|
Fly Phenotype (FP): phenotype
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: FP Hierarchy (fly phenotype from FlyBase controlled vocabulary with sub-ontology "phenotypic class")
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this FP term (Not in SDFP)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Aquaporin-like | 0 | DIRECT |
Sema domain | 0 | DIRECT |
Orange domain-like | 0 | DIRECT |
L30e-like | 0 | DIRECT |
GINS helical bundle-like | 0 | DIRECT |
Periplasmic binding protein-like I | 0 | DIRECT |
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
ARID-like | 0 | DIRECT |
Integrin domains | 0 | DIRECT |
Glutamine synthetase/guanido kinase | 0 | DIRECT |
CBS-domain pair | 0 | DIRECT |
Putative DNA-binding domain | 0 | DIRECT |
Roadblock/LC7 domain | 0 | DIRECT |
Ferritin-like | 0 | DIRECT |
Zn-binding ribosomal proteins | 0 | DIRECT |
TIMP-like | 0 | DIRECT |
Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
Tetrahydrobiopterin biosynthesis enzymes-like | 0 | DIRECT |
RNase III domain-like | 0 | DIRECT |
Ribosomal L27 protein-like | 0 | DIRECT |
Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
DEATH domain | 0 | DIRECT |
GroEL-intermediate domain like | 0 | DIRECT |
GroEL equatorial domain-like | 0 | DIRECT |
E2F-DP heterodimerization region | 0 | DIRECT |
ThrRS/AlaRS common domain | 0 | DIRECT |
lambda repressor-like DNA-binding domains | 0 | DIRECT |
Ribosomal protein L1 | 0 | DIRECT |
Nucleoporin domain | 0 | DIRECT |
Translation proteins SH3-like domain | 0 | DIRECT |
HLH, helix-loop-helix DNA-binding domain | 0 | DIRECT |
Caspase-like | 0 | DIRECT |
PYP-like sensor domain (PAS domain) | 0 | DIRECT |
Mob1/phocein | 0 | DIRECT |
PriA/YqbF domain | 0 | DIRECT |
Class I glutamine amidotransferase-like | 0 | DIRECT |
Retrovirus zinc finger-like domains | 0 | DIRECT |
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
Hormone receptor domain | 0 | DIRECT |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
L27 domain | 0 | DIRECT |
ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
Sec7 domain | 0 | DIRECT |
CAD & PB1 domains | 0 | DIRECT |
TATA-box binding protein-like | 0 | DIRECT |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
Multidrug efflux transporter AcrB transmembrane domain | 0 | DIRECT |
Seven-hairpin glycosidases | 0 | DIRECT |
Skp1 dimerisation domain-like | 0 | DIRECT |
HR1 repeat | 0 | DIRECT |
Smc hinge domain | 0 | DIRECT |
SPOC domain-like | 0 | DIRECT |
DEK C-terminal domain | 0 | DIRECT |
Transducin (alpha subunit), insertion domain | 0 | DIRECT |
Prefoldin | 0 | DIRECT |
KA1-like | 0 | DIRECT |
Restriction endonuclease-like | 0 | DIRECT |
A DNA-binding domain in eukaryotic transcription factors | 0 | DIRECT |
Plexin repeat | 0 | DIRECT |
Cytokine | 0 | DIRECT |
Snake toxin-like | 0 | DIRECT |
Bromodomain | 0 | DIRECT |
Toll/Interleukin receptor TIR domain | 0 | DIRECT |
Lipocalins | 0 | DIRECT |
YVTN repeat-like/Quinoprotein amine dehydrogenase | 0 | DIRECT |
S15/NS1 RNA-binding domain | 0 | DIRECT |
Zinc beta-ribbon | 0 | DIRECT |
Sec1/munc18-like (SM) proteins | 0 | DIRECT |
Succinyl-CoA synthetase domains | 0 | DIRECT |
PIN domain-like | 0 | DIRECT |
Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
Bet v1-like | 0 | DIRECT |
SAP domain | 0 | DIRECT |
Clathrin adaptor appendage domain | 0 | DIRECT |
SMAD/FHA domain | 0 | DIRECT |
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Riboflavin synthase domain-like | 0 | DIRECT |
vWA-like | 0 | DIRECT |
ACT-like | 0 | DIRECT |
HSP90 C-terminal domain | 0 | DIRECT |
HRDC-like | 0 | DIRECT |
Ribosomal protein S5 domain 2-like | 0 | DIRECT |
Regulator of G-protein signaling, RGS | 0 | DIRECT |
Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
PX domain | 0 | DIRECT |
Terpenoid synthases | 0 | DIRECT |
Translational machinery components | 0 | DIRECT |
SAND domain-like | 0 | DIRECT |
PapD-like | 0 | DIRECT |
Rudiment single hybrid motif | 0 | DIRECT |
Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Tropomyosin | 0 | DIRECT |
4Fe-4S ferredoxins | 0 | DIRECT |
B-box zinc-binding domain | 0 | DIRECT |
Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
Nop domain | 0 | DIRECT |
ACP-like | 0 | DIRECT |
2Fe-2S ferredoxin-like | 0 | DIRECT |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
RBP11-like subunits of RNA polymerase | 0 | DIRECT |
DNA-binding domain | 0 | DIRECT |
SMAD MH1 domain | 0 | DIRECT |
Aldolase | 0 | DIRECT |
Subtilisin-like | 0 | DIRECT |
PreATP-grasp domain | 0 | DIRECT |
Insulin-like | 0 | DIRECT |
Spectrin repeat | 0 | DIRECT |
Sm-like ribonucleoproteins | 0 | DIRECT |
Taf5 N-terminal domain-like | 0 | DIRECT |
Pectin lyase-like | 0 | DIRECT |
GroEL apical domain-like | 0 | DIRECT |
Ribonuclease PH domain 2-like | 0 | DIRECT |
SAICAR synthase-like | 0 | DIRECT |
Nuclear receptor ligand-binding domain | 0 | DIRECT |
SNARE-like | 0 | DIRECT |
Cu,Zn superoxide dismutase-like | 0 | DIRECT |
DNA/RNA polymerases | 0 | DIRECT |
dsRNA-binding domain-like | 0 | DIRECT |
JAB1/MPN domain | 0 | DIRECT |
Class II aaRS ABD-related | 0 | DIRECT |
Homeodomain-like | 0.000002727 | DIRECT |
ARM repeat | 0.00002446 | DIRECT |
SH3-domain | 0.00007519 | DIRECT |
Protein kinase-like (PK-like) | 0.0001984 | DIRECT |
EGF/Laminin | 0.01402 | INHERITED FROM: lethal - all die before end of first instar larval stage || lethal - all die before end of pupal stage || lethal - all die before end of larval stage || cell polarity defective || lethal - all die before end of embryonic stage || immune response defective || size defective || lethal - all die before end of P-stage || lethal - all die before end of prepupal stage || some die during embryonic stage || planar polarity defective |
Nucleotidylyl transferase | 0.0687 | INHERITED FROM: decreased cell size |
beta-sandwich domain of Sec23/24 | 0.08083 | INHERITED FROM: lethal - all die before end of pupal stage || lethal - all die before end of larval stage || lethal - all die before end of embryonic stage || some die during larval stage || cell shape defective |
Cysteine-rich domain | 0.08083 | INHERITED FROM: wound healing defective |
Leucine zipper domain | 0.09382 | INHERITED FROM: lethal - all die before end of first instar larval stage || lethal - all die before end of pupal stage || lethal - all die before end of larval stage || developmental rate defective || increased mortality |
PDZ domain-like | 0.09497 | INHERITED FROM: cell polarity defective |
Cyclin-like | 0.1077 | INHERITED FROM: mitotic cell cycle defective || cell cycle defective |
Periplasmic binding protein-like II | 0.1135 | INHERITED FROM: feeding behavior defective || sensory perception defective || neurophysiology defective |
EF-hand | 0.1194 | INHERITED FROM: flightless |
BRCT domain | 0.1261 | INHERITED FROM: radiation sensitive |
FYVE/PHD zinc finger | 0.1272 | INHERITED FROM: modifier of variegation |
Fibronectin type III | 0.1486 | INHERITED FROM: cell adhesion defective |
SNARE fusion complex | 0.1486 | INHERITED FROM: uncoordinated || neurophysiology defective || increased mortality during development |
beta-beta-alpha zinc fingers | 0.1577 | INHERITED FROM: visible |
Concanavalin A-like lectins/glucanases | 0.2061 | INHERITED FROM: cell polarity defective |
C2 domain (Calcium/lipid-binding domain, CaLB) | 0.2169 | INHERITED FROM: neurophysiology defective |
Tudor/PWWP/MBT | 0.2247 | INHERITED FROM: neoplasia |
N-acetylmuramoyl-L-alanine amidase-like | 0.2353 | INHERITED FROM: immune response defective |
Cysteine proteinases | 0.2483 | INHERITED FROM: behavior defective |
Chromo domain-like | 0.2799 | INHERITED FROM: non-suppressor of variegation || suppressor of variegation || modifier of variegation |
Ankyrin repeat | 0.2802 | INHERITED FROM: behavior defective || chemosensitive behavior defective || thermotaxis behavior defective || sensory perception defective || neurophysiology defective |
Macro domain-like | 0.3656 | INHERITED FROM: sterile || male sterile |
SCOP hierarchy in SUPERFAMILY | 0.3946 | INHERITED FROM: cell lethal || Minute |
SH2 domain | 0.3958 | INHERITED FROM: planar polarity defective |
P-loop containing nucleoside triphosphate hydrolases | 0.4022 | INHERITED FROM: cell cycle defective |
Voltage-gated potassium channels | 0.4264 | INHERITED FROM: behavior defective || chemical resistant || neurophysiology defective || chemical sensitive |
Growth factor receptor domain | 0.4264 | INHERITED FROM: cell polarity defective || planar polarity defective |
POZ domain | 0.4636 | INHERITED FROM: sleep defective || body color defective |
SAM/Pointed domain | 0.4657 | INHERITED FROM: increased cell number |
Cystine-knot cytokines | 0.4769 | INHERITED FROM: circadian rhythm defective |
PAZ domain | 0.4908 | INHERITED FROM: mitotic cell cycle defective || cell cycle defective || suppressor of variegation || modifier of variegation |
RNA-binding domain, RBD | 0.5299 | INHERITED FROM: lethal |
Tubulin nucleotide-binding domain-like | 0.5391 | INHERITED FROM: cell cycle defective |
Ribonuclease H-like | 0.5719 | INHERITED FROM: melanotic mass phenotype |
Glucocorticoid receptor-like (DNA-binding domain) | 0.5828 | INHERITED FROM: visible |
