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Enzyme Commission (EC): Carbon-carbon lyases

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <7>
+ 1:   Lyases [4] <8>(182|225) (183|104|38)
0:   Carbon-carbon lyases [4.1] <4>(71|84) (71|30|8)
- 1:   Carboxy-lyases [4.1.1] <119>(50|57) (50|19|5)
- 1:   Aldehyde-lyases [4.1.2] <66>(13|17) (13|5|2)
- 1:   Oxo-acid-lyases [4.1.3] <47>(13|14) (13|6|2)
- 1:   Other carbon-carbon lyases [4.1.99] <25>(9|8) (9|2|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
RraA-like0Direct
MK0786-like0Direct
RibA-like0Direct
RuBisCo, C-terminal domain0Direct
ADC-like0Direct
S-adenosylmethionine decarboxylase0Direct
Aldolase0Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0Direct
Ribulose-phoshate binding barrel0Direct
PEP carboxykinase-like0Direct
FMN-binding split barrel0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
Ornithine decarboxylase C-terminal domain0Direct
Cryptochrome/photolyase FAD-binding domain0Direct
Cryptochrome/photolyase, N-terminal domain0Direct
Radical SAM enzymes0Direct
RuBisCO, small subunit0Direct
UROD/MetE-like0Direct
UraD-Like0Direct
AF0104/ALDC/Ptd012-like0Direct
YrdC/RibB0Direct
Chorismate lyase-like0Direct
UbiD C-terminal domain-like0Direct
DHS-like NAD/FAD-binding domain0Direct
Pyruvoyl-dependent histidine and arginine decarboxylases0Direct
PEP carboxykinase N-terminal domain0Direct
post-HMGL domain-like0Direct
Alanine racemase C-terminal domain-like0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0Direct
RuBisCO, large subunit, small (N-terminal) domain0Direct
PLP-binding barrel0Direct
ADC synthase0Direct
CoaB-like0Direct
Acetoacetate decarboxylase-like0Direct
Sulfolobus fructose-1,6-bisphosphatase-like0Direct
PLP-dependent transferases0.0000000000002742Direct
Tetrahydrobiopterin biosynthesis enzymes-like0.00000004966Direct
Tautomerase/MIF0.0000006262Direct
Thiamin diphosphate-binding fold (THDP-binding)0.000003491Direct
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK0.0001071Direct
D-aminoacid aminotransferase-like PLP-dependent enzymes0.003544Inherited
Rudiment single hybrid motif0.0571Inherited
CoA-dependent acyltransferases0.1921Inherited
PFL-like glycyl radical enzymes0.2382Inherited
2-methylcitrate dehydratase PrpD0.6223Inherited
FAH0.7077Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.919Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
AraD/HMP-PK domain-like1Inherited
RmlC-like cupins1Inherited
CheY-like1Inherited
Ferritin-like1Inherited
Metallo-dependent hydrolases1Inherited
FAD/NAD(P)-binding domain1Inherited
EF-hand1Inherited
Periplasmic binding protein-like II1Inherited
Ribosomal protein S5 domain 2-like1Inherited
Dihydropteroate synthetase-like1Inherited
ClpP/crotonase1Inherited
SAICAR synthase-like1Inherited
Molybdenum cofactor biosynthesis protein C, MoaC1Inherited
Aminoacid dehydrogenase-like, N-terminal domain1Inherited
Flavoproteins1Inherited
GHMP Kinase, C-terminal domain1Inherited
NagB/RpiA/CoA transferase-like1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
Class I glutamine amidotransferase-like1Inherited
PRTase-like1Inherited
FAD-linked reductases, C-terminal domain1Inherited
PreATP-grasp domain1Inherited
Isocitrate/Isopropylmalate dehydrogenase-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
PEP carboxykinase C-terminal domain0Direct
UbiD C-terminal domain-like0Direct
Pyruvate oxidase and decarboxylase PP module0Direct
Arginine decarboxylase0Direct
Alanine racemase-like, N-terminal domain0Direct
Cryptochrome/photolyase FAD-binding domain0Direct
PMT1231-like0Direct
UbiD middle domain-like0Direct
S-adenosylmethionine decarboxylase0Direct
Pyridoxal-dependent decarboxylase0Direct
PEP carboxykinase N-terminal domain0Direct
RuBisCo, large subunit, C-terminal domain0Direct
Bacterial S-adenosylmethionine decarboxylase0Direct
Pyruvoyl dependent aspartate decarboxylase, ADC0Direct
Ornithine decarboxylase C-terminal domain0Direct
RibA-like0Direct
Class II FBP aldolase0Direct
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB0Direct
HMGL-like0Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0Direct
Tryptophan biosynthesis enzymes0Direct
Ribulose 1,5-bisphosphate carboxylase-oxygenase0Direct
Ornithine decarboxylase major domain0Direct
ADC synthase0Direct
Cryptochrome/photolyase, N-terminal domain0Direct
HpcH/HpaI aldolase0Direct
Acetoacetate decarboxylase-like0Direct
Mevalonate 5-diphosphate decarboxylase0Direct
DmpG/LeuA communication domain-like0Direct
MK0786-like0Direct
Sulfolobus fructose-1,6-bisphosphatase-like0Direct
UraD-like0Direct
Chorismate lyase0Direct
Pyruvate oxidase and decarboxylase, middle domain0Direct
DHN aldolase/epimerase0Direct
Ornithine decarboxylase N-terminal "wing" domain0Direct
