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Enzyme Commission (EC): Transferring one-carbon groups

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <7>
+ 1:   Transferases [2] <10>(449|681) (448|544|277)
0:   Transferring one-carbon groups [2.1] <5>(86|125) (86|79|29)
- 1:   Methyltransferases [2.1.1] <368>(66|102) (66|59|13)
- 1:   Carboxy- and carbamoyltransferases [2.1.3] <15>(6|8) (7|9|8)
- 1:   Hydroxymethyl-, formyl- and related transferases [2.1.2] <14>(17|17) (17|12|8)
- 1:   Amidinotransferases [2.1.4] <2>(1|1) (1|0|0)
- 1:   Methylenetransferases [2.1.5] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SSo0622-like0Direct
Thymidylate synthase/dCMP hydroxymethylase0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
FAD/NAD(P)-binding domain0Direct
Flavivirus capsid protein C0Direct
Methylated DNA-protein cysteine methyltransferase domain0Direct
Putative methyltransferase TM0872, insert domain0Direct
RuBisCo LSMT C-terminal, substrate-binding domain0Direct
Chemotaxis receptor methyltransferase CheR, N-terminal domain0Direct
Tetrapyrrole methylase0Direct
ClpP/crotonase0Direct
FMT C-terminal domain-like0Direct
Viral glycoprotein, central and dimerisation domains0Direct
UROD/MetE-like0Direct
Ada DNA repair protein, N-terminal domain (N-Ada 10)0Direct
KRAB domain (Kruppel-associated box)0Direct
Aspartate/ornithine carbamoyltransferase0Direct
Aminomethyltransferase beta-barrel domain0Direct
L30e-like0Direct
SET domain0Direct
Folate-binding domain0Direct
alpha/beta knot0Direct
Methionine synthase activation domain-like0Direct
Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain0Direct
Methylated DNA-protein cysteine methyltransferase, C-terminal domain0Direct
Homocysteine S-methyltransferase0Direct
Thymidylate synthase-complementing protein Thy10Direct
Methionine synthase domain0Direct
Methylglyoxal synthase-like0Direct
S-adenosyl-L-methionine-dependent methyltransferases0Direct
Formiminotransferase domain of formiminotransferase-cyclodeaminase.0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
NusB-like0Direct
Siroheme synthase middle domains-like0Direct
Monomethylamine methyltransferase MtmB0Direct
CbiD-like0Direct
Formyltransferase0Direct
Cytidine deaminase-like0Direct
RNA-binding domain, RBD0.0000000001071Direct
DNA-binding domain0.0000000003352Direct
Cobalamin (vitamin B12)-binding domain0.000000001078Direct
Tudor/PWWP/MBT0.00000001391Direct
Methenyltetrahydrofolate cyclohydrolase-like0.00000002524Direct
HMG-box0.00000002524Direct
PLP-dependent transferases0.0000001964Direct
Dihydropteroate synthetase-like0.000003173Direct
Galactose oxidase, central domain0.00003109Direct
Chromo domain-like0.0000473Direct
Dihydrofolate reductase-like0.0005567Direct
FYVE/PHD zinc finger0.0007297Direct
FAD-linked reductases, C-terminal domain0.00112Inherited
Kelch motif0.00235Inherited
WW domain0.003067Inherited
Nucleotide-binding domain0.004643Inherited
CYTH-like phosphatases0.01009Inherited
Radical SAM enzymes0.04133Inherited
beta-beta-alpha zinc fingers0.05584Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.1078Inherited
Homeodomain-like0.2545Inherited
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0.3882Inherited
"Winged helix" DNA-binding domain0.5763Inherited
Trypsin-like serine proteases0.7363Inherited
Bromodomain0.9755Inherited
Carbamoyl phosphate synthetase, small subunit N-terminal domain0.9944Inherited
alpha/beta-Hydrolases1Inherited
Rudiment single hybrid motif1Inherited
E set domains1Inherited
PreATP-grasp domain1Inherited
PUA domain-like1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
SH3-domain1Inherited
Carbamoyl phosphate synthetase, large subunit connection domain1Inherited
Nucleic acid-binding proteins1Inherited
DNA ligase/mRNA capping enzyme, catalytic domain1Inherited
TPR-like1Inherited
PurM N-terminal domain-like1Inherited
Ankyrin repeat1Inherited
Pentein1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
HD-domain/PDEase-like1Inherited
THUMP domain-like1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
DNA/RNA polymerases1Inherited
