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Enzyme Commission (EC): Acting on the CH-CH group of donors

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <7>
+ 1:   Oxidoreductases [1] <26>(213|314) (212|187|94)
0:   Acting on the CH-CH group of donors [1.3] <9>(40|44) (40|25|12)
- 1:   With NAD(+) or NADP(+) as acceptor [1.3.1] <123>(28|28) (28|20|10)
- 1:   With other acceptors [1.3.99] <43>(3|3) (3|1|0)
- 1:   With an iron-sulfur protein as acceptor [1.3.7] <15>(3|2) (3|0|0)
- 1:   With oxygen as acceptor [1.3.3] <15>(6|6) (6|3|1)
- 1:   With a flavin as acceptor [1.3.8] <14>(2|2) (2|1|0)
- 1:   With a quinone or related compound as acceptor [1.3.5] <6>(7|7) (7|3|1)
- 1:   With other, known, acceptors [1.3.98] <6>(2|2) (2|0|0)
- 1:   With a cytochrome as acceptor [1.3.2] <3>(0|0) (0|0|0)
- 1:   With a disulfide as acceptor [1.3.4] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Acyl-CoA dehydrogenase NM domain-like0Direct
FMN-linked oxidoreductases0Direct
"Helical backbone" metal receptor0Direct
Heme oxygenase-like0Direct
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain0Direct
Tetrapyrrole methylase0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
alpha-helical ferredoxin0Direct
Coproporphyrinogen III oxidase0Direct
Siroheme synthase middle domains-like0Direct
FAD-binding/transporter-associated domain-like0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
2Fe-2S ferredoxin-like0.00000000000001828Direct
FabD/lysophospholipase-like0.0000002666Direct
Tudor/PWWP/MBT0.00004062Direct
Chorismate mutase II0.00008261Direct
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.0002281Direct
Nucleotide-binding domain0.0004176Direct
ACP-like0.004702Inherited
Ubiquitin-like0.005616Inherited
FAD/NAD(P)-binding domain0.02713Inherited
GroES-like0.0275Inherited
ACT-like0.2832Inherited
Thioesterase/thiol ester dehydrase-isomerase0.4306Inherited
Multiheme cytochromes0.7521Inherited
4Fe-4S ferredoxins1Inherited
Radical SAM enzymes1Inherited
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain1Inherited
alpha/beta-Hydrolases1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
NAD(P)-linked oxidoreductase1Inherited
Inosine monophosphate dehydrogenase (IMPDH)1Inherited
Flavoproteins1Inherited
Thiolase-like1Inherited
FAD-linked reductases, C-terminal domain1Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
Dehydroquinate synthase-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain0Direct
acyl-CoA oxidase C-terminal domains0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain0Direct
Siroheme synthase middle domains-like0Direct
TyrA dimerization domain-like0Direct
FMN-linked oxidoreductases0Direct
Coproporphyrinogen III oxidase0Direct
2Fe-2S ferredoxin domains from multidomain proteins0Direct
Tetrapyrrole methylase0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
Biliverdin reductase0Direct
Nitrogenase iron-molybdenum protein0Direct
Siroheme synthase N-terminal domain-like0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
acyl-CoA oxidase N-terminal domains0Direct
PqqC-like0Direct
Nitrogenase iron protein-like0Direct
Oxygen-independent coproporphyrinogen III oxidase HemN0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain0Direct
Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain0Direct
Dihydropyrimidine dehydrogenase, N-terminal domain0.000000000009313Direct
Acyl-carrier protein (ACP)0.00000000003432Direct
FabD-like0.0000000002618Direct
Thioesterase domain of polypeptide, polyketide and fatty acid synthases0.00000002109Direct
N-terminal domain of adrenodoxin reductase-like0.00000005312Direct
Tudor domain0.0000006461Direct
Tyrosine-dependent oxidoreductases0.000001134Direct
MaoC-like0.0001295Direct
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.0006392Direct
L-aminoacid/polyamine oxidase0.0007251Direct
Alcohol dehydrogenase-like, C-terminal domain0.00553Inherited
Ferredoxin domains from multidomain proteins0.01145Inherited
Alcohol dehydrogenase-like, N-terminal domain0.02227Inherited
NADPH-dependent FMN reductase0.1188Inherited
Thiolase-related0.2322Inherited
Glucose 6-phosphate dehydrogenase-like0.3167Inherited
Di-heme elbow motif0.6825Inherited
Iron-containing alcohol dehydrogenase0.8241Inherited
Aldo-keto reductases (NADP)0.9364Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain1Inherited
FAD-linked reductases, N-terminal domain1Inherited
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain1Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Tetrapyrrole methylase0Direct
Heme oxygenase-like0Direct
Siroheme synthase middle domains-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
FMN-linked oxidoreductases0Direct
Coproporphyrinogen III oxidase0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
"Helical backbone" metal receptor0Direct