cAMP-binding domain-like | 0.6079 | INHERITED FROM: sensory perception defective || hyperactive |
Cadherin-like | 0.6079 | INHERITED FROM: cell polarity defective |
Family A G protein-coupled receptor-like | 0.6326 | INHERITED FROM: behavior defective || hypoactive || mating defective |
Neurotransmitter-gated ion-channel transmembrane pore | 0.6518 | INHERITED FROM: phototaxis defective || chemical resistant |
Nicotinic receptor ligand binding domain-like | 0.6518 | INHERITED FROM: phototaxis defective || chemical resistant |
SET domain | 0.7326 | INHERITED FROM: homeotic || non-suppressor of variegation || suppressor of variegation || modifier of variegation |
Immunoglobulin | 0.7885 | INHERITED FROM: cell migration defective |
Nucleotide cyclase | 0.8452 | INHERITED FROM: taste perception defective |
NAD(P)-binding Rossmann-fold domains | 0.9439 | INHERITED FROM: electrophoretic variant |
alpha/beta-Hydrolases | 1 | INHERITED FROM: electrophoretic variant |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Aquaporin-like | 0 | Direct |
Sema domain | 0 | Direct |
Orange domain-like | 0 | Direct |
L30e-like | 0 | Direct |
GINS helical bundle-like | 0 | Direct |
Periplasmic binding protein-like I | 0 | Direct |
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | Direct |
ARID-like | 0 | Direct |
Integrin domains | 0 | Direct |
Glutamine synthetase/guanido kinase | 0 | Direct |
CBS-domain pair | 0 | Direct |
Putative DNA-binding domain | 0 | Direct |
Roadblock/LC7 domain | 0 | Direct |
Ferritin-like | 0 | Direct |
Zn-binding ribosomal proteins | 0 | Direct |
TIMP-like | 0 | Direct |
Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
Tetrahydrobiopterin biosynthesis enzymes-like | 0 | Direct |
RNase III domain-like | 0 | Direct |
Ribosomal L27 protein-like | 0 | Direct |
Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
DEATH domain | 0 | Direct |
GroEL-intermediate domain like | 0 | Direct |
GroEL equatorial domain-like | 0 | Direct |
E2F-DP heterodimerization region | 0 | Direct |
ThrRS/AlaRS common domain | 0 | Direct |
lambda repressor-like DNA-binding domains | 0 | Direct |
Ribosomal protein L1 | 0 | Direct |
Nucleoporin domain | 0 | Direct |
Translation proteins SH3-like domain | 0 | Direct |
HLH, helix-loop-helix DNA-binding domain | 0 | Direct |
Caspase-like | 0 | Direct |
PYP-like sensor domain (PAS domain) | 0 | Direct |
Mob1/phocein | 0 | Direct |
PriA/YqbF domain | 0 | Direct |
Class I glutamine amidotransferase-like | 0 | Direct |
Retrovirus zinc finger-like domains | 0 | Direct |
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
Hormone receptor domain | 0 | Direct |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
L27 domain | 0 | Direct |
ValRS/IleRS/LeuRS editing domain | 0 | Direct |
Formin homology 2 domain (FH2 domain) | 0 | Direct |
Sec7 domain | 0 | Direct |
CAD & PB1 domains | 0 | Direct |
TATA-box binding protein-like | 0 | Direct |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
Multidrug efflux transporter AcrB transmembrane domain | 0 | Direct |
Seven-hairpin glycosidases | 0 | Direct |
Skp1 dimerisation domain-like | 0 | Direct |
HR1 repeat | 0 | Direct |
Smc hinge domain | 0 | Direct |
SPOC domain-like | 0 | Direct |
DEK C-terminal domain | 0 | Direct |
Transducin (alpha subunit), insertion domain | 0 | Direct |
Prefoldin | 0 | Direct |
KA1-like | 0 | Direct |
Restriction endonuclease-like | 0 | Direct |
A DNA-binding domain in eukaryotic transcription factors | 0 | Direct |
Plexin repeat | 0 | Direct |
Cytokine | 0 | Direct |
Snake toxin-like | 0 | Direct |
Bromodomain | 0 | Direct |
Toll/Interleukin receptor TIR domain | 0 | Direct |
Lipocalins | 0 | Direct |
YVTN repeat-like/Quinoprotein amine dehydrogenase | 0 | Direct |
S15/NS1 RNA-binding domain | 0 | Direct |
Zinc beta-ribbon | 0 | Direct |
Sec1/munc18-like (SM) proteins | 0 | Direct |
Succinyl-CoA synthetase domains | 0 | Direct |
PIN domain-like | 0 | Direct |
Blood coagulation inhibitor (disintegrin) | 0 | Direct |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
Bet v1-like | 0 | Direct |
SAP domain | 0 | Direct |
Clathrin adaptor appendage domain | 0 | Direct |
SMAD/FHA domain | 0 | Direct |
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Riboflavin synthase domain-like | 0 | Direct |
vWA-like | 0 | Direct |
ACT-like | 0 | Direct |
HSP90 C-terminal domain | 0 | Direct |
HRDC-like | 0 | Direct |
Ribosomal protein S5 domain 2-like | 0 | Direct |
Regulator of G-protein signaling, RGS | 0 | Direct |
Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
PX domain | 0 | Direct |
Terpenoid synthases | 0 | Direct |
Translational machinery components | 0 | Direct |
SAND domain-like | 0 | Direct |
PapD-like | 0 | Direct |
Rudiment single hybrid motif | 0 | Direct |
Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Tropomyosin | 0 | Direct |
4Fe-4S ferredoxins | 0 | Direct |
B-box zinc-binding domain | 0 | Direct |
Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
Nop domain | 0 | Direct |
ACP-like | 0 | Direct |
2Fe-2S ferredoxin-like | 0 | Direct |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
RBP11-like subunits of RNA polymerase | 0 | Direct |
DNA-binding domain | 0 | Direct |
SMAD MH1 domain | 0 | Direct |
Aldolase | 0 | Direct |
Subtilisin-like | 0 | Direct |
PreATP-grasp domain | 0 | Direct |
Insulin-like | 0 | Direct |
Spectrin repeat | 0 | Direct |
Sm-like ribonucleoproteins | 0 | Direct |
Taf5 N-terminal domain-like | 0 | Direct |
Pectin lyase-like | 0 | Direct |
GroEL apical domain-like | 0 | Direct |
Ribonuclease PH domain 2-like | 0 | Direct |
SAICAR synthase-like | 0 | Direct |
Nuclear receptor ligand-binding domain | 0 | Direct |
SNARE-like | 0 | Direct |
Cu,Zn superoxide dismutase-like | 0 | Direct |
DNA/RNA polymerases | 0 | Direct |
dsRNA-binding domain-like | 0 | Direct |
JAB1/MPN domain | 0 | Direct |
Class II aaRS ABD-related | 0 | Direct |
Homeodomain-like | 0.000002727 | Direct |
ARM repeat | 0.00002446 | Direct |
SH3-domain | 0.00007519 | Direct |
Protein kinase-like (PK-like) | 0.0001984 | Direct |
EGF/Laminin | 0.01402 | Inherited |
Nucleotidylyl transferase | 0.0687 | Inherited |
beta-sandwich domain of Sec23/24 | 0.08083 | Inherited |
Cysteine-rich domain | 0.08083 | Inherited |
Leucine zipper domain | 0.09382 | Inherited |
PDZ domain-like | 0.09497 | Inherited |
Cyclin-like | 0.1077 | Inherited |
Periplasmic binding protein-like II | 0.1135 | Inherited |
EF-hand | 0.1194 | Inherited |
BRCT domain | 0.1261 | Inherited |
FYVE/PHD zinc finger | 0.1272 | Inherited |
Fibronectin type III | 0.1486 | Inherited |
SNARE fusion complex | 0.1486 | Inherited |
beta-beta-alpha zinc fingers | 0.1577 | Inherited |
Concanavalin A-like lectins/glucanases | 0.2061 | Inherited |
C2 domain (Calcium/lipid-binding domain, CaLB) | 0.2169 | Inherited |
Tudor/PWWP/MBT | 0.2247 | Inherited |
N-acetylmuramoyl-L-alanine amidase-like | 0.2353 | Inherited |
Cysteine proteinases | 0.2483 | Inherited |
Chromo domain-like | 0.2799 | Inherited |
Ankyrin repeat | 0.2802 | Inherited |
Macro domain-like | 0.3656 | Inherited |
SCOP hierarchy in SUPERFAMILY | 0.3946 | Inherited |
SH2 domain | 0.3958 | Inherited |
P-loop containing nucleoside triphosphate hydrolases | 0.4022 | Inherited |
Voltage-gated potassium channels | 0.4264 | Inherited |
Growth factor receptor domain | 0.4264 | Inherited |
POZ domain | 0.4636 | Inherited |
SAM/Pointed domain | 0.4657 | Inherited |
Cystine-knot cytokines | 0.4769 | Inherited |
PAZ domain | 0.4908 | Inherited |
RNA-binding domain, RBD | 0.5299 | Inherited |
Tubulin nucleotide-binding domain-like | 0.5391 | Inherited |
Ribonuclease H-like | 0.5719 | Inherited |
Glucocorticoid receptor-like (DNA-binding domain) | 0.5828 | Inherited |
cAMP-binding domain-like | 0.6079 | Inherited |
Cadherin-like | 0.6079 | Inherited |
Family A G protein-coupled receptor-like | 0.6326 | Inherited |
Neurotransmitter-gated ion-channel transmembrane pore | 0.6518 | Inherited |
Nicotinic receptor ligand binding domain-like | 0.6518 | Inherited |
SET domain | 0.7326 | Inherited |
Immunoglobulin | 0.7885 | Inherited |
Nucleotide cyclase | 0.8452 | Inherited |
NAD(P)-binding Rossmann-fold domains | 0.9439 | Inherited |
alpha/beta-Hydrolases | 1 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this FP term (Not in SDFP)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Single strand DNA-binding domain, SSB | 0 | DIRECT |
Hypoxia-inducible factor Hif2a, C-terminal domain | 0 | DIRECT |
TBP-associated factors, TAFs | 0 | DIRECT |
Myb/SANT domain | 0 | DIRECT |
DEK C-terminal domain | 0 | DIRECT |
Ngr ectodomain-like | 0 | DIRECT |
beta-CASP RNA-metabolising hydrolases | 0 | DIRECT |
Isoprenyl diphosphate synthases | 0 | DIRECT |
Subtilases | 0 | DIRECT |
HLH, helix-loop-helix DNA-binding domain | 0 | DIRECT |
Extracellular domain of cell surface receptors | 0 | DIRECT |
MIF4G domain-like | 0 | DIRECT |
Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | DIRECT |
Ferredoxin domains from multidomain proteins | 0 | DIRECT |
Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | DIRECT |
Astacin | 0 | DIRECT |
Leucine aminopeptidase (Aminopeptidase A), N-terminal domain | 0 | DIRECT |
2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
