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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this FP term (Not in SDFP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Skp1 dimerisation domain-like	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
Bromodomain	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
KA1-like	0	DIRECT
Nuclear receptor ligand-binding domain	0	DIRECT
HR1 repeat	0	DIRECT
S15/NS1 RNA-binding domain	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Orange domain-like	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Subtilisin-like	0	DIRECT
Sec7 domain	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Putative DNA-binding domain	0	DIRECT
Insulin-like	0	DIRECT
Lipocalins	0	DIRECT
Mob1/phocein	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Translational machinery components	0	DIRECT
SMAD MH1 domain	0	DIRECT
Taf5 N-terminal domain-like	0	DIRECT
SMAD/FHA domain	0	DIRECT
SAP domain	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
Nop domain	0	DIRECT
GINS helical bundle-like	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Restriction endonuclease-like	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
DNA/RNA polymerases	0	DIRECT
PIN domain-like	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
PreATP-grasp domain	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Aquaporin-like	0	DIRECT
TATA-box binding protein-like	0	DIRECT
PX domain	0	DIRECT
vWA-like	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
CBS-domain pair	0	DIRECT
Caspase-like	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Pectin lyase-like	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
ARID-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
ACP-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
SNARE-like	0	DIRECT
GroEL apical domain-like	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
Aldolase	0	DIRECT
Ribosomal protein L1	0	DIRECT
SPOC domain-like	0	DIRECT
Smc hinge domain	0	DIRECT
Tetrahydrobiopterin biosynthesis enzymes-like	0	DIRECT
Sema domain	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Cytokine	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
DNA-binding domain	0	DIRECT
Bet v1-like	0	DIRECT
YVTN repeat-like/Quinoprotein amine dehydrogenase	0	DIRECT
Spectrin repeat	0	DIRECT
Tropomyosin	0	DIRECT
Prefoldin	0	DIRECT
Integrin domains	0	DIRECT
Ferritin-like	0	DIRECT
Sm-like ribonucleoproteins	0	DIRECT
Toll/Interleukin receptor TIR domain	0	DIRECT
PriA/YqbF domain	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
CAD & PB1 domains	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Snake toxin-like	0	DIRECT
RNase III domain-like	0	DIRECT
Terpenoid synthases	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
SAND domain-like	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0	DIRECT
TIMP-like	0	DIRECT
JAB1/MPN domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
A DNA-binding domain in eukaryotic transcription factors	0	DIRECT
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
ACT-like	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Zinc beta-ribbon	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
DEATH domain	0	DIRECT
Plexin repeat	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
Nucleoporin domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
DEK C-terminal domain	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
HRDC-like	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
L27 domain	0	DIRECT
SAICAR synthase-like	0	DIRECT
Hormone receptor domain	0	DIRECT
PapD-like	0	DIRECT
Homeodomain-like	0.000002467	DIRECT
ARM repeat	0.0000182	DIRECT
SH3-domain	0.0000632	DIRECT
Protein kinase-like (PK-like)	0.0001282	DIRECT
EGF/Laminin	0.01287	INHERITED FROM: lethal - all die before end of first instar larval stage || lethal - all die before end of P-stage || lethal - all die before end of embryonic stage || cell migration defective || cell polarity defective || immune response defective || lethal - all die before end of prepupal stage || lethal - all die before end of pupal stage || size defective || lethal - all die before end of larval stage || planar polarity defective || some die during embryonic stage
Nucleotidylyl transferase	0.06585	INHERITED FROM: decreased cell size
beta-sandwich domain of Sec23/24	0.07766	INHERITED FROM: cell shape defective || lethal - all die before end of embryonic stage || lethal - all die before end of pupal stage || lethal - all die before end of larval stage || some die during larval stage
