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Fly Anatomy (FA): organ system subdivision
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: FA Hierarchy (fly anatomy from FlyBase anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this FA term (SDFA level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
Eps15 homology domain (EH domain) | 0 | DIRECT |
ARID domain | 0 | DIRECT |
Extracellular domain of cell surface receptors | 0 | DIRECT |
Forkhead DNA-binding domain | 0 | DIRECT |
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
cAMP-binding domain | 0 | DIRECT |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
Regulator of G-protein signaling, RGS | 0 | DIRECT |
Smc hinge domain | 0 | DIRECT |
Serpins | 0 | DIRECT |
Diacylglycerol kinase-like | 0 | DIRECT |
Dachshund-homology domain | 0 | DIRECT |
Myb/SANT domain | 0 | DIRECT |
EF-hand modules in multidomain proteins | 0 | DIRECT |
Pepsin-like | 0 | DIRECT |
SPRY domain | 0 | DIRECT |
BC ATP-binding domain-like | 0 | DIRECT |
Rhomboid-like | 0 | DIRECT |
Metal cation-transporting ATPase, ATP-binding domain N | 0 | DIRECT |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
Laminin-type module | 0 | DIRECT |
Transforming growth factor (TGF)-beta | 0 | DIRECT |
Plexin repeat | 0 | DIRECT |
Third domain of FERM | 0 | DIRECT |
L27 domain | 0 | DIRECT |
Arrestin/Vps26-like | 0 | DIRECT |
Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
SAP domain | 0 | DIRECT |
Mob1/phocein | 0 | DIRECT |
Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
Hairy Orange domain | 0 | DIRECT |
RNase III catalytic domain-like | 0 | DIRECT |
SMAD MH1 domain | 0 | DIRECT |
Frizzled cysteine-rich domain | 0 | DIRECT |
BC N-terminal domain-like | 0 | DIRECT |
Synaptotagmin-like (S variant) | 0 | DIRECT |
Fibroblast growth factors (FGF) | 0 | DIRECT |
Erythroid transcription factor GATA-1 | 0 | DIRECT |
First domain of FERM | 0 | DIRECT |
Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
Sema domain | 0 | DIRECT |
p120GAP domain-like | 0 | DIRECT |
POU-specific domain | 0 | DIRECT |
L-arabinose binding protein-like | 0 | DIRECT |
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
SCF ubiquitin ligase complex WHB domain | 0 | DIRECT |
Cullin homology domain | 0 | DIRECT |
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
Integrin domains | 0 | DIRECT |
Cullin repeat | 0 | DIRECT |
A DNA-binding domain in eukaryotic transcription factors | 0 | DIRECT |
PX domain | 0 | DIRECT |
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | DIRECT |
Single strand DNA-binding domain, SSB | 0 | DIRECT |
Phosphate binding protein-like | 0 | DIRECT |
Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | DIRECT |
Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
Second domain of FERM | 0 | DIRECT |
MIR domain | 0 | DIRECT |
Choline/Carnitine O-acyltransferase | 0 | DIRECT |
Homeodomain | 0.000000000004015 | DIRECT |
HLH, helix-loop-helix DNA-binding domain | 0.00001073 | DIRECT |
Fibronectin type III | 0.0006876 | DIRECT |
Protein kinases, catalytic subunit | 0.003053 | INHERITED FROM: intestinal stem cell || synaptic neuropil || photoreceptor cell R8 of pale ommatidium |
Classic zinc finger, C2H2 | 0.00547 | INHERITED FROM: region of integument |
Nuclear receptor ligand-binding domain | 0.01107 | INHERITED FROM: protocerebrum || central brain || synaptic neuropil block || supraesophageal ganglion neuron || neuropil || mushroom body gamma-lobe || synaptic neuropil |
SH2 domain | 0.01239 | INHERITED FROM: midline crossing tract || wing blade || ommatidium || adult peripheral nervous system || photoreceptor cell R7 |
Nuclear receptor | 0.02682 | INHERITED FROM: abdominal neuromere || synaptic neuropil block || larval abdominal neuromere || supraesophageal ganglion neuron || mushroom body gamma-lobe |
HMG-box | 0.04438 | INHERITED FROM: adult external thorax || wing |
Higher-molecular-weight phosphotyrosine protein phosphatases | 0.06292 | INHERITED FROM: intersegmental nerve |
Paired domain | 0.06292 | INHERITED FROM: EG neuron || RP2 motor neuron || EL neuron |
Ngr ectodomain-like | 0.06292 | INHERITED FROM: intersegmental nerve of A1-7 || abdominal intersegmental nerve || intersegmental nerve branch ISNb of A1-7 |
I set domains | 0.0863 | INHERITED FROM: connective || LN period neuron || leg taste bristle chemosensory neuron || neuropil glial sheath || synaptic neuropil block || segmental subdivision of organ system || s-LNv neuron || synaptic neuropil || antennal lobe glomerulus || gustatory receptor neuron || interface glial cell || tract neuropil || commissure || adult brain || LNv neuron |