lambda repressor-like DNA-binding domains1Inherited
PurM C-terminal domain-like1Inherited
Clavaminate synthase-like1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Salicylic acid carboxyl methyltransferase (SAMT)0Direct
RPA4359-like0Direct
Arginine methyltransferase0Direct
Monomethylamine methyltransferase MtmB0Direct
Glycine N-methyltransferase0Direct
Cobalamin-independent methionine synthase0Direct
Histone lysine methyltransferases0Direct
Aminomethyltransferase beta-barrel domain0Direct
MraW-like putative methyltransferases0Direct
Aminomethyltransferase folate-binding domain0Direct
COMT-like0Direct
Hypothetical RNA methyltransferase domain (HRMD)0Direct
N-6 DNA Methylase-like0Direct
Methyltransferase 10 domain0Direct
Ketopantoate hydroxymethyltransferase PanB0Direct
N6 adenine-specific DNA methylase, DAM0Direct
Protein-L-isoaspartyl O-methyltransferase0Direct
Siroheme synthase middle domains-like0Direct
YbeA-like0Direct
Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain0Direct
RuBisCo LSMT C-terminal, substrate-binding domain0Direct
mRNA cap methylase0Direct
Plant O-methyltransferase, C-terminal domain0Direct
Biotin dependent carboxylase carboxyltransferase domain0Direct
Methylated DNA-protein cysteine methyltransferase domain0Direct
Amidinotransferase0Direct
tRNA(m1G37)-methyltransferase TrmD0Direct
UbiE/COQ5-like0Direct
Siroheme synthase N-terminal domain-like0Direct
Histamine methyltransferase0Direct
Thymidylate synthase-complementing protein Thy10Direct
Post formyltransferase domain0Direct
RNA 2'-O ribose methyltransferase substrate binding domain0Direct
Chemotaxis receptor methyltransferase CheR, N-terminal domain0Direct
Tetrapyrrole methylase0Direct
Formyltransferase0Direct
Methionine synthase SAM-binding domain0Direct
RNA helicase0Direct
mRNA cap (Guanine N-7) methyltransferase0Direct
Plant O-methyltransferase, N-terminal domain0Direct
Arylamine N-methyltransferase0Direct
RuBisCo LSMT catalytic domain0Direct
(Uracil-5-)-methyltransferase0Direct
Class II viral fusion proteins C-terminal domain0Direct
Guanidinoacetate methyltransferase0Direct
NOL1/NOP2/sun0Direct
Aspartate/ornithine carbamoyltransferase0Direct
SpoU-like RNA 2'-O ribose methyltransferase0Direct
Homocysteine S-methyltransferase0Direct
Glucose-inhibited division protein B (GidB)0Direct
RmsB N-terminal domain-like0Direct
Chemotaxis receptor methyltransferase CheR, C-terminal domain0Direct
YggJ N-terminal domain-like0Direct
Putative methyltransferase TM0872, insert domain0Direct
Precorrin-6Y methyltransferase (CbiT)0Direct
PWWP domain0Direct
Leucine carboxy methyltransferase Ppm10Direct
RNA methyltransferase FtsJ0Direct
TrmB-like0Direct
AD-003 protein-like0Direct
tRNA(1-methyladenosine) methyltransferase-like0Direct
TRM1-like0Direct
rRNA adenine dimethylase-like0Direct
AF0751-like0Direct
YhhF-like0Direct
Methyltetrahydrofolate-utiluzing methyltransferases0Direct
Flavivirus capsid protein C0Direct
AF1056-like0Direct
Formiminotransferase domain of formiminotransferase-cyclodeaminase.0Direct
Hypothetical protein MJ08820Direct
AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC0Direct
Methylated DNA-protein cysteine methyltransferase, C-terminal domain0Direct
DNA methylase TaqI, N-terminal domain0Direct
SSo0622-like0Direct
YggJ C-terminal domain-like0Direct
Thiopurine S-methyltransferase0Direct
YhiQ-like0Direct
Met-10+ protein-like0Direct
KRAB domain (Kruppel-associated box)0Direct
Thymidylate synthase/dCMP hydroxymethylase0Direct
Inosicase0Direct
GABA-aminotransferase-like0Direct
hypothetical RNA methyltransferase0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Type II DNA methylase0Direct
Ada DNA repair protein, N-terminal domain (N-Ada 10)0Direct
TRAM domain0Direct
Catalytic, N-terminal domain of histone methyltransferase Dot1l0Direct
Methionine synthase domain0Direct
N5-glutamine methyltransferase, HemK0Direct
Mycolic acid cyclopropane synthase0Direct
CbiD-like0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
Viral glycoprotein, central and dimerisation domains0Direct
Chromo domain0.00000000000006908Direct
