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Enzyme Commission (EC): Acting on acid anhydrides

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <7>
+ 1:   Hydrolases [3] <13>(403|678) (402|422|208)
0:   Acting on acid anhydrides [3.6] <5>(106|134) (105|104|67)
- 1:   In phosphorus-containing anhydrides [3.6.1] <73>(49|62) (49|44|30)
- 1:   Acting on acid anhydrides; catalyzing transmembrane movement of substances [3.6.3] <56>(7|8) (7|4|1)
- 1:   Acting on ATP; involved in cellular and subcellular movement [3.6.4] <13>(60|73) (59|62|33)
- 1:   Acting on GTP; involved in cellular and subcellular movement [3.6.5] <7>(5|5) (5|6|4)
- 1:   In sulfonyl-containing anhydrides [3.6.2] <2>(1|1) (1|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
DHH phosphoesterases0Direct
Flavivirus capsid protein C0Direct
Sec63 N-terminal domain-like0Direct
"Winged helix" DNA-binding domain0Direct
Nucleic acid-binding proteins0Direct
EF-G C-terminal domain-like0Direct
HIT-like0Direct
EndoU-like0Direct
Cdc48 domain 2-like0Direct
Viral glycoprotein, central and dimerisation domains0Direct
Viral leader polypeptide zinc finger0Direct
Acylphosphatase/BLUF domain-like0Direct
DNA helicase RuvA subunit, C-terminal domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
SPOC domain-like0Direct
DNA primase core0Direct
dUTPase-like0Direct
BRK domain-like0Direct
ITPase-like0Direct
Inorganic pyrophosphatase0Direct
RuvA domain 2-like0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Origin of replication-binding domain, RBD-like0Direct
Initiation factor IF2/eIF5b, domain 30Direct
Apyrase0Direct
Positive stranded ssRNA viruses0Direct
GroEL equatorial domain-like0Direct
Restriction endonuclease-like0Direct
all-alpha NTP pyrophosphatases0Direct
DNA/RNA polymerases0Direct
Translation proteins0Direct
Chromo domain-like0Direct
C-terminal domain of Ku800Direct
Metallo-dependent phosphatases0Direct
Rap30/74 interaction domains0Direct
Dcp2 domain-like0Direct
AN1-like Zinc finger0Direct
Nudix0Direct
Soluble domain of poliovirus core protein 3a0Direct
N-terminal domain of DnaB helicase0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
mRNA decapping enzyme DcpS N-terminal domain0Direct
ABC transporter transmembrane region5.057e-16Direct
vWA-like0.0000000000003116Direct
Trypsin-like serine proteases0.000000000001998Direct
Tudor/PWWP/MBT0.0000000001135Direct
HMA, heavy metal-associated domain0.0000000006341Direct
SAP domain0.000000009468Direct
GroEL-intermediate domain like0.00000001274Direct
Coronavirus NSP7-like0.00000002506Direct
Coronavirus NSP8-like0.00000002506Direct
Coronavirus NSP10-like0.00000002506Direct
Replicase NSP90.00000002506Direct
SCOP hierarchy in SUPERFAMILY0.00000003083Direct
Prokaryotic type I DNA topoisomerase0.00000003371Direct
MIT domain0.0000000486Direct
Homing endonucleases0.000000114Direct
GroEL apical domain-like0.0000002597Direct
E set domains0.0000003316Direct
HRDC-like0.000001594Direct
Hedgehog/intein (Hint) domain0.000001999Direct
Somatomedin B domain0.00000809Direct
NSP3A-like0.00001114Direct
F-box domain0.0000227Direct
RNA-binding domain, RBD0.0000936Direct
Calcium ATPase, transduction domain A0.0002291Direct
Calcium ATPase, transmembrane domain M0.0002398Direct
His-Me finger endonucleases0.0002877Direct
R3H domain0.0006592Direct
FYVE/PHD zinc finger0.002292Inherited
CYTH-like phosphatases0.002505Inherited
post-AAA+ oligomerization domain-like0.003797Inherited
Bromodomain0.003824Inherited
Ankyrin repeat0.006618Inherited
SARS Nsp1-like0.01556Inherited
S15/NS1 RNA-binding domain0.02864Inherited
WW domain0.04755Inherited
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain0.06858Inherited
CCCH zinc finger0.07298Inherited
Retrovirus zinc finger-like domains0.152Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.164Inherited
UBA-like0.207Inherited
ADC-like0.2287Inherited
HD-domain/PDEase-like0.2335Inherited
NTF2-like0.312Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.3175Inherited
Clavaminate synthase-like0.6221Inherited
Retrovirus capsid dimerization domain-like0.6811Inherited
Actin-like ATPase domain0.8266Inherited
HisI-like0.845Inherited
Retrovirus capsid protein, N-terminal core domain0.9793Inherited