Erythroid transcription factor GATA-1 | 0 | DIRECT |
Class I alpha-1;2-mannosidase, catalytic domain | 0 | DIRECT |
Forkhead DNA-binding domain | 0 | DIRECT |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
Penta-EF-hand proteins | 0 | DIRECT |
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
CAD domain | 0 | DIRECT |
ZZ domain | 0 | DIRECT |
Armadillo repeat | 0 | DIRECT |
Ribonuclease PH domain 1-like | 0 | DIRECT |
FHA domain | 0 | DIRECT |
Transforming growth factor (TGF)-beta | 0 | DIRECT |
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
GroEL-like chaperone, intermediate domain | 0 | DIRECT |
H-NOX domain | 0 | DIRECT |
Transcriptional factor domain | 0 | DIRECT |
L-arabinose binding protein-like | 0 | DIRECT |
Aquaporin-like | 0 | DIRECT |
Histidine acid phosphatase | 0 | DIRECT |
Protein serine/threonine phosphatase | 0 | DIRECT |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
MBT repeat | 0 | DIRECT |
Fibroblast growth factors (FGF) | 0 | DIRECT |
Histone lysine methyltransferases | 0 | DIRECT |
T-box | 0 | DIRECT |
Nuclear receptor | 0 | DIRECT |
ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
L30e/L7ae ribosomal proteins | 0 | DIRECT |
BC C-terminal domain-like | 0 | DIRECT |
Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
Paired domain | 0 | DIRECT |
La domain | 0 | DIRECT |
ARID domain | 0 | DIRECT |
Clathrin coat assembly domain | 0 | DIRECT |
Laminin-type module | 0 | DIRECT |
Neurolysin-like | 0 | DIRECT |
SMAD MH1 domain | 0 | DIRECT |
Bromodomain | 0 | DIRECT |
Clathrin adaptor core protein | 0 | DIRECT |
S-adenosylhomocystein hydrolase | 0 | DIRECT |
Acyl-carrier protein (ACP) | 0 | DIRECT |
Calmodulin-like | 0 | DIRECT |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
Tropomyosin | 0 | DIRECT |
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
BAR domain | 0 | DIRECT |
B-box zinc-binding domain | 0 | DIRECT |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Nop domain | 0 | DIRECT |
Nuclear receptor ligand-binding domain | 0 | DIRECT |
Hsp90 middle domain | 0 | DIRECT |
GMC oxidoreductases | 0 | DIRECT |
SAP domain | 0 | DIRECT |
Sema domain | 0 | DIRECT |
RUNT domain | 0 | DIRECT |
Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | DIRECT |
MSP-like | 0 | DIRECT |
Aminoacid dehydrogenase-like, C-terminal domain | 0 | DIRECT |
Cell cycle transcription factor e2f-dp | 0 | DIRECT |
IF2B-like | 0 | DIRECT |
Laminin G-like module | 0 | DIRECT |
Dachshund-homology domain | 0 | DIRECT |
Regulator of G-protein signaling, RGS | 0 | DIRECT |
Sec1/munc18-like (SM) proteins | 0 | DIRECT |
Sec7 domain | 0 | DIRECT |
Group II chaperonin (CCT, TRIC), ATPase domain | 0 | DIRECT |
Transducin (alpha subunit), insertion domain | 0 | DIRECT |
Gelsolin-like | 0 | DIRECT |
Rhomboid-like | 0 | DIRECT |
Succinyl-CoA synthetase domains | 0 | DIRECT |
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
RecA protein-like (ATPase-domain) | 0 | DIRECT |
Leucine aminopeptidase, C-terminal domain | 0 | DIRECT |
Smc hinge domain | 0 | DIRECT |
Hormone receptor domain | 0 | DIRECT |
Ribosomal protein L1 | 0 | DIRECT |
Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
Diap1 N-terninal region-like | 0 | DIRECT |
Plexin repeat | 0 | DIRECT |
Spectrin repeat | 0 | DIRECT |
Ribonuclease PH domain 2-like | 0 | DIRECT |
Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
Cu,Zn superoxide dismutase-like | 0 | DIRECT |
Meta-cation ATPase, catalytic domain P | 0 | DIRECT |
Insulin-like | 0 | DIRECT |
Cyclin | 0 | DIRECT |
PLC-like (P variant) | 0 | DIRECT |
BC N-terminal domain-like | 0 | DIRECT |
GroEL-like chaperone, apical domain | 0 | DIRECT |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | DIRECT |
BC ATP-binding domain-like | 0 | DIRECT |
L27 domain | 0 | DIRECT |
SMAD domain | 0 | DIRECT |
ets domain | 0 | DIRECT |
RNase III catalytic domain-like | 0 | DIRECT |
Hairy Orange domain | 0 | DIRECT |
Toll/Interleukin receptor TIR domain | 0 | DIRECT |
a tRNA synthase domain | 0 | DIRECT |
Calpain large subunit, catalytic domain (domain II) | 0 | DIRECT |
Translational machinery components | 0 | DIRECT |
NHL repeat | 0 | DIRECT |
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0 | DIRECT |
Ubiquitin activating enzymes (UBA) | 0 | DIRECT |
Alcohol dehydrogenase-like, N-terminal domain | 0 | DIRECT |
Zf-UBP | 0 | DIRECT |
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
Succinyl-CoA synthetase, beta-chain, N-terminal domain | 0 | DIRECT |
PAPS sulfotransferase | 0 | DIRECT |
Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
Multidrug efflux transporter AcrB transmembrane domain | 0 | DIRECT |
Nitrogenase iron protein-like | 0 | DIRECT |
Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
Prefoldin | 0 | DIRECT |
Reprolysin-like | 0 | DIRECT |
Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
First domain of FERM | 0 | DIRECT |
POU-specific domain | 0 | DIRECT |
DEATH domain, DD | 0 | DIRECT |
Pointed domain | 0 | DIRECT |
Integrin domains | 0 | DIRECT |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
Skp1 dimerisation domain-like | 0 | DIRECT |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
Taf5 N-terminal domain-like | 0 | DIRECT |
CBS-domain pair | 0 | DIRECT |
HR1 repeat | 0 | DIRECT |
Chromo barrel domain | 0 | DIRECT |
Mob1/phocein | 0 | DIRECT |
MAM domain | 0 | DIRECT |
Retrovirus zinc finger-like domains | 0 | DIRECT |
Enabled/VASP homology 1 domain (EVH1 domain) | 0 | DIRECT |
A DNA-binding domain in eukaryotic transcription factors | 0 | DIRECT |
Inositol polyphosphate kinase (IPK) | 0 | DIRECT |
Caspase catalytic domain | 0 | DIRECT |
GroEL chaperone, ATPase domain | 0 | DIRECT |
PX domain | 0 | DIRECT |
Double-stranded RNA-binding domain (dsRBD) | 0 | DIRECT |
Alcohol dehydrogenase-like, C-terminal domain | 0 | DIRECT |
Roadblock/LC7 domain | 0 | DIRECT |
Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
Arrestin/Vps26-like | 0 | DIRECT |
Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
Eps15 homology domain (EH domain) | 0 | DIRECT |
TATA-box binding protein (TBP), C-terminal domain | 0 | DIRECT |
Protein kinases, catalytic subunit | 0.000007202 | DIRECT |
Homeodomain | 0.00002279 | DIRECT |
SH3-domain | 0.0001667 | DIRECT |
Pleckstrin-homology domain (PH domain) | 0.009906 | INHERITED FROM: some die during embryonic stage |
PDZ domain | 0.01908 | INHERITED FROM: cell polarity defective |
Motor proteins | 0.03119 | INHERITED FROM: lethal - all die before end of first instar larval stage || cell cycle defective || lethal - all die before end of larval stage || auditory perception defective || lethal - all die before end of embryonic stage |
I set domains | 0.05729 | INHERITED FROM: cell migration defective |
EGF-type module | 0.07803 | INHERITED FROM: lethal - all die before end of larval stage || hyperplasia || cell polarity defective || some die during pupal stage || increased occurrence of cell division || decreased occurrence of cell division || tumorigenic || increased cell number || lethal - all die before end of prepupal stage || planar polarity defective || cell shape defective |
Tandem AAA-ATPase domain | 0.09482 | INHERITED FROM: radiation sensitive || increased mortality || DNA repair defective |
Phosphate binding protein-like | 0.1036 | INHERITED FROM: neurophysiology defective |
Leucine zipper domain | 0.1036 | INHERITED FROM: lethal - all die before end of first instar larval stage || lethal - all die before end of pupal stage || lethal - all die before end of larval stage || developmental rate defective |
Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.1595 | INHERITED FROM: cell size defective || decreased cell size |
SAM (sterile alpha motif) domain | 0.185 | INHERITED FROM: homeotic || neoplasia |
Fibronectin type III | 0.2021 | INHERITED FROM: cell adhesion defective |
PHD domain | 0.2329 | INHERITED FROM: homeotic || modifier of variegation |
N-acetylmuramoyl-L-alanine amidase-like | 0.2418 | INHERITED FROM: immune response defective |
Dual specificity phosphatase-like | 0.2418 | INHERITED FROM: chemical resistant |
Classic zinc finger, C2H2 | 0.3236 | INHERITED FROM: visible |
Ankyrin repeat | 0.3672 | INHERITED FROM: behavior defective || chemosensitive behavior defective || thermotaxis behavior defective || sensory perception defective || neurophysiology defective |
Tetramerization domain of potassium channels | 0.3672 | INHERITED FROM: sleep defective || courtship behavior defective || circadian rhythm defective || neurophysiology defective || mating defective |
Extended AAA-ATPase domain | 0.3824 | INHERITED FROM: bang sensitive |
Glutathione peroxidase-like | 0.4248 | INHERITED FROM: stress response defective |
Pancreatic lipase, N-terminal domain | 0.4248 | INHERITED FROM: electrophoretic variant |
SH2 domain | 0.4418 | INHERITED FROM: planar polarity defective |
Rhodopsin-like | 0.4524 | INHERITED FROM: behavior defective || hypoactive || courtship behavior defective || mating defective |
Growth factor receptor domain | 0.4574 | INHERITED FROM: cell polarity defective || immune response defective || planar polarity defective |
Canonical RBD | 0.4844 | INHERITED FROM: lethal |
UBA domain | 0.4898 | INHERITED FROM: increased cell death |
