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Enzyme Commission (EC): Acting on the aldehyde or oxo group of donors

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <7>
+ 1:   Oxidoreductases [1] <26>(215|316) (214|192|95)
0:   Acting on the aldehyde or oxo group of donors [1.2] <8>(34|38) (34|26|14)
- 1:   With NAD(+) or NADP(+) as acceptor [1.2.1] <103>(14|15) (14|10|3)
- 1:   With oxygen as acceptor [1.2.3] <15>(9|8) (9|6|4)
- 1:   With an iron-sulfur protein as acceptor [1.2.7] <12>(11|8) (11|7|3)
- 1:   With other acceptors [1.2.99] <10>(6|5) (6|3|0)
- 1:   With a cytochrome as acceptor [1.2.2] <4>(0|0) (0|0|0)
- 1:   With a disulfide as acceptor [1.2.4] <4>(3|7) (3|2|1)
- 1:   With a quinone or similar compound as acceptor [1.2.5] <3>(1|1) (1|0|0)
- 1:   With other, known, acceptors [1.2.98] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
ALDH-like0Direct
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III0Direct
Glutamyl tRNA-reductase catalytic, N-terminal domain0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
N-terminal domain of bifunctional PutA protein0Direct
Glutamyl tRNA-reductase dimerization domain0Direct
Aldehyde ferredoxin oxidoreductase, C-terminal domains0Direct
NAD(P)-binding Rossmann-fold domains0Direct
Ribbon-helix-helix0Direct
Molybdenum cofactor-binding domain0Direct
CO dehydrogenase ISP C-domain like0Direct
Aldehyde ferredoxin oxidoreductase, N-terminal domain0Direct
TK C-terminal domain-like0Direct
CO dehydrogenase flavoprotein C-terminal domain-like5.058e-16Direct
FAD-linked reductases, C-terminal domain0.000000000007037Direct
CoA-dependent acyltransferases0.0000008531Direct
ACP-like0.0005672Direct
Alpha subunit of glutamate synthase, C-terminal domain0.001239Inherited
Galactose oxidase, central domain0.00362Inherited
2Fe-2S ferredoxin-like0.01134Inherited
Prismane protein-like0.0373Inherited
alpha-helical ferredoxin0.5596Inherited
Acetyl-CoA synthetase-like0.6568Inherited
FAD-linked oxidoreductase0.8377Inherited
FAD/NAD(P)-binding domain1Inherited
Carbamate kinase-like1Inherited
4Fe-4S ferredoxins1Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like1Inherited
ADC-like1Inherited
RmlC-like cupins1Inherited
E set domains1Inherited
FAD-binding/transporter-associated domain-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Aldehyde ferredoxin oxidoreductase, N-terminal domain0Direct
Glutamyl tRNA-reductase dimerization domain0Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
Glutamyl tRNA-reductase catalytic, N-terminal domain0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
CO dehydrogenase flavoprotein N-terminal domain-like0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
ALDH-like0Direct
Carbon monoxide dehydrogenase0Direct
Aldehyde ferredoxin oxidoreductase, C-terminal domains0Direct
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III0Direct
N-terminal domain of bifunctional PutA protein0Direct
PutA pre-N-terminal region-like0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
GMC oxidoreductases0Direct
Molybdenum cofactor-binding domain0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
PFOR Pyr module0Direct
GAPDH-like0Direct
CO dehydrogenase molybdoprotein N-domain-like1.846e-16Direct
CO dehydrogenase ISP C-domain like3.677e-16Direct
CO dehydrogenase flavoprotein C-terminal domain-like0.000000000000002537Direct
PFOR PP module0.00000000000001255Direct
Pyruvate-ferredoxin oxidoreductase, PFOR, domain II0.0000000000005928Direct
FAD-linked reductases, N-terminal domain0.00000000006835Direct
Transketolase C-terminal domain-like0.000000008204Direct
TK-like Pyr module0.000001055Direct
Peptidyl carrier domain0.000008076Direct
CAT-like0.00001361Direct
2Fe-2S ferredoxin domains from multidomain proteins0.00004126Direct
Germin/Seed storage 7S protein0.0002112Direct
Galactose oxidase, central domain0.001368Inherited
Alpha subunit of glutamate synthase, C-terminal domain0.001526Inherited
TK-like PP module0.003083Inherited
Proline dehydrohenase domain of bifunctional PutA protein0.1522Inherited
Acetyl-CoA synthetase-like0.8057Inherited
PyrH-like0.8151Inherited
Tyrosine-dependent oxidoreductases1Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
ALDH-like0Direct
Aldehyde ferredoxin oxidoreductase, C-terminal domains0Direct
Aldehyde ferredoxin oxidoreductase, N-terminal domain0Direct
CO dehydrogenase ISP C-domain like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
N-terminal domain of bifunctional PutA protein0Direct
Glutamyl tRNA-reductase catalytic, N-terminal domain0Direct
Ribbon-helix-helix0Direct
Molybdenum cofactor-binding domain0Direct
NAD(P)-binding Rossmann-fold domains0Direct
Glutamyl tRNA-reductase dimerization domain0Direct
TK C-terminal domain-like0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
CO dehydrogenase flavoprotein C-terminal domain-like3.526e-16Direct
FAD-linked reductases, C-terminal domain0.000000000005099Direct
CoA-dependent acyltransferases0.0000006652Direct
ACP-like0.0004662Direct
Alpha subunit of glutamate synthase, C-terminal domain0.001028Inherited
