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Enzyme Commission (EC): Acting on acid anhydrides

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <7>
+ 1:   Hydrolases [3] <13>(395|668) (394|418|206)
0:   Acting on acid anhydrides [3.6] <5>(99|125) (98|99|65)
- 1:   In phosphorus-containing anhydrides [3.6.1] <73>(47|60) (47|43|30)
- 1:   Acting on acid anhydrides; catalyzing transmembrane movement of substances [3.6.3] <56>(4|4) (4|1|0)
- 1:   Acting on ATP; involved in cellular and subcellular movement [3.6.4] <13>(57|70) (56|60|32)
- 1:   Acting on GTP; involved in cellular and subcellular movement [3.6.5] <7>(5|5) (5|6|4)
- 1:   In sulfonyl-containing anhydrides [3.6.2] <2>(1|1) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
HIT-like0Direct
Rap30/74 interaction domains0Direct
Nucleic acid-binding proteins0Direct
Flavivirus capsid protein C0Direct
ITPase-like0Direct
SPOC domain-like0Direct
Metallo-dependent phosphatases0Direct
BRK domain-like0Direct
Soluble domain of poliovirus core protein 3a0Direct
EF-G C-terminal domain-like0Direct
N-terminal domain of DnaB helicase0Direct
RuvA domain 2-like0Direct
Translation proteins0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
DNA helicase RuvA subunit, C-terminal domain0Direct
Apyrase0Direct
DNA/RNA polymerases0Direct
Dcp2 domain-like0Direct
Positive stranded ssRNA viruses0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Cdc48 domain 2-like0Direct
Acylphosphatase/BLUF domain-like0Direct
C-terminal domain of Ku800Direct
EndoU-like0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Origin of replication-binding domain, RBD-like0Direct
Inorganic pyrophosphatase0Direct
mRNA decapping enzyme DcpS N-terminal domain0Direct
all-alpha NTP pyrophosphatases0Direct
"Winged helix" DNA-binding domain0Direct
DHH phosphoesterases0Direct
Viral leader polypeptide zinc finger0Direct
dUTPase-like0Direct
Viral glycoprotein, central and dimerisation domains0Direct
Sec63 N-terminal domain-like0Direct
AN1-like Zinc finger0Direct
Nudix0Direct
Initiation factor IF2/eIF5b, domain 30Direct
Chromo domain-like0Direct
DNA primase core0Direct
Restriction endonuclease-like0Direct
Trypsin-like serine proteases0.00000000000005106Direct
vWA-like0.0000000000001456Direct
Tudor/PWWP/MBT0.00000000006418Direct
HMA, heavy metal-associated domain0.0000000003218Direct
SAP domain0.000000006874Direct
Replicase NSP90.00000001308Direct
Coronavirus NSP7-like0.00000001308Direct
Coronavirus NSP8-like0.00000001308Direct
Coronavirus NSP10-like0.00000001308Direct
Prokaryotic type I DNA topoisomerase0.00000002019Direct
MIT domain0.00000003313Direct
SCOP hierarchy in SUPERFAMILY0.00000003463Direct
E set domains0.00000005937Direct
Homing endonucleases0.0000000732Direct
HRDC-like0.0000009736Direct
Hedgehog/intein (Hint) domain0.000001372Direct
Somatomedin B domain0.000006161Direct
NSP3A-like0.000007186Direct
F-box domain0.00001937Direct
RNA-binding domain, RBD0.00006764Direct
His-Me finger endonucleases0.0002238Direct
R3H domain0.0005339Direct
FYVE/PHD zinc finger0.00154Inherited
CYTH-like phosphatases0.001937Inherited
Bromodomain0.003042Inherited
post-AAA+ oligomerization domain-like0.003178Inherited
Ankyrin repeat0.004636Inherited
Ribonuclease Rh-like0.01047Inherited
SARS Nsp1-like0.01383Inherited
WW domain0.03935Inherited
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain0.05895Inherited
CCCH zinc finger0.06446Inherited
Retrovirus zinc finger-like domains0.1164Inherited
ADC-like0.1715Inherited
UBA-like0.184Inherited
HD-domain/PDEase-like0.1901Inherited
Calcium ATPase, transduction domain A0.2126Inherited
Calcium ATPase, transmembrane domain M0.2156Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.2753Inherited
NTF2-like0.2893Inherited
Actin-like ATPase domain0.5981Inherited
Retrovirus capsid dimerization domain-like0.6189Inherited
Clavaminate synthase-like0.6246Inherited
HisI-like0.7459Inherited
Retrovirus capsid protein, N-terminal core domain0.9383Inherited
N-terminal Zn binding domain of HIV integrase0.9729Inherited
DNA-binding domain of retroviral integrase0.9961Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase1Inherited
Ribonuclease H-like1Inherited
SurE-like1Inherited
Cysteine proteinases1Inherited
HAD-like1Inherited
Retroviral matrix proteins1Inherited
PH domain-like1Inherited
Macro domain-like1Inherited
Alkaline phosphatase-like1Inherited
Acid proteases1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Viral proteases0Direct
Viral glycoprotein, central and dimerisation domains0Direct
Ku80 subunit middle domain0Direct
Tandem AAA-ATPase domain0Direct
C-terminal domain of Ku800Direct
XPF/Rad1/Mus81 nuclease0Direct
Elongation factors0Direct
