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Enzyme Commission (EC): Ligases

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   root [root] <7>
0:   Ligases [6] <6>(96|123) (95|112|69)
- 1:   Forming carbon-nitrogen bonds [6.3] <5>(59|78) (58|59|38)
- 1:   Forming carbon-oxygen bonds [6.1] <3>(28|31) (28|37|22)
- 1:   Forming carbon-carbon bonds [6.4] <1>(8|7) (8|4|1)
- 1:   Forming carbon-sulfur bonds [6.2] <1>(10|6) (11|7|1)
- 1:   Forming nitrogen-metal bonds [6.6] <1>(2|1) (2|0|0)
- 1:   Forming phosphoric ester bonds [6.5] <1>(8|10) (8|9|8)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Adenine nucleotide alpha hydrolases-like0Direct
An anticodon-binding domain of class I aminoacyl-tRNA synthetases0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
ThrRS/AlaRS common domain0Direct
MurCD N-terminal domain0Direct
Anticodon-binding domain of PheRS0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
MesJ substrate recognition domain-like0Direct
Nicotinate/Quinolinate PRTase N-terminal domain-like0Direct
Class I glutamine amidotransferase-like0Direct
PurM N-terminal domain-like0Direct
C-terminal domain of ProRS0Direct
MurD-like peptide ligases, catalytic domain0Direct
Argininosuccinate synthetase, C-terminal domain0Direct
Nicotinate/Quinolinate PRTase C-terminal domain-like0Direct
Carbamoyl phosphate synthetase, large subunit connection domain0Direct
FGAM synthase PurL, linker domain0Direct
GAD domain-like0Direct
C-terminal domain of transcriptional repressors0Direct
Putative DNA-binding domain0Direct
Methionyl-tRNA synthetase (MetRS), Zn-domain0Direct
Amidase signature (AS) enzymes0Direct
Nucleic acid-binding proteins0Direct
YbaK/ProRS associated domain0Direct
BRCT domain0Direct
CoaB-like0Direct
Acetyl-CoA synthetase-like0Direct
PheT/TilS domain0Direct
MurD-like peptide ligases, peptide-binding domain0Direct
Glutamine synthetase, N-terminal domain0Direct
MurE/MurF N-terminal domain0Direct
YegP-like0Direct
Glutamine synthetase/guanido kinase0Direct
CofE-like0Direct
Hypothetical protein PH16020Direct
PurS-like0Direct
RuvA domain 2-like0Direct
PurM C-terminal domain-like0Direct
Class II aaRS ABD-related0Direct
HD-domain/PDEase-like0Direct
Rudiment single hybrid motif0Direct
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain0Direct
Nucleotidylyl transferase0Direct
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)0Direct
TGS-like0Direct
tRNA-binding arm0Direct
Alpha-L RNA-binding motif0Direct
Methylglyoxal synthase-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Glutathione synthetase ATP-binding domain-like0Direct
Ribosomal protein L25-like0Direct
SufE/NifU0Direct
Translation proteins0Direct
Class II aaRS and biotin synthetases0Direct
ValRS/IleRS/LeuRS editing domain0Direct
GMP synthetase C-terminal dimerisation domain0Direct
PreATP-grasp domain0Direct
SAICAR synthase-like0Direct
RNA 3'-terminal phosphate cyclase, RPTC, insert domain0Direct
S15/NS1 RNA-binding domain0Direct
Succinyl-CoA synthetase domains0Direct
Carbamoyl phosphate synthetase, small subunit N-terminal domain0Direct
Single hybrid motif0.0000000000001255Direct
Activating enzymes of the ubiquitin-like proteins0.0004889Direct
PH0987 N-terminal domain-like0.004198Inherited
P-loop containing nucleoside triphosphate hydrolases0.01688Inherited
Formiminotransferase domain of formiminotransferase-cyclodeaminase.0.02464Inherited
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0.03756Inherited
FMN-dependent nitroreductase-like0.05509Inherited
vWA-like0.08182Inherited
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0.1047Inherited
Glycerol-3-phosphate (1)-acyltransferase0.1537Inherited
ACP-like0.5293Inherited
SCOP hierarchy in SUPERFAMILY0.9779Inherited
Cyclophilin-like1Inherited
PLP-dependent transferases1Inherited
"Helical backbone" metal receptor1Inherited
Carbon-nitrogen hydrolase1Inherited
Metallo-dependent hydrolases1Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
Actin-like ATPase domain1Inherited
CoA-dependent acyltransferases1Inherited
Formyltransferase1Inherited
NagB/RpiA/CoA transferase-like1Inherited
