SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Enzyme Commission (EC): Acting on acid anhydrides

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <7>
+ 1:   Hydrolases [3] <13>(395|668) (394|417|206)
0:   Acting on acid anhydrides [3.6] <5>(99|125) (98|99|65)
- 1:   In phosphorus-containing anhydrides [3.6.1] <73>(47|60) (47|43|30)
- 1:   Acting on acid anhydrides; catalyzing transmembrane movement of substances [3.6.3] <56>(4|4) (4|1|0)
- 1:   Acting on ATP; involved in cellular and subcellular movement [3.6.4] <13>(57|70) (56|60|32)
- 1:   Acting on GTP; involved in cellular and subcellular movement [3.6.5] <7>(5|5) (5|6|4)
- 1:   In sulfonyl-containing anhydrides [3.6.2] <2>(1|1) (1|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Viral glycoprotein, central and dimerisation domains0Direct
Sec63 N-terminal domain-like0Direct
Chromo domain-like0Direct
Rap30/74 interaction domains0Direct
DNA/RNA polymerases0Direct
ITPase-like0Direct
Metallo-dependent phosphatases0Direct
AN1-like Zinc finger0Direct
SPOC domain-like0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
HIT-like0Direct
Apyrase0Direct
DNA helicase RuvA subunit, C-terminal domain0Direct
Origin of replication-binding domain, RBD-like0Direct
Inorganic pyrophosphatase0Direct
all-alpha NTP pyrophosphatases0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
C-terminal domain of Ku800Direct
Nucleic acid-binding proteins0Direct
EndoU-like0Direct
Initiation factor IF2/eIF5b, domain 30Direct
Soluble domain of poliovirus core protein 3a0Direct
BRK domain-like0Direct
Dcp2 domain-like0Direct
dUTPase-like0Direct
Restriction endonuclease-like0Direct
Positive stranded ssRNA viruses0Direct
Translation proteins0Direct
"Winged helix" DNA-binding domain0Direct
DNA primase core0Direct
Acylphosphatase/BLUF domain-like0Direct
DHH phosphoesterases0Direct
EF-G C-terminal domain-like0Direct
Cdc48 domain 2-like0Direct
mRNA decapping enzyme DcpS N-terminal domain0Direct
Flavivirus capsid protein C0Direct
Viral leader polypeptide zinc finger0Direct
N-terminal domain of DnaB helicase0Direct
Nudix0Direct
RuvA domain 2-like0Direct
Trypsin-like serine proteases0.00000000000002993Direct
vWA-like0.0000000000001739Direct
Tudor/PWWP/MBT0.00000000007346Direct
HMA, heavy metal-associated domain0.0000000003269Direct
SAP domain0.000000007418Direct
Coronavirus NSP7-like0.00000001524Direct
Replicase NSP90.00000001524Direct
Coronavirus NSP8-like0.00000001524Direct
Coronavirus NSP10-like0.00000001524Direct
Prokaryotic type I DNA topoisomerase0.00000002052Direct
MIT domain0.00000003344Direct
SCOP hierarchy in SUPERFAMILY0.00000003953Direct
Homing endonucleases0.00000007583Direct
E set domains0.00000007787Direct
HRDC-like0.000001093Direct
Hedgehog/intein (Hint) domain0.0000015Direct
NSP3A-like0.00000796Direct
F-box domain0.00001945Direct
RNA-binding domain, RBD0.00007308Direct
Somatomedin B domain0.00009522Direct
R3H domain0.0005618Direct
FYVE/PHD zinc finger0.001554Inherited
CYTH-like phosphatases0.002059Inherited
His-Me finger endonucleases0.002103Inherited
Bromodomain0.003065Inherited
post-AAA+ oligomerization domain-like0.003197Inherited
Ankyrin repeat0.004958Inherited
SARS Nsp1-like0.01421Inherited
Ribonuclease Rh-like0.01741Inherited
WW domain0.03956Inherited
CCCH zinc finger0.06471Inherited
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain0.07705Inherited
Retrovirus zinc finger-like domains0.1243Inherited
ADC-like0.1727Inherited
HD-domain/PDEase-like0.2044Inherited
UBA-like0.2175Inherited
Calcium ATPase, transduction domain A0.2336Inherited
Calcium ATPase, transmembrane domain M0.2368Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.2848Inherited
NTF2-like0.2946Inherited
Actin-like ATPase domain0.4627Inherited
Retrovirus capsid dimerization domain-like0.6328Inherited
Clavaminate synthase-like0.6423Inherited
HisI-like0.7696Inherited
Retrovirus capsid protein, N-terminal core domain0.9477Inherited
N-terminal Zn binding domain of HIV integrase0.9804Inherited
HAD-like1Inherited
Ribonuclease H-like1Inherited
Acid proteases1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
Alkaline phosphatase-like1Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase1Inherited
DNA-binding domain of retroviral integrase1Inherited
Retroviral matrix proteins1Inherited
Macro domain-like1Inherited
Cysteine proteinases1Inherited
PH domain-like1Inherited
SurE-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Viral leader polypeptide zinc finger0Direct
Tandem AAA-ATPase domain0Direct
Initiation factor IF2/eIF5b, domain 30Direct
mRNA decapping enzyme DcpS C-terminal domain0Direct
Ppx/GppA phosphatase0Direct