Histone lysine methyltransferases | 0.11 | INHERITED FROM: metathoracic leg || haltere |
PLC-like (P variant) | 0.11 | INHERITED FROM: larval dorsal multidendritic neuron ddaC || larval dorsal multidendritic neuron || mesothoracic tergum |
Transducin (alpha subunit), insertion domain | 0.1918 | INHERITED FROM: eo neuron |
Toll/Interleukin receptor TIR domain | 0.1918 | INHERITED FROM: ventral nerve cord |
Calponin-homology domain, CH-domain | 0.2305 | INHERITED FROM: abdominal segmental nerve |
SMAD domain | 0.2517 | INHERITED FROM: wing blade || gut section || wing vein |
Spectrin repeat | 0.2763 | INHERITED FROM: longitudinal connective || connective || ipsilateral tract || copper cell || midgut enterocyte || tract || middle midgut |
Ankyrin repeat | 0.291 | INHERITED FROM: ventral multidendritic neuron |
SAM (sterile alpha motif) domain | 0.3392 | INHERITED FROM: mesothoracic leg || prothoracic leg || prothoracic tarsal segment || metatarsus of male prothoracic leg || prothoracic metatarsus || metatarsus || sex comb |
Cytochrome P450 | 0.3915 | INHERITED FROM: midline crossing tract || embryonic/larval foregut || embryonic/larval hindgut || midline glial cell || CNS glial cell || neuropil glial sheath || larval VNC neuropil glial cell || neuropil associated CNS glial cell || tract || midgut || larval neuropil glial cell || tract neuropil || hindgut || commissure |
Cyclin | 0.4238 | INHERITED FROM: tagmatic subdivision of organ system |
Growth factor receptor domain | 0.4621 | INHERITED FROM: dorsocentral bristle || salivary gland || proventriculus || tibia || integumentary specialisation || ocellar triangle || hindgut || ocellus |
EGF-type module | 0.5941 | INHERITED FROM: wing blade || adult external head || embryonic/larval midgut cell || adult midgut progenitor cell || proventriculus || ventral nervous system || hindgut |
Ubiquitin-related | 0.5969 | INHERITED FROM: mushroom body extrinsic neuron |
Cadherin | 0.6253 | INHERITED FROM: outer photoreceptor cell || photoreceptor cell R4 |
G proteins | 0.7714 | INHERITED FROM: wing hair |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | Direct |
Eps15 homology domain (EH domain) | 0 | Direct |
ARID domain | 0 | Direct |
Extracellular domain of cell surface receptors | 0 | Direct |
Forkhead DNA-binding domain | 0 | Direct |
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
cAMP-binding domain | 0 | Direct |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
Regulator of G-protein signaling, RGS | 0 | Direct |
Smc hinge domain | 0 | Direct |
Serpins | 0 | Direct |
Diacylglycerol kinase-like | 0 | Direct |
Dachshund-homology domain | 0 | Direct |
Myb/SANT domain | 0 | Direct |
EF-hand modules in multidomain proteins | 0 | Direct |
Pepsin-like | 0 | Direct |
SPRY domain | 0 | Direct |
BC ATP-binding domain-like | 0 | Direct |
Rhomboid-like | 0 | Direct |
Metal cation-transporting ATPase, ATP-binding domain N | 0 | Direct |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
Laminin-type module | 0 | Direct |
Transforming growth factor (TGF)-beta | 0 | Direct |
Plexin repeat | 0 | Direct |
Third domain of FERM | 0 | Direct |
L27 domain | 0 | Direct |
Arrestin/Vps26-like | 0 | Direct |
Cell cycle control phosphatase, catalytic domain | 0 | Direct |
SAP domain | 0 | Direct |
Mob1/phocein | 0 | Direct |
Class I glutamine amidotransferases (GAT) | 0 | Direct |
Hairy Orange domain | 0 | Direct |
RNase III catalytic domain-like | 0 | Direct |
SMAD MH1 domain | 0 | Direct |
Frizzled cysteine-rich domain | 0 | Direct |
BC N-terminal domain-like | 0 | Direct |
Synaptotagmin-like (S variant) | 0 | Direct |
Fibroblast growth factors (FGF) | 0 | Direct |
Erythroid transcription factor GATA-1 | 0 | Direct |
First domain of FERM | 0 | Direct |
Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
Sema domain | 0 | Direct |
p120GAP domain-like | 0 | Direct |
POU-specific domain | 0 | Direct |
L-arabinose binding protein-like | 0 | Direct |
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
SCF ubiquitin ligase complex WHB domain | 0 | Direct |
Cullin homology domain | 0 | Direct |
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
Integrin domains | 0 | Direct |
Cullin repeat | 0 | Direct |
A DNA-binding domain in eukaryotic transcription factors | 0 | Direct |
PX domain | 0 | Direct |
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | Direct |