Cysteine-rich domain	0.07766	INHERITED FROM: wound healing defective
PDZ domain-like	0.0908	INHERITED FROM: cell polarity defective
Leucine zipper domain	0.09114	INHERITED FROM: increased mortality || lethal - all die before end of first instar larval stage || developmental rate defective || lethal - all die before end of pupal stage || lethal - all die before end of larval stage
EF-hand	0.1034	INHERITED FROM: flightless
Cyclin-like	0.1055	INHERITED FROM: mitotic cell cycle defective || cell cycle defective
beta-beta-alpha zinc fingers	0.1123	INHERITED FROM: visible
BRCT domain	0.1232	INHERITED FROM: radiation sensitive
Fibronectin type III	0.1416	INHERITED FROM: cell adhesion defective
SNARE fusion complex	0.1448	INHERITED FROM: uncoordinated || increased mortality during development || neurophysiology defective
FYVE/PHD zinc finger	0.1489	INHERITED FROM: modifier of variegation
Concanavalin A-like lectins/glucanases	0.1979	INHERITED FROM: cell polarity defective
C2 domain (Calcium/lipid-binding domain, CaLB)	0.2093	INHERITED FROM: neurophysiology defective
Tudor/PWWP/MBT	0.2177	INHERITED FROM: neoplasia
Periplasmic binding protein-like II	0.2271	INHERITED FROM: sensory perception defective || neurophysiology defective || feeding behavior defective
N-acetylmuramoyl-L-alanine amidase-like	0.2305	INHERITED FROM: immune response defective
Cysteine proteinases	0.238	INHERITED FROM: behavior defective
Chromo domain-like	0.2739	INHERITED FROM: suppressor of variegation || non-suppressor of variegation || modifier of variegation
HMG-box	0.2903	INHERITED FROM: visible
Ankyrin repeat	0.3077	INHERITED FROM: behavior defective || sensory perception defective || neurophysiology defective || thermotaxis behavior defective
Macro domain-like	0.3598	INHERITED FROM: sterile || male sterile
SH2 domain	0.3868	INHERITED FROM: planar polarity defective
Growth factor receptor domain	0.4172	INHERITED FROM: cell polarity defective || planar polarity defective
P-loop containing nucleoside triphosphate hydrolases	0.4245	INHERITED FROM: cell cycle defective
Cystine-knot cytokines	0.4659	INHERITED FROM: circadian rhythm defective
POZ domain	0.4776	INHERITED FROM: sleep defective || body color defective
SAM/Pointed domain	0.4841	INHERITED FROM: increased cell number
MIR domain	0.4846	INHERITED FROM: locomotor behavior defective
PAZ domain	0.4846	INHERITED FROM: suppressor of variegation || mitotic cell cycle defective || cell cycle defective || modifier of variegation
Glucocorticoid receptor-like (DNA-binding domain)	0.4892	INHERITED FROM: visible
Tubulin nucleotide-binding domain-like	0.5323	INHERITED FROM: cell cycle defective
Nicotinic receptor ligand binding domain-like	0.6001	INHERITED FROM: phototaxis defective || chemical resistant || circadian rhythm defective
Neurotransmitter-gated ion-channel transmembrane pore	0.6001	INHERITED FROM: phototaxis defective || chemical resistant || circadian rhythm defective
cAMP-binding domain-like	0.6001	INHERITED FROM: hyperactive || sensory perception defective
Cadherin-like	0.6001	INHERITED FROM: cell polarity defective
Voltage-gated potassium channels	0.61	INHERITED FROM: behavior defective || neurophysiology defective || chemical resistant || circadian rhythm defective || chemical sensitive
SCOP hierarchy in SUPERFAMILY	0.646	INHERITED FROM: Minute || cell lethal
Family A G protein-coupled receptor-like	0.7196	INHERITED FROM: behavior defective || hypoactive || mating defective
SET domain	0.7267	INHERITED FROM: suppressor of variegation || non-suppressor of variegation || homeotic || modifier of variegation
Immunoglobulin	0.7734	INHERITED FROM: cell migration defective
Nucleotide cyclase	0.8389	INHERITED FROM: taste perception defective
NAD(P)-binding Rossmann-fold domains	0.9361	INHERITED FROM: electrophoretic variant
alpha/beta-Hydrolases	1	INHERITED FROM: electrophoretic variant

Family domains annotated to this FP term (Not in SDFP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0	DIRECT
PAPS sulfotransferase	0	DIRECT
Hairy Orange domain	0	DIRECT
Reprolysin-like	0	DIRECT
Calmodulin-like	0	DIRECT
Prefoldin	0	DIRECT
First domain of FERM	0	DIRECT
Aquaporin-like	0	DIRECT
Tropomyosin	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
Alcohol dehydrogenase-like, N-terminal domain	0	DIRECT
Sema domain	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Fibroblast growth factors (FGF)	0	DIRECT
Rhomboid-like	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
GroEL chaperone, ATPase domain	0	DIRECT
Taf5 N-terminal domain-like	0	DIRECT
