•  SEARCH

  • Keyword search
  • Sequence search
• 
  

•  BROWSE

  •   Organisms
  • Taxonomy
  • Statistics
  •   SCOP
  • Hierarchy
  •   Ontologies
  • GO
  • EC
  • Phenotype
• 
  

•  TOOLS

  • Compare genomes
  • Phylogenetic trees
  • Web services
  • Downloads
• 
  

•  ABOUT

  • Description
  • Publications
  • Documentation
• 
  

•  HELP

  • User support
  • Contact us
  • Email list
  • Sitemap

Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:

• Disease Ontology (DO) Ontology (DO)
  DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
  
• Human Phenotype (HP) Ontology (HP)
  HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
  
• Mouse Phenotype (MP) Ontology (MP)
  MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
  
• Worm Phenotype (WP) Ontology (WP)
  WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
  
• Yeast Phenotype (YP) Ontology (YP)
  Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
  
• Fly Phenotype (FP) Ontology (FP)
  FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
  
• Fly Anatomy (FA) Ontology (FA)
  FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
  
• Zebrafish Anatomy (ZA) Ontology (ZA)
  ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
  
• Xenopus Anatomy (XA) Ontology (XA)
  XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
  
• Arabidopsis Plant Ontology (AP) Ontology (AP)
  As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
  
• Enzyme Commission (EC) Ontology (EC)
  Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
  
• DrugBank ATC (DB) Ontology (DB)
  In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
  
• UniProtKB KeyWords (KW) Ontology (KW)
  Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
  
• UniProtKB UniPathway (UP) Ontology (UP)
  UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
  

Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
  
• Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations:
  For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
  

Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.

• Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
  
• Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations:
  For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
  