Beta-eliminating lyases0Direct
Phosphoenolpyruvate mutase/Isocitrate lyase-like0Direct
Phosphoenolpyruvate carboxylase0Direct
Histidine decarboxylase0Direct
Eukaryotic ODC-like0Direct
Uroporphyrinogen decarboxylase, UROD0Direct
MoCo biosynthesis proteins0Direct
Alpha-acetolactate decarboxylase-like0Direct
RraA-like0Direct
Decarboxylase0Direct
RuBisCO, small subunit0Direct
Class I aldolase0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD1.852e-16Direct
CoaB-like1.852e-16Direct
Pyruvate oxidase and decarboxylase Pyr module0.00000000000003661Direct
PP1699/LP2961-like0.00000000005706Direct
MIF-related0.00000001725Direct
Formaldehyde-activating enzyme, FAE0.0000001688Direct
6-pyruvoyl tetrahydropterin synthase0.000006903Direct
Germin/Seed storage 7S protein0.00001286Direct
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK0.0001291Direct
CAT-like0.01005Inherited
Branched-chain alpha-keto acid dehydrogenase Pyr module0.01148Inherited
PFL-like0.01179Inherited
D-aminoacid aminotransferase-like PLP-dependent enzymes0.01232Inherited
CoA transferase alpha subunit-like0.01599Inherited
Branched-chain alpha-keto acid dehydrogenase PP module0.02908Inherited
Dihydropteroate synthetase0.03159Inherited
BC C-terminal domain-like0.06877Inherited
GMC oxidoreductases0.07899Inherited
Cytochrome p450 reductase N-terminal domain-like0.1042Inherited
Malic enzyme N-domain0.4578Inherited
2-methylcitrate dehydratase PrpD0.583Inherited
FAH0.6227Inherited
BC ATP-binding domain-like0.9204Inherited
BC N-terminal domain-like0.9649Inherited
FAD-linked reductases, N-terminal domain0.9734Inherited
AAT-like0.9745Inherited
AraD-like aldolase/epimerase0.9893Inherited
Dimeric isocitrate & isopropylmalate dehydrogenases1Inherited
SAICAR synthase1Inherited
Molybdenum cofactor biosynthesis protein C, MoaC1Inherited
Tyrosine-dependent oxidoreductases1Inherited
Class I glutamine amidotransferases (GAT)1Inherited
Crotonase-like1Inherited
Aminoacid dehydrogenase-like, C-terminal domain1Inherited
Phosphoribosyltransferases (PRTases)1Inherited
GHMP Kinase, N-terminal domain1Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
ADC-like0Direct
PEP carboxykinase-like0Direct
post-HMGL domain-like0Direct
Alanine racemase C-terminal domain-like0Direct
CoaB-like0Direct
DHS-like NAD/FAD-binding domain0Direct
RibA-like0Direct
MK0786-like0Direct
AF0104/ALDC/Ptd012-like0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0Direct
Aldolase0Direct
RuBisCO, large subunit, small (N-terminal) domain0Direct
Cryptochrome/photolyase FAD-binding domain0Direct
UraD-Like0Direct
Ornithine decarboxylase C-terminal domain0Direct
Ribulose-phoshate binding barrel0Direct
Chorismate lyase-like0Direct
UbiD C-terminal domain-like0Direct
Pyruvoyl-dependent histidine and arginine decarboxylases0Direct
RuBisCO, small subunit0Direct
Cryptochrome/photolyase, N-terminal domain0Direct
UROD/MetE-like0Direct
RuBisCo, C-terminal domain0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
PLP-binding barrel0Direct
PEP carboxykinase N-terminal domain0Direct
YrdC/RibB0Direct
Acetoacetate decarboxylase-like0Direct
FMN-binding split barrel0Direct
RraA-like0Direct
S-adenosylmethionine decarboxylase0Direct
ADC synthase0Direct
Radical SAM enzymes0Direct
Sulfolobus fructose-1,6-bisphosphatase-like0Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0Direct
PLP-dependent transferases0.0000000000001958Direct
Tetrahydrobiopterin biosynthesis enzymes-like0.00000003789Direct
Tautomerase/MIF0.0000004867Direct
Thiamin diphosphate-binding fold (THDP-binding)0.000002747Direct
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK0.00008666Direct
D-aminoacid aminotransferase-like PLP-dependent enzymes0.002967Inherited
Rudiment single hybrid motif0.04951Inherited
CoA-dependent acyltransferases0.1704Inherited
PFL-like glycyl radical enzymes0.2125Inherited
2-methylcitrate dehydratase PrpD0.5714Inherited
FAH0.6509Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.8492Inherited
Dihydropteroate synthetase-like0.9749Inherited
AraD/HMP-PK domain-like0.9781Inherited
FAD-linked reductases, C-terminal domain0.9991Inherited
EF-hand1Inherited
GHMP Kinase, C-terminal domain1Inherited
Flavoproteins1Inherited
CheY-like1Inherited
FAD/NAD(P)-binding domain1Inherited
Isocitrate/Isopropylmalate dehydrogenase-like1Inherited
ClpP/crotonase1Inherited
SAICAR synthase-like1Inherited
PreATP-grasp domain1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
PRTase-like1Inherited
Class I glutamine amidotransferase-like1Inherited
Ribosomal protein S5 domain 2-like1Inherited
Ferritin-like1Inherited
Aminoacid dehydrogenase-like, N-terminal domain1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
Molybdenum cofactor biosynthesis protein C, MoaC1Inherited