ClpP/crotonase1Inherited
Composite domain of metallo-dependent hydrolases1Inherited
GST C-terminal domain-like1Inherited
Aldolase1Inherited
post-HMGL domain-like1Inherited
Aspartate/ornithine carbamoyltransferase1Inherited
alpha/beta-Hydrolases1Inherited
EPT/RTPC-like1Inherited
"Winged helix" DNA-binding domain1Inherited
Acyl-CoA N-acyltransferases (Nat)1Inherited
Aminoacid dehydrogenase-like, N-terminal domain1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nitrogenase iron protein-like0Direct
C-terminal domain of class I lysyl-tRNA synthetase0Direct
CoaB-like0Direct
Glutathionylspermidine synthase substrate-binding domain-like0Direct
Hypothetical protein PH16020Direct
Domains B1 and B5 of PheRS-beta, PheT0Direct
NAD+-dependent DNA ligase, domain 30Direct
Glutamate-cysteine ligase family 2 (GCS2)0Direct
AlaX-M N-terminal domain-like0Direct
Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain0Direct
Class I glutamine amidotransferases (GAT)0Direct
Methionyl-tRNA synthetase (MetRS), Zn-domain0Direct
Monomeric nicotinate phosphoribosyltransferase C-terminal domain0Direct
Ubiquitin activating enzymes (UBA)0Direct
YbaK/ProRS associated domain0Direct
PurP ATP-binding domain-like0Direct
RNA 3'-terminal phosphate cyclase, RPTC0Direct
SAICAR synthase0Direct
BC ATP-binding domain-like0Direct
Phenylalanyl-tRNA synthetase (PheRS)0Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0Direct
Folylpolyglutamate synthetase, C-terminal domain0Direct
MurCDEF C-terminal domain0Direct
MesJ substrate recognition domain-like0Direct
Carbamoyl phosphate synthetase, small subunit N-terminal domain0Direct
DNA ligase/mRNA capping enzyme postcatalytic domain0Direct
SP1160 C-terminal domain-like0Direct
Anticodon-binding domain of PheRS0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
ATP-dependent DNA ligase catalytic domain0Direct
MurE/MurF N-terminal domain0Direct
Threonyl-tRNA synthetase (ThrRS), second 'additional' domain0Direct
tRNA-Ile-lysidine synthetase, TilS, C-terminal domain0Direct
Glutamine synthetase catalytic domain0Direct
FGAM synthase PurL, PurS-like domain0Direct
ATP-binding domain of peptide synthetases0Direct
CofE-like0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
C-terminal domain of glutamyl-tRNA synthetase (GluRS)0Direct
CoA-binding domain0Direct
Valyl-tRNA synthetase (ValRS) C-terminal domain0Direct
Adenylation domain of NAD+-dependent DNA ligase0Direct
Glutathionylspermidine synthase ATP-binding domain-like0Direct
Glutamine synthetase, N-terminal domain0Direct
GAD domain0Direct
D-Alanine ligase N-terminal domain0Direct
PP-loop ATPase0Direct
Biotin repressor (BirA)0Direct
Folylpolyglutamate synthetase0Direct
Methenyltetrahydrofolate synthetase0Direct
Monomeric nicotinate phosphoribosyltransferase N-terminal domain-like0Direct
BC N-terminal domain-like0Direct
N-type ATP pyrophosphatases0Direct
PurS subunit of FGAM synthetase0Direct
Biotin holoenzyme synthetase0Direct
GMP synthetase C-terminal dimerisation domain0Direct
Myf domain0Direct
Argininosuccinate synthetase, C-terminal domain0Direct
YegP-like0Direct
TGS domain0Direct
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)0Direct
Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)0Direct
MurCD N-terminal domain0Direct
FGAM synthase PurL, linker domain0Direct
MurCDEF0Direct
Tyrosyl-tRNA synthetase (TyrRS), C-terminal domain0Direct
Succinyl-CoA synthetase domains0Direct
RNA ligase0Direct
Glutamate-cysteine ligase0Direct
PurP N-terminal domain-like0Direct
Lysine biosynthesis enzyme LysX ATP-binding domain0Direct
Anticodon-binding domain0Direct
CHAP domain0Direct
C-terminal domain of ProRS0Direct
Amidase signature (AS) enzymes0Direct
Carbamoyl phosphate synthetase, large subunit connection domain0Direct
Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain0Direct
a tRNA synthase domain0Direct
RNA 3'-terminal phosphate cyclase, RPTC, insert domain0Direct
ValRS/IleRS/LeuRS editing domain0Direct
BC C-terminal domain-like0Direct
Prokaryotic glutathione synthetase, N-terminal domain0Direct
