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Enzyme Commission (EC): Phosphoric diester hydrolases

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Hydrolases [3] <13>(395|668) (394|418|206)
+ 1:   Acting on ester bonds [3.1] <23>(156|225) (156|126|55)
0:   Phosphoric diester hydrolases [3.1.4] <61>(31|30) (31|22|13)
- 1:   2',3'-cyclic-nucleotide 2'-phosphodiesterase [3.1.4.16](2|2) (2|1|0)
- 1:   2',3'-cyclic-nucleotide 3'-phosphodiesterase [3.1.4.37](1|2) (1|1|0)
- 1:   3',5'-cyclic-AMP phosphodiesterase [3.1.4.53](3|2) (3|0|0)
- 1:   3',5'-cyclic-GMP phosphodiesterase [3.1.4.35](2|2) (2|2|1)
- 1:   3',5'-cyclic-nucleotide phosphodiesterase [3.1.4.17](3|1) (3|1|1)
- 1:   7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase [3.1.4.56](0|0) (0|0|0)
- 1:   Alkylglycerophosphoethanolamine phosphodiesterase [3.1.4.39](3|2) (3|2|1)
- 1:   CMP-N-acylneuraminate phosphodiesterase [3.1.4.40](0|0) (0|0|0)
- 1:   Cyclic-di-AMP phosphodiesterase [3.1.4.59](1|0) (1|0|0)
- 1:   Cyclic-guanylate-specific phosphodiesterase [3.1.4.52](3|2) (3|1|0)
- 1:   Deleted entry [3.1.4.26](0|0) (0|0|0)
- 1:   Deleted entry [3.1.4.32](0|0) (0|0|0)
- 1:   Deleted entry [3.1.4.24](0|0) (0|0|0)
- 1:   Deleted entry [3.1.4.29](0|0) (0|0|0)
- 1:   Deleted entry [3.1.4.34](0|0) (0|0|0)
- 1:   Deleted entry [3.1.4.33](0|0) (0|0|0)
- 1:   Dolichylphosphate-glucose phosphodiesterase [3.1.4.48](0|0) (0|0|0)
- 1:   Dolichylphosphate-mannose phosphodiesterase [3.1.4.49](0|0) (0|0|0)
- 1:   Glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase [3.1.4.51](0|0) (0|0|0)
- 1:   Glycerol-1,2-cyclic-phosphate 2-phosphodiesterase [3.1.4.42](0|0) (0|0|0)
- 1:   Glycerophosphocholine cholinephosphodiesterase [3.1.4.38](1|0) (1|0|0)
- 1:   Glycerophosphocholine phosphodiesterase [3.1.4.2](1|2) (1|0|0)
- 1:   Glycerophosphodiester phosphodiesterase [3.1.4.46](0|1) (1|1|0)
- 1:   Glycerophosphoinositol glycerophosphodiesterase [3.1.4.44](0|1) (0|0|0)
- 1:   Glycerophosphoinositol inositolphosphodiesterase [3.1.4.43](0|0) (0|0|0)
- 1:   Glycosylphosphatidylinositol phospholipase D [3.1.4.50](1|1) (1|0|0)
- 1:   N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [3.1.4.45](0|0) (0|0|0)
- 1:   N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D [3.1.4.54](1|0) (1|0|0)
- 1:   PApA phosphodiesterase [3.1.4.60](0|0) (0|0|0)
- 1:   Phosphodiesterase I [3.1.4.1](3|1) (3|3|2)
- 1:   Phosphoinositide phospholipase C [3.1.4.11](9|9) (9|8|6)
- 1:   Phospholipase C [3.1.4.3](2|2) (2|1|0)
- 1:   Phospholipase D [3.1.4.4](3|2) (3|4|3)
- 1:   Phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase [3.1.4.57](0|0) (0|0|0)
- 1:   Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase [3.1.4.55](0|0) (0|0|0)
- 1:   RNA 2',3'-cyclic 3'-phosphodiesterase [3.1.4.58](1|1) (1|0|0)
- 1:   Serine-ethanolaminephosphate phosphodiesterase [3.1.4.13](0|0) (0|0|0)
- 1:   Sphingomyelin phosphodiesterase [3.1.4.12](2|1) (2|0|0)
- 1:   Sphingomyelin phosphodiesterase D [3.1.4.41](0|0) (0|0|0)
- 1:   Transferred entry: 2.7.7.89 [3.1.4.15](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.11.1 [3.1.4.25](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.11.2 [3.1.4.27](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.11.3 [3.1.4.28](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.11.4 [3.1.4.31](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.13.1 [3.1.4.20](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.13.3 [3.1.4.19](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.16.1 [3.1.4.18](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.21.1 [3.1.4.5](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.21.2 [3.1.4.30](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.22.1 [3.1.4.6](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.27.3 [3.1.4.8](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.30.1 [3.1.4.21](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.30.2 [3.1.4.9](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.31.1 [3.1.4.7](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.4.43 [3.1.4.36](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.4.53 [3.1.4.n1](0|0) (0|0|0)
