terminal domain
  • 48056 - Di-copper centre-containing domain
  • 81296 - E set domains
  • 0Direct
    63380,52343,54292
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 54292 - 2Fe-2S ferredoxin-like
  • 0.000000002508Direct
    54292,63380,52343
  • 54292 - 2Fe-2S ferredoxin-like
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.00004692Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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