Eukaryotic glutathione synthetase ATP-binding domain0Direct
B3/B4 domain of PheRS, PheT0Direct
DNA ligase0Direct
Succinyl-CoA synthetase, beta-chain, N-terminal domain0Direct
Seryl-tRNA synthetase (SerRS)0Direct
Acetyl-CoA synthetase-like0Direct
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain0Direct
Eukaryotic glutathione synthetase, substrate-binding domain0Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0Direct
Anticodon-binding domain of Class II aaRS0Direct
AlaX-like0Direct
PurM C-terminal domain-like0Direct
PurM N-terminal domain-like0Direct
Conserved carboxylase domain0.0000000000002456Direct
Biotinyl/lipoyl-carrier proteins and domains0.000000000003794Direct
NadC C-terminal domain-like0.000004221Direct
NadC N-terminal domain-like0.00001014Direct
PH0987 N-terminal domain-like0.001717Inherited
PH0987 C-terminal domain-like0.004544Inherited
Thioesterase domain of polypeptide, polyketide and fatty acid synthases0.01133Inherited
Peptidyl carrier domain0.01605Inherited
Formiminotransferase domain of formiminotransferase-cyclodeaminase.0.02672Inherited
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0.04037Inherited
NADH oxidase/flavin reductase0.1129Inherited
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0.1767Inherited
Class II glutamine amidotransferases0.1965Inherited
LplA-like0.7052Inherited
GABA-aminotransferase-like1Inherited
Aspartate/ornithine carbamoyltransferase1Inherited
Aminoacid dehydrogenase-like, C-terminal domain1Inherited
HMGL-like1Inherited
Biotin dependent carboxylase carboxyltransferase domain1Inherited
Hydantoinase (dihydropyrimidinase), catalytic domain1Inherited
Nucleotide and nucleoside kinases1Inherited
CoaX-like1Inherited
Nitrogenase iron-molybdenum protein1Inherited
HD domain1Inherited
Formyltransferase1Inherited
Deoxycytidylate deaminase-like1Inherited
Tetrahydrofolate dehydrogenase/cyclohydrolase1Inherited
Extended AAA-ATPase domain1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Glutamine synthetase, N-terminal domain0Direct
MurD-like peptide ligases, catalytic domain0Direct
Class I glutamine amidotransferase-like0Direct
YegP-like0Direct
MurE/MurF N-terminal domain0Direct
Nucleic acid-binding proteins0Direct
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain0Direct
HD-domain/PDEase-like0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
RuvA domain 2-like0Direct
Alpha-L RNA-binding motif0Direct
FGAM synthase PurL, linker domain0Direct
Class II aaRS ABD-related0Direct
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)0Direct
BRCT domain0Direct
Glutamine synthetase/guanido kinase0Direct
RNA 3'-terminal phosphate cyclase, RPTC, insert domain0Direct
Carbamoyl phosphate synthetase, large subunit connection domain0Direct
PreATP-grasp domain0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Amidase signature (AS) enzymes0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
SAICAR synthase-like0Direct
TGS-like0Direct
Argininosuccinate synthetase, C-terminal domain0Direct
Anticodon-binding domain of PheRS0Direct
PurM N-terminal domain-like0Direct
tRNA-binding arm0Direct
ThrRS/AlaRS common domain0Direct
CofE-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
MurCD N-terminal domain0Direct
Translation proteins0Direct
Rudiment single hybrid motif0Direct
Nicotinate/Quinolinate PRTase N-terminal domain-like0Direct
PheT/TilS domain0Direct
Hypothetical protein PH16020Direct
Adenine nucleotide alpha hydrolases-like0Direct
Methionyl-tRNA synthetase (MetRS), Zn-domain0Direct
MesJ substrate recognition domain-like0Direct
Succinyl-CoA synthetase domains0Direct
Methylglyoxal synthase-like0Direct
GMP synthetase C-terminal dimerisation domain0Direct
PurM C-terminal domain-like0Direct
Nicotinate/Quinolinate PRTase C-terminal domain-like0Direct
Nucleotidylyl transferase0Direct
MurD-like peptide ligases, peptide-binding domain0Direct
GAD domain-like0Direct
Glutathione synthetase ATP-binding domain-like0Direct
Acetyl-CoA synthetase-like0Direct
PurS-like0Direct
C-terminal domain of transcriptional repressors0Direct
Carbamoyl phosphate synthetase, small subunit N-terminal domain0Direct
