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Enzyme Commission (EC): Acting on carbon-nitrogen bonds, other than peptide bonds

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <7>
+ 1:   Hydrolases [3] <13>(396|669) (395|421|209)
0:   Acting on carbon-nitrogen bonds, other than peptide bonds [3.5] <6>(72|104) (72|40|18)
- 1:   In linear amides [3.5.1] <136>(38|49) (38|20|7)
- 1:   In cyclic amidines [3.5.4] <49>(17|22) (17|10|3)
- 1:   In linear amidines [3.5.3] <26>(10|14) (10|5|1)
- 1:   In cyclic amides [3.5.2] <20>(14|16) (14|10|9)
- 1:   In other compounds [3.5.99] <11>(4|4) (4|0|0)
- 1:   In nitriles [3.5.5] <8>(1|1) (1|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Zn-dependent exopeptidases0Direct
Methylglyoxal synthase-like0Direct
Bacterial exopeptidase dimerisation domain0Direct
Urease, beta-subunit0Direct
YrdC/RibB0Direct
SpoIIaa-like0Direct
Metallo-dependent hydrolases0Direct
Isochorismatase-like hydrolases0Direct
Methylesterase CheB, C-terminal domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Glycoside hydrolase/deacetylase0Direct
CheY-like0Direct
Carbon-nitrogen hydrolase0Direct
Putative cyclase0Direct
CinA-like0Direct
LmbE-like0Direct
HisI-like0Direct
Transthyretin (synonym: prealbumin)0Direct
Glutaminase/Asparaginase0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
RibA-like0Direct
Cytidine deaminase-like0Direct
Tetrahydrobiopterin biosynthesis enzymes-like0Direct
CNF1/YfiH-like putative cysteine hydrolases0Direct
Class I glutamine amidotransferase-like0Direct
Arginase/deacetylase0Direct
NagB/RpiA/CoA transferase-like0Direct
Peptide deformylase0Direct
beta-lactamase/transpeptidase-like0Direct
Creatininase0Direct
Composite domain of metallo-dependent hydrolases0Direct
Pentein0Direct
Urease, gamma-subunit0Direct
Prokaryotic SH3-related domain0Direct
Acetamidase/Formamidase-like0Direct
NAD(P)-binding Rossmann-fold domains0Direct
Archaeal IMP cyclohydrolase PurO0Direct
dUTPase-like0Direct
Peptidylarginine deiminase Pad4, middle domain0Direct
Methenyltetrahydromethanopterin cyclohydrolase0Direct
PUG domain-like0.00000000001663Direct
HCP-like0.00000000001983Direct
PH0987 N-terminal domain-like0.00000001648Direct
YjgF-like0.00000002304Direct
Heme oxygenase-like0.000006581Direct
Dihydrofolate reductase-like0.0001088Direct
LysM domain0.0004154Direct
Ribosomal protein S5 domain 2-like0.002197Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.007415Inherited
Amidase signature (AS) enzymes0.01127Inherited
Ankyrin repeat0.02728Inherited
Cell wall binding repeat0.06938Inherited
Cupredoxins0.2707Inherited
Carbamoyl phosphate synthetase, small subunit N-terminal domain0.7573Inherited
Carbamoyl phosphate synthetase, large subunit connection domain0.9786Inherited
Cysteine proteinases1Inherited
"Winged helix" DNA-binding domain1Inherited
Creatinase/prolidase N-terminal domain1Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)1Inherited
alpha/beta-Hydrolases1Inherited
all-alpha NTP pyrophosphatases1Inherited
ACT-like1Inherited
Cyclophilin-like1Inherited
PreATP-grasp domain1Inherited
Formyltransferase1Inherited
dsRNA-binding domain-like1Inherited
RmlC-like cupins1Inherited
Galactose-binding domain-like1Inherited
Aspartate/ornithine carbamoyltransferase1Inherited
Creatinase/aminopeptidase1Inherited
PGBD-like1Inherited
Metallo-hydrolase/oxidoreductase1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Methylesterase CheB, C-terminal domain0Direct
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB0Direct
Peptidylarginine deiminase Pad4, catalytic C-terminal domain0Direct
alpha-Subunit of urease0Direct
Arginine deiminase0Direct
Dihydroorotase0Direct
LmbE-like0Direct
Zn metallo-beta-lactamase0Direct
CinA-like0Direct
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase LpxC0Direct
Cytidine deaminase0Direct
Glutaminase0Direct
Tetrahydrofolate dehydrogenase/cyclohydrolase0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Peptide deformylase0Direct
