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Enzyme Commission (EC): Cysteine endopeptidases

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Hydrolases [3] <13>(395|668) (394|418|206)
+ 1:   Acting on peptide bonds (peptidases) [3.4] <19>(114|168) (114|130|72)
0:   Cysteine endopeptidases [3.4.22] <71>(24|30) (24|22|12)
- 1:   Actinidain [3.4.22.14](0|0) (0|0|0)
- 1:   Adenain [3.4.22.39](1|1) (1|0|0)
- 1:   Ananain [3.4.22.31](0|0) (0|0|0)
- 1:   Asclepain [3.4.22.7](0|0) (0|0|0)
- 1:   Bleomycin hydrolase [3.4.22.40](0|1) (1|0|0)
- 1:   Calicivirin [3.4.22.66](3|2) (3|3|2)
- 1:   Calpain-1 [3.4.22.52](2|3) (2|2|1)
- 1:   Calpain-2 [3.4.22.53](2|3) (2|2|1)
- 1:   Calpain-3 [3.4.22.54](2|3) (2|1|0)
- 1:   Cancer procoagulant [3.4.22.26](0|0) (0|0|0)
- 1:   Caricain [3.4.22.30](0|0) (0|0|0)
- 1:   Caspase-1 [3.4.22.36](2|2) (2|1|0)
- 1:   Caspase-10 [3.4.22.63](0|0) (0|0|0)
- 1:   Caspase-11 [3.4.22.64](0|0) (0|0|0)
- 1:   Caspase-2 [3.4.22.55](2|2) (2|1|0)
- 1:   Caspase-3 [3.4.22.56](1|1) (1|0|0)
- 1:   Caspase-4 [3.4.22.57](0|0) (0|0|0)
- 1:   Caspase-5 [3.4.22.58](0|0) (0|0|0)
- 1:   Caspase-6 [3.4.22.59](1|1) (1|0|0)
- 1:   Caspase-7 [3.4.22.60](1|1) (1|0|0)
- 1:   Caspase-8 [3.4.22.61](2|2) (2|2|1)
- 1:   Caspase-9 [3.4.22.62](0|0) (0|0|0)
- 1:   Cathepsin B [3.4.22.1](0|1) (0|0|0)
- 1:   Cathepsin F [3.4.22.41](0|0) (0|0|0)
- 1:   Cathepsin H [3.4.22.16](0|1) (0|0|0)
- 1:   Cathepsin K [3.4.22.38](0|1) (0|0|0)
- 1:   Cathepsin L [3.4.22.15](1|1) (1|0|0)
- 1:   Cathepsin O [3.4.22.42](0|0) (0|0|0)
- 1:   Cathepsin S [3.4.22.27](0|0) (0|0|0)
- 1:   Cathepsin T [3.4.22.24](0|0) (0|0|0)
- 1:   Cathepsin V [3.4.22.43](0|0) (0|0|0)
- 1:   Chymopapain [3.4.22.6](0|0) (0|0|0)
- 1:   Clostripain [3.4.22.8](0|0) (0|0|0)
- 1:   Cruzipain [3.4.22.51](0|0) (0|0|0)
- 1:   Deleted entry [3.4.22.13](0|0) (0|0|0)
- 1:   Deleted entry [3.4.22.20](0|0) (0|0|0)
- 1:   Ficain [3.4.22.3](0|0) (0|0|0)
- 1:   Fruit bromelain [3.4.22.33](0|0) (0|0|0)
- 1:   Gingipain K [3.4.22.47](0|1) (1|0|0)
- 1:   Gingipain R [3.4.22.37](2|2) (2|1|0)
- 1:   Glycyl endopeptidase [3.4.22.25](0|0) (0|0|0)
- 1:   Helper-component proteinase [3.4.22.45](4|3) (4|2|0)
- 1:   Histolysain [3.4.22.35](0|0) (0|0|0)
- 1:   L-peptidase [3.4.22.46](1|3) (2|3|1)
- 1:   Legumain [3.4.22.34](0|0) (0|0|0)
- 1:   Nuclear-inclusion-a endopeptidase [3.4.22.44](3|2) (3|2|0)
- 1:   Papain [3.4.22.2](0|0) (0|0|0)
- 1:   Peptidase 1 (mite) [3.4.22.65](0|0) (0|0|0)
- 1:   Picornain 2A [3.4.22.29](5|4) (5|5|4)
- 1:   Picornain 3C [3.4.22.28](6|6) (6|7|6)
- 1:   SARS coronavirus main proteinase [3.4.22.69](10|10) (10|6|2)
- 1:   Separase [3.4.22.49](0|0) (0|0|0)
- 1:   Sortase A [3.4.22.70](1|1) (1|0|0)
- 1:   Sortase B [3.4.22.71](0|0) (0|0|0)
- 1:   Staphopain [3.4.22.48](1|1) (1|1|0)
- 1:   Stem bromelain [3.4.22.32](0|0) (0|0|0)
- 1:   Streptopain [3.4.22.10](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.19.9 [3.4.22.12](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.21.26 [3.4.22.18](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.21.48 [3.4.22.9](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.21.61 [3.4.22.23](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.22.32 and 3.4.22.33 [3.4.22.4](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.22.33 [3.4.22.5](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.22.52 and 3.4.22.53 [3.4.22.17](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.24.15 [3.4.22.19](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.24.37 [3.4.22.22](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.24.56 [3.4.22.11](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.25.1 [3.4.22.21](0|0) (0|0|0)
- 1:   Ulp1 peptidase [3.4.22.68](0|0) (0|0|0)
- 1:   V-cath endopeptidase [3.4.22.50](1|1) (1|0|0)
- 1:   Zingipain [3.4.22.67](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Soluble domain of poliovirus core protein 3a0Direct
Cystatin/monellin0Direct
EF-hand0Direct
Cysteine proteinases0Direct
DNA/RNA polymerases0Direct
Replicase NSP90Direct
Coronavirus NSP7-like0Direct
Coronavirus NSP8-like0Direct
SARS Nsp1-like0Direct
Positive stranded ssRNA viruses0Direct
Calpain large subunit, middle domain (domain III)0Direct
Trypsin-like serine proteases0Direct
Caspase-like0Direct
EndoU-like0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Viral leader polypeptide zinc finger0Direct
NSP3A-like0Direct
TMV-like viral coat proteins0Direct
Coronavirus NSP10-like0Direct
Sortase0Direct
DEATH domain0Direct
Macro domain-like0.01161Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.01455Inherited
E set domains0.9159Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Coronavirus NSP10-like0Direct