NTF2-like0Direct
MazG-like0Direct
Macro domain0Direct
Achaeal helicase C-terminal domain0Direct
DNA helicase RuvA subunit, C-terminal domain0Direct
HIT (HINT, histidine triad) family of protein kinase-interacting proteins0Direct
Nsp15 N-terminal domain-like0Direct
CDH-like0Direct
mRNA decapping enzyme-like0Direct
Inorganic pyrophosphatase0Direct
HisE-like (PRA-PH)0Direct
mRNA decapping enzyme DcpS C-terminal domain0Direct
Ku70 subunit N-terminal domain0Direct
N-terminal domain of DnaB helicase0Direct
HRDC domain from helicases0Direct
MgsA/YrvN C-terminal domain-like0Direct
DNA helicase RuvA subunit, middle domain0Direct
Cdc48 N-terminal domain-like0Direct
Actin/HSP700Direct
mRNA cap methylase0Direct
DNA-binding domain from rap300Direct
Acylphosphatase-like0Direct
BRK domain-like0Direct
Caliciviridae-like VP0Direct
Picornaviridae-like VP (VP1, VP2, VP3 and VP4)0Direct
mRNA decapping enzyme DcpS N-terminal domain0Direct
Chromo domain0Direct
ADPRibase-Mn-like0Direct
RNA-dependent RNA-polymerase0Direct
Replication initiation protein E10Direct
Helicase DNA-binding domain0Direct
Helicase-like "domain" of reverse gyrase0Direct
Ppx/GppA phosphatase0Direct
RecG "wedge" domain0Direct
Rap30/74 interaction domains0Direct
dUTPase-like0Direct
Flavivirus capsid protein C0Direct
RecQ helicase DNA-binding domain-like0Direct
Viral leader polypeptide zinc finger0Direct
Ku80 subunit N-terminal domain0Direct
Exodeoxyribonuclease V beta chain (RecB), C-terminal domain0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
Nsp15 C-terminal domain-like0Direct
Ku70 subunit middle domain0Direct
AN1-like Zinc finger0Direct
TIP49 domain0Direct
Initiation factor IF2/eIF5b, domain 30Direct
Cdc48 domain 2-like0Direct
FMDV leader protease0Direct
Maf-like0Direct
Ppx associated domain0Direct
DNA helicase RuvA subunit, N-terminal domain0Direct
NADH pyrophosphatase0Direct
EF-G/eEF-2 domains III and V0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
G proteins0Direct
Extended AAA-ATPase domain0Direct
Dcp2 box A domain0Direct
MutT-like0Direct
ITPase (Ham1)0Direct
Manganese-dependent inorganic pyrophosphatase (family II)0Direct
GUCT domain0Direct
Sec63 C-terminal domain-like0Direct
Sec63 N-terminal domain0Direct
Soluble domain of poliovirus core protein 3a0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
RNA helicase0Direct
Apyrase0Direct
Viral cysteine protease of trypsin fold0Direct
Class II viral fusion proteins C-terminal domain0Direct
CYTH domain0.000000000000001461Direct
Mason-Pfizer monkey virus matrix protein0.00000000002231Direct
HMA, heavy metal-associated domain0.0000000001373Direct
SAP domain0.000000003115Direct
Coronavirus NSP10-like0.000000003415Direct
Coronavirus NSP7-like0.000000003415Direct
Replicase NSP90.000000003415Direct
Coronavirus NSP8-like0.000000003415Direct
MIT domain0.000000007051Direct
Prokaryotic type I DNA topoisomerase0.000000008845Direct
Tudor domain0.000001788Direct
NSP3A-like0.00000274Direct
Somatomedin B domain0.00000311Direct
Intein (protein splicing domain)0.000003488Direct
F-box domain0.00001362Direct
AlkB-like0.00008952Direct
Protein serine/threonine phosphatase0.0002796Direct
R3H domain0.0003115Direct
Bromodomain0.002119Inherited
Ankyrin repeat0.002568Inherited
Ribonuclease Rh-like0.007634Inherited
PHD domain0.00853Inherited
SARS Nsp1-like0.009778Inherited
SPRY domain0.01476Inherited
WW domain0.02916Inherited
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain0.04006Inherited
5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain0.04006Inherited
Pleckstrin-homology domain (PH domain)0.04541Inherited
Meta-cation ATPase, catalytic domain P0.048Inherited
CCCH zinc finger0.05099Inherited
Retrovirus zinc finger-like domains0.06354Inherited
NagD-like0.1219Inherited
Calcium ATPase, transduction domain A0.2106Inherited
Canonical RBD0.2339Inherited
Retrovirus capsid protein C-terminal domain0.4852Inherited
HisI-like0.5319Inherited
beta-Phosphoglucomutase-like0.5832Inherited
RecA protein-like (ATPase-domain)0.6577Inherited
Calcium ATPase, transmembrane domain M0.6912Inherited
Retroviral protease (retropepsin)0.7106Inherited
Retrovirus capsid protein, N-terminal core domain0.7782Inherited
L-histidinol dehydrogenase HisD0.8198Inherited
N-terminal Zn binding domain of HIV integrase0.8555Inherited
DNA-binding domain of retroviral integrase0.883Inherited
Retroviral integrase, catalytic domain1Inherited
Ribonuclease H1Inherited
SurE-like1Inherited
Reverse transcriptase1Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
all-alpha NTP pyrophosphatases0Direct
Dcp2 domain-like0Direct
HIT-like0Direct
ITPase-like0Direct
DNA/RNA polymerases0Direct