Synaptotagmin-like (S variant) | 0.5063 | INHERITED FROM: neurophysiology defective |
Tubulin, GTPase domain | 0.5619 | INHERITED FROM: cell cycle defective |
PAZ domain | 0.5688 | INHERITED FROM: mitotic cell cycle defective || cell cycle defective || suppressor of variegation || modifier of variegation |
Voltage-gated potassium channels | 0.6585 | INHERITED FROM: chemosensitive behavior defective || neurophysiology defective |
Neurotransmitter-gated ion-channel transmembrane pore | 0.6829 | INHERITED FROM: phototaxis defective || temperature response defective || chemical resistant |
cAMP-binding domain | 0.6829 | INHERITED FROM: sensory perception defective || hyperactive |
Cadherin | 0.6829 | INHERITED FROM: cell polarity defective |
G proteins | 0.7288 | INHERITED FROM: body size defective || immune response defective |
Acetylcholinesterase-like | 0.765 | INHERITED FROM: electrophoretic variant |
Nicotinic receptor ligand binding domain-like | 0.7689 | INHERITED FROM: phototaxis defective || chemical resistant |
Adenylyl and guanylyl cyclase catalytic domain | 0.8661 | INHERITED FROM: taste perception defective |
Neutral endopeptidase (neprilysin) | 0.9652 | INHERITED FROM: female semi-sterile || semi-sterile |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Single strand DNA-binding domain, SSB | 0 | Direct |
Hypoxia-inducible factor Hif2a, C-terminal domain | 0 | Direct |
TBP-associated factors, TAFs | 0 | Direct |
Myb/SANT domain | 0 | Direct |
DEK C-terminal domain | 0 | Direct |
Ngr ectodomain-like | 0 | Direct |
beta-CASP RNA-metabolising hydrolases | 0 | Direct |
Isoprenyl diphosphate synthases | 0 | Direct |
Subtilases | 0 | Direct |
HLH, helix-loop-helix DNA-binding domain | 0 | Direct |
Extracellular domain of cell surface receptors | 0 | Direct |
MIF4G domain-like | 0 | Direct |
Dimeric isocitrate & isopropylmalate dehydrogenases | 0 | Direct |
Ferredoxin domains from multidomain proteins | 0 | Direct |
Sm motif of small nuclear ribonucleoproteins, SNRNP | 0 | Direct |
Astacin | 0 | Direct |
Leucine aminopeptidase (Aminopeptidase A), N-terminal domain | 0 | Direct |
2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
Erythroid transcription factor GATA-1 | 0 | Direct |
Class I alpha-1;2-mannosidase, catalytic domain | 0 | Direct |
Forkhead DNA-binding domain | 0 | Direct |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
Penta-EF-hand proteins | 0 | Direct |
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
CAD domain | 0 | Direct |
ZZ domain | 0 | Direct |
Armadillo repeat | 0 | Direct |
Ribonuclease PH domain 1-like | 0 | Direct |
FHA domain | 0 | Direct |
Transforming growth factor (TGF)-beta | 0 | Direct |
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
GroEL-like chaperone, intermediate domain | 0 | Direct |
H-NOX domain | 0 | Direct |
Transcriptional factor domain | 0 | Direct |
L-arabinose binding protein-like | 0 | Direct |
Aquaporin-like | 0 | Direct |
Histidine acid phosphatase | 0 | Direct |
Protein serine/threonine phosphatase | 0 | Direct |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
MBT repeat | 0 | Direct |
Fibroblast growth factors (FGF) | 0 | Direct |
Histone lysine methyltransferases | 0 | Direct |
T-box | 0 | Direct |
Nuclear receptor | 0 | Direct |
ValRS/IleRS/LeuRS editing domain | 0 | Direct |
Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
L30e/L7ae ribosomal proteins | 0 | Direct |
BC C-terminal domain-like | 0 | Direct |
Anticodon-binding domain of Class II aaRS | 0 | Direct |
Paired domain | 0 | Direct |
La domain | 0 | Direct |
ARID domain | 0 | Direct |
Clathrin coat assembly domain | 0 | Direct |
Laminin-type module | 0 | Direct |
Neurolysin-like | 0 | Direct |
SMAD MH1 domain | 0 | Direct |
Bromodomain | 0 | Direct |
Clathrin adaptor core protein | 0 | Direct |
S-adenosylhomocystein hydrolase | 0 | Direct |
Acyl-carrier protein (ACP) | 0 | Direct |
Calmodulin-like | 0 | Direct |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
Tropomyosin | 0 | Direct |
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
BAR domain | 0 | Direct |
B-box zinc-binding domain | 0 | Direct |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Nop domain | 0 | Direct |
Nuclear receptor ligand-binding domain | 0 | Direct |
Hsp90 middle domain | 0 | Direct |
GMC oxidoreductases | 0 | Direct |
SAP domain | 0 | Direct |
Sema domain | 0 | Direct |
RUNT domain | 0 | Direct |
Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | Direct |
MSP-like | 0 | Direct |
Aminoacid dehydrogenase-like, C-terminal domain | 0 | Direct |
Cell cycle transcription factor e2f-dp | 0 | Direct |
IF2B-like | 0 | Direct |
Laminin G-like module | 0 | Direct |
Dachshund-homology domain | 0 | Direct |
Regulator of G-protein signaling, RGS | 0 | Direct |
Sec1/munc18-like (SM) proteins | 0 | Direct |
Sec7 domain | 0 | Direct |
Group II chaperonin (CCT, TRIC), ATPase domain | 0 | Direct |
Transducin (alpha subunit), insertion domain | 0 | Direct |
Gelsolin-like | 0 | Direct |
Rhomboid-like | 0 | Direct |
Succinyl-CoA synthetase domains | 0 | Direct |
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
RecA protein-like (ATPase-domain) | 0 | Direct |
Leucine aminopeptidase, C-terminal domain | 0 | Direct |
Smc hinge domain | 0 | Direct |
Hormone receptor domain | 0 | Direct |
Ribosomal protein L1 | 0 | Direct |
Cell cycle control phosphatase, catalytic domain | 0 | Direct |
Diap1 N-terninal region-like | 0 | Direct |
Plexin repeat | 0 | Direct |
Spectrin repeat | 0 | Direct |
Ribonuclease PH domain 2-like | 0 | Direct |
Blood coagulation inhibitor (disintegrin) | 0 | Direct |
Cu,Zn superoxide dismutase-like | 0 | Direct |
Meta-cation ATPase, catalytic domain P | 0 | Direct |
Insulin-like | 0 | Direct |
Cyclin | 0 | Direct |
PLC-like (P variant) | 0 | Direct |
BC N-terminal domain-like | 0 | Direct |
GroEL-like chaperone, apical domain | 0 | Direct |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | Direct |
BC ATP-binding domain-like | 0 | Direct |
L27 domain | 0 | Direct |
SMAD domain | 0 | Direct |
ets domain | 0 | Direct |
RNase III catalytic domain-like | 0 | Direct |
Hairy Orange domain | 0 | Direct |
Toll/Interleukin receptor TIR domain | 0 | Direct |
a tRNA synthase domain | 0 | Direct |
Calpain large subunit, catalytic domain (domain II) | 0 | Direct |
Translational machinery components | 0 | Direct |
NHL repeat | 0 | Direct |
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0 | Direct |
Ubiquitin activating enzymes (UBA) | 0 | Direct |
Alcohol dehydrogenase-like, N-terminal domain | 0 | Direct |
Zf-UBP | 0 | Direct |
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | Direct |
Succinyl-CoA synthetase, beta-chain, N-terminal domain | 0 | Direct |
PAPS sulfotransferase | 0 | Direct |
Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
Class I glutamine amidotransferases (GAT) | 0 | Direct |
Multidrug efflux transporter AcrB transmembrane domain | 0 | Direct |
Nitrogenase iron protein-like | 0 | Direct |
Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
Prefoldin | 0 | Direct |
Reprolysin-like | 0 | Direct |
Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
First domain of FERM | 0 | Direct |
POU-specific domain | 0 | Direct |
DEATH domain, DD | 0 | Direct |
Pointed domain | 0 | Direct |
Integrin domains | 0 | Direct |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
Skp1 dimerisation domain-like | 0 | Direct |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
XPF/Rad1/Mus81 nuclease | 0 | Direct |
Taf5 N-terminal domain-like | 0 | Direct |
CBS-domain pair | 0 | Direct |
HR1 repeat | 0 | Direct |
Chromo barrel domain | 0 | Direct |
Mob1/phocein | 0 | Direct |
MAM domain | 0 | Direct |
Retrovirus zinc finger-like domains | 0 | Direct |
Enabled/VASP homology 1 domain (EVH1 domain) | 0 | Direct |
A DNA-binding domain in eukaryotic transcription factors | 0 | Direct |
Inositol polyphosphate kinase (IPK) | 0 | Direct |
Caspase catalytic domain | 0 | Direct |
GroEL chaperone, ATPase domain | 0 | Direct |
PX domain | 0 | Direct |
Double-stranded RNA-binding domain (dsRBD) | 0 | Direct |
Alcohol dehydrogenase-like, C-terminal domain | 0 | Direct |
Roadblock/LC7 domain | 0 | Direct |
Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
Arrestin/Vps26-like | 0 | Direct |
Formin homology 2 domain (FH2 domain) | 0 | Direct |
Eps15 homology domain (EH domain) | 0 | Direct |
TATA-box binding protein (TBP), C-terminal domain | 0 | Direct |
Protein kinases, catalytic subunit | 0.000007202 | Direct |
Homeodomain | 0.00002279 | Direct |
SH3-domain | 0.0001667 | Direct |
Pleckstrin-homology domain (PH domain) | 0.009906 | Inherited |
PDZ domain | 0.01908 | Inherited |
Motor proteins | 0.03119 | Inherited |
I set domains | 0.05729 | Inherited |
EGF-type module | 0.07803 | Inherited |
Tandem AAA-ATPase domain | 0.09482 | Inherited |
Phosphate binding protein-like | 0.1036 | Inherited |
Leucine zipper domain | 0.1036 | Inherited |
Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.1595 | Inherited |
SAM (sterile alpha motif) domain | 0.185 | Inherited |
Fibronectin type III | 0.2021 | Inherited |
PHD domain | 0.2329 | Inherited |
N-acetylmuramoyl-L-alanine amidase-like | 0.2418 | Inherited |