Caspase catalytic domain0Direct
Macro domain0Direct
Gingipain R (RgpB), N-terminal domain0Direct
TMV-like viral coat proteins0Direct
Nsp15 N-terminal domain-like0Direct
Papain-like0Direct
NSP3A-like0Direct
Caspase recruitment domain, CARD0Direct
Caliciviridae-like VP0Direct
Picornaviridae-like VP (VP1, VP2, VP3 and VP4)0Direct
Calpain large subunit, middle domain (domain III)0Direct
RNA-dependent RNA-polymerase0Direct
DEATH effector domain, DED0Direct
Penta-EF-hand proteins0Direct
Gingipain R (RgpB), C-terminal domain0Direct
SARS Nsp1-like0Direct
Viral leader polypeptide zinc finger0Direct
Nsp15 C-terminal domain-like0Direct
Coronavirus NSP7-like0Direct
Replicase NSP90Direct
FMDV leader protease0Direct
Sortase0Direct
Adenain-like0Direct
Coronavirus NSP8-like0Direct
Staphopain B, prodomain0Direct
Soluble domain of poliovirus core protein 3a0Direct
Viral cysteine protease of trypsin fold0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
Viral proteases0.0000000222Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
EF-hand0Direct
DNA/RNA polymerases0Direct
Coronavirus NSP10-like0Direct
Calpain large subunit, middle domain (domain III)0Direct
EndoU-like0Direct
Positive stranded ssRNA viruses0Direct
NSP3A-like0Direct
Sortase0Direct
Cystatin/monellin0Direct
Coronavirus NSP7-like0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
TMV-like viral coat proteins0Direct
Caspase-like0Direct
Viral leader polypeptide zinc finger0Direct
Replicase NSP90Direct
Cysteine proteinases0Direct
Trypsin-like serine proteases0Direct
SARS Nsp1-like0Direct
Soluble domain of poliovirus core protein 3a0Direct
Coronavirus NSP8-like0Direct
DEATH domain0Direct
Macro domain-like0.009866Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.01239Inherited
E set domains0.8463Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50494,56672
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    143076,101816
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 0Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0Direct
    159936,53335
  • 159936 - NSP3A-like
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    52540,89043
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 0Direct
    54403,54001
  • 54403 - Cystatin/monellin
  • 54001 - Cysteine proteinases
  • 0Direct
    52129,81296
  • 52129 - Caspase-like
  • 81296 - E set domains
  • 0Direct
    88633,50494
  • 88633 - Positive stranded ssRNA viruses
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    49758,47473
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    101816,144246
  • 101816 - Replicase NSP9
  • 144246 - Coronavirus NSP10-like
  • 0Direct
    56672,88633
  • 56672 - DNA/RNA polymerases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    140367,143076
  • 140367 - Coronavirus NSP7-like
  • 143076 - Coronavirus NSP8-like
  • 0Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    89043,50494
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    159936,52949
  • 159936 - NSP3A-like
  • 52949 - Macro domain-like
  • 0Direct
    88633,88633
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    54001,88633
  • 54001 - Cysteine proteinases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    53335,142877
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 142877 - EndoU-like
  • 0Direct
    50494,52540
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 8.811e-16Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000000006305Direct
    52540,56672
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0.00002535Direct

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    88633,50494,52540
  • 88633 - Positive stranded ssRNA viruses
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    54001,49758,47473
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0Direct
    50494,52540,56672
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    54001,88633,88633
  • 54001 - Cysteine proteinases
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    143076,101816,144246
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 144246 - Coronavirus NSP10-like
  • 0Direct
    89043,50494,56672
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    52540,89043,50494
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    50494,56672,88633
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    88633,88633,88633
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    50494,52540,89043
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 0Direct
    140367,143076,101816
  • 140367 - Coronavirus NSP7-like
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)