MAM domain	0	DIRECT
BC C-terminal domain-like	0	DIRECT
Single strand DNA-binding domain, SSB	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
PLC-like (P variant)	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
A DNA-binding domain in eukaryotic transcription factors	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
Ferredoxin domains from multidomain proteins	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
RUNT domain	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
Acyl-carrier protein (ACP)	0	DIRECT
Armadillo repeat	0	DIRECT
Cyclin	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase, UCH	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Transcriptional factor domain	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
MIF4G domain-like	0	DIRECT
SMAD domain	0	DIRECT
T-box	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Forkhead DNA-binding domain	0	DIRECT
L27 domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
DEK C-terminal domain	0	DIRECT
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Gelsolin-like	0	DIRECT
Leucine aminopeptidase (Aminopeptidase A), N-terminal domain	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0	DIRECT
Nop domain	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
SMAD MH1 domain	0	DIRECT
Myb/SANT domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Neurolysin-like	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
IF2B-like	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
Transforming growth factor (TGF)-beta	0	DIRECT
a tRNA synthase domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
Nuclear receptor	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
Insulin-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0	DIRECT
Sec7 domain	0	DIRECT
Extracellular domain of cell surface receptors	0	DIRECT
MBT repeat	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
DEATH domain, DD	0	DIRECT
Hypoxia-inducible factor Hif2a, C-terminal domain	0	DIRECT
Smc hinge domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Succinyl-CoA synthetase, beta-chain, N-terminal domain	0	DIRECT
Translational machinery components	0	DIRECT
Nitrogenase iron protein-like	0	DIRECT
Paired domain	0	DIRECT
Caspase catalytic domain	0	DIRECT
ARID domain	0	DIRECT
PX domain	0	DIRECT
Enabled/VASP homology 1 domain (EVH1 domain)	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
Arrestin/Vps26-like	0	DIRECT
Laminin-type module	0	DIRECT
La domain	0	DIRECT
GroEL-like chaperone, intermediate domain	0	DIRECT
Subtilases	0	DIRECT
Hormone receptor domain	0	DIRECT
Rel/Dorsal transcription factors, DNA-binding domain	0	DIRECT
Zf-UBP	0	DIRECT
Astacin	0	DIRECT
Bromodomain	0	DIRECT
Spectrin repeat	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
Ngr ectodomain-like	0	DIRECT
CBS-domain pair	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Pointed domain	0	DIRECT
Histidine acid phosphatase	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
HR1 repeat	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Diap1 N-terninal region-like	0	DIRECT
GroEL-like chaperone, apical domain	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
RNase III catalytic domain-like	0	DIRECT
S-adenosylhomocystein hydrolase	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Plexin repeat	0	DIRECT
Double-stranded RNA-binding domain (dsRBD)	0	DIRECT
CAD domain	0	DIRECT
GMC oxidoreductases	0	DIRECT
SAP domain	0	DIRECT
Chromo barrel domain	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
BAR domain	0	DIRECT
POU-specific domain	0	DIRECT
Toll/Interleukin receptor TIR domain	0	DIRECT
Mob1/phocein	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
Leucine aminopeptidase, C-terminal domain	0	DIRECT
Integrin domains	0	DIRECT
L-arabinose binding protein-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
Penta-EF-hand proteins	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
BC N-terminal domain-like	0	DIRECT
Laminin G-like module	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
FHA domain	0	DIRECT
Isoprenyl diphosphate synthases	0	DIRECT
ets domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
NHL repeat	0	DIRECT
Dachshund-homology domain	0	DIRECT
Nuclear receptor ligand-binding domain	0	DIRECT
H-NOX domain	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
ZZ domain	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
MSP-like	0	DIRECT
TATA-box binding protein (TBP), C-terminal domain	0	DIRECT
Protein serine/threonine phosphatase	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