Actin/HSP700Direct
NTF2-like0Direct
dUTPase-like0Direct
EF-G/eEF-2 domains III and V0Direct
CDH-like0Direct
GUCT domain0Direct
RecQ helicase DNA-binding domain-like0Direct
Ppx associated domain0Direct
Ku80 subunit N-terminal domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
MazG-like0Direct
RNA helicase0Direct
Elongation factors0Direct
Sec63 C-terminal domain-like0Direct
Maf-like0Direct
MgsA/YrvN C-terminal domain-like0Direct
Manganese-dependent inorganic pyrophosphatase (family II)0Direct
Cdc48 domain 2-like0Direct
Picornaviridae-like VP (VP1, VP2, VP3 and VP4)0Direct
HIT (HINT, histidine triad) family of protein kinase-interacting proteins0Direct
Apyrase0Direct
Class II viral fusion proteins C-terminal domain0Direct
mRNA decapping enzyme-like0Direct
XPF/Rad1/Mus81 nuclease0Direct
mRNA decapping enzyme DcpS N-terminal domain0Direct
MutT-like0Direct
N-terminal domain of DnaB helicase0Direct
NADH pyrophosphatase0Direct
Viral proteases0Direct
HisE-like (PRA-PH)0Direct
Inorganic pyrophosphatase0Direct
RecG "wedge" domain0Direct
Rap30/74 interaction domains0Direct
TIP49 domain0Direct
DNA helicase RuvA subunit, C-terminal domain0Direct
ADPRibase-Mn-like0Direct
Achaeal helicase C-terminal domain0Direct
Replication initiation protein E10Direct
Sec63 N-terminal domain0Direct
ITPase (Ham1)0Direct
Ku80 subunit middle domain0Direct
Nsp15 C-terminal domain-like0Direct
BRK domain-like0Direct
Chromo domain0Direct
Viral glycoprotein, central and dimerisation domains0Direct
DNA-binding domain from rap300Direct
DNA helicase RuvA subunit, N-terminal domain0Direct
Viral cysteine protease of trypsin fold0Direct
G proteins0Direct
Acylphosphatase-like0Direct
mRNA cap methylase0Direct
Caliciviridae-like VP0Direct
Flavivirus capsid protein C0Direct
FMDV leader protease0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Soluble domain of poliovirus core protein 3a0Direct
Dcp2 box A domain0Direct
AN1-like Zinc finger0Direct
Extended AAA-ATPase domain0Direct
RNA-dependent RNA-polymerase0Direct
Macro domain0Direct
Helicase-like "domain" of reverse gyrase0Direct
Ku70 subunit N-terminal domain0Direct
DNA helicase RuvA subunit, middle domain0Direct
C-terminal domain of Ku800Direct
Ku70 subunit middle domain0Direct
Cdc48 N-terminal domain-like0Direct
Exodeoxyribonuclease V beta chain (RecB), C-terminal domain0Direct
Helicase DNA-binding domain0Direct
HRDC domain from helicases0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
Nsp15 N-terminal domain-like0Direct
CYTH domain0.000000000000001464Direct
Mason-Pfizer monkey virus matrix protein0.00000000002274Direct
HMA, heavy metal-associated domain0.0000000001373Direct
SAP domain0.000000003167Direct
Coronavirus NSP10-like0.000000003526Direct
Replicase NSP90.000000003526Direct
Coronavirus NSP7-like0.000000003526Direct
Coronavirus NSP8-like0.000000003526Direct
MIT domain0.000000007058Direct
Prokaryotic type I DNA topoisomerase0.000000008853Direct
Tudor domain0.000001818Direct
NSP3A-like0.000002801Direct
Intein (protein splicing domain)0.000003531Direct
F-box domain0.00001363Direct
Somatomedin B domain0.00005146Direct
AlkB-like0.0001432Direct
Protein serine/threonine phosphatase0.0002907Direct
R3H domain0.0003149Direct
Bromodomain0.002121Inherited
Ankyrin repeat0.00273Inherited
PHD domain0.008534Inherited
SARS Nsp1-like0.009837Inherited
Ribonuclease Rh-like0.01279Inherited
SPRY domain0.01477Inherited
WW domain0.02919Inherited
Pleckstrin-homology domain (PH domain)0.04592Inherited
CCCH zinc finger0.05105Inherited
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain0.05144Inherited
5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain0.05144Inherited
Meta-cation ATPase, catalytic domain P0.05552Inherited
Retrovirus zinc finger-like domains0.06452Inherited
NagD-like0.1227Inherited
Calcium ATPase, transduction domain A0.2296Inherited
Canonical RBD0.2348Inherited
Retrovirus capsid protein C-terminal domain0.4879Inherited
HisI-like0.5365Inherited
beta-Phosphoglucomutase-like0.6074Inherited
RecA protein-like (ATPase-domain)0.6577Inherited
Calcium ATPase, transmembrane domain M0.6911Inherited
Retroviral protease (retropepsin)0.713Inherited
L-histidinol dehydrogenase HisD0.7786Inherited
Retrovirus capsid protein, N-terminal core domain0.7804Inherited
N-terminal Zn binding domain of HIV integrase0.857Inherited
DNA-binding domain of retroviral integrase0.8847Inherited
SurE-like1Inherited
Reverse transcriptase1Inherited
Ribonuclease H1Inherited
Retroviral integrase, catalytic domain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Rap30/74 interaction domains0Direct
Acylphosphatase/BLUF domain-like0Direct