Viral glycoprotein, central and dimerisation domains0Direct
EF-G C-terminal domain-like0Direct
RuvA domain 2-like0Direct
mRNA decapping enzyme DcpS N-terminal domain0Direct
Apyrase0Direct
EndoU-like0Direct
"Winged helix" DNA-binding domain0Direct
Positive stranded ssRNA viruses0Direct
Initiation factor IF2/eIF5b, domain 30Direct
DNA primase core0Direct
DNA helicase RuvA subunit, C-terminal domain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
N-terminal domain of DnaB helicase0Direct
Acylphosphatase/BLUF domain-like0Direct
Translation proteins0Direct
Nucleic acid-binding proteins0Direct
Sec63 N-terminal domain-like0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Origin of replication-binding domain, RBD-like0Direct
C-terminal domain of Ku800Direct
Viral leader polypeptide zinc finger0Direct
dUTPase-like0Direct
Rap30/74 interaction domains0Direct
Metallo-dependent phosphatases0Direct
Soluble domain of poliovirus core protein 3a0Direct
Cdc48 domain 2-like0Direct
BRK domain-like0Direct
Chromo domain-like0Direct
DHH phosphoesterases0Direct
Flavivirus capsid protein C0Direct
SPOC domain-like0Direct
AN1-like Zinc finger0Direct
Restriction endonuclease-like0Direct
Nudix0Direct
Inorganic pyrophosphatase0Direct
Trypsin-like serine proteases0.00000000000003618Direct
vWA-like0.0000000000001034Direct
Tudor/PWWP/MBT0.00000000004706Direct
HMA, heavy metal-associated domain0.0000000002382Direct
SAP domain0.000000005188Direct
Coronavirus NSP10-like0.000000009916Direct
Coronavirus NSP7-like0.000000009916Direct
Replicase NSP90.000000009916Direct
Coronavirus NSP8-like0.000000009916Direct
Prokaryotic type I DNA topoisomerase0.00000001532Direct
MIT domain0.00000002519Direct
E set domains0.00000004533Direct
Homing endonucleases0.00000005596Direct
HRDC-like0.0000007592Direct
Hedgehog/intein (Hint) domain0.000001073Direct
Somatomedin B domain0.000004855Direct
NSP3A-like0.000005669Direct
F-box domain0.00001544Direct
RNA-binding domain, RBD0.00005438Direct
His-Me finger endonucleases0.0001822Direct
R3H domain0.0004379Direct
FYVE/PHD zinc finger0.001277Inherited
CYTH-like phosphatases0.001613Inherited
Bromodomain0.002546Inherited
post-AAA+ oligomerization domain-like0.00266Inherited
Ankyrin repeat0.003891Inherited
Ribonuclease Rh-like0.008881Inherited
SARS Nsp1-like0.01176Inherited
WW domain0.03389Inherited
5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain0.05114Inherited
CCCH zinc finger0.05597Inherited
Retrovirus zinc finger-like domains0.1019Inherited
ADC-like0.1516Inherited
UBA-like0.1629Inherited
HD-domain/PDEase-like0.1685Inherited
Calcium ATPase, transduction domain A0.189Inherited
Calcium ATPase, transmembrane domain M0.1918Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.2479Inherited
NTF2-like0.261Inherited
Actin-like ATPase domain0.5492Inherited
Retrovirus capsid dimerization domain-like0.5681Inherited
Clavaminate synthase-like0.5736Inherited
HisI-like0.6865Inherited
Retrovirus capsid protein, N-terminal core domain0.8676Inherited
N-terminal Zn binding domain of HIV integrase0.9005Inherited
DNA-binding domain of retroviral integrase0.9229Inherited
Alkaline phosphatase-like0.9611Inherited
HAD-like1Inherited
Ribonuclease H-like1Inherited
Acid proteases1Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase1Inherited
PH domain-like1Inherited
SurE-like1Inherited
Retroviral matrix proteins1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
Macro domain-like1Inherited
Cysteine proteinases1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
140586,55811
  • 140586 - Dcp2 domain-like
  • 55811 - Nudix
  • 0Direct
    52540,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    55608,56712
  • 55608 - Homing endonucleases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    53335,52949
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 52949 - Macro domain-like
  • 0Direct
    53335,56672
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    50494,56672
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    101386,53720
  • 101386 - all-alpha NTP pyrophosphatases
  • 53720 - ALDH-like
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    52540,49899
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    50249,47781
  • 50249 - Nucleic acid-binding proteins
  • 47781 - RuvA domain 2-like
  • 0Direct
    46785,158702
  • 46785 - "Winged helix" DNA-binding domain
  • 158702 - Sec63 N-terminal domain-like
  • 0Direct
    51283,51283
  • 51283 - dUTPase-like
  • 51283 - dUTPase-like
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    47781,46929
  • 47781 - RuvA domain 2-like
  • 46929 - DNA helicase RuvA subunit, C-terminal domain
  • 0Direct
    56731,52540
  • 56731 - DNA primase core