Superfamily domains annotated to this FP term (Not in SDFP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Aquaporin-like	0	DIRECT
Sema domain	0	DIRECT
Orange domain-like	0	DIRECT
L30e-like	0	DIRECT
GINS helical bundle-like	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0	DIRECT
ARID-like	0	DIRECT
Integrin domains	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
CBS-domain pair	0	DIRECT
Putative DNA-binding domain	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Ferritin-like	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
TIMP-like	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Tetrahydrobiopterin biosynthesis enzymes-like	0	DIRECT
RNase III domain-like	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
DEATH domain	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
Ribosomal protein L1	0	DIRECT
Nucleoporin domain	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Caspase-like	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
Mob1/phocein	0	DIRECT
PriA/YqbF domain	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Hormone receptor domain	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0	DIRECT
L27 domain	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Sec7 domain	0	DIRECT
CAD & PB1 domains	0	DIRECT
TATA-box binding protein-like	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
HR1 repeat	0	DIRECT
Smc hinge domain	0	DIRECT
SPOC domain-like	0	DIRECT
DEK C-terminal domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Prefoldin	0	DIRECT
KA1-like	0	DIRECT
Restriction endonuclease-like	0	DIRECT
A DNA-binding domain in eukaryotic transcription factors	0	DIRECT
Plexin repeat	0	DIRECT
Cytokine	0	DIRECT
Snake toxin-like	0	DIRECT
Bromodomain	0	DIRECT
Toll/Interleukin receptor TIR domain	0	DIRECT
Lipocalins	0	DIRECT
YVTN repeat-like/Quinoprotein amine dehydrogenase	0	DIRECT
S15/NS1 RNA-binding domain	0	DIRECT
Zinc beta-ribbon	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
PIN domain-like	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Bet v1-like	0	DIRECT
SAP domain	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
SMAD/FHA domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
vWA-like	0	DIRECT
ACT-like	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
HRDC-like	0	DIRECT
Ribosomal protein S5 domain 2-like	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
PX domain	0	DIRECT
Terpenoid synthases	0	DIRECT
Translational machinery components	0	DIRECT
SAND domain-like	0	DIRECT
PapD-like	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Tropomyosin	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
Nop domain	0	DIRECT
ACP-like	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
DNA-binding domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
Aldolase	0	DIRECT
Subtilisin-like	0	DIRECT
PreATP-grasp domain	0	DIRECT
Insulin-like	0	DIRECT
Spectrin repeat	0	DIRECT
Sm-like ribonucleoproteins	0	DIRECT
Taf5 N-terminal domain-like	0	DIRECT
Pectin lyase-like	0	DIRECT
GroEL apical domain-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
SAICAR synthase-like	0	DIRECT
Nuclear receptor ligand-binding domain	0	DIRECT
SNARE-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
DNA/RNA polymerases	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
JAB1/MPN domain	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
Homeodomain-like	0.000002727	DIRECT
ARM repeat	0.00002446	DIRECT
SH3-domain	0.00007519	DIRECT
Protein kinase-like (PK-like)	0.0001984	DIRECT
EGF/Laminin	0.01402	INHERITED FROM: lethal - all die before end of first instar larval stage || lethal - all die before end of pupal stage || lethal - all die before end of larval stage || cell polarity defective || lethal - all die before end of embryonic stage || immune response defective || size defective || lethal - all die before end of P-stage || lethal - all die before end of prepupal stage || some die during embryonic stage || planar polarity defective
Nucleotidylyl transferase	0.0687	INHERITED FROM: decreased cell size
