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Enzyme Commission (EC): Non-specific serine/threonine protein kinase

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   root [root] <7>
+ + + 3:   Transferases [2] <10>(447|682) (446|545|278)
+ + 2:   Transferring phosphorus-containing groups [2.7] <15>(255|337) (254|318|190)
+ 1:   Protein-serine/threonine kinases [2.7.11] <35>(59|62) (58|92|40)
0:   Non-specific serine/threonine protein kinase [2.7.11.1](34|39) (34|61|25)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
MAST3 pre-PK domain-like0Direct
G protein-binding domain0Direct
RCC1/BLIP-II0Direct
Penicillin-binding protein 2x (pbp-2x), c-terminal domain0Direct
RNI-like0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
TAF(II)230 TBP-binding fragment0Direct
DEATH domain0Direct
Ankyrin repeat0Direct
Concanavalin A-like lectins/glucanases0Direct
Tricorn protease domain 20Direct
Doublecortin (DC)0Direct
L domain-like0Direct
alpha-D-mannose-specific plant lectins0Direct
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)0Direct
DBL homology domain (DH-domain)0Direct
KA1-like0Direct
Spectrin repeat0Direct
SMAD/FHA domain5.103e-16Direct
MIT domain0.00000000000002311Direct
CRAL/TRIO domain0.0000000000001085Direct
TPR-like0.000000000001461Direct
Myosin rod fragments0.00000000001272Direct
ARM repeat0.0000000001005Direct
PX domain0.000000001902Direct
EF-hand0.0000000689Direct
GTPase activation domain, GAP0.0000000982Direct
UBA-like0.000000185Direct
PYP-like sensor domain (PAS domain)0.0000002161Direct
Chaperone J-domain0.0000008482Direct
Cyclin-like0.000006665Direct
C-type lectin-like0.000007485Direct
PDZ domain-like0.000411Direct
Bromodomain0.0005897Direct


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
beta-lactamase inhibitor protein-II, BLIP-II0Direct
TAF(II)230 TBP-binding fragment0Direct
Myosin rod fragments0Direct
RhoA-binding domain0Direct
Kinase associated domain 1, KA10Direct
MAST3 pre-PK domain-like0Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
Cyclin0Direct
Doublecortin (DC)0Direct
DBL homology domain (DH-domain)0Direct
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)0Direct
RIO1-like kinases0Direct
Polygalacturonase inhibiting protein PGIP0Direct
Legume lectins0Direct
DEATH domain, DD0Direct
Ssp2 C-terminal domain-like0Direct
Histidine kinase0Direct
Ankyrin repeat0Direct
alpha-D-mannose-specific plant lectins0Direct
LIM domain0Direct
Spectrin repeat0Direct
FHA domain3.695e-16Direct
RWD domain0.000000000000002189Direct
MIT domain0.000000000000009223Direct
Regulator of chromosome condensation RCC10.0000000000004004Direct
Motor proteins0.00000000001284Direct
Quinoprotein alcohol dehydrogenase-like0.00000000005005Direct
PX domain0.00000000101Direct
Flavin-binding PAS domain0.00000000178Direct
Calmodulin-like0.00000004663Direct
Phoshoinositide 3-kinase (PI3K) helical domain0.00000009839Direct
BCR-homology GTPase activation domain (BH-domain)0.00000009844Direct
Chaperone J-domain0.0000008216Direct
Tetratricopeptide repeat (TPR)0.000001703Direct
Sulfatase-modifying factor-like0.00000301Direct
UBA domain0.00003175Direct
Ras-binding domain, RBD0.0005697Direct
Bromodomain0.0006137Direct
Caspase recruitment domain, CARD0.0006891Direct


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Spectrin repeat0Direct
Penicillin-binding protein 2x (pbp-2x), c-terminal domain0Direct
G protein-binding domain0Direct
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)0Direct
Tricorn protease domain 20Direct
Quinoprotein alcohol dehydrogenase-like0Direct
alpha-D-mannose-specific plant lectins0Direct
Ankyrin repeat0Direct
DBL homology domain (DH-domain)0Direct
TAF(II)230 TBP-binding fragment0Direct
RCC1/BLIP-II0Direct
Doublecortin (DC)0Direct
KA1-like0Direct
DEATH domain0Direct
MAST3 pre-PK domain-like0Direct
RNI-like0Direct
Concanavalin A-like lectins/glucanases0Direct
L domain-like0Direct
SMAD/FHA domain3.545e-16Direct
MIT domain0.00000000000001632Direct
CRAL/TRIO domain0.000000000000077Direct
TPR-like0.000000000001051Direct
Myosin rod fragments0.000000000009218Direct
ARM repeat0.00000000007386Direct
PX domain0.000000001422Direct
EF-hand0.00000005259Direct
GTPase activation domain, GAP0.0000000751Direct
UBA-like0.0000001422Direct
PYP-like sensor domain (PAS domain)0.0000001663Direct
Chaperone J-domain0.0000006608Direct
Cyclin-like0.000005252Direct
C-type lectin-like0.000005904Direct
PDZ domain-like0.0003353Direct
Bromodomain0.0004836Direct