Cobalamin (vitamin B12)-binding domain0.00000000008164Direct
Viral proteases0.0000000001254Direct
HMG-box0.00000001084Direct
Methenyltetrahydrofolate cyclohydrolase-like0.00000001084Direct
Dihydrofolate reductases0.0000114Direct
Hypoxia-inducible factor HIF ihhibitor (FIH1)0.00006346Direct
Canonical RBD0.0001072Direct
PHD domain0.0005293Direct
WW domain0.001943Inherited
SRA domain-like0.01316Inherited
AlkB-like0.02096Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.06542Inherited
Classic zinc finger, C2H20.3035Inherited
Hydantoinase (dihydropyrimidinase), catalytic domain0.7694Inherited
RNA-dependent RNA-polymerase0.8202Inherited
Carbamoyl phosphate synthetase, small subunit N-terminal domain0.8498Inherited
Bromodomain0.9Inherited
Biotin biosynthesis protein BioH0.91Inherited
BC N-terminal domain-like1Inherited
Spermidine synthase1Inherited
MoCo biosynthesis proteins1Inherited
BC C-terminal domain-like1Inherited
Ankyrin repeat1Inherited
Uroporphyrinogen decarboxylase, UROD1Inherited
PurM N-terminal domain-like1Inherited
PurM C-terminal domain-like1Inherited
Carbamoyl phosphate synthetase, large subunit connection domain1Inherited
BC ATP-binding domain-like1Inherited
Tyrosine-dependent oxidoreductases1Inherited
SH3-domain1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Homocysteine S-methyltransferase0Direct
RuBisCo LSMT C-terminal, substrate-binding domain0Direct
Viral glycoprotein, central and dimerisation domains0Direct
Aminomethyltransferase beta-barrel domain0Direct
Methylglyoxal synthase-like0Direct
Cytidine deaminase-like0Direct
SET domain0Direct
S-adenosyl-L-methionine-dependent methyltransferases0Direct
Aspartate/ornithine carbamoyltransferase0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
Siroheme synthase middle domains-like0Direct
Thymidylate synthase/dCMP hydroxymethylase0Direct
L30e-like0Direct
UROD/MetE-like0Direct
Thymidylate synthase-complementing protein Thy10Direct
Putative methyltransferase TM0872, insert domain0Direct
Ada DNA repair protein, N-terminal domain (N-Ada 10)0Direct
Formiminotransferase domain of formiminotransferase-cyclodeaminase.0Direct
Formyltransferase0Direct
NusB-like0Direct
Methylated DNA-protein cysteine methyltransferase, C-terminal domain0Direct
SSo0622-like0Direct
FMT C-terminal domain-like0Direct
ClpP/crotonase0Direct
FAD/NAD(P)-binding domain0Direct
Tetrapyrrole methylase0Direct
CbiD-like0Direct
Flavivirus capsid protein C0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
Methionine synthase domain0Direct
Methionine synthase activation domain-like0Direct
alpha/beta knot0Direct
KRAB domain (Kruppel-associated box)0Direct
Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain0Direct
Folate-binding domain0Direct
Monomethylamine methyltransferase MtmB0Direct
Methylated DNA-protein cysteine methyltransferase domain0Direct
Chemotaxis receptor methyltransferase CheR, N-terminal domain0Direct
RNA-binding domain, RBD0.00000000007898Direct
DNA-binding domain0.0000000002485Direct
Cobalamin (vitamin B12)-binding domain0.0000000008056Direct
Tudor/PWWP/MBT0.00000001055Direct
HMG-box0.00000001919Direct
Methenyltetrahydrofolate cyclohydrolase-like0.00000001919Direct
PLP-dependent transferases0.0000001514Direct
Dihydropteroate synthetase-like0.000002498Direct
Galactose oxidase, central domain0.00002488Direct
Chromo domain-like0.00003794Direct
Dihydrofolate reductase-like0.0004569Direct
FYVE/PHD zinc finger0.0006008Direct
FAD-linked reductases, C-terminal domain0.0009272Direct
Kelch motif0.001959Inherited
WW domain0.002567Inherited
Nucleotide-binding domain0.003895Inherited
CYTH-like phosphatases0.008551Inherited
Radical SAM enzymes0.03558Inherited
beta-beta-alpha zinc fingers0.04835Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.09427Inherited
Homeodomain-like0.2271Inherited
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0.3513Inherited
"Winged helix" DNA-binding domain0.5279Inherited
Trypsin-like serine proteases0.6763Inherited
Bromodomain0.9017Inherited
Carbamoyl phosphate synthetase, small subunit N-terminal domain0.9202Inherited
TPR-like0.9743Inherited