Metallo-dependent hydrolases1Inherited
NagB/RpiA/CoA transferase-like1Inherited
Periplasmic binding protein-like II1Inherited
RmlC-like cupins1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52518,52467
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52467 - DHS-like NAD/FAD-binding domain
  • 0Direct
    52507,102645
  • 52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
  • 102645 - CoaB-like
  • 0Direct
    51366,51366
  • 51366 - Ribulose-phoshate binding barrel
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    56529,56529
  • 56529 - FAH
  • 56529 - FAH
  • 0Direct
    56104,52255
  • 56104 - SAICAR synthase-like
  • 52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
  • 0Direct
    54966,51649
  • 54966 - RuBisCO, large subunit, small (N-terminal) domain
  • 51649 - RuBisCo, C-terminal domain
  • 0Direct
    55821,142695
  • 55821 - YrdC/RibB
  • 142695 - RibA-like
  • 0Direct
    52425,48173
  • 52425 - Cryptochrome/photolyase, N-terminal domain
  • 48173 - Cryptochrome/photolyase FAD-binding domain
  • 0Direct
    51419,50621
  • 51419 - PLP-binding barrel
  • 50621 - Alanine racemase C-terminal domain-like
  • 0Direct
    68923,53795
  • 68923 - PEP carboxykinase N-terminal domain
  • 53795 - PEP carboxykinase-like
  • 0Direct
    56322,52317
  • 56322 - ADC synthase
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    50475,143968
  • 50475 - FMN-binding split barrel
  • 143968 - UbiD C-terminal domain-like
  • 0Direct
    52467,52518
  • 52467 - DHS-like NAD/FAD-binding domain
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    55620,55083
  • 55620 - Tetrahydrobiopterin biosynthesis enzymes-like
  • 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
  • 0Direct
    52317,47648
  • 52317 - Class I glutamine amidotransferase-like
  • 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
  • 0Direct
    51246,52255
  • 51246 - Rudiment single hybrid motif
  • 52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
  • 0Direct
    53271,51366
  • 53271 - PRTase-like
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    51569,89000
  • 51569 - Aldolase
  • 89000 - post-HMGL domain-like
  • 0Direct
    52172,53383
  • 52172 - CheY-like
  • 53383 - PLP-dependent transferases
  • 0Direct
    53383,55904
  • 53383 - PLP-dependent transferases
  • 55904 - Ornithine decarboxylase C-terminal domain
  • 0Direct
    54211,51366
  • 54211 - Ribosomal protein S5 domain 2-like
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    52317,51366
  • 52317 - Class I glutamine amidotransferase-like
  • 51366 - Ribulose-phoshate binding barrel
  • 0.000004197Direct
    55083,51717
  • 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
  • 51717 - Dihydropteroate synthetase-like
  • 0.0002308Direct
    55620,55620
  • 55620 - Tetrahydrobiopterin biosynthesis enzymes-like
  • 55620 - Tetrahydrobiopterin biosynthesis enzymes-like
  • 0.0006783Direct
    100950,100950
  • 100950 - NagB/RpiA/CoA transferase-like
  • 100950 - NagB/RpiA/CoA transferase-like
  • 0.002891Inherited
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.04951Inherited
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.9546Inherited
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0.9591Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 1Inherited
    54211,55060
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55060 - GHMP Kinase, C-terminal domain
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52317,51366,51366
  • 52317 - Class I glutamine amidotransferase-like
  • 51366 - Ribulose-phoshate binding barrel
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    55620,55083,51717
  • 55620 - Tetrahydrobiopterin biosynthesis enzymes-like
  • 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
  • 51717 - Dihydropteroate synthetase-like
  • 0Direct
    52172,53383,55904
  • 52172 - CheY-like
  • 53383 - PLP-dependent transferases
  • 55904 - Ornithine decarboxylase C-terminal domain
  • 0Direct
    55620,55620,55083
  • 55620 - Tetrahydrobiopterin biosynthesis enzymes-like
  • 55620 - Tetrahydrobiopterin biosynthesis enzymes-like
  • 55083 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
  • 0Direct
    56059,51246,52255
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
  • 0Direct
    52317,47648,52418
  • 52317 - Class I glutamine amidotransferase-like
  • 47648 - Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
  • 52418 - Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
  • 0Direct
    52518,52467,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52467 - DHS-like NAD/FAD-binding domain
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.0481Inherited


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