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,89043
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 0Direct
    50494,52540
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53300,100939
  • 53300 - vWA-like
  • 100939 - SPOC domain-like
  • 0Direct
    50916,46785
  • 50916 - Rap30/74 interaction domains
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    55464,52540
  • 55464 - Origin of replication-binding domain, RBD-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    -9,52540
  • -9 - PDB
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    100939,101420
  • 100939 - SPOC domain-like
  • 101420 - C-terminal domain of Ku80
  • 0Direct
    52540,47370
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47370 - Bromodomain
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,142877
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 142877 - EndoU-like
  • 0Direct
    141734,101386
  • 141734 - HisI-like
  • 101386 - all-alpha NTP pyrophosphatases
  • 0Direct
    50249,52540
  • 50249 - Nucleic acid-binding proteins
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,54928
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    102860,54197
  • 102860 - mRNA decapping enzyme DcpS N-terminal domain
  • 54197 - HIT-like
  • 0Direct
    88633,50494
  • 88633 - Positive stranded ssRNA viruses
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    52540,48403
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48403 - Ankyrin repeat
  • 0Direct
    52540,57756
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    160481,160481
  • 160481 - BRK domain-like
  • 160481 - BRK domain-like
  • 0Direct
    48024,52540
  • 48024 - N-terminal domain of DnaB helicase
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,52156
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 0Direct
    100939,68906
  • 100939 - SPOC domain-like
  • 68906 - SAP domain
  • 0Direct
    52540,-8
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • -8 - ECOD
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    55811,55811
  • 55811 - Nudix
  • 55811 - Nudix
  • 0Direct
    53067,109604
  • 53067 - Actin-like ATPase domain
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    52540,47819
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47819 - HRDC-like
  • 0Direct
    52540,-9
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • -9 - PDB
  • 0Direct
    50447,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    56672,88633
  • 56672 - DNA/RNA polymerases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    116846,52540
  • 116846 - MIT domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    49899,52540
  • 49899 - Concanavalin A-like lectins/glucanases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,56712
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    52156,50447
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 50447 - Translation proteins
  • 0Direct
    158702,81296
  • 158702 - Sec63 N-terminal domain-like
  • 81296 - E set domains
  • 0Direct
    101386,101386
  • 101386 - all-alpha NTP pyrophosphatases
  • 101386 - all-alpha NTP pyrophosphatases
  • 0Direct
    56983,81296
  • 56983 - Viral glycoprotein, central and dimerisation domains
  • 81296 - E set domains
  • 0Direct
    89043,50494
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    46785,47819
  • 46785 - "Winged helix" DNA-binding domain
  • 47819 - HRDC-like
  • 0Direct
    158702,52540
  • 158702 - Sec63 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    88633,88633
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    52540,56672
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    54980,54980
  • 54980 - EF-G C-terminal domain-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    54001,88633
  • 54001 - Cysteine proteinases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    56672,52540
  • 56672 - DNA/RNA polymerases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53335,142877
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 142877 - EndoU-like
  • 0Direct
    52540,51294
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51294 - Hedgehog/intein (Hint) domain
  • 0.0000000000003441Direct
    48403,52540
  • 48403 - Ankyrin repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00000000001846Direct
    57756,51283
  • 57756 - Retrovirus zinc finger-like domains
  • 51283 - dUTPase-like
  • 0.00000000004233Direct
    51283,50630
  • 51283 - dUTPase-like
  • 50630 - Acid proteases
  • 0.00000000004233Direct
    51197,52540