Ribonuclease H-like1Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase1Inherited
Acid proteases1Inherited
DNA-binding domain of retroviral integrase1Inherited
Class II aaRS ABD-related1Inherited
Retroviral matrix proteins1Inherited
Ribonuclease Rh-like1Inherited
SurE-like1Inherited
Alkaline phosphatase-like1Inherited
Cysteine proteinases1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
PH domain-like1Inherited
Macro domain-like1Inherited
N-terminal Zn binding domain of HIV integrase1Inherited
HAD-like1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
MazG-like0Direct
Ku80 subunit N-terminal domain0Direct
Maf-like0Direct
Viral cysteine protease of trypsin fold0Direct
DNA helicase RuvA subunit, C-terminal domain0Direct
Macro domain0Direct
DNA helicase RuvA subunit, N-terminal domain0Direct
RecG "wedge" domain0Direct
NADH pyrophosphatase0Direct
mRNA cap methylase0Direct
GroEL-like chaperone, intermediate domain0Direct
Achaeal helicase C-terminal domain0Direct
RecQ helicase DNA-binding domain-like0Direct
Chromo domain0Direct
HisE-like (PRA-PH)0Direct
MgsA/YrvN C-terminal domain-like0Direct
DNA-binding domain from rap300Direct
Soluble domain of poliovirus core protein 3a0Direct
Viral leader polypeptide zinc finger0Direct
Initiation factor IF2/eIF5b, domain 30Direct
ITPase (Ham1)0Direct
AN1-like Zinc finger0Direct
TIP49 domain0Direct
Helicase-like "domain" of reverse gyrase0Direct
Replication initiation protein E10Direct
RNA-dependent RNA-polymerase0Direct
Ku70 subunit N-terminal domain0Direct
BRK domain-like0Direct
Nsp15 C-terminal domain-like0Direct
HRDC domain from helicases0Direct
Actin/HSP700Direct
RNA helicase0Direct
Ppx associated domain0Direct
Dcp2 box A domain0Direct
Class II viral fusion proteins C-terminal domain0Direct
Sec63 C-terminal domain-like0Direct
Elongation factors0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Ku80 subunit middle domain0Direct
Cdc48 domain 2-like0Direct
Rap30/74 interaction domains0Direct
Sec63 N-terminal domain0Direct
EF-G/eEF-2 domains III and V0Direct
Exodeoxyribonuclease V beta chain (RecB), C-terminal domain0Direct
FMDV leader protease0Direct
Ppx/GppA phosphatase0Direct
Viral proteases0Direct
Picornaviridae-like VP (VP1, VP2, VP3 and VP4)0Direct
mRNA decapping enzyme DcpS N-terminal domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
ABC transporter ATPase domain-like0Direct
mRNA decapping enzyme DcpS C-terminal domain0Direct
mRNA decapping enzyme-like0Direct
Acylphosphatase-like0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
Flavivirus capsid protein C0Direct
GroEL-like chaperone, apical domain0Direct
Apyrase0Direct
Nsp15 N-terminal domain-like0Direct
Inorganic pyrophosphatase0Direct
dUTPase-like0Direct
Manganese-dependent inorganic pyrophosphatase (family II)0Direct
G proteins0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
C-terminal domain of Ku800Direct
Tandem AAA-ATPase domain0Direct
GroEL chaperone, ATPase domain0Direct
DNA helicase RuvA subunit, middle domain0Direct
MutT-like0Direct
Extended AAA-ATPase domain0Direct
GUCT domain0Direct
Ku70 subunit middle domain0Direct
HIT (HINT, histidine triad) family of protein kinase-interacting proteins0Direct
Caliciviridae-like VP0Direct
Helicase DNA-binding domain0Direct
CDH-like0Direct
NTF2-like0Direct
N-terminal domain of DnaB helicase0Direct
ADPRibase-Mn-like0Direct
Cdc48 N-terminal domain-like0Direct
Viral glycoprotein, central and dimerisation domains0Direct
ABC transporter transmembrane region0.000000000000001457Direct
CYTH domain0.00000000000000236Direct
Mason-Pfizer monkey virus matrix protein0.00000000003519Direct
HMA, heavy metal-associated domain0.0000000002925Direct
SAP domain0.000000004488Direct
Replicase NSP90.000000007235Direct
Coronavirus NSP8-like0.000000007235Direct
Coronavirus NSP10-like0.000000007235Direct
Coronavirus NSP7-like0.000000007235Direct
MIT domain0.00000001087Direct
Prokaryotic type I DNA topoisomerase0.000000016Direct
Tudor domain0.000002571Direct
Somatomedin B domain0.000004265Direct
Intein (protein splicing domain)0.000004557Direct
NSP3A-like0.000004567Direct
Meta-cation ATPase, catalytic domain P0.000005052Direct