Dual specificity phosphatase-like | 0.2418 | Inherited |
Classic zinc finger, C2H2 | 0.3236 | Inherited |
Ankyrin repeat | 0.3672 | Inherited |
Tetramerization domain of potassium channels | 0.3672 | Inherited |
Extended AAA-ATPase domain | 0.3824 | Inherited |
Glutathione peroxidase-like | 0.4248 | Inherited |
Pancreatic lipase, N-terminal domain | 0.4248 | Inherited |
SH2 domain | 0.4418 | Inherited |
Rhodopsin-like | 0.4524 | Inherited |
Growth factor receptor domain | 0.4574 | Inherited |
Canonical RBD | 0.4844 | Inherited |
UBA domain | 0.4898 | Inherited |
Synaptotagmin-like (S variant) | 0.5063 | Inherited |
Tubulin, GTPase domain | 0.5619 | Inherited |
PAZ domain | 0.5688 | Inherited |
Voltage-gated potassium channels | 0.6585 | Inherited |
Neurotransmitter-gated ion-channel transmembrane pore | 0.6829 | Inherited |
cAMP-binding domain | 0.6829 | Inherited |
Cadherin | 0.6829 | Inherited |
G proteins | 0.7288 | Inherited |
Acetylcholinesterase-like | 0.765 | Inherited |
Nicotinic receptor ligand binding domain-like | 0.7689 | Inherited |
Adenylyl and guanylyl cyclase catalytic domain | 0.8661 | Inherited |
Neutral endopeptidase (neprilysin) | 0.9652 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
 |
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this FP term (Not in SPFP)
Highlighted in gray are those with FDR>0.001
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
DNA-binding domain | 0 | DIRECT |
Ribosomal L27 protein-like | 0 | DIRECT |
Plexin repeat | 0 | DIRECT |
DNA/RNA polymerases | 0 | DIRECT |
HLH, helix-loop-helix DNA-binding domain | 0 | DIRECT |
Seven-hairpin glycosidases | 0 | DIRECT |
KA1-like | 0 | DIRECT |
Tetrahydrobiopterin biosynthesis enzymes-like | 0 | DIRECT |
Sm-like ribonucleoproteins | 0 | DIRECT |
TATA-box binding protein-like | 0 | DIRECT |
Ribonuclease PH domain 2-like | 0 | DIRECT |
Zn-binding ribosomal proteins | 0 | DIRECT |
Class I glutamine amidotransferase-like | 0 | DIRECT |
HR1 repeat | 0 | DIRECT |
SMAD/FHA domain | 0 | DIRECT |
SAP domain | 0 | DIRECT |
4Fe-4S ferredoxins | 0 | DIRECT |
2Fe-2S ferredoxin-like | 0 | DIRECT |
SMAD MH1 domain | 0 | DIRECT |
Class II aaRS ABD-related | 0 | DIRECT |
SPOC domain-like | 0 | DIRECT |
Nuclear receptor ligand-binding domain | 0 | DIRECT |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
PYP-like sensor domain (PAS domain) | 0 | DIRECT |
PriA/YqbF domain | 0 | DIRECT |
Ribosomal protein L1 | 0 | DIRECT |
vWA-like | 0 | DIRECT |
ACT-like | 0 | DIRECT |
Skp1 dimerisation domain-like | 0 | DIRECT |
GINS helical bundle-like | 0 | DIRECT |
GroEL-intermediate domain like | 0 | DIRECT |
Restriction endonuclease-like | 0 | DIRECT |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
Caspase-like | 0 | DIRECT |
Cytokine | 0 | DIRECT |
DEATH domain | 0 | DIRECT |
Orange domain-like | 0 | DIRECT |
Cysteine-rich DNA binding domain, (DM domain) | 0 | DIRECT |
Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
Glutamine synthetase/guanido kinase | 0 | DIRECT |
ThrRS/AlaRS common domain | 0 | DIRECT |
Terpenoid synthases | 0 | DIRECT |
Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
Aldolase | 0 | DIRECT |
RBP11-like subunits of RNA polymerase | 0 | DIRECT |
Ferritin-like | 0 | DIRECT |
Subtilisin-like | 0 | DIRECT |
Regulator of G-protein signaling, RGS | 0 | DIRECT |
Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
Roadblock/LC7 domain | 0 | DIRECT |
Toll/Interleukin receptor TIR domain | 0 | DIRECT |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
Retrovirus zinc finger-like domains | 0 | DIRECT |
Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
Integrin domains | 0 | DIRECT |
GroEL apical domain-like | 0 | DIRECT |
Snake toxin-like | 0 | DIRECT |
HRDC-like | 0 | DIRECT |
DEK C-terminal domain | 0 | DIRECT |
Nucleoporin domain | 0 | DIRECT |
Aquaporin-like | 0 | DIRECT |
Cu,Zn superoxide dismutase-like | 0 | DIRECT |
TIMP-like | 0 | DIRECT |
S15/NS1 RNA-binding domain | 0 | DIRECT |
GroEL equatorial domain-like | 0 | DIRECT |
ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
ARID-like | 0 | DIRECT |
Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
B-box zinc-binding domain | 0 | DIRECT |
Hormone receptor domain | 0 | DIRECT |
JAB1/MPN domain | 0 | DIRECT |
Lipocalins | 0 | DIRECT |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
Clathrin adaptor appendage domain | 0 | DIRECT |
L30e-like | 0 | DIRECT |
Sec7 domain | 0 | DIRECT |
A DNA-binding domain in eukaryotic transcription factors | 0 | DIRECT |
E2F-DP heterodimerization region | 0 | DIRECT |
Transducin (alpha subunit), insertion domain | 0 | DIRECT |
CBS-domain pair | 0 | DIRECT |
Tropomyosin | 0 | DIRECT |
SNARE-like | 0 | DIRECT |
Nop domain | 0 | DIRECT |
PX domain | 0 | DIRECT |
lambda repressor-like DNA-binding domains | 0 | DIRECT |
Translational machinery components | 0 | DIRECT |
Multidrug efflux transporter AcrB transmembrane domain | 0 | DIRECT |
Ribosomal protein S5 domain 2-like | 0 | DIRECT |
Succinyl-CoA synthetase domains | 0 | DIRECT |
Rudiment single hybrid motif | 0 | DIRECT |
Taf5 N-terminal domain-like | 0 | DIRECT |
Smc hinge domain | 0 | DIRECT |
SAICAR synthase-like | 0 | DIRECT |
YVTN repeat-like/Quinoprotein amine dehydrogenase | 0 | DIRECT |
Sema domain | 0 | DIRECT |
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | DIRECT |
PapD-like | 0 | DIRECT |
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
Mob1/phocein | 0 | DIRECT |
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | DIRECT |
Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
CAD & PB1 domains | 0 | DIRECT |
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
HSP90 C-terminal domain | 0 | DIRECT |
Spectrin repeat | 0 | DIRECT |
Putative DNA-binding domain | 0 | DIRECT |
Bromodomain | 0 | DIRECT |
SAND domain-like | 0 | DIRECT |
Sec1/munc18-like (SM) proteins | 0 | DIRECT |
L27 domain | 0 | DIRECT |
RNase III domain-like | 0 | DIRECT |
ACP-like | 0 | DIRECT |
Riboflavin synthase domain-like | 0 | DIRECT |
Translation proteins SH3-like domain | 0 | DIRECT |
Periplasmic binding protein-like I | 0 | DIRECT |
dsRNA-binding domain-like | 0 | DIRECT |
Prefoldin | 0 | DIRECT |
PreATP-grasp domain | 0 | DIRECT |
Insulin-like | 0 | DIRECT |
Pectin lyase-like | 0 | DIRECT |
Bet v1-like | 0 | DIRECT |
Zinc beta-ribbon | 0 | DIRECT |
PIN domain-like | 0 | DIRECT |
Homeodomain-like | 0.000001983 | DIRECT |
ARM repeat | 0.00001808 | DIRECT |
SH3-domain | 0.00005622 | DIRECT |
Protein kinase-like (PK-like) | 0.0001503 | DIRECT |
EGF/Laminin | 0.01152 | INHERITED FROM: some die during embryonic stage || planar polarity defective || lethal - all die before end of pupal stage || cell polarity defective || size defective || lethal - all die before end of first instar larval stage || lethal - all die before end of P-stage || lethal - all die before end of larval stage || immune response defective || lethal - all die before end of embryonic stage || lethal - all die before end of prepupal stage |
p53-like transcription factors | 0.05902 | INHERITED FROM: increased cell size |
Nucleotidylyl transferase | 0.05902 | INHERITED FROM: decreased cell size |
beta-sandwich domain of Sec23/24 | 0.06971 | INHERITED FROM: lethal - all die before end of pupal stage || lethal - all die before end of first instar larval stage || some die during larval stage || lethal - all die before end of larval stage || cell shape defective || lethal - all die before end of embryonic stage |
Cysteine-rich domain | 0.06971 | INHERITED FROM: wound healing defective |
Leucine zipper domain | 0.08168 | INHERITED FROM: developmental rate defective || lethal - all die before end of pupal stage || lethal - all die before end of first instar larval stage || lethal - all die before end of larval stage || increased mortality |
PDZ domain-like | 0.08283 | INHERITED FROM: cell polarity defective |
Cyclin-like | 0.09426 | INHERITED FROM: mitotic cell cycle defective || cell cycle defective |
Periplasmic binding protein-like II | 0.0993 | INHERITED FROM: sensory perception defective || feeding behavior defective || neurophysiology defective |
EF-hand | 0.1043 | INHERITED FROM: flightless |
BRCT domain | 0.1101 | INHERITED FROM: radiation sensitive |
FYVE/PHD zinc finger | 0.111 | INHERITED FROM: modifier of variegation |
Fibronectin type III | 0.1303 | INHERITED FROM: cell adhesion defective |
SNARE fusion complex | 0.1303 | INHERITED FROM: uncoordinated || increased mortality during development || neurophysiology defective |
beta-beta-alpha zinc fingers | 0.1382 | INHERITED FROM: visible |
Concanavalin A-like lectins/glucanases | 0.1819 | INHERITED FROM: cell polarity defective |
C2 domain (Calcium/lipid-binding domain, CaLB) | 0.1921 | INHERITED FROM: neurophysiology defective |
Tudor/PWWP/MBT | 0.1987 | INHERITED FROM: sterile || neoplasia |
N-acetylmuramoyl-L-alanine amidase-like | 0.209 | INHERITED FROM: immune response defective |
Cysteine proteinases | 0.2217 | INHERITED FROM: behavior defective |
Chromo domain-like | 0.2523 | INHERITED FROM: modifier of variegation || non-suppressor of variegation || suppressor of variegation |