Ribosomal protein L25-like0Direct
S15/NS1 RNA-binding domain0Direct
Class II aaRS and biotin synthetases0Direct
Putative DNA-binding domain0Direct
SufE/NifU0Direct
CoaB-like0Direct
C-terminal domain of ProRS0Direct
YbaK/ProRS associated domain0Direct
An anticodon-binding domain of class I aminoacyl-tRNA synthetases0Direct
Single hybrid motif0.00000000000008929Direct
Activating enzymes of the ubiquitin-like proteins0.0004009Direct
PH0987 N-terminal domain-like0.003521Inherited
P-loop containing nucleoside triphosphate hydrolases0.0144Inherited
Formiminotransferase domain of formiminotransferase-cyclodeaminase.0.02113Inherited
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0.03234Inherited
FMN-dependent nitroreductase-like0.04774Inherited
vWA-like0.0713Inherited
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0.09149Inherited
Glycerol-3-phosphate (1)-acyltransferase0.1356Inherited
ACP-like0.4845Inherited
post-HMGL domain-like1Inherited
Aminoacid dehydrogenase-like, N-terminal domain1Inherited
"Winged helix" DNA-binding domain1Inherited
NagB/RpiA/CoA transferase-like1Inherited
GST C-terminal domain-like1Inherited
"Helical backbone" metal receptor1Inherited
Metallo-dependent hydrolases1Inherited
Actin-like ATPase domain1Inherited
Aldolase1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
CoA-dependent acyltransferases1Inherited
Cyclophilin-like1Inherited
Aspartate/ornithine carbamoyltransferase1Inherited
alpha/beta-Hydrolases1Inherited
EPT/RTPC-like1Inherited
PLP-dependent transferases1Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)1Inherited
Carbon-nitrogen hydrolase1Inherited
Composite domain of metallo-dependent hydrolases1Inherited
ClpP/crotonase1Inherited
Acyl-CoA N-acyltransferases (Nat)1Inherited
Formyltransferase1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50447,55186
  • 50447 - Translation proteins
  • 55186 - ThrRS/AlaRS common domain
  • 0Direct
    54368,55931
  • 54368 - Glutamine synthetase, N-terminal domain
  • 55931 - Glutamine synthetase/guanido kinase
  • 0Direct
    54001,56059
  • 54001 - Cysteine proteinases
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    101353,50447
  • 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
  • 50447 - Translation proteins
  • 0Direct
    52317,52440
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 0Direct
    50037,53067
  • 50037 - C-terminal domain of transcriptional repressors
  • 53067 - Actin-like ATPase domain
  • 0Direct
    144010,55469
  • 144010 - CofE-like
  • 55469 - FMN-dependent nitroreductase-like
  • 0Direct
    51735,53623
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 0Direct
    52210,52210
  • 52210 - Succinyl-CoA synthetase domains
  • 52210 - Succinyl-CoA synthetase domains
  • 0Direct
    52374,48163
  • 52374 - Nucleotidylyl transferase
  • 48163 - An anticodon-binding domain of class I aminoacyl-tRNA synthetases
  • 0Direct
    51246,55326
  • 51246 - Rudiment single hybrid motif
  • 55326 - PurM N-terminal domain-like
  • 0Direct
    50249,56037
  • 50249 - Nucleic acid-binding proteins
  • 56037 - PheT/TilS domain
  • 0Direct
    53244,52440
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 52440 - PreATP-grasp domain
  • 0Direct
    81271,55186
  • 81271 - TGS-like
  • 55186 - ThrRS/AlaRS common domain
  • 0Direct
    47323,46589
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 46589 - tRNA-binding arm
  • 0Direct
    55681,50037
  • 55681 - Class II aaRS and biotin synthetases
  • 50037 - C-terminal domain of transcriptional repressors
  • 0Direct
    47616,52374
  • 47616 - GST C-terminal domain-like
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    56037,53271
  • 56037 - PheT/TilS domain
  • 53271 - PRTase-like
  • 0Direct
    52954,64586
  • 52954 - Class II aaRS ABD-related
  • 64586 - C-terminal domain of ProRS
  • 0Direct
    55190,52374
  • 55190 - Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    55681,55826
  • 55681 - Class II aaRS and biotin synthetases
  • 55826 - YbaK/ProRS associated domain
  • 0Direct
    55186,55681