F-box domain0.00001628Direct
AlkB-like0.000119Direct
Calcium ATPase, transduction domain A0.000209Direct
Calcium ATPase, transmembrane domain M0.000386Direct
R3H domain0.0003973Direct
Protein serine/threonine phosphatase0.0006868Direct
Bromodomain0.002736Inherited
Ankyrin repeat0.003857Inherited
SARS Nsp1-like0.01122Inherited
PHD domain0.01132Inherited
SPRY domain0.01969Inherited
a tRNA synthase domain0.02253Inherited
WW domain0.03614Inherited
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain0.04787Inherited
5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain0.04787Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.05579Inherited
Pleckstrin-homology domain (PH domain)0.05809Inherited
CCCH zinc finger0.0586Inherited
Retrovirus zinc finger-like domains0.08929Inherited
NagD-like0.1386Inherited
Canonical RBD0.2557Inherited
Retrovirus capsid protein C-terminal domain0.55Inherited
beta-Phosphoglucomutase-like0.6452Inherited
HisI-like0.6486Inherited
Retroviral protease (retropepsin)0.777Inherited
RecA protein-like (ATPase-domain)0.8115Inherited
Retrovirus capsid protein, N-terminal core domain0.834Inherited
L-histidinol dehydrogenase HisD0.8646Inherited
N-terminal Zn binding domain of HIV integrase0.8992Inherited
DNA-binding domain of retroviral integrase0.9233Inherited
Ribonuclease Rh-like0.9619Inherited
Reverse transcriptase1Inherited
Retroviral integrase, catalytic domain1Inherited
Nitrogenase iron protein-like1Inherited
SurE-like1Inherited
Anticodon-binding domain of Class II aaRS1Inherited
Ribonuclease H1Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
AN1-like Zinc finger0Direct
Viral leader polypeptide zinc finger0Direct
Dcp2 domain-like0Direct
DNA/RNA polymerases0Direct
GroEL equatorial domain-like0Direct
Viral glycoprotein, central and dimerisation domains0Direct
Restriction endonuclease-like0Direct
Positive stranded ssRNA viruses0Direct
Metallo-dependent phosphatases0Direct
Inorganic pyrophosphatase0Direct
Cdc48 domain 2-like0Direct
N-terminal domain of DnaB helicase0Direct
Acylphosphatase/BLUF domain-like0Direct
Soluble domain of poliovirus core protein 3a0Direct
EndoU-like0Direct
"Winged helix" DNA-binding domain0Direct
EF-G C-terminal domain-like0Direct
DNA primase core0Direct
Chromo domain-like0Direct
Nudix0Direct
BRK domain-like0Direct
C-terminal domain of Ku800Direct
Sec63 N-terminal domain-like0Direct
Rap30/74 interaction domains0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
ITPase-like0Direct
all-alpha NTP pyrophosphatases0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Flavivirus capsid protein C0Direct
DNA helicase RuvA subunit, C-terminal domain0Direct
mRNA decapping enzyme DcpS N-terminal domain0Direct
Origin of replication-binding domain, RBD-like0Direct
Initiation factor IF2/eIF5b, domain 30Direct
Apyrase0Direct
Translation proteins0Direct
RuvA domain 2-like0Direct
Nucleic acid-binding proteins0Direct
dUTPase-like0Direct
HIT-like0Direct
SPOC domain-like0Direct
DHH phosphoesterases0Direct
ABC transporter transmembrane region3.528e-16Direct
vWA-like0.0000000000002227Direct
Trypsin-like serine proteases0.000000000001444Direct
Tudor/PWWP/MBT0.00000000008368Direct
HMA, heavy metal-associated domain0.0000000004725Direct
SAP domain0.000000007159Direct
GroEL-intermediate domain like0.000000009664Direct
Replicase NSP90.00000001906Direct
Coronavirus NSP8-like0.00000001906Direct
Coronavirus NSP10-like0.00000001906Direct
Coronavirus NSP7-like0.00000001906Direct
Prokaryotic type I DNA topoisomerase0.00000002567Direct
MIT domain0.00000003708Direct
Homing endonucleases0.0000000874Direct
GroEL apical domain-like0.0000002006Direct
E set domains0.0000002565Direct
HRDC-like0.00000125Direct
Hedgehog/intein (Hint) domain0.00000157Direct
Somatomedin B domain0.000006401Direct
NSP3A-like0.000008843Direct
F-box domain0.00001812Direct
RNA-binding domain, RBD0.00007558Direct
Calcium ATPase, transduction domain A0.0001865Direct
Calcium ATPase, transmembrane domain M0.0001952Direct
His-Me finger endonucleases0.0002347Direct
R3H domain0.000542Direct
FYVE/PHD zinc finger0.00191Inherited
CYTH-like phosphatases0.00209Inherited
post-AAA+ oligomerization domain-like0.00318Inherited