Protein kinases, catalytic subunit	0.000005168	DIRECT
Homeodomain	0.00002152	DIRECT
SH3-domain	0.0001415	DIRECT
PDZ domain	0.01808	INHERITED FROM: cell polarity defective
Motor proteins	0.02953	INHERITED FROM: lethal - all die before end of first instar larval stage || lethal - all die before end of embryonic stage || cell cycle defective || lethal - all die before end of larval stage || auditory perception defective
I set domains	0.05501	INHERITED FROM: cell migration defective
EGF-type module	0.07455	INHERITED FROM: hyperplasia || cell shape defective || cell polarity defective || some die during pupal stage || tumorigenic || increased occurrence of cell division || lethal - all die before end of prepupal stage || decreased occurrence of cell division || lethal - all die before end of larval stage || increased cell number || planar polarity defective
Tandem AAA-ATPase domain	0.08922	INHERITED FROM: increased mortality || DNA repair defective || radiation sensitive
Leucine zipper domain	0.09996	INHERITED FROM: lethal - all die before end of first instar larval stage || developmental rate defective || lethal - all die before end of pupal stage || lethal - all die before end of larval stage
Phosphate binding protein-like	0.09996	INHERITED FROM: smell perception defective || neurophysiology defective
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0.1553	INHERITED FROM: cell size defective || decreased cell size
SAM (sterile alpha motif) domain	0.1801	INHERITED FROM: neoplasia || homeotic
Fibronectin type III	0.1934	INHERITED FROM: cell adhesion defective
PHD domain	0.2259	INHERITED FROM: homeotic || modifier of variegation
Classic zinc finger, C2H2	0.2291	INHERITED FROM: visible
Dual specificity phosphatase-like	0.2365	INHERITED FROM: chemical resistant
N-acetylmuramoyl-L-alanine amidase-like	0.2365	INHERITED FROM: immune response defective
Tetramerization domain of potassium channels	0.364	INHERITED FROM: sleep defective || neurophysiology defective || mating defective || circadian rhythm defective || courtship behavior defective
Ankyrin repeat	0.3943	INHERITED FROM: behavior defective || sensory perception defective || neurophysiology defective || thermotaxis behavior defective
Extended AAA-ATPase domain	0.4026	INHERITED FROM: bang sensitive
Pancreatic lipase, N-terminal domain	0.4217	INHERITED FROM: electrophoretic variant
Glutathione peroxidase-like	0.4217	INHERITED FROM: stress response defective
SH2 domain	0.4331	INHERITED FROM: planar polarity defective
Growth factor receptor domain	0.4537	INHERITED FROM: cell polarity defective || immune response defective || planar polarity defective
MIR domain	0.4848	INHERITED FROM: locomotor behavior defective
UBA domain	0.4848	INHERITED FROM: increased cell death
Synaptotagmin-like (S variant)	0.4989	INHERITED FROM: neurophysiology defective
Tubulin, GTPase domain	0.5555	INHERITED FROM: cell cycle defective
PAZ domain	0.5644	INHERITED FROM: suppressor of variegation || mitotic cell cycle defective || cell cycle defective || modifier of variegation
Rhodopsin-like	0.5697	INHERITED FROM: behavior defective || hypoactive || mating defective || courtship behavior defective
Neurotransmitter-gated ion-channel transmembrane pore	0.6346	INHERITED FROM: phototaxis defective || chemical resistant || circadian rhythm defective
cAMP-binding domain	0.6792	INHERITED FROM: hyperactive || sensory perception defective
Cadherin	0.6792	INHERITED FROM: cell polarity defective
G proteins	0.7127	INHERITED FROM: immune response defective || body size defective
Acetylcholinesterase-like	0.7588	INHERITED FROM: electrophoretic variant
Nicotinic receptor ligand binding domain-like	0.764	INHERITED FROM: phototaxis defective || chemical resistant
Voltage-gated potassium channels	0.8193	INHERITED FROM: neurophysiology defective
Adenylyl and guanylyl cyclase catalytic domain	0.8609	INHERITED FROM: taste perception defective
Neutral endopeptidase (neprilysin)	0.9629	INHERITED FROM: female semi-sterile || semi-sterile

Trees by TreeVector

A presence/absence matrix is generated using protein domain architecture data for all genomes in SUPERFAMILY. The PAUP software is used to produce a single, large tree topology using heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as if individual trees had been produced. However, this data is extracted from the single large tree. This produces a higher quality topology than if the trees had been produced on their own, and allows the trees to be displayed instantly.