Ankyrin repeat | 0.2527 | INHERITED FROM: behavior defective || sensory perception defective || neurophysiology defective || thermotaxis behavior defective || chemosensitive behavior defective |
HMG-box | 0.2711 | INHERITED FROM: visible |
Macro domain-like | 0.3346 | INHERITED FROM: sterile || male sterile |
SH2 domain | 0.3631 | INHERITED FROM: planar polarity defective || visible |
P-loop containing nucleoside triphosphate hydrolases | 0.3694 | INHERITED FROM: cell cycle defective |
Voltage-gated potassium channels | 0.394 | INHERITED FROM: behavior defective || circadian rhythm defective || chemical sensitive || chemical resistant || neurophysiology defective |
Growth factor receptor domain | 0.394 | INHERITED FROM: planar polarity defective || cell polarity defective |
POZ domain | 0.4305 | INHERITED FROM: sleep defective || body color defective |
SAM/Pointed domain | 0.4326 | INHERITED FROM: increased cell number |
Cystine-knot cytokines | 0.4432 | INHERITED FROM: circadian rhythm defective |
PAZ domain | 0.4579 | INHERITED FROM: modifier of variegation || mitotic cell cycle defective || suppressor of variegation || cell cycle defective |
RNA-binding domain, RBD | 0.4973 | INHERITED FROM: lethal |
Tubulin nucleotide-binding domain-like | 0.507 | INHERITED FROM: cell cycle defective |
Ribonuclease H-like | 0.5408 | INHERITED FROM: melanotic mass phenotype |
Glucocorticoid receptor-like (DNA-binding domain) | 0.5523 | INHERITED FROM: visible |
Cadherin-like | 0.5769 | INHERITED FROM: cell polarity defective |
cAMP-binding domain-like | 0.5769 | INHERITED FROM: sensory perception defective || hyperactive |
Family A G protein-coupled receptor-like | 0.6027 | INHERITED FROM: behavior defective || mating defective || hypoactive |
Neurotransmitter-gated ion-channel transmembrane pore | 0.6232 | INHERITED FROM: circadian rhythm defective || chemical resistant || phototaxis defective |
Nicotinic receptor ligand binding domain-like | 0.6232 | INHERITED FROM: circadian rhythm defective || chemical resistant || phototaxis defective |
SET domain | 0.7077 | INHERITED FROM: modifier of variegation || non-suppressor of variegation || homeotic || suppressor of variegation |
Immunoglobulin | 0.7625 | INHERITED FROM: cell migration defective |
Nucleotide cyclase | 0.8238 | INHERITED FROM: taste perception defective |
NAD(P)-binding Rossmann-fold domains | 0.9289 | INHERITED FROM: electrophoretic variant |
alpha/beta-Hydrolases | 1 | INHERITED FROM: electrophoretic variant |
Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
DNA-binding domain | 0 | Direct |
Ribosomal L27 protein-like | 0 | Direct |
Plexin repeat | 0 | Direct |
DNA/RNA polymerases | 0 | Direct |
HLH, helix-loop-helix DNA-binding domain | 0 | Direct |
Seven-hairpin glycosidases | 0 | Direct |
KA1-like | 0 | Direct |
Tetrahydrobiopterin biosynthesis enzymes-like | 0 | Direct |
Sm-like ribonucleoproteins | 0 | Direct |
TATA-box binding protein-like | 0 | Direct |
Ribonuclease PH domain 2-like | 0 | Direct |
Zn-binding ribosomal proteins | 0 | Direct |
Class I glutamine amidotransferase-like | 0 | Direct |
HR1 repeat | 0 | Direct |
SMAD/FHA domain | 0 | Direct |
SAP domain | 0 | Direct |
4Fe-4S ferredoxins | 0 | Direct |
2Fe-2S ferredoxin-like | 0 | Direct |
SMAD MH1 domain | 0 | Direct |
Class II aaRS ABD-related | 0 | Direct |
SPOC domain-like | 0 | Direct |
Nuclear receptor ligand-binding domain | 0 | Direct |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
PYP-like sensor domain (PAS domain) | 0 | Direct |
PriA/YqbF domain | 0 | Direct |
Ribosomal protein L1 | 0 | Direct |
vWA-like | 0 | Direct |
ACT-like | 0 | Direct |
Skp1 dimerisation domain-like | 0 | Direct |
GINS helical bundle-like | 0 | Direct |
GroEL-intermediate domain like | 0 | Direct |
Restriction endonuclease-like | 0 | Direct |
C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
Caspase-like | 0 | Direct |
Cytokine | 0 | Direct |
DEATH domain | 0 | Direct |
Orange domain-like | 0 | Direct |
Cysteine-rich DNA binding domain, (DM domain) | 0 | Direct |
Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
Glutamine synthetase/guanido kinase | 0 | Direct |
ThrRS/AlaRS common domain | 0 | Direct |
Terpenoid synthases | 0 | Direct |
Formin homology 2 domain (FH2 domain) | 0 | Direct |
Aldolase | 0 | Direct |
RBP11-like subunits of RNA polymerase | 0 | Direct |
Ferritin-like | 0 | Direct |
Subtilisin-like | 0 | Direct |
Regulator of G-protein signaling, RGS | 0 | Direct |
Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
Roadblock/LC7 domain | 0 | Direct |
Toll/Interleukin receptor TIR domain | 0 | Direct |
C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
Retrovirus zinc finger-like domains | 0 | Direct |
Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
Integrin domains | 0 | Direct |
GroEL apical domain-like | 0 | Direct |
Snake toxin-like | 0 | Direct |
HRDC-like | 0 | Direct |
DEK C-terminal domain | 0 | Direct |
Nucleoporin domain | 0 | Direct |
Aquaporin-like | 0 | Direct |
Cu,Zn superoxide dismutase-like | 0 | Direct |
TIMP-like | 0 | Direct |
S15/NS1 RNA-binding domain | 0 | Direct |
GroEL equatorial domain-like | 0 | Direct |
ValRS/IleRS/LeuRS editing domain | 0 | Direct |
ARID-like | 0 | Direct |
Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
Blood coagulation inhibitor (disintegrin) | 0 | Direct |
B-box zinc-binding domain | 0 | Direct |
Hormone receptor domain | 0 | Direct |
JAB1/MPN domain | 0 | Direct |
Lipocalins | 0 | Direct |
beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
Clathrin adaptor appendage domain | 0 | Direct |
L30e-like | 0 | Direct |
Sec7 domain | 0 | Direct |
A DNA-binding domain in eukaryotic transcription factors | 0 | Direct |
E2F-DP heterodimerization region | 0 | Direct |
Transducin (alpha subunit), insertion domain | 0 | Direct |
CBS-domain pair | 0 | Direct |
Tropomyosin | 0 | Direct |
SNARE-like | 0 | Direct |
Nop domain | 0 | Direct |
PX domain | 0 | Direct |
lambda repressor-like DNA-binding domains | 0 | Direct |
Translational machinery components | 0 | Direct |
Multidrug efflux transporter AcrB transmembrane domain | 0 | Direct |
Ribosomal protein S5 domain 2-like | 0 | Direct |
Succinyl-CoA synthetase domains | 0 | Direct |
Rudiment single hybrid motif | 0 | Direct |
Taf5 N-terminal domain-like | 0 | Direct |
Smc hinge domain | 0 | Direct |
SAICAR synthase-like | 0 | Direct |
YVTN repeat-like/Quinoprotein amine dehydrogenase | 0 | Direct |
Sema domain | 0 | Direct |
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0 | Direct |
PapD-like | 0 | Direct |
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
Mob1/phocein | 0 | Direct |
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0 | Direct |
Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
CAD & PB1 domains | 0 | Direct |
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
HSP90 C-terminal domain | 0 | Direct |
Spectrin repeat | 0 | Direct |
Putative DNA-binding domain | 0 | Direct |
Bromodomain | 0 | Direct |
SAND domain-like | 0 | Direct |
Sec1/munc18-like (SM) proteins | 0 | Direct |
L27 domain | 0 | Direct |
RNase III domain-like | 0 | Direct |
ACP-like | 0 | Direct |
Riboflavin synthase domain-like | 0 | Direct |
Translation proteins SH3-like domain | 0 | Direct |
Periplasmic binding protein-like I | 0 | Direct |
dsRNA-binding domain-like | 0 | Direct |
Prefoldin | 0 | Direct |
PreATP-grasp domain | 0 | Direct |
Insulin-like | 0 | Direct |
Pectin lyase-like | 0 | Direct |
Bet v1-like | 0 | Direct |
Zinc beta-ribbon | 0 | Direct |
PIN domain-like | 0 | Direct |
Homeodomain-like | 0.000001983 | Direct |
ARM repeat | 0.00001808 | Direct |
SH3-domain | 0.00005622 | Direct |
Protein kinase-like (PK-like) | 0.0001503 | Direct |
EGF/Laminin | 0.01152 | Inherited |
p53-like transcription factors | 0.05902 | Inherited |
Nucleotidylyl transferase | 0.05902 | Inherited |
beta-sandwich domain of Sec23/24 | 0.06971 | Inherited |
Cysteine-rich domain | 0.06971 | Inherited |
Leucine zipper domain | 0.08168 | Inherited |
PDZ domain-like | 0.08283 | Inherited |
Cyclin-like | 0.09426 | Inherited |
Periplasmic binding protein-like II | 0.0993 | Inherited |
EF-hand | 0.1043 | Inherited |
BRCT domain | 0.1101 | Inherited |
FYVE/PHD zinc finger | 0.111 | Inherited |
Fibronectin type III | 0.1303 | Inherited |
SNARE fusion complex | 0.1303 | Inherited |
beta-beta-alpha zinc fingers | 0.1382 | Inherited |
Concanavalin A-like lectins/glucanases | 0.1819 | Inherited |
C2 domain (Calcium/lipid-binding domain, CaLB) | 0.1921 | Inherited |
Tudor/PWWP/MBT | 0.1987 | Inherited |
N-acetylmuramoyl-L-alanine amidase-like | 0.209 | Inherited |
Cysteine proteinases | 0.2217 | Inherited |
Chromo domain-like | 0.2523 | Inherited |
Ankyrin repeat | 0.2527 | Inherited |
HMG-box | 0.2711 | Inherited |
Macro domain-like | 0.3346 | Inherited |
SH2 domain | 0.3631 | Inherited |
P-loop containing nucleoside triphosphate hydrolases | 0.3694 | Inherited |
Voltage-gated potassium channels | 0.394 | Inherited |
Growth factor receptor domain | 0.394 | Inherited |
POZ domain | 0.4305 | Inherited |
SAM/Pointed domain | 0.4326 | Inherited |
Cystine-knot cytokines | 0.4432 | Inherited |
PAZ domain | 0.4579 | Inherited |
RNA-binding domain, RBD | 0.4973 | Inherited |