beta-sandwich domain of Sec23/24	0.08083	INHERITED FROM: lethal - all die before end of pupal stage || lethal - all die before end of larval stage || lethal - all die before end of embryonic stage || some die during larval stage || cell shape defective
Cysteine-rich domain	0.08083	INHERITED FROM: wound healing defective
Leucine zipper domain	0.09382	INHERITED FROM: lethal - all die before end of first instar larval stage || lethal - all die before end of pupal stage || lethal - all die before end of larval stage || developmental rate defective || increased mortality
PDZ domain-like	0.09497	INHERITED FROM: cell polarity defective
Cyclin-like	0.1077	INHERITED FROM: mitotic cell cycle defective || cell cycle defective
Periplasmic binding protein-like II	0.1135	INHERITED FROM: feeding behavior defective || sensory perception defective || neurophysiology defective
EF-hand	0.1194	INHERITED FROM: flightless
BRCT domain	0.1261	INHERITED FROM: radiation sensitive
FYVE/PHD zinc finger	0.1272	INHERITED FROM: modifier of variegation
Fibronectin type III	0.1486	INHERITED FROM: cell adhesion defective
SNARE fusion complex	0.1486	INHERITED FROM: uncoordinated || neurophysiology defective || increased mortality during development
beta-beta-alpha zinc fingers	0.1577	INHERITED FROM: visible
Concanavalin A-like lectins/glucanases	0.2061	INHERITED FROM: cell polarity defective
C2 domain (Calcium/lipid-binding domain, CaLB)	0.2169	INHERITED FROM: neurophysiology defective
Tudor/PWWP/MBT	0.2247	INHERITED FROM: neoplasia
N-acetylmuramoyl-L-alanine amidase-like	0.2353	INHERITED FROM: immune response defective
Cysteine proteinases	0.2483	INHERITED FROM: behavior defective
Chromo domain-like	0.2799	INHERITED FROM: non-suppressor of variegation || suppressor of variegation || modifier of variegation
Ankyrin repeat	0.2802	INHERITED FROM: behavior defective || chemosensitive behavior defective || thermotaxis behavior defective || sensory perception defective || neurophysiology defective
Macro domain-like	0.3656	INHERITED FROM: sterile || male sterile
SCOP hierarchy in SUPERFAMILY	0.3946	INHERITED FROM: cell lethal || Minute
SH2 domain	0.3958	INHERITED FROM: planar polarity defective
P-loop containing nucleoside triphosphate hydrolases	0.4022	INHERITED FROM: cell cycle defective
Voltage-gated potassium channels	0.4264	INHERITED FROM: behavior defective || chemical resistant || neurophysiology defective || chemical sensitive
Growth factor receptor domain	0.4264	INHERITED FROM: cell polarity defective || planar polarity defective
POZ domain	0.4636	INHERITED FROM: sleep defective || body color defective
SAM/Pointed domain	0.4657	INHERITED FROM: increased cell number
Cystine-knot cytokines	0.4769	INHERITED FROM: circadian rhythm defective
PAZ domain	0.4908	INHERITED FROM: mitotic cell cycle defective || cell cycle defective || suppressor of variegation || modifier of variegation
RNA-binding domain, RBD	0.5299	INHERITED FROM: lethal
Tubulin nucleotide-binding domain-like	0.5391	INHERITED FROM: cell cycle defective
Ribonuclease H-like	0.5719	INHERITED FROM: melanotic mass phenotype
Glucocorticoid receptor-like (DNA-binding domain)	0.5828	INHERITED FROM: visible
cAMP-binding domain-like	0.6079	INHERITED FROM: sensory perception defective || hyperactive
Cadherin-like	0.6079	INHERITED FROM: cell polarity defective
Family A G protein-coupled receptor-like	0.6326	INHERITED FROM: behavior defective || hypoactive || mating defective
Neurotransmitter-gated ion-channel transmembrane pore	0.6518	INHERITED FROM: phototaxis defective || chemical resistant
Nicotinic receptor ligand binding domain-like	0.6518	INHERITED FROM: phototaxis defective || chemical resistant
SET domain	0.7326	INHERITED FROM: homeotic || non-suppressor of variegation || suppressor of variegation || modifier of variegation
Immunoglobulin	0.7885	INHERITED FROM: cell migration defective
Nucleotide cyclase	0.8452	INHERITED FROM: taste perception defective
NAD(P)-binding Rossmann-fold domains	0.9439	INHERITED FROM: electrophoretic variant
alpha/beta-Hydrolases	1	INHERITED FROM: electrophoretic variant