Metallo-dependent phosphatases0Direct
Nudix0Direct
Dcp2 domain-like0Direct
Restriction endonuclease-like0Direct
DNA helicase RuvA subunit, C-terminal domain0Direct
Cdc48 domain 2-like0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Nucleic acid-binding proteins0Direct
HIT-like0Direct
SPOC domain-like0Direct
EF-G C-terminal domain-like0Direct
BRK domain-like0Direct
Sec63 N-terminal domain-like0Direct
ITPase-like0Direct
dUTPase-like0Direct
Viral leader polypeptide zinc finger0Direct
DHH phosphoesterases0Direct
Chromo domain-like0Direct
AN1-like Zinc finger0Direct
DNA primase core0Direct
Positive stranded ssRNA viruses0Direct
"Winged helix" DNA-binding domain0Direct
N-terminal domain of DnaB helicase0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Origin of replication-binding domain, RBD-like0Direct
Translation proteins0Direct
Flavivirus capsid protein C0Direct
Inorganic pyrophosphatase0Direct
all-alpha NTP pyrophosphatases0Direct
Apyrase0Direct
C-terminal domain of Ku800Direct
RuvA domain 2-like0Direct
DNA/RNA polymerases0Direct
EndoU-like0Direct
Initiation factor IF2/eIF5b, domain 30Direct
mRNA decapping enzyme DcpS N-terminal domain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Soluble domain of poliovirus core protein 3a0Direct
Viral glycoprotein, central and dimerisation domains0Direct
Trypsin-like serine proteases0.00000000000002115Direct
vWA-like0.0000000000001237Direct
Tudor/PWWP/MBT0.00000000005383Direct
HMA, heavy metal-associated domain0.0000000002418Direct
SAP domain0.000000005593Direct
Coronavirus NSP7-like0.00000001153Direct
Replicase NSP90.00000001153Direct
Coronavirus NSP8-like0.00000001153Direct
Coronavirus NSP10-like0.00000001153Direct
Prokaryotic type I DNA topoisomerase0.00000001556Direct
MIT domain0.00000002541Direct
Homing endonucleases0.0000000579Direct
E set domains0.00000005943Direct
HRDC-like0.0000008527Direct
Hedgehog/intein (Hint) domain0.000001173Direct
NSP3A-like0.000006287Direct
F-box domain0.0000155Direct
RNA-binding domain, RBD0.00005877Direct
Somatomedin B domain0.0000768Direct
R3H domain0.0004604Direct
FYVE/PHD zinc finger0.001288Inherited
CYTH-like phosphatases0.001713Inherited
His-Me finger endonucleases0.00175Inherited
Bromodomain0.002562Inherited
post-AAA+ oligomerization domain-like0.002674Inherited
Ankyrin repeat0.00416Inherited
SARS Nsp1-like0.01209Inherited
Ribonuclease Rh-like0.01485Inherited
WW domain0.03404Inherited
CCCH zinc finger0.05614Inherited
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain0.06696Inherited
Retrovirus zinc finger-like domains0.1088Inherited
ADC-like0.1526Inherited
HD-domain/PDEase-like0.1814Inherited
UBA-like0.1933Inherited
Calcium ATPase, transduction domain A0.2081Inherited
Calcium ATPase, transmembrane domain M0.2111Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.2566Inherited
NTF2-like0.2657Inherited
Actin-like ATPase domain0.4218Inherited
Retrovirus capsid dimerization domain-like0.5811Inherited
Clavaminate synthase-like0.5898Inherited
HisI-like0.7084Inherited
Retrovirus capsid protein, N-terminal core domain0.8765Inherited
N-terminal Zn binding domain of HIV integrase0.9076Inherited
DNA-binding domain of retroviral integrase0.9289Inherited
Acid proteases1Inherited
HAD-like1Inherited
SurE-like1Inherited
PH domain-like1Inherited
Retroviral matrix proteins1Inherited
Macro domain-like1Inherited
Alkaline phosphatase-like1Inherited
Ribonuclease H-like1Inherited
Cysteine proteinases1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
53335,52949
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 52949 - Macro domain-like
  • 0Direct
    50447,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    48024,52540
  • 48024 - N-terminal domain of DnaB helicase
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50916,46785
  • 50916 - Rap30/74 interaction domains
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    55811,55811
  • 55811 - Nudix
  • 55811 - Nudix
  • 0Direct
    52540,56672
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    50249,47781
  • 50249 - Nucleic acid-binding proteins
  • 47781 - RuvA domain 2-like
  • 0Direct
    51283,51283
  • 51283 - dUTPase-like
  • 51283 - dUTPase-like
  • 0Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    140586,55811
  • 140586 - Dcp2 domain-like
  • 55811 - Nudix
  • 0Direct
    55464,52540
  • 55464 - Origin of replication-binding domain, RBD-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,47819
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47819 - HRDC-like
  • 0Direct
    50249,52540
  • 50249 - Nucleic acid-binding proteins
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,-9