lambda repressor-like DNA-binding domains0.9917Inherited
SH3-domain1Inherited
THUMP domain-like1Inherited
DNA/RNA polymerases1Inherited
Carbamoyl phosphate synthetase, large subunit connection domain1Inherited
E set domains1Inherited
Clavaminate synthase-like1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
alpha/beta-Hydrolases1Inherited
Ankyrin repeat1Inherited
Rudiment single hybrid motif1Inherited
HD-domain/PDEase-like1Inherited
PurM N-terminal domain-like1Inherited
PreATP-grasp domain1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
Pentein1Inherited
DNA ligase/mRNA capping enzyme, catalytic domain1Inherited
PUA domain-like1Inherited
Nucleic acid-binding proteins1Inherited
PurM C-terminal domain-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57903,82199
  • 57903 - FYVE/PHD zinc finger
  • 82199 - SET domain
  • 0Direct
    53335,53383
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 53383 - PLP-dependent transferases
  • 0Direct
    46785,53335
  • 46785 - "Winged helix" DNA-binding domain
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    82199,81822
  • 82199 - SET domain
  • 81822 - RuBisCo LSMT C-terminal, substrate-binding domain
  • 0Direct
    54928,51197
  • 54928 - RNA-binding domain, RBD
  • 51197 - Clavaminate synthase-like
  • 0Direct
    54160,53335
  • 54160 - Chromo domain-like
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    47413,53335
  • 47413 - lambda repressor-like DNA-binding domains
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    53155,46767
  • 53155 - Methylated DNA-protein cysteine methyltransferase domain
  • 46767 - Methylated DNA-protein cysteine methyltransferase, C-terminal domain
  • 0Direct
    53335,51905
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    88697,75217
  • 88697 - PUA domain-like
  • 75217 - alpha/beta knot
  • 0Direct
    48452,53335
  • 48452 - TPR-like
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    63748,82199
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 0Direct
    56983,81296
  • 56983 - Viral glycoprotein, central and dimerisation domains
  • 81296 - E set domains
  • 0Direct
    50486,51735
  • 50486 - FMT C-terminal domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    47757,53335
  • 47757 - Chemotaxis receptor methyltransferase CheR, N-terminal domain
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    53335,56672
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    55315,75217
  • 55315 - L30e-like
  • 75217 - alpha/beta knot
  • 0Direct
    82199,48452
  • 82199 - SET domain
  • 48452 - TPR-like
  • 0Direct
    56042,53328
  • 56042 - PurM C-terminal domain-like
  • 53328 - Formyltransferase
  • 0Direct
    51197,53335
  • 51197 - Clavaminate synthase-like
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    50965,51197
  • 50965 - Galactose oxidase, central domain
  • 51197 - Clavaminate synthase-like
  • 0Direct
    143437,53335
  • 143437 - THUMP domain-like
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    75217,75217
  • 75217 - alpha/beta knot
  • 75217 - alpha/beta knot
  • 0Direct
    75217,54593
  • 75217 - alpha/beta knot
  • 54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
  • 0Direct
    57903,63748
  • 57903 - FYVE/PHD zinc finger
  • 63748 - Tudor/PWWP/MBT
  • 0Direct
    48403,82199
  • 48403 - Ankyrin repeat
  • 82199 - SET domain
  • 0Direct
    53335,50249
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    55154,56091
  • 55154 - CYTH-like phosphatases
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    54160,82199
  • 54160 - Chromo domain-like
  • 82199 - SET domain
  • 0Direct
    88697,53335
  • 88697 - PUA domain-like
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    47644,52242
  • 47644 - Methionine synthase domain
  • 52242 - Cobalamin (vitamin B12)-binding domain
  • 0Direct
    75615,53790
  • 75615 - Siroheme synthase middle domains-like
  • 53790 - Tetrapyrrole methylase
  • 0Direct
    82199,57903
  • 82199 - SET domain
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    50044,53335