  • 55186 - ThrRS/AlaRS common domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    52317,52402
  • 52317 - Class I glutamine amidotransferase-like
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 0Direct
    53623,53244
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    55205,52913
  • 55205 - EPT/RTPC-like
  • 52913 - RNA 3'-terminal phosphate cyclase, RPTC, insert domain
  • 0Direct
    54810,54810
  • 54810 - GMP synthetase C-terminal dimerisation domain
  • 54810 - GMP synthetase C-terminal dimerisation domain
  • 0Direct
    52021,52317
  • 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    82829,56037
  • 82829 - MesJ substrate recognition domain-like
  • 56037 - PheT/TilS domain
  • 0Direct
    47323,50249
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    55681,82649
  • 55681 - Class II aaRS and biotin synthetases
  • 82649 - SufE/NifU
  • 0Direct
    50891,160467
  • 50891 - Cyclophilin-like
  • 160467 - PH0987 N-terminal domain-like
  • 0Direct
    109604,47323
  • 109604 - HD-domain/PDEase-like
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    47781,52113
  • 47781 - RuvA domain 2-like
  • 52113 - BRCT domain
  • 0Direct
    46955,56037
  • 46955 - Putative DNA-binding domain
  • 56037 - PheT/TilS domain
  • 0Direct
    57770,52374
  • 57770 - Methionyl-tRNA synthetase (MetRS), Zn-domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    55681,55261
  • 55681 - Class II aaRS and biotin synthetases
  • 55261 - GAD domain-like
  • 0Direct
    54675,51690
  • 54675 - Nicotinate/Quinolinate PRTase N-terminal domain-like
  • 51690 - Nicotinate/Quinolinate PRTase C-terminal domain-like
  • 0Direct
    55205,55205
  • 55205 - EPT/RTPC-like
  • 55205 - EPT/RTPC-like
  • 0Direct
    69572,69572
  • 69572 - Activating enzymes of the ubiquitin-like proteins
  • 69572 - Activating enzymes of the ubiquitin-like proteins
  • 0Direct
    52374,160113
  • 52374 - Nucleotidylyl transferase
  • 160113 - YegP-like
  • 0Direct
    50249,46955
  • 50249 - Nucleic acid-binding proteins
  • 46955 - Putative DNA-binding domain
  • 0Direct
    47060,52374
  • 47060 - S15/NS1 RNA-binding domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    47060,47060
  • 47060 - S15/NS1 RNA-binding domain
  • 47060 - S15/NS1 RNA-binding domain
  • 0Direct
    56235,52402
  • 56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases)
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 0Direct
    52374,50249
  • 52374 - Nucleotidylyl transferase
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    47060,55681
  • 47060 - S15/NS1 RNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    52402,54810
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 54810 - GMP synthetase C-terminal dimerisation domain
  • 0Direct
    47323,47323
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    52402,69864
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 69864 - Argininosuccinate synthetase, C-terminal domain
  • 0Direct
    55931,56059
  • 55931 - Glutamine synthetase/guanido kinase
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    101353,55186
  • 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
  • 55186 - ThrRS/AlaRS common domain
  • 0Direct
    117018,56091
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    55681,54991
  • 55681 - Class II aaRS and biotin synthetases
  • 54991 - Anticodon-binding domain of PheRS
  • 0Direct
    56059,52440
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52440 - PreATP-grasp domain
  • 0Direct
    82697,109736
  • 82697 - PurS-like
  • 109736 - FGAM synthase PurL, linker domain
  • 0Direct
    -7,52317
  • -7 - CATH
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    56042,52317
  • 56042 - PurM C-terminal domain-like
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    63418,53623
  • 63418 - MurE/MurF N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 0Direct
    56104,52255
  • 56104 - SAICAR synthase-like
  • 52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
  • 0Direct
    52335,51556