Tubulin nucleotide-binding domain-like | 0.507 | Inherited |
Ribonuclease H-like | 0.5408 | Inherited |
Glucocorticoid receptor-like (DNA-binding domain) | 0.5523 | Inherited |
Cadherin-like | 0.5769 | Inherited |
cAMP-binding domain-like | 0.5769 | Inherited |
Family A G protein-coupled receptor-like | 0.6027 | Inherited |
Neurotransmitter-gated ion-channel transmembrane pore | 0.6232 | Inherited |
Nicotinic receptor ligand binding domain-like | 0.6232 | Inherited |
SET domain | 0.7077 | Inherited |
Immunoglobulin | 0.7625 | Inherited |
Nucleotide cyclase | 0.8238 | Inherited |
NAD(P)-binding Rossmann-fold domains | 0.9289 | Inherited |
alpha/beta-Hydrolases | 1 | Inherited |
(show details)
Supra-domains annotated to this FP term (Not in SPFP)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
48425,50729 48425 - Sec7 domain 50729 - PH domain-like | 0 | DIRECT |
50615,52540 50615 - N-terminal domain of alpha and beta subunits of F1 ATP synthase 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49417,81296 49417 - p53-like transcription factors 81296 - E set domains | 0 | DIRECT |
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like | 0 | DIRECT |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 0 | DIRECT |
50677,52374 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase | 0 | DIRECT |
57850,57850 57850 - RING/U-box 57850 - RING/U-box | 0 | DIRECT |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0 | DIRECT |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | DIRECT |
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like | 0 | DIRECT |
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like | 0 | DIRECT |
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain | 0 | DIRECT |
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM | 0 | DIRECT |
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region | 0 | DIRECT |
46689,46689 46689 - Homeodomain-like 46689 - Homeodomain-like | 0 | DIRECT |
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like | 0 | DIRECT |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0 | DIRECT |
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
101288,50156 101288 - L27 domain 50156 - PDZ domain-like | 0 | DIRECT |
55486,57552 55486 - Metalloproteases ("zincins"), catalytic domain 57552 - Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like | 0 | DIRECT |
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0 | DIRECT |
56059,51246 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif | 0 | DIRECT |
57716,46689 57716 - Glucocorticoid receptor-like (DNA-binding domain) 46689 - Homeodomain-like | 0 | DIRECT |
55945,55945 55945 - TATA-box binding protein-like 55945 - TATA-box binding protein-like | 0 | DIRECT |
55021,56534 55021 - ACT-like 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
46785,54928 46785 - "Winged helix" DNA-binding domain 54928 - RNA-binding domain, RBD | 0 | DIRECT |
57184,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | DIRECT |
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0 | DIRECT |
54211,54980 54211 - Ribosomal protein S5 domain 2-like 54980 - EF-G C-terminal domain-like | 0 | DIRECT |
54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | DIRECT |
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like | 0 | DIRECT |
63748,63748 63748 - Tudor/PWWP/MBT 63748 - Tudor/PWWP/MBT | 0 | DIRECT |
54980,54211 54980 - EF-G C-terminal domain-like 54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat | 0 | DIRECT |
55681,52954 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related | 0 | DIRECT |
52440,56059 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like | 0 | DIRECT |
101912,103575 101912 - Sema domain 103575 - Plexin repeat | 0 | DIRECT |
52058,52058 52058 - L domain-like 52058 - L domain-like | 0 | DIRECT |
50044,52540 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
55753,55753 55753 - Actin depolymerizing proteins 55753 - Actin depolymerizing proteins | 0 | DIRECT |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0 | DIRECT |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0 | DIRECT |
111418,81321 111418 - Hormone receptor domain 81321 - Family A G protein-coupled receptor-like | 0 | DIRECT |
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin | 0 | DIRECT |
52949,53187 52949 - Macro domain-like 53187 - Zn-dependent exopeptidases | 0 | DIRECT |
56059,52210 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
52058,48726 52058 - L domain-like 48726 - Immunoglobulin | 0 | DIRECT |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger | 0 | DIRECT |
49899,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin | 0 | DIRECT |
57196,49854 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain | 0 | DIRECT |
50044,50044 50044 - SH3-domain 50044 - SH3-domain | 0 | DIRECT |
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
55550,50044 55550 - SH2 domain 50044 - SH3-domain | 0 | DIRECT |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52113,52113 52113 - BRCT domain 52113 - BRCT domain | 0 | DIRECT |
54534,48452 54534 - FKBP-like 48452 - TPR-like | 0 | DIRECT |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.1534 | INHERITED FROM: cell migration defective || cell adhesion defective |
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like | 0.209 | INHERITED FROM: auditory perception defective |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.2195 | INHERITED FROM: cell migration defective || cell adhesion defective |
51045,51045 51045 - WW domain 51045 - WW domain | 0.2464 | INHERITED FROM: increased cell number |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.3213 | INHERITED FROM: cell migration defective || cell adhesion defective |
48403,48403 48403 - Ankyrin repeat 48403 - Ankyrin repeat | 0.3346 | INHERITED FROM: sensory perception defective || chemosensitive behavior defective |
49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0.362 | INHERITED FROM: behavior defective || cell polarity defective |
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.3916 | INHERITED FROM: hyperplasia || planar polarity defective || increased occurrence of cell division || decreased occurrence of cell division |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.4292 | INHERITED FROM: visible |
101690,53098 101690 - PAZ domain 53098 - Ribonuclease H-like | 0.5377 | INHERITED FROM: modifier of variegation || mitotic cell cycle defective || suppressor of variegation || cell cycle defective |
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.6232 | INHERITED FROM: circadian rhythm defective || chemical resistant || phototaxis defective |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.6509 | INHERITED FROM: auditory perception defective || radiation sensitive || DNA repair defective |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 0.6728 | INHERITED FROM: cell polarity defective |
57625,57625 57625 - Invertebrate chitin-binding proteins 57625 - Invertebrate chitin-binding proteins | 0.7495 | INHERITED FROM: body size defective |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
48425,50729 48425 - Sec7 domain 50729 - PH domain-like | 0 | Direct |
50615,52540 50615 - N-terminal domain of alpha and beta subunits of F1 ATP synthase 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49417,81296 49417 - p53-like transcription factors 81296 - E set domains | 0 | Direct |
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like | 0 | Direct |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 0 | Direct |
50677,52374 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase | 0 | Direct |
57850,57850 57850 - RING/U-box 57850 - RING/U-box | 0 | Direct |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0 | Direct |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | Direct |
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0 | Direct |
54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like | 0 | Direct |
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like | 0 | Direct |
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain | 0 | Direct |
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM | 0 | Direct |
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region | 0 | Direct |
46689,46689 46689 - Homeodomain-like 46689 - Homeodomain-like | 0 | Direct |
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like | 0 | Direct |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0 | Direct |
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
101288,50156 101288 - L27 domain 50156 - PDZ domain-like | 0 | Direct |
55486,57552 55486 - Metalloproteases ("zincins"), catalytic domain 57552 - Blood coagulation inhibitor (disintegrin) | 0 | Direct |
47413,46689 47413 - lambda repressor-like DNA-binding domains 46689 - Homeodomain-like | 0 | Direct |
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0 | Direct |
56059,51246 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif | 0 | Direct |
57716,46689 57716 - Glucocorticoid receptor-like (DNA-binding domain) 46689 - Homeodomain-like | 0 | Direct |
55945,55945 55945 - TATA-box binding protein-like 55945 - TATA-box binding protein-like | 0 | Direct |