Bromodomain0.003203Inherited
Ankyrin repeat0.005574Inherited
SARS Nsp1-like0.01325Inherited
S15/NS1 RNA-binding domain0.02455Inherited
WW domain0.04101Inherited
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain0.05954Inherited
CCCH zinc finger0.06339Inherited
Retrovirus zinc finger-like domains0.1339Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.1448Inherited
UBA-like0.1837Inherited
ADC-like0.2035Inherited
HD-domain/PDEase-like0.2079Inherited
NTF2-like0.2814Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.2865Inherited
Clavaminate synthase-like0.5702Inherited
Retrovirus capsid dimerization domain-like0.625Inherited
Actin-like ATPase domain0.7608Inherited
HisI-like0.7782Inherited
Retrovirus capsid protein, N-terminal core domain0.9054Inherited
N-terminal Zn binding domain of HIV integrase0.9311Inherited
DNA-binding domain of retroviral integrase0.9506Inherited
Ribonuclease Rh-like0.9694Inherited
Alkaline phosphatase-like0.9892Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
SurE-like1Inherited
Macro domain-like1Inherited
Ribonuclease H-like1Inherited
PH domain-like1Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase1Inherited
Retroviral matrix proteins1Inherited
HAD-like1Inherited
Acid proteases1Inherited
Cysteine proteinases1Inherited
Class II aaRS ABD-related1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50494,56672
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    53300,100939
  • 53300 - vWA-like
  • 100939 - SPOC domain-like
  • 0Direct
    160481,160481
  • 160481 - BRK domain-like
  • 160481 - BRK domain-like
  • 0Direct
    54001,88633
  • 54001 - Cysteine proteinases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    52540,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    48024,52540
  • 48024 - N-terminal domain of DnaB helicase
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    51283,51283
  • 51283 - dUTPase-like
  • 51283 - dUTPase-like
  • 0Direct
    158702,81296
  • 158702 - Sec63 N-terminal domain-like
  • 81296 - E set domains
  • 0Direct
    52540,49899
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    89043,50494
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    46785,158702
  • 46785 - "Winged helix" DNA-binding domain
  • 158702 - Sec63 N-terminal domain-like
  • 0Direct
    52540,57756
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    50447,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,142877
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 142877 - EndoU-like
  • 0Direct
    52540,54928
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    47781,46929
  • 47781 - RuvA domain 2-like
  • 46929 - DNA helicase RuvA subunit, C-terminal domain
  • 0Direct
    55464,52540
  • 55464 - Origin of replication-binding domain, RBD-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    141734,101386
  • 141734 - HisI-like
  • 101386 - all-alpha NTP pyrophosphatases
  • 0Direct
    56983,81296
  • 56983 - Viral glycoprotein, central and dimerisation domains
  • 81296 - E set domains
  • 0Direct
    101386,53720
  • 101386 - all-alpha NTP pyrophosphatases
  • 53720 - ALDH-like
  • 0Direct
    53335,142877
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 142877 - EndoU-like
  • 0Direct
    53335,56672
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    -9,52540
  • -9 - PDB
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,89043
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 0Direct
    88633,50494
  • 88633 - Positive stranded ssRNA viruses
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    55608,56712
  • 55608 - Homing endonucleases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    52540,47819
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47819 - HRDC-like
  • 0Direct
    100939,68906
  • 100939 - SPOC domain-like
  • 68906 - SAP domain
  • 0Direct
    53067,109604
  • 53067 - Actin-like ATPase domain
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    56672,52540
  • 56672 - DNA/RNA polymerases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53335,52949
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 52949 - Macro domain-like