  • 52335 - Methylglyoxal synthase-like
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    52777,53474
  • 52777 - CoA-dependent acyltransferases
  • 53474 - alpha/beta-Hydrolases
  • 0Direct
    56317,52402
  • 56317 - Carbon-nitrogen hydrolase
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 0Direct
    56059,52335
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52335 - Methylglyoxal synthase-like
  • 0Direct
    47781,47781
  • 47781 - RuvA domain 2-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    46589,55681
  • 46589 - tRNA-binding arm
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    55729,52374
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    46785,55681
  • 46785 - "Winged helix" DNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    51984,53623
  • 51984 - MurCD N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 0Direct
    50249,47781
  • 50249 - Nucleic acid-binding proteins
  • 47781 - RuvA domain 2-like
  • 0Direct
    48108,52440
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 0Direct
    56042,53328
  • 56042 - PurM C-terminal domain-like
  • 53328 - Formyltransferase
  • 0Direct
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 0Direct
    52374,55174
  • 52374 - Nucleotidylyl transferase
  • 55174 - Alpha-L RNA-binding motif
  • 0Direct
    56042,55326
  • 56042 - PurM C-terminal domain-like
  • 55326 - PurM N-terminal domain-like
  • 0Direct
    52374,50715
  • 52374 - Nucleotidylyl transferase
  • 50715 - Ribosomal protein L25-like
  • 0Direct
    50249,52113
  • 50249 - Nucleic acid-binding proteins
  • 52113 - BRCT domain
  • 0Direct
    47323,47060
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 47060 - S15/NS1 RNA-binding domain
  • 0Direct
    56059,48108
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 0Direct
    55326,56042
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    52540,52317
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    51735,52210
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 52210 - Succinyl-CoA synthetase domains
  • 0Direct
    56059,53623
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 0Direct
    52402,56037
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 56037 - PheT/TilS domain
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    56037,46955
  • 56037 - PheT/TilS domain
  • 46955 - Putative DNA-binding domain
  • 0Direct
    69593,56801
  • 69593 - Glycerol-3-phosphate (1)-acyltransferase
  • 56801 - Acetyl-CoA synthetase-like
  • 0Direct
    109736,55326
  • 109736 - FGAM synthase PurL, linker domain
  • 55326 - PurM N-terminal domain-like
  • 0Direct
    55681,101353
  • 55681 - Class II aaRS and biotin synthetases
  • 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    46955,55681
  • 46955 - Putative DNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    52402,82829
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 82829 - MesJ substrate recognition domain-like
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0.0000000000002095Direct
    52507,102645
  • 52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
  • 102645 - CoaB-like
  • 0.000000000002663Direct
    52374,52540
  • 52374 - Nucleotidylyl transferase
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0000000002821Direct
    52540,-7
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • -7 - CATH
  • 0.000004921Direct
    56801,47336
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 0.00004619Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.0001747Direct
    52777,56801
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 0.001463Inherited
    160467,50891
  • 160467 - PH0987 N-terminal domain-like
  • 50891 - Cyclophilin-like
  • 0.003521Inherited
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.01309Inherited
    47336,52777
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 0.016Inherited
    55116,55116
  • 55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
  • 55116 - Formiminotransferase domain of formiminotransferase-cyclodeaminase.