55021,56534 55021 - ACT-like 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
46785,54928 46785 - "Winged helix" DNA-binding domain 54928 - RNA-binding domain, RBD | 0 | Direct |
57184,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | Direct |
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0 | Direct |
54211,54980 54211 - Ribosomal protein S5 domain 2-like 54980 - EF-G C-terminal domain-like | 0 | Direct |
54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | Direct |
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like | 0 | Direct |
63748,63748 63748 - Tudor/PWWP/MBT 63748 - Tudor/PWWP/MBT | 0 | Direct |
54980,54211 54980 - EF-G C-terminal domain-like 54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat | 0 | Direct |
55681,52954 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related | 0 | Direct |
52440,56059 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like | 0 | Direct |
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like | 0 | Direct |
101912,103575 101912 - Sema domain 103575 - Plexin repeat | 0 | Direct |
52058,52058 52058 - L domain-like 52058 - L domain-like | 0 | Direct |
50044,52540 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
55753,55753 55753 - Actin depolymerizing proteins 55753 - Actin depolymerizing proteins | 0 | Direct |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0 | Direct |
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain | 0 | Direct |
111418,81321 111418 - Hormone receptor domain 81321 - Family A G protein-coupled receptor-like | 0 | Direct |
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin | 0 | Direct |
52949,53187 52949 - Macro domain-like 53187 - Zn-dependent exopeptidases | 0 | Direct |
56059,52210 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains | 0 | Direct |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
52058,48726 52058 - L domain-like 48726 - Immunoglobulin | 0 | Direct |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger | 0 | Direct |
49899,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin | 0 | Direct |
57196,49854 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain | 0 | Direct |
50044,50044 50044 - SH3-domain 50044 - SH3-domain | 0 | Direct |
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
55550,50044 55550 - SH2 domain 50044 - SH3-domain | 0 | Direct |
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52113,52113 52113 - BRCT domain 52113 - BRCT domain | 0 | Direct |
54534,48452 54534 - FKBP-like 48452 - TPR-like | 0 | Direct |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.1534 | Inherited |
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like | 0.209 | Inherited |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.2195 | Inherited |
51045,51045 51045 - WW domain 51045 - WW domain | 0.2464 | Inherited |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.3213 | Inherited |
48403,48403 48403 - Ankyrin repeat 48403 - Ankyrin repeat | 0.3346 | Inherited |
49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0.362 | Inherited |
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain | 0.3916 | Inherited |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.4292 | Inherited |
101690,53098 101690 - PAZ domain 53098 - Ribonuclease H-like | 0.5377 | Inherited |
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.6232 | Inherited |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.6509 | Inherited |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 0.6728 | Inherited |
57625,57625 57625 - Invertebrate chitin-binding proteins 57625 - Invertebrate chitin-binding proteins | 0.7495 | Inherited |
(show details)
Supra-domains annotated to this FP term (Not in SPFP)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,57850,57850 57850 - RING/U-box 57850 - RING/U-box 57850 - RING/U-box | 0 | DIRECT |
50615,52540,47917 50615 - N-terminal domain of alpha and beta subunits of F1 ATP synthase 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
55753,55753,55753 55753 - Actin depolymerizing proteins 55753 - Actin depolymerizing proteins 55753 - Actin depolymerizing proteins | 0 | DIRECT |
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat | 0 | DIRECT |
50156,50044,52540 50156 - PDZ domain-like 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52440,56059,51246 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif | 0 | DIRECT |
49265,48726,48726 49265 - Fibronectin type III 48726 - Immunoglobulin 48726 - Immunoglobulin | 0 | DIRECT |
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like | 0 | DIRECT |
101288,50156,50044 101288 - L27 domain 50156 - PDZ domain-like 50044 - SH3-domain | 0 | DIRECT |
48452,48452,48452 48452 - TPR-like 48452 - TPR-like 48452 - TPR-like | 0 | DIRECT |
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0 | DIRECT |
49899,57196,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin 57196 - EGF/Laminin | 0 | DIRECT |
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57184,57196,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57196 - EGF/Laminin | 0 | DIRECT |
57196,49899,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
52058,52058,52058 52058 - L domain-like 52058 - L domain-like 52058 - L domain-like | 0 | DIRECT |
57196,57184,57196 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | DIRECT |
54980,54211,54980 54980 - EF-G C-terminal domain-like 54211 - Ribosomal protein S5 domain 2-like 54980 - EF-G C-terminal domain-like | 0 | DIRECT |
81296,81296,81296 81296 - E set domains 81296 - E set domains 81296 - E set domains | 0 | DIRECT |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.04242 | INHERITED FROM: cell migration defective |
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.1303 | INHERITED FROM: cell migration defective || some die during embryonic stage || planar polarity defective || cell polarity defective || size defective || lethal - all die before end of first instar larval stage || cell adhesion defective || lethal - all die before end of embryonic stage |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.2203 | INHERITED FROM: cell adhesion defective |
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2867 | INHERITED FROM: auditory perception defective || sensory perception defective |
57625,57625,57625 57625 - Invertebrate chitin-binding proteins 57625 - Invertebrate chitin-binding proteins 57625 - Invertebrate chitin-binding proteins | 0.4579 | INHERITED FROM: size defective || body size defective |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 0.7195 | INHERITED FROM: cell polarity defective |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.8525 | INHERITED FROM: visible |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,57850,57850 57850 - RING/U-box 57850 - RING/U-box 57850 - RING/U-box | 0 | Direct |
50615,52540,47917 50615 - N-terminal domain of alpha and beta subunits of F1 ATP synthase 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
55753,55753,55753 55753 - Actin depolymerizing proteins 55753 - Actin depolymerizing proteins 55753 - Actin depolymerizing proteins | 0 | Direct |
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat | 0 | Direct |
50156,50044,52540 50156 - PDZ domain-like 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52440,56059,51246 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif | 0 | Direct |
49265,48726,48726 49265 - Fibronectin type III 48726 - Immunoglobulin 48726 - Immunoglobulin | 0 | Direct |
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like | 0 | Direct |
101288,50156,50044 101288 - L27 domain 50156 - PDZ domain-like 50044 - SH3-domain | 0 | Direct |
48452,48452,48452 48452 - TPR-like 48452 - TPR-like 48452 - TPR-like | 0 | Direct |
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0 | Direct |
49899,57196,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin 57196 - EGF/Laminin | 0 | Direct |
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57184,57196,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57196 - EGF/Laminin | 0 | Direct |
57196,49899,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
52058,52058,52058 52058 - L domain-like 52058 - L domain-like 52058 - L domain-like | 0 | Direct |
57196,57184,57196 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | Direct |
54980,54211,54980 54980 - EF-G C-terminal domain-like 54211 - Ribosomal protein S5 domain 2-like 54980 - EF-G C-terminal domain-like | 0 | Direct |
81296,81296,81296 81296 - E set domains 81296 - E set domains 81296 - E set domains | 0 | Direct |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.04242 | Inherited |
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.1303 | Inherited |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.2203 | Inherited |
52540,52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2867 | Inherited |
57625,57625,57625 57625 - Invertebrate chitin-binding proteins 57625 - Invertebrate chitin-binding proteins 57625 - Invertebrate chitin-binding proteins | 0.4579 | Inherited |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 0.7195 | Inherited |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.8525 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
 |
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|