Glutaminase/Asparaginase0Direct
Penicillin acylase, catalytic domain0Direct
Dimethylarginine dimethylaminohydrolase DDAH0Direct
Transthyretin (synonym: prealbumin)0Direct
LamB/YcsF-like0Direct
Z-DNA binding domain0Direct
Allantoicase repeat0Direct
D-aminoacylase, catalytic domain0Direct
Deoxycytidylate deaminase-like0Direct
N-acetylglucosamine-6-phosphate deacetylase, NagA0Direct
Archaeal IMP cyclohydrolase PurO0Direct
Isochorismatase-like hydrolases0Direct
Class I glutamine amidotransferases (GAT)0Direct
Histone deacetylase, HDAC0Direct
GTP cyclohydrolase I0Direct
Urease, gamma-subunit0Direct
Hydantoinase (dihydropyrimidinase)0Direct
D-aminoacylase0Direct
Peptidylarginine deiminase Pad4, N-terminal domain0Direct
Arginase-like amidino hydrolases0Direct
YlbA-like0Direct
Cytosine deaminase catalytic domain0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
N-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain0Direct
SAH/MTA deaminase-like0Direct
RibA-like0Direct
alpha-subunit of urease, catalytic domain0Direct
Bacterial dinuclear zinc exopeptidases0Direct
beta-Lactamase/D-ala carboxypeptidase0Direct
DJ-1/PfpI0Direct
HisI-like0Direct
Putative serine hydrolase Ydr428c0Direct
NagB-like0Direct
Extended PAW domain0Direct
AstE/AspA-like0Direct
Putative cyclase0Direct
Adenosine/AMP deaminase0Direct
Peptidylarginine deiminase Pad4, middle domain0Direct
Creatininase0Direct
GW domain0Direct
CheY-related0Direct
Imidazolonepropionase-like0Direct
Carbamilase0Direct
Bacterial exopeptidase dimerisation domain0Direct
Succinylarginine dihydrolase-like0Direct
Porphyromonas-type peptidylarginine deiminase0Direct
AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC0Direct
SAH/MTA deaminase-like0Direct
Inosicase0Direct
Urease, beta-subunit0Direct
Acetamidase/Formamidase-like0Direct
CheD-like0Direct
Imidazolonepropionase-like0Direct
Methenyltetrahydromethanopterin cyclohydrolase0Direct
dUTPase-like0Direct
YdjC-like0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
TENA/THI-43.693e-16Direct
Transglutaminase core0.000000000000001826Direct
HCP-like0.00000000000009595Direct
Nitrilase0.0000000000001092Direct
RibD C-terminal domain-like0.00000000000179Direct
(Glycosyl)asparaginase0.00000000001455Direct
PUG domain0.00000000001838Direct
YjgF/L-PSP0.00000000238Direct
PH0987 C-terminal domain-like0.00000001658Direct
PH0987 N-terminal domain-like0.0000003362Direct
NodB-like polysaccharide deacetylase0.0000006067Direct
Peptidoglycan binding domain, PGBD0.00002295Direct
LysM domain0.0004719Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.01144Inherited
Amidase signature (AS) enzymes0.01865Inherited
Ankyrin repeat0.02942Inherited
Cell wall binding repeat0.06732Inherited
Carbamoyl phosphate synthetase, small subunit N-terminal domain0.7597Inherited
Carbamoyl phosphate synthetase, large subunit connection domain0.953Inherited
L-histidinol dehydrogenase HisD0.9603Inherited
Zf-UBP1Inherited
Carboxylesterase1Inherited
Class II glutamine amidotransferases1Inherited
Creatinase/prolidase N-terminal domain1Inherited
Formyltransferase1Inherited
Double-stranded RNA-binding domain (dsRBD)1Inherited
BC N-terminal domain-like1Inherited
Aspartate/ornithine carbamoyltransferase1Inherited
Creatinase/aminopeptidase1Inherited
HisE-like (PRA-PH)1Inherited
BC ATP-binding domain-like1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Glutaminase/Asparaginase0Direct
Methylglyoxal synthase-like0Direct
CinA-like0Direct
HisI-like0Direct
Peptide deformylase0Direct
YrdC/RibB0Direct
Carbon-nitrogen hydrolase0Direct
Glycoside hydrolase/deacetylase0Direct
Archaeal IMP cyclohydrolase PurO0Direct
NagB/RpiA/CoA transferase-like0Direct
Putative cyclase0Direct
Peptidylarginine deiminase Pad4, middle domain0Direct
Urease, gamma-subunit0Direct
CNF1/YfiH-like putative cysteine hydrolases0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Methenyltetrahydromethanopterin cyclohydrolase0Direct