Supra-domains annotated to this FP term (Not in SPFP)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Zn-binding ribosomal proteins	0	DIRECT
Mob1/phocein	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
HRDC-like	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Translational machinery components	0	DIRECT
CAD & PB1 domains	0	DIRECT
KA1-like	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
PIN domain-like	0	DIRECT
HR1 repeat	0	DIRECT
Lipocalins	0	DIRECT
PapD-like	0	DIRECT
SAICAR synthase-like	0	DIRECT
Toll/Interleukin receptor TIR domain	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
ARID-like	0	DIRECT
A DNA-binding domain in eukaryotic transcription factors	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
GINS helical bundle-like	0	DIRECT
TIMP-like	0	DIRECT
Ferritin-like	0	DIRECT
ACT-like	0	DIRECT
Sm-like ribonucleoproteins	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
SAP domain	0	DIRECT
Aquaporin-like	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
SPOC domain-like	0	DIRECT
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Hormone receptor domain	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
Taf5 N-terminal domain-like	0	DIRECT
SNARE-like	0	DIRECT
L27 domain	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
DNA/RNA polymerases	0	DIRECT
Sema domain	0	DIRECT
Tetrahydrobiopterin biosynthesis enzymes-like	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
YVTN repeat-like/Quinoprotein amine dehydrogenase	0	DIRECT
Insulin-like	0	DIRECT
TATA-box binding protein-like	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Prefoldin	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
DNA-binding domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Nucleoporin domain	0	DIRECT
Bet v1-like	0	DIRECT
DEATH domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
Putative DNA-binding domain	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Bromodomain	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
Zinc beta-ribbon	0	DIRECT
Nop domain	0	DIRECT
Snake toxin-like	0	DIRECT
vWA-like	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
SMAD MH1 domain	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
ACP-like	0	DIRECT
Plexin repeat	0	DIRECT
CBS-domain pair	0	DIRECT
Nuclear receptor ligand-binding domain	0	DIRECT
DEK C-terminal domain	0	DIRECT
SAND domain-like	0	DIRECT
PriA/YqbF domain	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
SMAD/FHA domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Restriction endonuclease-like	0	DIRECT
RNase III domain-like	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Tropomyosin	0	DIRECT
Sec7 domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
Integrin domains	0	DIRECT
Cytokine	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
GroEL apical domain-like	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
S15/NS1 RNA-binding domain	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
JAB1/MPN domain	0	DIRECT
Terpenoid synthases	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
Pectin lyase-like	0	DIRECT
Aldolase	0	DIRECT
Subtilisin-like	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0	DIRECT
Smc hinge domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
Caspase-like	0	DIRECT
Orange domain-like	0	DIRECT
PX domain	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
Spectrin repeat	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
PreATP-grasp domain	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Homeodomain-like	0.000001832	DIRECT
ARM repeat	0.00001372	DIRECT
SH3-domain	0.00004799	DIRECT
Protein kinase-like (PK-like)	0.00009805	DIRECT
"Winged helix" DNA-binding domain	0.0009399	DIRECT
EGF/Laminin	0.01061	INHERITED FROM: size defective || lethal - all die before end of first instar larval stage || some die during embryonic stage || lethal - all die before end of larval stage || lethal - all die before end of prepupal stage || lethal - all die before end of embryonic stage || planar polarity defective || cell migration defective || immune response defective || lethal - all die before end of pupal stage || cell polarity defective || lethal - all die before end of P-stage || cell adhesion defective
Nucleotidylyl transferase	0.05664	INHERITED FROM: decreased cell size