- 1:   Transferred entry: 4.6.1.13 [3.1.4.10](0|0) (0|0|0)
- 1:   Transferred entry: 4.6.1.14 [3.1.4.47](0|0) (0|0|0)
- 1:   Transferred entry: 4.6.1.18 [3.1.4.22](0|0) (0|0|0)
- 1:   Transferred entry: 4.6.1.19 [3.1.4.23](0|0) (0|0|0)
- 1:   [Acyl-carrier-protein] phosphodiesterase [3.1.4.14](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
HD-domain/PDEase-like0Direct
GAF domain-like0Direct
EF-hand0Direct
EAL domain-like0Direct
Somatomedin B domain0Direct
LigT-like0Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0Direct
PH domain-like0Direct
PLC-like phosphodiesterases0Direct
Phospholipase D/nuclease0Direct
PX domain0Direct
C-terminal domain of PLC-beta0Direct
His-Me finger endonucleases5.081e-16Direct
Alkaline phosphatase-like0.0000000000001914Direct
Integrin alpha N-terminal domain0.0000000000003412Direct
Ras GEF0.000000000006729Direct
PYP-like sensor domain (PAS domain)0.0000000003089Direct
Phospholipase C/P1 nuclease0.00000000118Direct
SH3-domain0.00000002077Direct
Saposin0.0000001378Direct
Nucleotide cyclase0.00001258Direct
SH2 domain0.00003264Direct
DNase I-like0.0000741Direct
Metallo-dependent phosphatases0.0001031Direct
DHH phosphoesterases0.0001115Direct
Ankyrin repeat0.000349Direct
Starch-binding domain-like0.001013Inherited
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain0.001952Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.004562Inherited
Ubiquitin-like0.01885Inherited
Metallo-hydrolase/oxidoreductase1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
GAF domain0Direct
GpdQ-like0Direct
2',3'-cyclic nucleotide 3'-phosphodiesterase, catalytic domain0Direct
2'-5' RNA ligase LigT0Direct
EAL domain0Direct
Phospholipase C0Direct
Sphingomyelin phosphodiesterase-like0Direct
PLC-like (P variant)0Direct
tRNA splicing product Appr>p cyclic nucleotide phosphodiesterase0Direct
Mammalian PLC0Direct
Glycerophosphoryl diester phosphodiesterase0Direct
PDEase0Direct
PX domain0Direct
Alpha-toxin, C-terminal domain0Direct
Integrin alpha N-terminal domain0Direct
Pleckstrin-homology domain (PH domain)0Direct
EF-hand modules in multidomain proteins0Direct
C-terminal domain of PLC-beta0Direct
Somatomedin B domain0Direct
Nuclease0Direct
Ras GEF0.0000000000003284Direct
SH3-domain0.0000000001481Direct
DNA/RNA non-specific endonuclease0.00000000252Direct
Ras-binding domain, RBD0.00000001308Direct
GGDEF domain0.00000001762Direct
SH2 domain0.0000003758Direct
Ankyrin repeat0.00002148Direct
Starch-binding domain0.00005947Direct
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain0.0001018Direct
5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain0.0001018Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
EF-hand0Direct
EAL domain-like0Direct
PLC-like phosphodiesterases0Direct
PH domain-like0Direct
PX domain0Direct
Phospholipase D/nuclease0Direct
LigT-like0Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0Direct
GAF domain-like0Direct
HD-domain/PDEase-like0Direct
C-terminal domain of PLC-beta0Direct
Somatomedin B domain0Direct
His-Me finger endonucleases3.539e-16Direct
Alkaline phosphatase-like0.0000000000001364Direct