  • 0Direct
    52540,-9
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • -9 - PDB
  • 0Direct
    52540,47370
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47370 - Bromodomain
  • 0Direct
    56731,52540
  • 56731 - DNA primase core
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,-8
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • -8 - ECOD
  • 0Direct
    101386,101386
  • 101386 - all-alpha NTP pyrophosphatases
  • 101386 - all-alpha NTP pyrophosphatases
  • 0Direct
    158702,52540
  • 158702 - Sec63 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50916,46785
  • 50916 - Rap30/74 interaction domains
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    140586,55811
  • 140586 - Dcp2 domain-like
  • 55811 - Nudix
  • 0Direct
    52540,48403
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48403 - Ankyrin repeat
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    100939,101420
  • 100939 - SPOC domain-like
  • 101420 - C-terminal domain of Ku80
  • 0Direct
    50249,47781
  • 50249 - Nucleic acid-binding proteins
  • 47781 - RuvA domain 2-like
  • 0Direct
    52156,50447
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 50447 - Translation proteins
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    46785,47819
  • 46785 - "Winged helix" DNA-binding domain
  • 47819 - HRDC-like
  • 0Direct
    102860,54197
  • 102860 - mRNA decapping enzyme DcpS N-terminal domain
  • 54197 - HIT-like
  • 0Direct
    88633,88633
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    49899,52540
  • 49899 - Concanavalin A-like lectins/glucanases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    116846,52540
  • 116846 - MIT domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50494,52540
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,56672
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    52540,56712
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    55811,55811
  • 55811 - Nudix
  • 55811 - Nudix
  • 0Direct
    50249,52540
  • 50249 - Nucleic acid-binding proteins
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54980,54980
  • 54980 - EF-G C-terminal domain-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    52540,52156
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 0Direct
    56672,88633
  • 56672 - DNA/RNA polymerases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1.772e-16Direct
    52540,51294
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51294 - Hedgehog/intein (Hint) domain
  • 0.0000000000005586Direct
    48403,52540
  • 48403 - Ankyrin repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00000000002663Direct
    57756,51283
  • 57756 - Retrovirus zinc finger-like domains
  • 51283 - dUTPase-like
  • 0.00000000006338Direct
    51283,50630
  • 51283 - dUTPase-like
  • 50630 - Acid proteases
  • 0.00000000006338Direct
    51197,52540
  • 51197 - Clavaminate synthase-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0000000001082Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0.000000007159Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000009664Direct
    101816,144246
  • 101816 - Replicase NSP9
  • 144246 - Coronavirus NSP10-like
  • 0.00000001906Direct
    140367,143076
  • 140367 - Coronavirus NSP7-like
  • 143076 - Coronavirus NSP8-like
  • 0.00000001906Direct
    143076,101816
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 0.00000001906Direct
    51294,55608
  • 51294 - Hedgehog/intein (Hint) domain
  • 55608 - Homing endonucleases
  • 0.00000005371Direct
    53649,54060
  • 53649 - Alkaline phosphatase-like
  • 54060 - His-Me finger endonucleases
  • 0.0000003293Direct
    56712,51294
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0.000003831Direct
    90188,53649
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0.000006401Direct
    90188,90188
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 0.00002434Direct
    53098,51283
  • 53098 - Ribonuclease H-like
  • 51283 - dUTPase-like
  • 0.00009113Direct
    51283,46919
  • 51283 - dUTPase-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0.00009113Direct
    55608,52540