Family domains annotated to this FP term (Not in SDFP)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Single strand DNA-binding domain, SSB	0	DIRECT
Hypoxia-inducible factor Hif2a, C-terminal domain	0	DIRECT
TBP-associated factors, TAFs	0	DIRECT
Myb/SANT domain	0	DIRECT
DEK C-terminal domain	0	DIRECT
Ngr ectodomain-like	0	DIRECT
beta-CASP RNA-metabolising hydrolases	0	DIRECT
Isoprenyl diphosphate synthases	0	DIRECT
Subtilases	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Extracellular domain of cell surface receptors	0	DIRECT
MIF4G domain-like	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
Ferredoxin domains from multidomain proteins	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
Astacin	0	DIRECT
Leucine aminopeptidase (Aminopeptidase A), N-terminal domain	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
Forkhead DNA-binding domain	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Penta-EF-hand proteins	0	DIRECT
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0	DIRECT
CAD domain	0	DIRECT
ZZ domain	0	DIRECT
Armadillo repeat	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
FHA domain	0	DIRECT
Transforming growth factor (TGF)-beta	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
GroEL-like chaperone, intermediate domain	0	DIRECT
H-NOX domain	0	DIRECT
Transcriptional factor domain	0	DIRECT
L-arabinose binding protein-like	0	DIRECT
Aquaporin-like	0	DIRECT
Histidine acid phosphatase	0	DIRECT
Protein serine/threonine phosphatase	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
MBT repeat	0	DIRECT
Fibroblast growth factors (FGF)	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
T-box	0	DIRECT
Nuclear receptor	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
L30e/L7ae ribosomal proteins	0	DIRECT
BC C-terminal domain-like	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
Paired domain	0	DIRECT
La domain	0	DIRECT
ARID domain	0	DIRECT
Clathrin coat assembly domain	0	DIRECT
Laminin-type module	0	DIRECT
Neurolysin-like	0	DIRECT
SMAD MH1 domain	0	DIRECT
Bromodomain	0	DIRECT
Clathrin adaptor core protein	0	DIRECT
S-adenosylhomocystein hydrolase	0	DIRECT
Acyl-carrier protein (ACP)	0	DIRECT
Calmodulin-like	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Tropomyosin	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
BAR domain	0	DIRECT
B-box zinc-binding domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Nop domain	0	DIRECT
Nuclear receptor ligand-binding domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
GMC oxidoreductases	0	DIRECT
SAP domain	0	DIRECT
Sema domain	0	DIRECT
RUNT domain	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase, UCH	0	DIRECT
MSP-like	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
IF2B-like	0	DIRECT
Laminin G-like module	0	DIRECT
Dachshund-homology domain	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
Sec7 domain	0	DIRECT
Group II chaperonin (CCT, TRIC), ATPase domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
Gelsolin-like	0	DIRECT
Rhomboid-like	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
RecA protein-like (ATPase-domain)	0	DIRECT
Leucine aminopeptidase, C-terminal domain	0	DIRECT
Smc hinge domain	0	DIRECT
Hormone receptor domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
Diap1 N-terninal region-like	0	DIRECT
Plexin repeat	0	DIRECT
Spectrin repeat	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Meta-cation ATPase, catalytic domain P	0	DIRECT
Insulin-like	0	DIRECT
Cyclin	0	DIRECT
PLC-like (P variant)	0	DIRECT
BC N-terminal domain-like	0	DIRECT
GroEL-like chaperone, apical domain	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
L27 domain	0	DIRECT
SMAD domain	0	DIRECT
ets domain	0	DIRECT
RNase III catalytic domain-like	0	DIRECT
Hairy Orange domain	0	DIRECT
Toll/Interleukin receptor TIR domain	0	DIRECT
a tRNA synthase domain	0	DIRECT
Calpain large subunit, catalytic domain (domain II)	0	DIRECT
Translational machinery components	0	DIRECT
NHL repeat	0	DIRECT
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
Alcohol dehydrogenase-like, N-terminal domain	0	DIRECT
Zf-UBP	0	DIRECT
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0	DIRECT
Succinyl-CoA synthetase, beta-chain, N-terminal domain	0	DIRECT
PAPS sulfotransferase	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Nitrogenase iron protein-like	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Group II chaperonin (CCT, TRIC), apical domain	0	DIRECT
Prefoldin	0	DIRECT
Reprolysin-like	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
First domain of FERM	0	DIRECT
POU-specific domain	0	DIRECT
DEATH domain, DD	0	DIRECT
Pointed domain	0	DIRECT
Integrin domains	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
Taf5 N-terminal domain-like	0	DIRECT
CBS-domain pair	0	DIRECT
HR1 repeat	0	DIRECT
Chromo barrel domain	0	DIRECT