Integrin alpha N-terminal domain0.0000000000002439Direct
Ras GEF0.000000000004874Direct
PYP-like sensor domain (PAS domain)0.0000000002286Direct
Phospholipase C/P1 nuclease0.0000000008809Direct
SH3-domain0.00000001576Direct
Saposin0.0000001058Direct
Nucleotide cyclase0.000009987Direct
SH2 domain0.0000261Direct
DNase I-like0.00005965Direct
Metallo-dependent phosphatases0.00008341Direct
DHH phosphoesterases0.00009026Direct
Ankyrin repeat0.0002848Direct
Starch-binding domain-like0.0008363Direct
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain0.001625Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.00383Inherited
Ubiquitin-like0.01611Inherited
Metallo-hydrolase/oxidoreductase1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55073,141868
  • 55073 - Nucleotide cyclase
  • 141868 - EAL domain-like
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    49562,56024
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 56024 - Phospholipase D/nuclease
  • 0Direct
    52540,55144
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 55144 - LigT-like
  • 0Direct
    49562,54236
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 54236 - Ubiquitin-like
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    51695,51695
  • 51695 - PLC-like phosphodiesterases
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    50729,56024
  • 50729 - PH domain-like
  • 56024 - Phospholipase D/nuclease
  • 0Direct
    64268,50729
  • 64268 - PX domain
  • 50729 - PH domain-like
  • 0Direct
    50044,51695
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    53649,54060
  • 53649 - Alkaline phosphatase-like
  • 54060 - His-Me finger endonucleases
  • 0Direct
    90188,90188
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 0Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    90188,53649
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    56024,56024
  • 56024 - Phospholipase D/nuclease
  • 56024 - Phospholipase D/nuclease
  • 0Direct
    48537,49723
  • 48537 - Phospholipase C/P1 nuclease
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0Direct
    54236,54236
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0.00000004378Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0000001765Direct
    56300,55816
  • 56300 - Metallo-dependent phosphatases
  • 55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain
  • 0.001625Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    47473,51695,49562
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    55550,50044,51695
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    50044,51695,49562
  • 50044 - SH3-domain
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    56024,56024,56024
  • 56024 - Phospholipase D/nuclease
  • 56024 - Phospholipase D/nuclease
  • 56024 - Phospholipase D/nuclease
  • 0Direct
    50729,56024,56024
  • 50729 - PH domain-like
  • 56024 - Phospholipase D/nuclease
  • 56024 - Phospholipase D/nuclease
  • 0Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    55781,55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    90188,53649,54060
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 54060 - His-Me finger endonucleases
  • 0Direct
    49562,54236,54236
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 54236 - Ubiquitin-like
  • 54236 - Ubiquitin-like
  • 0Direct
    64268,50729,56024
  • 64268 - PX domain
  • 50729 - PH domain-like
  • 56024 - Phospholipase D/nuclease
  • 0Direct
    55550,55550,50044
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    90188,90188,53649
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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