  • 55608 - Homing endonucleases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000222Direct
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.0003029Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.001726Inherited
    -8,52540
  • -8 - ECOD
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002076Inherited
    56672,46919
  • 56672 - DNA/RNA polymerases
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0.002076Inherited
    52540,48019
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48019 - post-AAA+ oligomerization domain-like
  • 0.00318Inherited
    47060,55681
  • 47060 - S15/NS1 RNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0.003308Inherited
    159936,52949
  • 159936 - NSP3A-like
  • 52949 - Macro domain-like
  • 0.01325Inherited
    159936,53335
  • 159936 - NSP3A-like
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0.02114Inherited
    56300,55816
  • 56300 - Metallo-dependent phosphatases
  • 55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain
  • 0.05954Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.1351Inherited
    47943,47353
  • 47943 - Retrovirus capsid protein, N-terminal core domain
  • 47353 - Retrovirus capsid dimerization domain-like
  • 0.625Inherited
    46919,53098
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 0.9311Inherited
    53098,50122
  • 53098 - Ribonuclease H-like
  • 50122 - DNA-binding domain of retroviral integrase
  • 0.9506Inherited
    47353,57756
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 0.9966Inherited
    56672,53098
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 1Inherited
    53098,46919
  • 53098 - Ribonuclease H-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 1Inherited
    50630,56672
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 1Inherited
    57756,50630
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50494,56672,88633
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    52540,46785,47819
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 47819 - HRDC-like
  • 0Direct
    52540,52540,142877
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 142877 - EndoU-like
  • 0Direct
    48024,52540,51294
  • 48024 - N-terminal domain of DnaB helicase
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    51197,52540,52540
  • 51197 - Clavaminate synthase-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,52156,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 50447 - Translation proteins
  • 0Direct
    46785,158702,81296
  • 46785 - "Winged helix" DNA-binding domain
  • 158702 - Sec63 N-terminal domain-like
  • 81296 - E set domains
  • 0Direct
    52540,46785,158702
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 158702 - Sec63 N-terminal domain-like
  • 0Direct
    52540,89043,50494
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    52540,52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    141734,101386,53720
  • 141734 - HisI-like
  • 101386 - all-alpha NTP pyrophosphatases
  • 53720 - ALDH-like
  • 0Direct
    50494,52540,89043
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 0Direct
    54001,88633,88633
  • 54001 - Cysteine proteinases
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    52540,50447,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    50249,52540,52540
  • 50249 - Nucleic acid-binding proteins
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50494,52540,52540
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,52540,56712
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    53300,100939,68906
  • 53300 - vWA-like
  • 100939 - SPOC domain-like
  • 68906 - SAP domain
  • 0Direct
    52540,48403,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48403 - Ankyrin repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    158702,52540,52540
  • 158702 - Sec63 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50494,52540,56672
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    52540,52540,47370
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47370 - Bromodomain
  • 0Direct
    89043,50494,56672
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    46785,158702,52540