Single strand DNA-binding domain, SSB | 0 | Direct |
Phosphate binding protein-like | 0 | Direct |
Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | Direct |
Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
Second domain of FERM | 0 | Direct |
MIR domain | 0 | Direct |
Choline/Carnitine O-acyltransferase | 0 | Direct |
Homeodomain | 0.000000000004015 | Direct |
HLH, helix-loop-helix DNA-binding domain | 0.00001073 | Direct |
Fibronectin type III | 0.0006876 | Direct |
Protein kinases, catalytic subunit | 0.003053 | Inherited |
Classic zinc finger, C2H2 | 0.00547 | Inherited |
Nuclear receptor ligand-binding domain | 0.01107 | Inherited |
SH2 domain | 0.01239 | Inherited |
Nuclear receptor | 0.02682 | Inherited |
HMG-box | 0.04438 | Inherited |
Higher-molecular-weight phosphotyrosine protein phosphatases | 0.06292 | Inherited |
Paired domain | 0.06292 | Inherited |
Ngr ectodomain-like | 0.06292 | Inherited |
I set domains | 0.0863 | Inherited |
Histone lysine methyltransferases | 0.11 | Inherited |
PLC-like (P variant) | 0.11 | Inherited |
Transducin (alpha subunit), insertion domain | 0.1918 | Inherited |
Toll/Interleukin receptor TIR domain | 0.1918 | Inherited |
Calponin-homology domain, CH-domain | 0.2305 | Inherited |
SMAD domain | 0.2517 | Inherited |
Spectrin repeat | 0.2763 | Inherited |
Ankyrin repeat | 0.291 | Inherited |
SAM (sterile alpha motif) domain | 0.3392 | Inherited |
Cytochrome P450 | 0.3915 | Inherited |
Cyclin | 0.4238 | Inherited |
Growth factor receptor domain | 0.4621 | Inherited |
EGF-type module | 0.5941 | Inherited |
Ubiquitin-related | 0.5969 | Inherited |
Cadherin | 0.6253 | Inherited |
G proteins | 0.7714 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
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Supra-domains annotated to this FA term (SPFA level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
74788,75632 74788 - Cullin repeat-like 75632 - Cullin homology domain | 0 | DIRECT |
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like | 0 | DIRECT |
52058,48726 52058 - L domain-like 48726 - Immunoglobulin | 0 | DIRECT |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0 | DIRECT |
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like | 0 | DIRECT |
49562,49562 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
52440,56059 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
101912,103575 101912 - Sema domain 103575 - Plexin repeat | 0 | DIRECT |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0 | DIRECT |
51045,51045 51045 - WW domain 51045 - WW domain | 0 | DIRECT |
48425,50729 48425 - Sec7 domain 50729 - PH domain-like | 0 | DIRECT |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | DIRECT |
47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain | 0 | DIRECT |
49417,81296 49417 - p53-like transcription factors 81296 - E set domains | 0 | DIRECT |
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger | 0 | DIRECT |
81660,56784 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like | 0 | DIRECT |
75632,46785 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
81383,52047 81383 - F-box domain 52047 - RNI-like | 0 | DIRECT |
52058,52058 52058 - L domain-like 52058 - L domain-like | 0 | DIRECT |
51206,51206 51206 - cAMP-binding domain-like 51206 - cAMP-binding domain-like | 0 | DIRECT |
47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
55550,50044 55550 - SH2 domain 50044 - SH3-domain | 0 | DIRECT |
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0 | DIRECT |
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like | 0 | DIRECT |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 0 | DIRECT |
48403,48403 48403 - Ankyrin repeat 48403 - Ankyrin repeat | 0 | DIRECT |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | DIRECT |
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM | 0 | DIRECT |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.00001118 | DIRECT |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.02415 | INHERITED FROM: segmental subdivision of organ system || synaptic neuropil || synaptic neuropil block || connective || leg taste bristle chemosensory neuron || antennal lobe glomerulus || central nervous system || commissure || s-LNv neuron || LNv neuron || neuropil glial sheath || tract neuropil |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.05409 | INHERITED FROM: adult antennal lobe glomerulus || connective || leg taste bristle chemosensory neuron || antennal lobe glomerulus || gustatory receptor neuron || commissure || s-LNv neuron || giant fiber neuron || LNv neuron || neuropil associated CNS glial cell || lobe system of adult mushroom body || adult antennal lobe || tract neuropil |