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
56112,50985
  • 56112 - Protein kinase-like (PK-like)
  • 50985 - RCC1/BLIP-II
  • 0Direct
    48403,56112
  • 48403 - Ankyrin repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    56112,50998
  • 56112 - Protein kinase-like (PK-like)
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 0Direct
    52058,52047
  • 52058 - L domain-like
  • 52047 - RNI-like
  • 0Direct
    -9,-7
  • -9 - PDB
  • -7 - CATH
  • 0Direct
    55073,56112
  • 55073 - Nucleotide cyclase
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0Direct
    52058,52540
  • 52058 - L domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57716,50156
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 50156 - PDZ domain-like
  • 0Direct
    50044,48065
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    53850,56112
  • 53850 - Periplasmic binding protein-like II
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    52058,56112
  • 52058 - L domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49879,56112
  • 49879 - SMAD/FHA domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50156,56112
  • 50156 - PDZ domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47212,56112
  • 47212 - FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52047,52047
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 0Direct
    47986,56112
  • 47986 - DEATH domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49899,56112
  • 49899 - Concanavalin A-like lectins/glucanases
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52087,46966
  • 52087 - CRAL/TRIO domain
  • 46966 - Spectrin repeat
  • 0Direct
    56112,55681
  • 56112 - Protein kinase-like (PK-like)
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    56112,103243
  • 56112 - Protein kinase-like (PK-like)
  • 103243 - KA1-like
  • 0Direct
    56112,54928
  • 56112 - Protein kinase-like (PK-like)
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    56112,116846
  • 56112 - Protein kinase-like (PK-like)
  • 116846 - MIT domain
  • 0Direct
    56112,48403
  • 56112 - Protein kinase-like (PK-like)
  • 48403 - Ankyrin repeat
  • 0Direct
    47370,47370
  • 47370 - Bromodomain
  • 47370 - Bromodomain
  • 0Direct
    56112,52799
  • 56112 - Protein kinase-like (PK-like)
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    52047,52058
  • 52047 - RNI-like
  • 52058 - L domain-like
  • 0Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    48726,56112
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50998,56112
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    56112,90257
  • 56112 - Protein kinase-like (PK-like)
  • 90257 - Myosin rod fragments
  • 0Direct
    46785,56112
  • 46785 - "Winged helix" DNA-binding domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    64268,56112
  • 64268 - PX domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    116846,116846
  • 116846 - MIT domain
  • 116846 - MIT domain
  • 0Direct
    52047,56112
  • 52047 - RNI-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    89837,89837
  • 89837 - Doublecortin (DC)
  • 89837 - Doublecortin (DC)
  • 0Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    55021,56112
  • 55021 - ACT-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    53067,56112
  • 53067 - Actin-like ATPase domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    56112,48371
  • 56112 - Protein kinase-like (PK-like)
  • 48371 - ARM repeat
  • 0Direct
    50729,69322
  • 50729 - PH domain-like
  • 69322 - Tricorn protease domain 2
  • 0Direct
    51110,51110
  • 51110 - alpha-D-mannose-specific plant lectins
  • 51110 - alpha-D-mannose-specific plant lectins
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    56112,48452
  • 56112 - Protein kinase-like (PK-like)
  • 48452 - TPR-like
  • 0Direct
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    50729,50044
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.000000000000812Direct
    56112,50044
  • 56112 - Protein kinase-like (PK-like)
  • 50044 - SH3-domain
  • 0.0000000002451Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.00000003374Direct
    56112,47473
  • 56112 - Protein kinase-like (PK-like)
  • 47473 - EF-hand
  • 0.00000005259Direct
    56112,52540
  • 56112 - Protein kinase-like (PK-like)
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0000002251Direct
    48403,47769
  • 48403 - Ankyrin repeat
  • 47769 - SAM/Pointed domain
  • 0.000001513Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.000002967Direct
    53850,53850
  • 53850 - Periplasmic binding protein-like II
  • 53850 - Periplasmic binding protein-like II
  • 0.000008599Direct
    48403,52540
  • 48403 - Ankyrin repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0000133Direct
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.0000517Direct
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.0003353Direct

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    56112,48726,48726
  • 56112 - Protein kinase-like (PK-like)
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    52058,52047,52058
  • 52058 - L domain-like
  • 52047 - RNI-like
  • 52058 - L domain-like
  • 0Direct
    50044,48065,50729
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    48726,48726,56112
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49265,48726,49265
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0Direct
    52047,52058,56112
  • 52047 - RNI-like
  • 52058 - L domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    56112,48403,52540
  • 56112 - Protein kinase-like (PK-like)
  • 48403 - Ankyrin repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52047,52047,56112
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    52058,52058,56112
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    53850,53850,56112
  • 53850 - Periplasmic binding protein-like II
  • 53850 - Periplasmic binding protein-like II
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57716,57716,50156
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 50156 - PDZ domain-like
  • 0Direct
    57889,50729,69322
  • 57889 - Cysteine-rich domain
  • 50729 - PH domain-like
  • 69322 - Tricorn protease domain 2
  • 0Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    56112,52799,49562
  • 56112 - Protein kinase-like (PK-like)
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    57716,50156,56112
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 50156 - PDZ domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    56112,116846,116846
  • 56112 - Protein kinase-like (PK-like)
  • 116846 - MIT domain
  • 116846 - MIT domain
  • 0Direct
    48065,50729,50044
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0Direct
    -9,-7,56112
  • -9 - PDB
  • -7 - CATH
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52087,46966,46966
  • 52087 - CRAL/TRIO domain
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0Direct
    52058,52047,56112
  • 52058 - L domain-like
  • 52047 - RNI-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52047,52047,52058
  • 52047 - RNI-like
  • 52047 - RNI-like
  • 52058 - L domain-like
  • 0Direct
    52058,52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.0000000000001287Direct
    49265,48726,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0000000000001287Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.00000002662Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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