Zn-dependent exopeptidases0Direct
Acetamidase/Formamidase-like0Direct
CheY-like0Direct
Creatininase0Direct
Metallo-dependent hydrolases0Direct
Cytidine deaminase-like0Direct
NAD(P)-binding Rossmann-fold domains0Direct
LmbE-like0Direct
Methylesterase CheB, C-terminal domain0Direct
Composite domain of metallo-dependent hydrolases0Direct
Isochorismatase-like hydrolases0Direct
beta-lactamase/transpeptidase-like0Direct
Transthyretin (synonym: prealbumin)0Direct
Bacterial exopeptidase dimerisation domain0Direct
Pentein0Direct
Arginase/deacetylase0Direct
RibA-like0Direct
Urease, beta-subunit0Direct
SpoIIaa-like0Direct
dUTPase-like0Direct
Tetrahydrobiopterin biosynthesis enzymes-like0Direct
Class I glutamine amidotransferase-like0Direct
Prokaryotic SH3-related domain0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
PUG domain-like0.00000000001206Direct
HCP-like0.0000000000144Direct
PH0987 N-terminal domain-like0.00000001247Direct
YjgF-like0.00000001747Direct
Heme oxygenase-like0.000005179Direct
Dihydrofolate reductase-like0.00008787Direct
LysM domain0.0003388Direct
Ribosomal protein S5 domain 2-like0.001829Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.006252Inherited
Amidase signature (AS) enzymes0.009556Inherited
Ankyrin repeat0.02339Inherited
Cell wall binding repeat0.06021Inherited
Cupredoxins0.2427Inherited
Carbamoyl phosphate synthetase, small subunit N-terminal domain0.6968Inherited
Carbamoyl phosphate synthetase, large subunit connection domain0.9058Inherited
all-alpha NTP pyrophosphatases0.9399Inherited
Cyclophilin-like0.9472Inherited
PGBD-like0.9864Inherited
Galactose-binding domain-like1Inherited
"Winged helix" DNA-binding domain1Inherited
PreATP-grasp domain1Inherited
RmlC-like cupins1Inherited
Formyltransferase1Inherited
Creatinase/prolidase N-terminal domain1Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)1Inherited
dsRNA-binding domain-like1Inherited
alpha/beta-Hydrolases1Inherited
Metallo-hydrolase/oxidoreductase1Inherited
Cysteine proteinases1Inherited
Aspartate/ornithine carbamoyltransferase1Inherited
Creatinase/aminopeptidase1Inherited
ACT-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    55846,47090
  • 55846 - N-acetylmuramoyl-L-alanine amidase-like
  • 47090 - PGBD-like
  • 0Direct
    56601,52091
  • 56601 - beta-lactamase/transpeptidase-like
  • 52091 - SpoIIaa-like
  • 0Direct
    54001,49785
  • 54001 - Cysteine proteinases
  • 49785 - Galactose-binding domain-like
  • 0Direct
    54111,51278
  • 54111 - Urease, gamma-subunit
  • 51278 - Urease, beta-subunit
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    101386,53720
  • 101386 - all-alpha NTP pyrophosphatases
  • 53720 - ALDH-like
  • 0Direct
    51278,51338
  • 51278 - Urease, beta-subunit
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    55021,53328
  • 55021 - ACT-like
  • 53328 - Formyltransferase
  • 0Direct
    52335,53927
  • 52335 - Methylglyoxal synthase-like
  • 53927 - Cytidine deaminase-like
  • 0Direct
    54211,54637
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    53927,53927
  • 53927 - Cytidine deaminase-like
  • 53927 - Cytidine deaminase-like
  • 0Direct
    49503,110083
  • 49503 - Cupredoxins
  • 110083 - Peptidylarginine deiminase Pad4, middle domain
  • 0Direct
    54211,54211
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    141734,101386
  • 141734 - HisI-like
  • 101386 - all-alpha NTP pyrophosphatases
  • 0Direct
    110083,55909
  • 110083 - Peptidylarginine deiminase Pad4, middle domain
  • 55909 - Pentein
  • 0Direct
    52172,52738
  • 52172 - CheY-like
  • 52738 - Methylesterase CheB, C-terminal domain
  • 0Direct
    56601,48403
  • 56601 - beta-lactamase/transpeptidase-like
  • 48403 - Ankyrin repeat
  • 0Direct
    53927,53597
  • 53927 - Cytidine deaminase-like
  • 53597 - Dihydrofolate reductase-like
  • 0Direct
    53774,48403
  • 53774 - Glutaminase/Asparaginase
  • 48403 - Ankyrin repeat
  • 0Direct
    143503,54001