Mob1/phocein	0	DIRECT
MAM domain	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Enabled/VASP homology 1 domain (EVH1 domain)	0	DIRECT
A DNA-binding domain in eukaryotic transcription factors	0	DIRECT
Inositol polyphosphate kinase (IPK)	0	DIRECT
Caspase catalytic domain	0	DIRECT
GroEL chaperone, ATPase domain	0	DIRECT
PX domain	0	DIRECT
Double-stranded RNA-binding domain (dsRBD)	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Rel/Dorsal transcription factors, DNA-binding domain	0	DIRECT
Arrestin/Vps26-like	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Eps15 homology domain (EH domain)	0	DIRECT
TATA-box binding protein (TBP), C-terminal domain	0	DIRECT
Protein kinases, catalytic subunit	0.000007202	DIRECT
Homeodomain	0.00002279	DIRECT
SH3-domain	0.0001667	DIRECT
Pleckstrin-homology domain (PH domain)	0.009906	INHERITED FROM: some die during embryonic stage
PDZ domain	0.01908	INHERITED FROM: cell polarity defective
Motor proteins	0.03119	INHERITED FROM: lethal - all die before end of first instar larval stage || cell cycle defective || lethal - all die before end of larval stage || auditory perception defective || lethal - all die before end of embryonic stage
I set domains	0.05729	INHERITED FROM: cell migration defective
EGF-type module	0.07803	INHERITED FROM: lethal - all die before end of larval stage || hyperplasia || cell polarity defective || some die during pupal stage || increased occurrence of cell division || decreased occurrence of cell division || tumorigenic || increased cell number || lethal - all die before end of prepupal stage || planar polarity defective || cell shape defective
Tandem AAA-ATPase domain	0.09482	INHERITED FROM: radiation sensitive || increased mortality || DNA repair defective
Phosphate binding protein-like	0.1036	INHERITED FROM: neurophysiology defective
Leucine zipper domain	0.1036	INHERITED FROM: lethal - all die before end of first instar larval stage || lethal - all die before end of pupal stage || lethal - all die before end of larval stage || developmental rate defective
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0.1595	INHERITED FROM: cell size defective || decreased cell size
SAM (sterile alpha motif) domain	0.185	INHERITED FROM: homeotic || neoplasia
Fibronectin type III	0.2021	INHERITED FROM: cell adhesion defective
PHD domain	0.2329	INHERITED FROM: homeotic || modifier of variegation
N-acetylmuramoyl-L-alanine amidase-like	0.2418	INHERITED FROM: immune response defective
Dual specificity phosphatase-like	0.2418	INHERITED FROM: chemical resistant
Classic zinc finger, C2H2	0.3236	INHERITED FROM: visible
Ankyrin repeat	0.3672	INHERITED FROM: behavior defective || chemosensitive behavior defective || thermotaxis behavior defective || sensory perception defective || neurophysiology defective
Tetramerization domain of potassium channels	0.3672	INHERITED FROM: sleep defective || courtship behavior defective || circadian rhythm defective || neurophysiology defective || mating defective
Extended AAA-ATPase domain	0.3824	INHERITED FROM: bang sensitive
Glutathione peroxidase-like	0.4248	INHERITED FROM: stress response defective
Pancreatic lipase, N-terminal domain	0.4248	INHERITED FROM: electrophoretic variant
SH2 domain	0.4418	INHERITED FROM: planar polarity defective
Rhodopsin-like	0.4524	INHERITED FROM: behavior defective || hypoactive || courtship behavior defective || mating defective
Growth factor receptor domain	0.4574	INHERITED FROM: cell polarity defective || immune response defective || planar polarity defective
Canonical RBD	0.4844	INHERITED FROM: lethal
UBA domain	0.4898	INHERITED FROM: increased cell death
Synaptotagmin-like (S variant)	0.5063	INHERITED FROM: neurophysiology defective
Tubulin, GTPase domain	0.5619	INHERITED FROM: cell cycle defective
PAZ domain	0.5688	INHERITED FROM: mitotic cell cycle defective || cell cycle defective || suppressor of variegation || modifier of variegation
Voltage-gated potassium channels	0.6585	INHERITED FROM: chemosensitive behavior defective || neurophysiology defective
Neurotransmitter-gated ion-channel transmembrane pore	0.6829	INHERITED FROM: phototaxis defective || temperature response defective || chemical resistant
cAMP-binding domain	0.6829	INHERITED FROM: sensory perception defective || hyperactive
Cadherin	0.6829	INHERITED FROM: cell polarity defective
G proteins	0.7288	INHERITED FROM: body size defective || immune response defective
Acetylcholinesterase-like	0.765	INHERITED FROM: electrophoretic variant
Nicotinic receptor ligand binding domain-like	0.7689	INHERITED FROM: phototaxis defective || chemical resistant
Adenylyl and guanylyl cyclase catalytic domain	0.8661	INHERITED FROM: taste perception defective
Neutral endopeptidase (neprilysin)	0.9652	INHERITED FROM: female semi-sterile || semi-sterile