49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0.07214 | INHERITED FROM: photoreceptor cell R4 || peripheral nervous system |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.09713 | INHERITED FROM: ipsilateral tract || connective || tract || longitudinal connective || middle midgut || midgut enterocyte || copper cell || adult protocerebrum || tract neuropil |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1749 | INHERITED FROM: eo neuron |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0.1749 | INHERITED FROM: sclerite |
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.1749 | INHERITED FROM: joint || wing vein || photoreceptor cell R7 || scutum || intersegmental nerve || leg || inner photoreceptor cell || integumentary specialisation || wing blade dorsal compartment || proventriculus |
81296,81296 81296 - E set domains 81296 - E set domains | 0.235 | INHERITED FROM: intersegmental nerve || abdominal segmental nerve || abdominal intersegmental nerve || segmental nerve || abdominal nerve |
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain | 0.3135 | INHERITED FROM: embryonic/larval peripheral nervous system |
52799,52799 52799 - (Phosphotyrosine protein) phosphatases II 52799 - (Phosphotyrosine protein) phosphatases II | 0.3135 | INHERITED FROM: intersegmental nerve || nerve || abdominal segmental nerve || embryonic/larval peripheral nervous system || segmental nerve || abdominal nerve |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.3521 | INHERITED FROM: joint || secondary pigment cell || eye photoreceptor cell stalk || ocellus || postfrons || intersegmental nerve branch ISNb of A1-7 || ventral nervous system || frons || wing blade dorsal compartment || proventriculus || tertiary pigment cell |
57184,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0.3877 | INHERITED FROM: integumentary specialisation |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 0.5938 | INHERITED FROM: photoreceptor cell R4 || outer photoreceptor cell || wing hair |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
74788,75632 74788 - Cullin repeat-like 75632 - Cullin homology domain | 0 | Direct |
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like | 0 | Direct |
52058,48726 52058 - L domain-like 48726 - Immunoglobulin | 0 | Direct |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0 | Direct |
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like | 0 | Direct |
49562,49562 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
52440,56059 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0 | Direct |
101912,103575 101912 - Sema domain 103575 - Plexin repeat | 0 | Direct |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0 | Direct |
51045,51045 51045 - WW domain 51045 - WW domain | 0 | Direct |
48425,50729 48425 - Sec7 domain 50729 - PH domain-like | 0 | Direct |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | Direct |
47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain | 0 | Direct |
49417,81296 49417 - p53-like transcription factors 81296 - E set domains | 0 | Direct |
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger | 0 | Direct |
81660,56784 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like | 0 | Direct |
75632,46785 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
81383,52047 81383 - F-box domain 52047 - RNI-like | 0 | Direct |
52058,52058 52058 - L domain-like 52058 - L domain-like | 0 | Direct |
51206,51206 51206 - cAMP-binding domain-like 51206 - cAMP-binding domain-like | 0 | Direct |
47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like | 0 | Direct |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
55550,50044 55550 - SH2 domain 50044 - SH3-domain | 0 | Direct |
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0 | Direct |
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like | 0 | Direct |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 0 | Direct |
48403,48403 48403 - Ankyrin repeat 48403 - Ankyrin repeat | 0 | Direct |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | Direct |
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM | 0 | Direct |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.00001118 | Direct |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.02415 | Inherited |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.05409 | Inherited |
