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Enzyme Commission (EC): Protein-tyrosine kinases

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Transferases [2] <10>(445|680) (444|535|275)
+ 1:   Transferring phosphorus-containing groups [2.7] <15>(255|337) (254|318|190)
0:   Protein-tyrosine kinases [2.7.10] <2>(26|29) (26|32|22)
- 1:   Non-specific protein-tyrosine kinase [2.7.10.2](12|14) (12|13|8)
- 1:   Receptor protein-tyrosine kinase [2.7.10.1](13|14) (13|19|14)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SH2 domain0Direct
Protein kinase-like (PK-like)0Direct
E set domains0Direct
Galactose-binding domain-like0Direct
BAR/IMD domain-like0Direct
PH domain-like0Direct
Plexin repeat0Direct
L domain-like0Direct
Immunoglobulin0Direct
YWTD domain0Direct
Cadherin-like0Direct
Fibronectin type III0Direct
FAT domain of focal adhesion kinase0Direct
Sema domain0Direct
SAM/Pointed domain0Direct
SH3-domain0Direct
Second domain of FERM0Direct
Growth factor receptor domain0Direct
Kringle-like0.000000001905Direct
Bromodomain0.0000003601Direct
Ubiquitin-like0.000008754Direct
FYVE/PHD zinc finger0.00006969Direct
DEATH domain0.0005914Direct
RNI-like0.001086Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2217Inherited
Cysteine-rich domain0.4529Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
YWTD domain0Direct
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0Direct
Plexin repeat0Direct
Sema domain0Direct
Growth factor receptor domain0Direct
SH3-domain0Direct
FAT domain of focal adhesion kinase0Direct
SH2 domain0Direct
V set domains (antibody variable domain-like)0Direct
Third domain of FERM0Direct
FCH domain0Direct
I set domains0Direct
Fibronectin type III0Direct
Ngr ectodomain-like0Direct
SAM (sterile alpha motif) domain0Direct
First domain of FERM0Direct
Protein kinases, catalytic subunit0Direct
Ephrin receptor ligand binding domain0Direct
L domain0Direct
Second domain of FERM0Direct
Kringle modules0.0000000005556Direct
Bromodomain0.0000004202Direct
Caspase recruitment domain, CARD0.000002421Direct
PHD domain0.000004437Direct
Pleckstrin-homology domain (PH domain)0.000008448Direct
Polygalacturonase inhibiting protein PGIP0.0004204Direct
PLC-like (P variant)0.01113Inherited
Nitrogenase iron protein-like0.1386Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.3608Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Plexin repeat0Direct
BAR/IMD domain-like0Direct
Galactose-binding domain-like0Direct
SAM/Pointed domain0Direct
Immunoglobulin0Direct
YWTD domain0Direct
SH3-domain0Direct
Second domain of FERM0Direct
L domain-like0Direct
Cadherin-like0Direct
PH domain-like0Direct
FAT domain of focal adhesion kinase0Direct
SH2 domain0Direct
Protein kinase-like (PK-like)0Direct
Fibronectin type III0Direct
Sema domain0Direct
Growth factor receptor domain0Direct
E set domains0Direct
Kringle-like0.000000001421Direct
Bromodomain0.0000002778Direct
Ubiquitin-like0.000006912Direct
FYVE/PHD zinc finger0.00005592Direct
DEATH domain0.0004846Direct
RNI-like0.000895Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.197Inherited
Cysteine-rich domain0.4125Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0Direct
    57440,56112
  • 57440 - Kringle-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    56112,50044
  • 56112 - Protein kinase-like (PK-like)
  • 50044 - SH3-domain
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    103575,81296
  • 103575 - Plexin repeat
  • 81296 - E set domains
  • 0Direct
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0Direct
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    63825,49265
  • 63825 - YWTD domain
  • 49265 - Fibronectin type III
  • 0Direct
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0Direct
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0Direct
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    49265,63825
  • 49265 - Fibronectin type III
  • 63825 - YWTD domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.000000000000006986Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0000000001154Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.000000007673Direct
    50729,50044
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.00000007395Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0000006385Direct
    52058,56112
  • 52058 - L domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00003852Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.0004846Direct
    52058,52047
  • 52058 - L domain-like
  • 52047 - RNI-like
  • 0.0008961Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.08813Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    103575,81296,81296
  • 103575 - Plexin repeat
  • 81296 - E set domains
  • 81296 - E set domains
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    101912,103575,81296
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 81296 - E set domains
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    52058,57184,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    63825,49265,63825
  • 63825 - YWTD domain
  • 49265 - Fibronectin type III
  • 63825 - YWTD domain
  • 0Direct
    49785,57184,49265
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    47031,50729,56112
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47031,50729,55550
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0Direct
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0Direct
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.000000000000347Direct
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0000000000003521Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.0004846Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)