  • 143503 - PUG domain-like
  • 54001 - Cysteine proteinases
  • 0Direct
    53187,55031
  • 53187 - Zn-dependent exopeptidases
  • 55031 - Bacterial exopeptidase dimerisation domain
  • 0Direct
    52768,52768
  • 52768 - Arginase/deacetylase
  • 52768 - Arginase/deacetylase
  • 0Direct
    55821,142695
  • 55821 - YrdC/RibB
  • 142695 - RibA-like
  • 0Direct
    52335,51556
  • 52335 - Methylglyoxal synthase-like
  • 51556 - Metallo-dependent hydrolases
  • 0.000000001097Direct
    160467,50891
  • 160467 - PH0987 N-terminal domain-like
  • 50891 - Cyclophilin-like
  • 0.00000001247Direct
    52317,52440
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 0.0000000596Direct
    54106,54001
  • 54106 - LysM domain
  • 54001 - Cysteine proteinases
  • 0.00000225Direct
    52317,51366
  • 52317 - Class I glutamine amidotransferase-like
  • 51366 - Ribulose-phoshate binding barrel
  • 0.001239Inherited
    47090,47090
  • 47090 - PGBD-like
  • 47090 - PGBD-like
  • 0.003272Inherited
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.01309Inherited
    54106,54106
  • 54106 - LysM domain
  • 54106 - LysM domain
  • 0.01867Inherited
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.03322Inherited
    52021,52317
  • 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
  • 52317 - Class I glutamine amidotransferase-like
  • 0.6968Inherited
    56059,52335
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52335 - Methylglyoxal synthase-like
  • 0.8331Inherited
    48108,52440
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 0.8959Inherited
    56059,48108
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 0.9025Inherited
    53092,55920
  • 53092 - Creatinase/prolidase N-terminal domain
  • 55920 - Creatinase/aminopeptidase
  • 1Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51338,51556,51338
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    51278,51338,51556
  • 51278 - Urease, beta-subunit
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    49503,110083,55909
  • 49503 - Cupredoxins
  • 110083 - Peptidylarginine deiminase Pad4, middle domain
  • 55909 - Pentein
  • 0Direct
    54768,54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    54111,51278,51338
  • 54111 - Urease, gamma-subunit
  • 51278 - Urease, beta-subunit
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    143503,54001,49785
  • 143503 - PUG domain-like
  • 54001 - Cysteine proteinases
  • 49785 - Galactose-binding domain-like
  • 0Direct
    54211,54211,54637
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    141734,101386,53720
  • 141734 - HisI-like
  • 101386 - all-alpha NTP pyrophosphatases
  • 53720 - ALDH-like
  • 0Direct
    52335,51556,51338
  • 52335 - Methylglyoxal synthase-like
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0.00000000002742Direct
    56059,52335,51556
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52335 - Methylglyoxal synthase-like
  • 51556 - Metallo-dependent hydrolases
  • 0.000000001097Direct
    52317,52440,56059
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.0000000596Direct
    52021,52317,52440
  • 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 0.0000000596Direct
    54106,54106,54001
  • 54106 - LysM domain
  • 54106 - LysM domain
  • 54001 - Cysteine proteinases
  • 0.000009675Direct
    54106,54106,54106
  • 54106 - LysM domain
  • 54106 - LysM domain
  • 54106 - LysM domain
  • 0.005279Inherited
    52440,56059,52335
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52335 - Methylglyoxal synthase-like
  • 0.8287Inherited
    56059,48108,52440
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 0.8924Inherited
    48108,52440,56059
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.8959Inherited
    52440,56059,48108
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 0.9025Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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