  • 50044 - SH3-domain
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    103025,101790
  • 103025 - Folate-binding domain
  • 101790 - Aminomethyltransferase beta-barrel domain
  • 0Direct
    48013,53335
  • 48013 - NusB-like
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    82282,51717
  • 82282 - Homocysteine S-methyltransferase
  • 51717 - Dihydropteroate synthetase-like
  • 0Direct
    75217,109604
  • 75217 - alpha/beta knot
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    53335,50965
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 50965 - Galactose oxidase, central domain
  • 0Direct
    55116,55116
  • 55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
  • 55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
  • 0Direct
    57884,46689
  • 57884 - Ada DNA repair protein, N-terminal domain (N-Ada 10)
  • 46689 - Homeodomain-like
  • 0Direct
    51726,51726
  • 51726 - UROD/MetE-like
  • 51726 - UROD/MetE-like
  • 0Direct
    53790,53335
  • 53790 - Tetrapyrrole methylase
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    51717,47644
  • 51717 - Dihydropteroate synthetase-like
  • 47644 - Methionine synthase domain
  • 0Direct
    53335,53335
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    117281,51197
  • 117281 - Kelch motif
  • 51197 - Clavaminate synthase-like
  • 0Direct
    53328,50486
  • 53328 - Formyltransferase
  • 50486 - FMT C-terminal domain-like
  • 0Direct
    53597,55831
  • 53597 - Dihydrofolate reductase-like
  • 55831 - Thymidylate synthase/dCMP hydroxymethylase
  • 0Direct
    52335,51556
  • 52335 - Methylglyoxal synthase-like
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    52335,53927
  • 52335 - Methylglyoxal synthase-like
  • 53927 - Cytidine deaminase-like
  • 0Direct
    50249,53335
  • 50249 - Nucleic acid-binding proteins
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    52242,56507
  • 52242 - Cobalamin (vitamin B12)-binding domain
  • 56507 - Methionine synthase activation domain-like
  • 0Direct
    82185,82199
  • 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
  • 82199 - SET domain
  • 0Direct
    88697,82199
  • 88697 - PUA domain-like
  • 82199 - SET domain
  • 0Direct
    53335,81799
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 81799 - Putative methyltransferase TM0872, insert domain
  • 0Direct
    54171,82199
  • 54171 - DNA-binding domain
  • 82199 - SET domain
  • 0Direct
    55116,101262
  • 55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
  • 101262 - Methenyltetrahydrofolate cyclohydrolase-like
  • 0Direct
    51735,75615
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 75615 - Siroheme synthase middle domains-like
  • 0Direct
    50494,52540
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00000000009883Direct
    52317,52440
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 0.0000000001904Direct
    51246,55326
  • 51246 - Rudiment single hybrid motif
  • 55326 - PurM N-terminal domain-like
  • 0.0000001891Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.000001463Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0.000002105Direct
    53474,53335
  • 53474 - alpha/beta-Hydrolases
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0.00008221Direct
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.0002118Direct
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.001389Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.09845Inherited
    51971,54373
  • 51971 - Nucleotide-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.1239Inherited
    52021,52317
  • 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
  • 52317 - Class I glutamine amidotransferase-like
  • 0.9202Inherited
    48108,52440
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 1Inherited
    53383,53383
  • 53383 - PLP-dependent transferases
  • 53383 - PLP-dependent transferases
  • 1Inherited
    56042,55326
  • 56042 - PurM C-terminal domain-like
  • 55326 - PurM N-terminal domain-like
  • 1Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 1Inherited
    55326,56042