Trees by TreeVector

A presence/absence matrix is generated using protein domain architecture data for all genomes in SUPERFAMILY. The PAUP software is used to produce a single, large tree topology using heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as if individual trees had been produced. However, this data is extracted from the single large tree. This produces a higher quality topology than if the trees had been produced on their own, and allows the trees to be displayed instantly.

Supra-domains annotated to this FP term (Not in SPFP)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
DNA-binding domain	0	DIRECT
Ribosomal L27 protein-like	0	DIRECT
Plexin repeat	0	DIRECT
DNA/RNA polymerases	0	DIRECT
HLH, helix-loop-helix DNA-binding domain	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
KA1-like	0	DIRECT
Tetrahydrobiopterin biosynthesis enzymes-like	0	DIRECT
Sm-like ribonucleoproteins	0	DIRECT
TATA-box binding protein-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Zn-binding ribosomal proteins	0	DIRECT
Class I glutamine amidotransferase-like	0	DIRECT
HR1 repeat	0	DIRECT
SMAD/FHA domain	0	DIRECT
SAP domain	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
SMAD MH1 domain	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
SPOC domain-like	0	DIRECT
Nuclear receptor ligand-binding domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
PYP-like sensor domain (PAS domain)	0	DIRECT
PriA/YqbF domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
vWA-like	0	DIRECT
ACT-like	0	DIRECT
Skp1 dimerisation domain-like	0	DIRECT
GINS helical bundle-like	0	DIRECT
GroEL-intermediate domain like	0	DIRECT
Restriction endonuclease-like	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Caspase-like	0	DIRECT
Cytokine	0	DIRECT
DEATH domain	0	DIRECT
Orange domain-like	0	DIRECT
Cysteine-rich DNA binding domain, (DM domain)	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
ThrRS/AlaRS common domain	0	DIRECT
Terpenoid synthases	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Aldolase	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Ferritin-like	0	DIRECT
Subtilisin-like	0	DIRECT
Regulator of G-protein signaling, RGS	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Toll/Interleukin receptor TIR domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Retrovirus zinc finger-like domains	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Integrin domains	0	DIRECT
GroEL apical domain-like	0	DIRECT
Snake toxin-like	0	DIRECT
HRDC-like	0	DIRECT
DEK C-terminal domain	0	DIRECT
Nucleoporin domain	0	DIRECT
Aquaporin-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
TIMP-like	0	DIRECT
S15/NS1 RNA-binding domain	0	DIRECT
GroEL equatorial domain-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
ARID-like	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Blood coagulation inhibitor (disintegrin)	0	DIRECT
B-box zinc-binding domain	0	DIRECT
Hormone receptor domain	0	DIRECT
JAB1/MPN domain	0	DIRECT
Lipocalins	0	DIRECT
beta and beta-prime subunits of DNA dependent RNA-polymerase	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
L30e-like	0	DIRECT
Sec7 domain	0	DIRECT
A DNA-binding domain in eukaryotic transcription factors	0	DIRECT
E2F-DP heterodimerization region	0	DIRECT
Transducin (alpha subunit), insertion domain	0	DIRECT
CBS-domain pair	0	DIRECT
Tropomyosin	0	DIRECT
SNARE-like	0	DIRECT
Nop domain	0	DIRECT
PX domain	0	DIRECT
lambda repressor-like DNA-binding domains	0	DIRECT
Translational machinery components	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Ribosomal protein S5 domain 2-like	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
Taf5 N-terminal domain-like	0	DIRECT
Smc hinge domain	0	DIRECT
SAICAR synthase-like	0	DIRECT
YVTN repeat-like/Quinoprotein amine dehydrogenase	0	DIRECT
Sema domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
PapD-like	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Mob1/phocein	0	DIRECT
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
CAD & PB1 domains	0	DIRECT
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Spectrin repeat	0	DIRECT
Putative DNA-binding domain	0	DIRECT
Bromodomain	0	DIRECT
SAND domain-like	0	DIRECT
Sec1/munc18-like (SM) proteins	0	DIRECT
L27 domain	0	DIRECT
RNase III domain-like	0	DIRECT
ACP-like	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
Translation proteins SH3-like domain	0	DIRECT
Periplasmic binding protein-like I	0	DIRECT
dsRNA-binding domain-like	0	DIRECT
Prefoldin	0	DIRECT
PreATP-grasp domain	0	DIRECT
Insulin-like	0	DIRECT
Pectin lyase-like	0	DIRECT
Bet v1-like	0	DIRECT
Zinc beta-ribbon	0	DIRECT
PIN domain-like	0	DIRECT
Homeodomain-like	0.000001983	DIRECT
ARM repeat	0.00001808	DIRECT
SH3-domain	0.00005622	DIRECT
Protein kinase-like (PK-like)	0.0001503	DIRECT