  • 51197 - Clavaminate synthase-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00000000007806Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0.000000005188Direct
    143076,101816
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 0.000000009916Direct
    101816,144246
  • 101816 - Replicase NSP9
  • 144246 - Coronavirus NSP10-like
  • 0.000000009916Direct
    140367,143076
  • 140367 - Coronavirus NSP7-like
  • 143076 - Coronavirus NSP8-like
  • 0.000000009916Direct
    51294,55608
  • 51294 - Hedgehog/intein (Hint) domain
  • 55608 - Homing endonucleases
  • 0.00000003775Direct
    53649,54060
  • 53649 - Alkaline phosphatase-like
  • 54060 - His-Me finger endonucleases
  • 0.0000002465Direct
    56712,51294
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0.000003252Direct
    90188,53649
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0.000004855Direct
    90188,90188
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 0.00001897Direct
    53098,51283
  • 53098 - Ribonuclease H-like
  • 51283 - dUTPase-like
  • 0.00007289Direct
    51283,46919
  • 51283 - dUTPase-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0.00007289Direct
    55608,52540
  • 55608 - Homing endonucleases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0001895Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.0003319Direct
    56672,46919
  • 56672 - DNA/RNA polymerases
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0.001865Inherited
    -8,52540
  • -8 - ECOD
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.001865Inherited
    52540,48019
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48019 - post-AAA+ oligomerization domain-like
  • 0.00266Inherited
    159936,52949
  • 159936 - NSP3A-like
  • 52949 - Macro domain-like
  • 0.01176Inherited
    159936,53335
  • 159936 - NSP3A-like
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0.01917Inherited
    56300,55816
  • 56300 - Metallo-dependent phosphatases
  • 55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain
  • 0.05114Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.2621Inherited
    47943,47353
  • 47943 - Retrovirus capsid protein, N-terminal core domain
  • 47353 - Retrovirus capsid dimerization domain-like
  • 0.5681Inherited
    46919,53098
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 0.9005Inherited
    53098,50122
  • 53098 - Ribonuclease H-like
  • 50122 - DNA-binding domain of retroviral integrase
  • 0.9229Inherited
    47353,57756
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 0.9789Inherited
    56672,53098
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 1Inherited
    53098,46919
  • 53098 - Ribonuclease H-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 1Inherited
    50630,56672
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 1Inherited
    57756,50630
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53067,53067,109604
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    52540,52156,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 50447 - Translation proteins
  • 0Direct
    52540,52540,47819
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47819 - HRDC-like
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50447,54980,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    88633,50494,52540
  • 88633 - Positive stranded ssRNA viruses
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,48403,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48403 - Ankyrin repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    141734,101386,53720
  • 141734 - HisI-like
  • 101386 - all-alpha NTP pyrophosphatases
  • 53720 - ALDH-like
  • 0Direct
    56672,52540,52540
  • 56672 - DNA/RNA polymerases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,52540,56712
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    50494,52540,52540
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,46785,158702
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 158702 - Sec63 N-terminal domain-like
  • 0Direct
    52540,46785,47819
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 47819 - HRDC-like
  • 0Direct
    52540,49899,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    50494,52540,56672
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    48024,52540,51294
  • 48024 - N-terminal domain of DnaB helicase
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,56712,51294
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    53300,100939,101420
  • 53300 - vWA-like
  • 100939 - SPOC domain-like
  • 101420 - C-terminal domain of Ku80
  • 0Direct
    46785,158702,81296
  • 46785 - "Winged helix" DNA-binding domain
  • 158702 - Sec63 N-terminal domain-like
  • 81296 - E set domains
  • 0Direct