  • 0.02113Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.9267Inherited
    51569,89000
  • 51569 - Aldolase
  • 89000 - post-HMGL domain-like
  • 1Inherited
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 1Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 1Inherited
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55681,101353,50447
  • 55681 - Class II aaRS and biotin synthetases
  • 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
  • 50447 - Translation proteins
  • 0Direct
    55681,52954,64586
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 64586 - C-terminal domain of ProRS
  • 0Direct
    52021,52317,52440
  • 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 0Direct
    51246,55326,56042
  • 51246 - Rudiment single hybrid motif
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    53244,52440,56059
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    53623,53244,52440
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 52440 - PreATP-grasp domain
  • 0Direct
    52402,54810,54810
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 54810 - GMP synthetase C-terminal dimerisation domain
  • 54810 - GMP synthetase C-terminal dimerisation domain
  • 0Direct
    50249,52113,52113
  • 50249 - Nucleic acid-binding proteins
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    52317,52440,56059
  • 52317 - Class I glutamine amidotransferase-like
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    52317,52402,54810
  • 52317 - Class I glutamine amidotransferase-like
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 54810 - GMP synthetase C-terminal dimerisation domain
  • 0Direct
    48108,52440,56059
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    52777,52777,53474
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 53474 - alpha/beta-Hydrolases
  • 0Direct
    50249,47781,52113
  • 50249 - Nucleic acid-binding proteins
  • 47781 - RuvA domain 2-like
  • 52113 - BRCT domain
  • 0Direct
    117018,56091,50249
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    56059,48108,52440
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 52440 - PreATP-grasp domain
  • 0Direct
    51735,52210,52210
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 52210 - Succinyl-CoA synthetase domains
  • 52210 - Succinyl-CoA synthetase domains
  • 0Direct
    47060,55681,52954
  • 47060 - S15/NS1 RNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    81271,55186,55681
  • 81271 - TGS-like
  • 55186 - ThrRS/AlaRS common domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    56059,52335,51556
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52335 - Methylglyoxal synthase-like
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    50891,160467,50891
  • 50891 - Cyclophilin-like
  • 160467 - PH0987 N-terminal domain-like
  • 50891 - Cyclophilin-like
  • 0Direct
    46955,55681,54991
  • 46955 - Putative DNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 54991 - Anticodon-binding domain of PheRS
  • 0Direct
    55205,55205,52913
  • 55205 - EPT/RTPC-like
  • 55205 - EPT/RTPC-like
  • 52913 - RNA 3'-terminal phosphate cyclase, RPTC, insert domain
  • 0Direct
    56059,51246,55326
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 55326 - PurM N-terminal domain-like
  • 0Direct
    55190,52374,47323
  • 55190 - Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    52440,56059,52335
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52335 - Methylglyoxal synthase-like
  • 0Direct
    55186,55681,52954
  • 55186 - ThrRS/AlaRS common domain
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    50249,47781,47781
  • 50249 - Nucleic acid-binding proteins
  • 47781 - RuvA domain 2-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    55681,101353,55186
  • 55681 - Class II aaRS and biotin synthetases
  • 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
  • 55186 - ThrRS/AlaRS common domain
  • 0Direct
    55326,56042,53328
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 53328 - Formyltransferase
  • 0Direct
    50677,52374,47323
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    56042,55326,56042
  • 56042 - PurM C-terminal domain-like
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    46785,55681,50037
  • 46785 - "Winged helix" DNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 50037 - C-terminal domain of transcriptional repressors
  • 0Direct
    51984,53623,53244