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • -9 - PDB
  • 0Direct
    102860,54197
  • 102860 - mRNA decapping enzyme DcpS N-terminal domain
  • 54197 - HIT-like
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    56983,81296
  • 56983 - Viral glycoprotein, central and dimerisation domains
  • 81296 - E set domains
  • 0Direct
    101386,53720
  • 101386 - all-alpha NTP pyrophosphatases
  • 53720 - ALDH-like
  • 0Direct
    158702,52540
  • 158702 - Sec63 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    -9,52540
  • -9 - PDB
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    54001,88633
  • 54001 - Cysteine proteinases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    52540,-8
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • -8 - ECOD
  • 0Direct
    47781,46929
  • 47781 - RuvA domain 2-like
  • 46929 - DNA helicase RuvA subunit, C-terminal domain
  • 0Direct
    52156,50447
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 50447 - Translation proteins
  • 0Direct
    88633,88633
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    89043,50494
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    54980,54980
  • 54980 - EF-G C-terminal domain-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    101386,101386
  • 101386 - all-alpha NTP pyrophosphatases
  • 101386 - all-alpha NTP pyrophosphatases
  • 0Direct
    46785,47819
  • 46785 - "Winged helix" DNA-binding domain
  • 47819 - HRDC-like
  • 0Direct
    158702,81296
  • 158702 - Sec63 N-terminal domain-like
  • 81296 - E set domains
  • 0Direct
    50494,56672
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    52540,48403
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48403 - Ankyrin repeat
  • 0Direct
    53300,100939
  • 53300 - vWA-like
  • 100939 - SPOC domain-like
  • 0Direct
    52540,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    100939,101420
  • 100939 - SPOC domain-like
  • 101420 - C-terminal domain of Ku80
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    53335,142877
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 142877 - EndoU-like
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,49899
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    46785,158702
  • 46785 - "Winged helix" DNA-binding domain
  • 158702 - Sec63 N-terminal domain-like
  • 0Direct
    53067,109604
  • 53067 - Actin-like ATPase domain
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    52540,57756
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    52540,89043
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 0Direct
    56731,52540
  • 56731 - DNA primase core
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    100939,68906
  • 100939 - SPOC domain-like
  • 68906 - SAP domain
  • 0Direct
    52540,47370
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47370 - Bromodomain
  • 0Direct
    160481,160481
  • 160481 - BRK domain-like
  • 160481 - BRK domain-like
  • 0Direct
    52540,54928
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    50494,52540
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    88633,50494
  • 88633 - Positive stranded ssRNA viruses
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    52540,142877
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 142877 - EndoU-like
  • 0Direct
    49899,52540
  • 49899 - Concanavalin A-like lectins/glucanases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    141734,101386
  • 141734 - HisI-like
  • 101386 - all-alpha NTP pyrophosphatases
  • 0Direct
    56672,88633
  • 56672 - DNA/RNA polymerases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    53335,56672
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    116846,52540
  • 116846 - MIT domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56672,52540
  • 56672 - DNA/RNA polymerases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    55608,56712
  • 55608 - Homing endonucleases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    52540,52156
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 0Direct
    52540,56712
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    52540,51294
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51294 - Hedgehog/intein (Hint) domain
  • 0.0000000000003481Direct
    48403,52540
  • 48403 - Ankyrin repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00000000001861Direct
    57756,51283
  • 57756 - Retrovirus zinc finger-like domains
  • 51283 - dUTPase-like
  • 0.0000000000465Direct
    51283,50630
  • 51283 - dUTPase-like
  • 50630 - Acid proteases
  • 0.0000000000465Direct
    51197,52540