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain0Direct
FAD-binding/transporter-associated domain-like0Direct
alpha-helical ferredoxin0Direct
2Fe-2S ferredoxin-like0.00000000000001288Direct
FabD/lysophospholipase-like0.0000002052Direct
Tudor/PWWP/MBT0.00003248Direct
Chorismate mutase II0.00006645Direct
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.0001852Direct
Nucleotide-binding domain0.0003406Direct
ACP-like0.003942Inherited
Ubiquitin-like0.004719Inherited
FAD/NAD(P)-binding domain0.02326Inherited
GroES-like0.02358Inherited
ACT-like0.2549Inherited
Thioesterase/thiol ester dehydrase-isomerase0.3914Inherited
Multiheme cytochromes0.6919Inherited
NAD(P)-linked oxidoreductase0.9475Inherited
4Fe-4S ferredoxins0.9531Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like1Inherited
Dehydroquinate synthase-like1Inherited
Radical SAM enzymes1Inherited
Inosine monophosphate dehydrogenase (IMPDH)1Inherited
alpha/beta-Hydrolases1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain1Inherited
Flavoproteins1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
FAD-linked reductases, C-terminal domain1Inherited
Thiolase-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52151,51412
  • 52151 - FabD/lysophospholipase-like
  • 51412 - Inosine monophosphate dehydrogenase (IMPDH)
  • 0Direct
    51971,51395
  • 51971 - Nucleotide-binding domain
  • 51395 - FMN-linked oxidoreductases
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    54292,46548
  • 54292 - 2Fe-2S ferredoxin-like
  • 46548 - alpha-helical ferredoxin
  • 0Direct
    51735,75615
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 75615 - Siroheme synthase middle domains-like
  • 0Direct
    48695,51905
  • 48695 - Multiheme cytochromes
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    48179,55021
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 55021 - ACT-like
  • 0Direct
    54637,52151
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    48600,51735
  • 48600 - Chorismate mutase II
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    51395,54862
  • 51395 - FMN-linked oxidoreductases
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    56176,56194
  • 56176 - FAD-binding/transporter-associated domain-like
  • 56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
  • 0Direct
    75615,53790
  • 75615 - Siroheme synthase middle domains-like
  • 53790 - Tetrapyrrole methylase
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    47336,53474
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 0.000000001058Direct
    46548,51971
  • 46548 - alpha-helical ferredoxin
  • 51971 - Nucleotide-binding domain
  • 0.00000000195Direct
    51735,51735
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.000002657Direct
    51971,51971
  • 51971 - Nucleotide-binding domain
  • 51971 - Nucleotide-binding domain
  • 0.000006277Direct
    51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.000006775Direct
    52151,55048
  • 52151 - FabD/lysophospholipase-like
  • 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase
  • 0.0001852Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.02114Inherited
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0.2842Inherited
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 1Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 1Inherited
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51735,48179,55021
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 55021 - ACT-like
  • 0Direct
    48695,51905,56425
  • 48695 - Multiheme cytochromes
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    48600,51735,48179
  • 48600 - Chorismate mutase II
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    51971,51971,51395
  • 51971 - Nucleotide-binding domain
  • 51971 - Nucleotide-binding domain
  • 51395 - FMN-linked oxidoreductases
  • 0Direct
    51735,75615,53790
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 75615 - Siroheme synthase middle domains-like
  • 53790 - Tetrapyrrole methylase
  • 0Direct
    51971,51395,54862
  • 51971 - Nucleotide-binding domain
  • 51395 - FMN-linked oxidoreductases
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    51735,47336,53474
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 0.000000000005515Direct
    50129,51735,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.00000005559Direct
    46548,51971,51971
  • 46548 - alpha-helical ferredoxin
  • 51971 - Nucleotide-binding domain
  • 51971 - Nucleotide-binding domain
  • 0.0000000652Direct
    51735,51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.000004003Direct
    50129,51735,50129
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0.2739Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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