  • 51984 - MurCD N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    56091,50249,52113
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 52113 - BRCT domain
  • 0Direct
    82697,109736,55326
  • 82697 - PurS-like
  • 109736 - FGAM synthase PurL, linker domain
  • 55326 - PurM N-terminal domain-like
  • 0Direct
    56059,53623,53244
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    46955,56037,46955
  • 46955 - Putative DNA-binding domain
  • 56037 - PheT/TilS domain
  • 46955 - Putative DNA-binding domain
  • 0Direct
    52335,51556,51338
  • 52335 - Methylglyoxal synthase-like
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    47060,47060,47060
  • 47060 - S15/NS1 RNA-binding domain
  • 47060 - S15/NS1 RNA-binding domain
  • 47060 - S15/NS1 RNA-binding domain
  • 0Direct
    56091,50249,47781
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 47781 - RuvA domain 2-like
  • 0Direct
    52374,47323,47060
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 47060 - S15/NS1 RNA-binding domain
  • 0Direct
    52374,47323,46589
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 46589 - tRNA-binding arm
  • 0Direct
    47616,52374,50715
  • 47616 - GST C-terminal domain-like
  • 52374 - Nucleotidylyl transferase
  • 50715 - Ribosomal protein L25-like
  • 0Direct
    55326,56042,52317
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    55681,50037,53067
  • 55681 - Class II aaRS and biotin synthetases
  • 50037 - C-terminal domain of transcriptional repressors
  • 53067 - Actin-like ATPase domain
  • 0Direct
    55326,56042,55326
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 55326 - PurM N-terminal domain-like
  • 0Direct
    52402,82829,56037
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 82829 - MesJ substrate recognition domain-like
  • 56037 - PheT/TilS domain
  • 0Direct
    82829,56037,53271
  • 82829 - MesJ substrate recognition domain-like
  • 56037 - PheT/TilS domain
  • 53271 - PRTase-like
  • 0Direct
    101353,50447,55186
  • 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
  • 50447 - Translation proteins
  • 55186 - ThrRS/AlaRS common domain
  • 0Direct
    47060,47060,55681
  • 47060 - S15/NS1 RNA-binding domain
  • 47060 - S15/NS1 RNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    52540,-7,52317
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • -7 - CATH
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    52440,56059,48108
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
  • 0Direct
    50037,53067,53067
  • 50037 - C-terminal domain of transcriptional repressors
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    50249,46955,56037
  • 50249 - Nucleic acid-binding proteins
  • 46955 - Putative DNA-binding domain
  • 56037 - PheT/TilS domain
  • 0Direct
    50249,55681,55261
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 55261 - GAD domain-like
  • 0Direct
    47781,47781,52113
  • 47781 - RuvA domain 2-like
  • 47781 - RuvA domain 2-like
  • 52113 - BRCT domain
  • 0Direct
    56037,46955,55681
  • 56037 - PheT/TilS domain
  • 46955 - Putative DNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    50249,56037,46955
  • 50249 - Nucleic acid-binding proteins
  • 56037 - PheT/TilS domain
  • 46955 - Putative DNA-binding domain
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    63418,53623,53244
  • 63418 - MurE/MurF N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    51735,53623,53244
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    52374,47323,50249
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    54001,56059,52440
  • 54001 - Cysteine proteinases
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52440 - PreATP-grasp domain
  • 0Direct
    57770,52374,47323
  • 57770 - Methionyl-tRNA synthetase (MetRS), Zn-domain
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    109736,55326,56042
  • 109736 - FGAM synthase PurL, linker domain
  • 55326 - PurM N-terminal domain-like
  • 56042 - PurM C-terminal domain-like
  • 0Direct
    52777,52777,56801
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 0.0002788Direct
    52777,56801,47336
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 0.0006174Direct
    56801,47336,52777
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 0.002137Inherited
    47336,52777,52777
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.016Inherited


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