  • 46785 - "Winged helix" DNA-binding domain
  • 158702 - Sec63 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,52540,56672
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    53067,53067,109604
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    52540,56712,51294
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    50447,54980,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    56672,52540,52540
  • 56672 - DNA/RNA polymerases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,52540,47819
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47819 - HRDC-like
  • 0Direct
    52540,54980,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 54980 - EF-G C-terminal domain-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50630,56672,46919
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0Direct
    88633,50494,52540
  • 88633 - Positive stranded ssRNA viruses
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    88633,88633,88633
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    53300,100939,101420
  • 53300 - vWA-like
  • 100939 - SPOC domain-like
  • 101420 - C-terminal domain of Ku80
  • 0Direct
    50249,47781,46929
  • 50249 - Nucleic acid-binding proteins
  • 47781 - RuvA domain 2-like
  • 46929 - DNA helicase RuvA subunit, C-terminal domain
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    52540,49899,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51197,52540,56672
  • 51197 - Clavaminate synthase-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    57756,51283,50630
  • 57756 - Retrovirus zinc finger-like domains
  • 51283 - dUTPase-like
  • 50630 - Acid proteases
  • 0.00000000006338Direct
    140367,143076,101816
  • 140367 - Coronavirus NSP7-like
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 0.00000001906Direct
    143076,101816,144246
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 144246 - Coronavirus NSP10-like
  • 0.00000001906Direct
    52540,51294,55608
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51294 - Hedgehog/intein (Hint) domain
  • 55608 - Homing endonucleases
  • 0.00000008037Direct
    90188,53649,54060
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 54060 - His-Me finger endonucleases
  • 0.0000003293Direct
    47353,57756,57756
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0.0000008052Direct
    57756,57756,51283
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 51283 - dUTPase-like
  • 0.0000008052Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000003831Direct
    51283,50630,56672
  • 51283 - dUTPase-like
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 0.000003887Direct
    90188,90188,53649
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0.00002434Direct
    53098,51283,46919
  • 53098 - Ribonuclease H-like
  • 51283 - dUTPase-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0.00009113Direct
    51283,46919,53098
  • 51283 - dUTPase-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 0.00009113Direct
    56672,53098,51283
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 51283 - dUTPase-like
  • 0.00009113Direct
    56672,46919,53098
  • 56672 - DNA/RNA polymerases
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 0.002076Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.1199Inherited
    46919,53098,50122
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 50122 - DNA-binding domain of retroviral integrase
  • 0.9094Inherited
    47943,47353,57756
  • 47943 - Retrovirus capsid protein, N-terminal core domain
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 0.9966Inherited
    47353,57756,50630
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 1Inherited
    56672,53098,46919
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 1Inherited
    53098,46919,53098
  • 53098 - Ribonuclease H-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 1Inherited
    50630,56672,53098
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 1Inherited
    57756,50630,56672
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 1Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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