Galactose oxidase, central domain0.003036Inherited
2Fe-2S ferredoxin-like0.009632Inherited
Prismane protein-like0.03211Inherited
alpha-helical ferredoxin0.5117Inherited
Acetyl-CoA synthetase-like0.602Inherited
FAD-linked oxidoreductase0.771Inherited
Carbamate kinase-like0.9674Inherited
E set domains1Inherited
RmlC-like cupins1Inherited
4Fe-4S ferredoxins1Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like1Inherited
FAD-binding/transporter-associated domain-like1Inherited
FAD/NAD(P)-binding domain1Inherited
ADC-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52518,54862
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    81935,51730
  • 81935 - N-terminal domain of bifunctional PutA protein
  • 51730 - FAD-linked oxidoreductase
  • 0Direct
    53323,54862
  • 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    54292,47741
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 0Direct
    56821,46548
  • 56821 - Prismane protein-like
  • 46548 - alpha-helical ferredoxin
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    53323,52518
  • 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    53633,53720
  • 53633 - Carbamate kinase-like
  • 53720 - ALDH-like
  • 0Direct
    51730,53720
  • 51730 - FAD-linked oxidoreductase
  • 53720 - ALDH-like
  • 0Direct
    47598,81935
  • 47598 - Ribbon-helix-helix
  • 81935 - N-terminal domain of bifunctional PutA protein
  • 0Direct
    56228,48310
  • 56228 - Aldehyde ferredoxin oxidoreductase, N-terminal domain
  • 48310 - Aldehyde ferredoxin oxidoreductase, C-terminal domains
  • 0Direct
    54862,52518
  • 54862 - 4Fe-4S ferredoxins
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    69742,51735
  • 69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    51735,69075
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 69075 - Glutamyl tRNA-reductase dimerization domain
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    54665,56003
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 56003 - Molybdenum cofactor-binding domain
  • 0Direct
    69336,50692
  • 69336 - Alpha subunit of glutamate synthase, C-terminal domain
  • 50692 - ADC-like
  • 0Direct
    53720,56796
  • 53720 - ALDH-like
  • 56796 - Dehydroquinate synthase-like
  • 0Direct
    55447,54665
  • 55447 - CO dehydrogenase flavoprotein C-terminal domain-like
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 1.769e-16Direct
    56176,55447
  • 56176 - FAD-binding/transporter-associated domain-like
  • 55447 - CO dehydrogenase flavoprotein C-terminal domain-like
  • 3.526e-16Direct
    47741,56176
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 7.033e-16Direct
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.00000000000005877Direct
    52777,56801
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 0.0000001246Direct
    52922,52518
  • 52922 - TK C-terminal domain-like
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0.00000335Direct
    50965,81296
  • 50965 - Galactose oxidase, central domain
  • 81296 - E set domains
  • 0.001134Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52518,52922,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    52922,53323,54862
  • 52922 - TK C-terminal domain-like
  • 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    81935,51730,53720
  • 81935 - N-terminal domain of bifunctional PutA protein
  • 51730 - FAD-linked oxidoreductase
  • 53720 - ALDH-like
  • 0Direct
    69742,51735,69075
  • 69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 69075 - Glutamyl tRNA-reductase dimerization domain
  • 0Direct
    53323,52518,52922
  • 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    52518,52922,53323
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
  • 0Direct
    53323,54862,52518
  • 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
  • 54862 - 4Fe-4S ferredoxins
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    52922,52518,54862
  • 52922 - TK C-terminal domain-like
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    47598,81935,51730
  • 47598 - Ribbon-helix-helix
  • 81935 - N-terminal domain of bifunctional PutA protein
  • 51730 - FAD-linked oxidoreductase
  • 0Direct
    55447,54665,56003
  • 55447 - CO dehydrogenase flavoprotein C-terminal domain-like
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 56003 - Molybdenum cofactor-binding domain
  • 1.769e-16Direct
    56176,55447,54665
  • 56176 - FAD-binding/transporter-associated domain-like
  • 55447 - CO dehydrogenase flavoprotein C-terminal domain-like
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 1.769e-16Direct
    54292,47741,56176
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 7.033e-16Direct
    47741,56176,55447
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 55447 - CO dehydrogenase flavoprotein C-terminal domain-like
  • 0.000000000000003312Direct
    52518,52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0.262Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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