  • 51197 - Clavaminate synthase-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00000000007865Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0.000000005593Direct
    101816,144246
  • 101816 - Replicase NSP9
  • 144246 - Coronavirus NSP10-like
  • 0.00000001153Direct
    143076,101816
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 0.00000001153Direct
    140367,143076
  • 140367 - Coronavirus NSP7-like
  • 143076 - Coronavirus NSP8-like
  • 0.00000001153Direct
    51294,55608
  • 51294 - Hedgehog/intein (Hint) domain
  • 55608 - Homing endonucleases
  • 0.00000003806Direct
    56712,51294
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0.000003263Direct
    53649,54060
  • 53649 - Alkaline phosphatase-like
  • 54060 - His-Me finger endonucleases
  • 0.00000537Direct
    90188,90188
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 0.0000768Direct
    90188,53649
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0.0000768Direct
    51283,46919
  • 51283 - dUTPase-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0.0000768Direct
    53098,51283
  • 53098 - Ribonuclease H-like
  • 51283 - dUTPase-like
  • 0.0000768Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.00009302Direct
    55608,52540
  • 55608 - Homing endonucleases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0001902Direct
    -8,52540
  • -8 - ECOD
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.001912Inherited
    56672,46919
  • 56672 - DNA/RNA polymerases
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0.001912Inherited
    52540,48019
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48019 - post-AAA+ oligomerization domain-like
  • 0.002674Inherited
    159936,52949
  • 159936 - NSP3A-like
  • 52949 - Macro domain-like
  • 0.01209Inherited
    159936,53335
  • 159936 - NSP3A-like
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0.01961Inherited
    56300,55816
  • 56300 - Metallo-dependent phosphatases
  • 55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain
  • 0.06696Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.2634Inherited
    47943,47353
  • 47943 - Retrovirus capsid protein, N-terminal core domain
  • 47353 - Retrovirus capsid dimerization domain-like
  • 0.5811Inherited
    46919,53098
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 0.9076Inherited
    53098,50122
  • 53098 - Ribonuclease H-like
  • 50122 - DNA-binding domain of retroviral integrase
  • 0.9289Inherited
    47353,57756
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 0.9832Inherited
    53098,46919
  • 53098 - Ribonuclease H-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 1Inherited
    57756,50630
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 1Inherited
    56672,53098
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 1Inherited
    50630,56672
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50249,52540,52540
  • 50249 - Nucleic acid-binding proteins
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,52540,47370
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47370 - Bromodomain
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50249,47781,46929
  • 50249 - Nucleic acid-binding proteins
  • 47781 - RuvA domain 2-like
  • 46929 - DNA helicase RuvA subunit, C-terminal domain
  • 0Direct
    48024,52540,51294
  • 48024 - N-terminal domain of DnaB helicase
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    89043,50494,56672
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    52540,52540,56712
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    53300,100939,68906
  • 53300 - vWA-like
  • 100939 - SPOC domain-like
  • 68906 - SAP domain
  • 0Direct
    46785,158702,52540
  • 46785 - "Winged helix" DNA-binding domain
  • 158702 - Sec63 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,49899,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,56712,51294
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    54001,88633,88633
  • 54001 - Cysteine proteinases
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    50494,52540,52540
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51197,52540,56672
  • 51197 - Clavaminate synthase-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    50447,54980,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    50494,52540,89043
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 0Direct
    88633,50494,52540
  • 88633 - Positive stranded ssRNA viruses
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,48403,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48403 - Ankyrin repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,52156,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 50447 - Translation proteins