    51197,52540,56672
  • 51197 - Clavaminate synthase-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    52540,54980,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 54980 - EF-G C-terminal domain-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    52540,52540,56672
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    50249,47781,46929
  • 50249 - Nucleic acid-binding proteins
  • 47781 - RuvA domain 2-like
  • 46929 - DNA helicase RuvA subunit, C-terminal domain
  • 0Direct
    158702,52540,52540
  • 158702 - Sec63 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54001,88633,88633
  • 54001 - Cysteine proteinases
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    52540,52540,142877
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 142877 - EndoU-like
  • 0Direct
    52540,52540,47370
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47370 - Bromodomain
  • 0Direct
    89043,50494,56672
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50630,56672,46919
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0Direct
    51197,52540,52540
  • 51197 - Clavaminate synthase-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    46785,158702,52540
  • 46785 - "Winged helix" DNA-binding domain
  • 158702 - Sec63 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,89043,50494
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    50494,56672,88633
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    88633,88633,88633
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    50494,52540,89043
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 0Direct
    52540,50447,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    50249,52540,52540
  • 50249 - Nucleic acid-binding proteins
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53300,100939,68906
  • 53300 - vWA-like
  • 100939 - SPOC domain-like
  • 68906 - SAP domain
  • 0Direct
    57756,51283,50630
  • 57756 - Retrovirus zinc finger-like domains
  • 51283 - dUTPase-like
  • 50630 - Acid proteases
  • 0.00000000004233Direct
    143076,101816,144246
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 144246 - Coronavirus NSP10-like
  • 0.000000009916Direct
    140367,143076,101816
  • 140367 - Coronavirus NSP7-like
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 0.000000009916Direct
    52540,51294,55608
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51294 - Hedgehog/intein (Hint) domain
  • 55608 - Homing endonucleases
  • 0.00000006071Direct
    90188,53649,54060
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 54060 - His-Me finger endonucleases
  • 0.0000002465Direct
    47353,57756,57756
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0.0000006326Direct
    57756,57756,51283
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 51283 - dUTPase-like
  • 0.0000006326Direct
    51283,50630,56672
  • 51283 - dUTPase-like
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 0.000003135Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000003252Direct
    90188,90188,53649
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0.00001897Direct
    51283,46919,53098
  • 51283 - dUTPase-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 0.00007289Direct
    53098,51283,46919
  • 53098 - Ribonuclease H-like
  • 51283 - dUTPase-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 0.00007289Direct
    56672,53098,51283
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 51283 - dUTPase-like
  • 0.00007289Direct
    56672,46919,53098
  • 56672 - DNA/RNA polymerases
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 0.001865Inherited
    46919,53098,50122
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 50122 - DNA-binding domain of retroviral integrase
  • 0.8752Inherited
    47943,47353,57756
  • 47943 - Retrovirus capsid protein, N-terminal core domain
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 0.9789Inherited
    53098,46919,53098
  • 53098 - Ribonuclease H-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 53098 - Ribonuclease H-like
  • 1Inherited
    50630,56672,53098
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 1Inherited
    47353,57756,50630
  • 47353 - Retrovirus capsid dimerization domain-like
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 1Inherited
    57756,50630,56672
  • 57756 - Retrovirus zinc finger-like domains
  • 50630 - Acid proteases
  • 56672 - DNA/RNA polymerases
  • 1Inherited
    56672,53098,46919
  • 56672 - DNA/RNA polymerases
  • 53098 - Ribonuclease H-like
  • 46919 - N-terminal Zn binding domain of HIV integrase
  • 1Inherited


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