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 1Inherited
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 1Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 1Inherited
    56059,48108
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 1Inherited
    56059,52335
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52335 - Methylglyoxal synthase-like
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55326,56042,53328
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 53328 - Formyltransferase
  • 0Direct
    47644,52242,56507
  • 47644 - Methionine synthase domain
  • 52242 - Cobalamin (vitamin B12)-binding domain
  • 56507 - Methionine synthase activation domain-like
  • 0Direct
    57903,57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    55116,55116,101262
  • 55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
  • 55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
  • 101262 - Methenyltetrahydrofolate cyclohydrolase-like
  • 0Direct
    53335,51905,54373
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0Direct
    82282,51717,47644
  • 82282 - Homocysteine S-methyltransferase
  • 51717 - Dihydropteroate synthetase-like
  • 47644 - Methionine synthase domain
  • 0Direct
    50494,52540,52540
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56059,52335,51556
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52335 - Methylglyoxal synthase-like
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    54928,51197,53335
  • 54928 - RNA-binding domain, RBD
  • 51197 - Clavaminate synthase-like
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    52335,51556,51338
  • 52335 - Methylglyoxal synthase-like
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    51735,75615,53790
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 75615 - Siroheme synthase middle domains-like
  • 53790 - Tetrapyrrole methylase
  • 0Direct
    63748,82199,57903
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    53335,50965,51197
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 50965 - Galactose oxidase, central domain
  • 51197 - Clavaminate synthase-like
  • 0Direct
    57903,63748,82199
  • 57903 - FYVE/PHD zinc finger
  • 63748 - Tudor/PWWP/MBT
  • 82199 - SET domain
  • 0Direct
    51717,47644,52242
  • 51717 - Dihydropteroate synthetase-like
  • 47644 - Methionine synthase domain
  • 52242 - Cobalamin (vitamin B12)-binding domain
  • 0Direct
    53335,53383,53383
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 53383 - PLP-dependent transferases
  • 53383 - PLP-dependent transferases
  • 0Direct
    53328,50486,51735
  • 53328 - Formyltransferase
  • 50486 - FMT C-terminal domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    52317,52440,56059
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.0000000001904Direct
    52021,52317,52440
  • 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 0.0000000001904Direct
    51246,55326,56042
  • 51246 - Rudiment single hybrid motif
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0.0000001891Direct
    56059,51246,55326
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 55326 - PurM N-terminal domain-like
  • 0.0000001891Direct
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.02312Inherited
    52440,56059,52335
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52335 - Methylglyoxal synthase-like
  • 0.9999Inherited
    55326,56042,55326
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 55326 - PurM N-terminal domain-like
  • 1Inherited
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 1Inherited
    52440,56059,48108
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 1Inherited
    56042,55326,56042
  • 56042 - PurM C-terminal domain-like
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 1Inherited
    56059,48108,52440
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 1Inherited
    48108,52440,56059
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 1Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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