  • 0Direct
    141734,101386,53720
  • 141734 - HisI-like
  • 101386 - all-alpha NTP pyrophosphatases
  • 53720 - ALDH-like
  • 0Direct
    51197,52540,52540
  • 51197 - Clavaminate synthase-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    88633,88633,88633
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    52540,52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    52540,52540,47819
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47819 - HRDC-like
  • 0Direct
    52540,46785,158702
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 158702 - Sec63 N-terminal domain-like
  • 0Direct
    50630,56672,46919
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0Direct
    52540,50447,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,89043,50494
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    158702,52540,52540
  • 158702 - Sec63 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,52540,56672
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    52540,46785,47819
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 47819 - HRDC-like
  • 0Direct
    56672,52540,52540
  • 56672 - DNA/RNA polymerases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53300,100939,101420
  • 53300 - vWA-like
  • 100939 - SPOC domain-like
  • 101420 - C-terminal domain of Ku80
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    46785,158702,81296
  • 46785 - "Winged helix" DNA-binding domain
  • 158702 - Sec63 N-terminal domain-like
  • 81296 - E set domains
  • 0Direct
    53067,53067,109604
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    50494,52540,56672
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    50494,56672,88633
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    52540,52540,142877
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 142877 - EndoU-like
  • 0Direct
    52540,54980,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 54980 - EF-G C-terminal domain-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    57756,51283,50630
  • 57756 - Retrovirus zinc finger-like domains
  • 51283 - dUTPase-like
  • 50630 - Acid proteases
  • 0.0000000000465Direct
    140367,143076,101816
  • 140367 - Coronavirus NSP7-like
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 0.00000001153Direct
    143076,101816,144246
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 144246 - Coronavirus NSP10-like
  • 0.00000001153Direct
    52540,51294,55608
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51294 - Hedgehog/intein (Hint) domain
  • 55608 - Homing endonucleases
  • 0.00000006111Direct
    47353,57756,57756
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0.0000006694Direct
    57756,57756,51283
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 51283 - dUTPase-like
  • 0.0000006694Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000003263Direct
    51283,50630,56672
  • 51283 - dUTPase-like
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 0.000003294Direct
    90188,53649,54060
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 54060 - His-Me finger endonucleases
  • 0.00000537Direct
    56672,53098,51283
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 51283 - dUTPase-like
  • 0.0000768Direct
    90188,90188,53649
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0.0000768Direct
    53098,51283,46919
  • 53098 - Ribonuclease H-like
  • 51283 - dUTPase-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0.0000768Direct
    51283,46919,53098
  • 51283 - dUTPase-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 0.0000768Direct
    56672,46919,53098
  • 56672 - DNA/RNA polymerases
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 0.001912Inherited
    46919,53098,50122
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 50122 - DNA-binding domain of retroviral integrase
  • 0.8833Inherited
    47943,47353,57756
  • 47943 - Retrovirus capsid protein, N-terminal core domain
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 0.9832Inherited
    50630,56672,53098
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 1Inherited
    47353,57756,50630
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 1Inherited
    56672,53098,46919
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 1Inherited
    57756,50630,56672
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 1Inherited
    53098,46919,53098
  • 53098 - Ribonuclease H-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 1Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)