p53-like transcription factors	0.05664	INHERITED FROM: immune response defective || increased cell size
beta-sandwich domain of Sec23/24	0.06706	INHERITED FROM: lethal - all die before end of first instar larval stage || cell shape defective || some die during larval stage || lethal - all die before end of larval stage || lethal - all die before end of embryonic stage || lethal - all die before end of pupal stage
Cysteine-rich domain	0.06706	INHERITED FROM: wound healing defective
PDZ domain-like	0.07896	INHERITED FROM: cell polarity defective
Leucine zipper domain	0.07931	INHERITED FROM: lethal - all die before end of first instar larval stage || developmental rate defective || lethal - all die before end of larval stage || lethal - all die before end of pupal stage || increased mortality
EF-hand	0.09042	INHERITED FROM: flightless
Cyclin-like	0.09191	INHERITED FROM: cell cycle defective || cell number defective || mitotic cell cycle defective
beta-beta-alpha zinc fingers	0.09791	INHERITED FROM: visible
BRCT domain	0.1072	INHERITED FROM: radiation sensitive
Fibronectin type III	0.1239	INHERITED FROM: cell adhesion defective
SNARE fusion complex	0.1267	INHERITED FROM: increased mortality during development || neurophysiology defective || uncoordinated
FYVE/PHD zinc finger	0.1306	INHERITED FROM: modifier of variegation
Concanavalin A-like lectins/glucanases	0.1753	INHERITED FROM: cell polarity defective
C2 domain (Calcium/lipid-binding domain, CaLB)	0.1853	INHERITED FROM: neurophysiology defective
Tudor/PWWP/MBT	0.1935	INHERITED FROM: neoplasia || sterile
Periplasmic binding protein-like II	0.2019	INHERITED FROM: feeding behavior defective || neurophysiology defective || sensory perception defective
N-acetylmuramoyl-L-alanine amidase-like	0.205	INHERITED FROM: immune response defective
Cysteine proteinases	0.2125	INHERITED FROM: behavior defective
Chromo domain-like	0.2473	INHERITED FROM: modifier of variegation || non-suppressor of variegation || suppressor of variegation
HMG-box	0.2632	INHERITED FROM: visible
Ankyrin repeat	0.2794	INHERITED FROM: thermotaxis behavior defective || behavior defective || neurophysiology defective || sensory perception defective
Macro domain-like	0.3302	INHERITED FROM: sterile || male sterile
SH2 domain	0.3556	INHERITED FROM: visible || planar polarity defective
Growth factor receptor domain	0.3863	INHERITED FROM: planar polarity defective || cell polarity defective
P-loop containing nucleoside triphosphate hydrolases	0.3934	INHERITED FROM: cell cycle defective
Cystine-knot cytokines	0.434	INHERITED FROM: circadian rhythm defective
POZ domain	0.4455	INHERITED FROM: sleep defective || body color defective
SAM/Pointed domain	0.4523	INHERITED FROM: increased cell number
PAZ domain	0.4527	INHERITED FROM: modifier of variegation || cell cycle defective || mitotic cell cycle defective || suppressor of variegation
MIR domain	0.4527	INHERITED FROM: locomotor behavior defective
Glucocorticoid receptor-like (DNA-binding domain)	0.4571	INHERITED FROM: visible
Tubulin nucleotide-binding domain-like	0.5004	INHERITED FROM: cell cycle defective
cAMP-binding domain-like	0.5688	INHERITED FROM: sensory perception defective || hyperactive
Neurotransmitter-gated ion-channel transmembrane pore	0.5688	INHERITED FROM: circadian rhythm defective || phototaxis defective || chemical resistant
Cadherin-like	0.5688	INHERITED FROM: cell polarity defective
Nicotinic receptor ligand binding domain-like	0.5688	INHERITED FROM: circadian rhythm defective || phototaxis defective || chemical resistant
Voltage-gated potassium channels	0.5787	INHERITED FROM: behavior defective || circadian rhythm defective || chemical sensitive || neurophysiology defective || sensory perception defective || chemical resistant
Family A G protein-coupled receptor-like	0.6931	INHERITED FROM: mating defective || behavior defective || hypoactive
SET domain	0.7001	INHERITED FROM: modifier of variegation || homeotic || non-suppressor of variegation || suppressor of variegation
Immunoglobulin	0.747	INHERITED FROM: cell migration defective || cell adhesion defective
Nucleotide cyclase	0.8168	INHERITED FROM: taste perception defective
NAD(P)-binding Rossmann-fold domains	0.9209	INHERITED FROM: electrophoretic variant
alpha/beta-Hydrolases	1	INHERITED FROM: electrophoretic variant