49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0.07214 | Inherited |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0.09713 | Inherited |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1749 | Inherited |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0.1749 | Inherited |
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.1749 | Inherited |
81296,81296 81296 - E set domains 81296 - E set domains | 0.235 | Inherited |
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain | 0.3135 | Inherited |
52799,52799 52799 - (Phosphotyrosine protein) phosphatases II 52799 - (Phosphotyrosine protein) phosphatases II | 0.3135 | Inherited |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.3521 | Inherited |
57184,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0.3877 | Inherited |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 0.5938 | Inherited |
(show details)
Supra-domains annotated to this FA term (SPFA level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,49899,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
74788,75632,46785 74788 - Cullin repeat-like 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
52058,52058,52058 52058 - L domain-like 52058 - L domain-like 52058 - L domain-like | 0 | DIRECT |
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat | 0 | DIRECT |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like | 0 | DIRECT |
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
81660,56784,81665 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M | 0 | DIRECT |
81296,81296,81296 81296 - E set domains 81296 - E set domains 81296 - E set domains | 0 | DIRECT |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.00018 | DIRECT |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.1048 | INHERITED FROM: synaptic neuropil || connective || leg taste bristle chemosensory neuron || gustatory receptor neuron || commissure || s-LNv neuron || LNv neuron || tract neuropil |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.1063 | INHERITED FROM: adult antennal lobe glomerulus || connective || leg taste bristle chemosensory neuron || antennal lobe glomerulus || gustatory receptor neuron || s-LNv neuron || giant fiber neuron || eo neuron || LNv neuron || neuropil associated CNS glial cell || lobe system of adult mushroom body || neuropil glial sheath || embryonic/larval central nervous system || adult antennal lobe |
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.1229 | INHERITED FROM: joint || photoreceptor cell R1 || secondary pigment cell || eye photoreceptor cell stalk || ocellus || postfrons || photoreceptor cell R6 || ocellar triangle || ventral nervous system || frons || wing blade dorsal compartment || adult external head || proventriculus || tertiary pigment cell |
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.235 | INHERITED FROM: dorsal mesothorax || adult external mesothorax || scutum || intersegmental nerve || nerve || adult thoracic mechanosensory chaeta || integumentary specialisation || tergum || mesothoracic tergum |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 0.5938 | INHERITED FROM: photoreceptor cell R4 || outer photoreceptor cell || wing hair |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,49899,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
74788,75632,46785 74788 - Cullin repeat-like 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
52058,52058,52058 52058 - L domain-like 52058 - L domain-like 52058 - L domain-like | 0 | Direct |
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat | 0 | Direct |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like | 0 | Direct |
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
81660,56784,81665 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M | 0 | Direct |
81296,81296,81296 81296 - E set domains 81296 - E set domains 81296 - E set domains | 0 | Direct |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.00018 | Direct |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.1048 | Inherited |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.1063 | Inherited |
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.1229 | Inherited |
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.235 | Inherited |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 0.5938 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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