EGF/Laminin	0.01152	INHERITED FROM: some die during embryonic stage || planar polarity defective || lethal - all die before end of pupal stage || cell polarity defective || size defective || lethal - all die before end of first instar larval stage || lethal - all die before end of P-stage || lethal - all die before end of larval stage || immune response defective || lethal - all die before end of embryonic stage || lethal - all die before end of prepupal stage
p53-like transcription factors	0.05902	INHERITED FROM: increased cell size
Nucleotidylyl transferase	0.05902	INHERITED FROM: decreased cell size
beta-sandwich domain of Sec23/24	0.06971	INHERITED FROM: lethal - all die before end of pupal stage || lethal - all die before end of first instar larval stage || some die during larval stage || lethal - all die before end of larval stage || cell shape defective || lethal - all die before end of embryonic stage
Cysteine-rich domain	0.06971	INHERITED FROM: wound healing defective
Leucine zipper domain	0.08168	INHERITED FROM: developmental rate defective || lethal - all die before end of pupal stage || lethal - all die before end of first instar larval stage || lethal - all die before end of larval stage || increased mortality
PDZ domain-like	0.08283	INHERITED FROM: cell polarity defective
Cyclin-like	0.09426	INHERITED FROM: mitotic cell cycle defective || cell cycle defective
Periplasmic binding protein-like II	0.0993	INHERITED FROM: sensory perception defective || feeding behavior defective || neurophysiology defective
EF-hand	0.1043	INHERITED FROM: flightless
BRCT domain	0.1101	INHERITED FROM: radiation sensitive
FYVE/PHD zinc finger	0.111	INHERITED FROM: modifier of variegation
Fibronectin type III	0.1303	INHERITED FROM: cell adhesion defective
SNARE fusion complex	0.1303	INHERITED FROM: uncoordinated || increased mortality during development || neurophysiology defective
beta-beta-alpha zinc fingers	0.1382	INHERITED FROM: visible
Concanavalin A-like lectins/glucanases	0.1819	INHERITED FROM: cell polarity defective
C2 domain (Calcium/lipid-binding domain, CaLB)	0.1921	INHERITED FROM: neurophysiology defective
Tudor/PWWP/MBT	0.1987	INHERITED FROM: sterile || neoplasia
N-acetylmuramoyl-L-alanine amidase-like	0.209	INHERITED FROM: immune response defective
Cysteine proteinases	0.2217	INHERITED FROM: behavior defective
Chromo domain-like	0.2523	INHERITED FROM: modifier of variegation || non-suppressor of variegation || suppressor of variegation
Ankyrin repeat	0.2527	INHERITED FROM: behavior defective || sensory perception defective || neurophysiology defective || thermotaxis behavior defective || chemosensitive behavior defective
HMG-box	0.2711	INHERITED FROM: visible
Macro domain-like	0.3346	INHERITED FROM: sterile || male sterile
SH2 domain	0.3631	INHERITED FROM: planar polarity defective || visible
P-loop containing nucleoside triphosphate hydrolases	0.3694	INHERITED FROM: cell cycle defective
Voltage-gated potassium channels	0.394	INHERITED FROM: behavior defective || circadian rhythm defective || chemical sensitive || chemical resistant || neurophysiology defective
Growth factor receptor domain	0.394	INHERITED FROM: planar polarity defective || cell polarity defective
POZ domain	0.4305	INHERITED FROM: sleep defective || body color defective
SAM/Pointed domain	0.4326	INHERITED FROM: increased cell number
Cystine-knot cytokines	0.4432	INHERITED FROM: circadian rhythm defective
PAZ domain	0.4579	INHERITED FROM: modifier of variegation || mitotic cell cycle defective || suppressor of variegation || cell cycle defective
RNA-binding domain, RBD	0.4973	INHERITED FROM: lethal
Tubulin nucleotide-binding domain-like	0.507	INHERITED FROM: cell cycle defective
Ribonuclease H-like	0.5408	INHERITED FROM: melanotic mass phenotype
Glucocorticoid receptor-like (DNA-binding domain)	0.5523	INHERITED FROM: visible
Cadherin-like	0.5769	INHERITED FROM: cell polarity defective
cAMP-binding domain-like	0.5769	INHERITED FROM: sensory perception defective || hyperactive
Family A G protein-coupled receptor-like	0.6027	INHERITED FROM: behavior defective || mating defective || hypoactive
Neurotransmitter-gated ion-channel transmembrane pore	0.6232	INHERITED FROM: circadian rhythm defective || chemical resistant || phototaxis defective
Nicotinic receptor ligand binding domain-like	0.6232	INHERITED FROM: circadian rhythm defective || chemical resistant || phototaxis defective
SET domain	0.7077	INHERITED FROM: modifier of variegation || non-suppressor of variegation || homeotic || suppressor of variegation
Immunoglobulin	0.7625	INHERITED FROM: cell migration defective
Nucleotide cyclase	0.8238	INHERITED FROM: taste perception defective
NAD(P)-binding Rossmann-fold domains	0.9289	INHERITED FROM: electrophoretic variant
alpha/beta-Hydrolases	1	INHERITED FROM: electrophoretic variant