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Phenotypic Abnormality (PA): Abnormality of the genitourinary system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the genitourinary system [HP:0000119] <5>(73|72) (80|28|9)
- 1:   Urogenital fistula [HP:0100589] <5>(1|0) (1|0|0)
- 1:   Abnormality of the urinary system [HP:0000079] <4>(38|41) (45|15|7)
- 1:   Neoplasm of the genitourinary tract [HP:0007379] <4>(7|6) (9|2|1)
- 1:   Abnormality of the genital system [HP:0000078] <3>(35|34) (37|10|3)
- 1:   Cloacal abnormality [HP:0012620] <2>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
NAD kinase/diacylglycerol kinase-like0Direct
Smc hinge domain0Direct
Sec63 N-terminal domain-like0Direct
Lamin A/C globular tail domain0Direct
Insulin-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
DNA-glycosylase0Direct
Methylglyoxal synthase-like0Direct
Restriction endonuclease-like0Direct
Zn-finger domain of Sec23/240Direct
PRTase-like0Direct
SAND domain-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Tricorn protease domain 20Direct
DNA repair protein MutS, domain III0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Putative DNA-binding domain0Direct
ARID-like0Direct
Ribonuclease H-like0.01284Inherited
ClpP/crotonase0.02023Inherited
Alkaline phosphatase-like0.02223Inherited
RING/U-box0.02441Inherited
NagB/RpiA/CoA transferase-like0.03981Inherited
Bromodomain0.04653Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.04839Inherited
SET domain0.05962Inherited
(Trans)glycosidases0.06329Inherited
STAT0.06407Inherited
Transcription factor STAT-4 N-domain0.06407Inherited
"Winged helix" DNA-binding domain0.06789Inherited
Clavaminate synthase-like0.07124Inherited
BRCT domain0.07291Inherited
WD40 repeat-like0.07991Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1025Inherited
Acyl-CoA dehydrogenase NM domain-like0.1025Inherited
GroEL equatorial domain-like0.1028Inherited
CalX-like0.1028Inherited
HMG-box0.1113Inherited
Actin-like ATPase domain0.1118Inherited
C-type lectin-like0.1451Inherited
FYVE/PHD zinc finger0.1604Inherited
Adenine nucleotide alpha hydrolases-like0.1609Inherited
GAF domain-like0.1635Inherited
L-aspartase-like0.1635Inherited
4Fe-4S ferredoxins0.1635Inherited
RuvA domain 2-like0.1635Inherited
Homeodomain-like0.168Inherited
Protein kinase-like (PK-like)0.1785Inherited
PreATP-grasp domain0.2021Inherited
HD-domain/PDEase-like0.2021Inherited
MHC antigen-recognition domain0.2332Inherited
RNA-binding domain, RBD0.2791Inherited
Glutathione synthetase ATP-binding domain-like0.3321Inherited
Acyl-CoA N-acyltransferases (Nat)0.3326Inherited
TPR-like0.3416Inherited
Clc chloride channel0.3735Inherited
Chromo domain-like0.4006Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.4088Inherited
Nuclear receptor ligand-binding domain0.4111Inherited
Fibrinogen C-terminal domain-like0.5195Inherited
Cysteine-rich domain0.5362Inherited
Mitochondrial carrier0.5395Inherited
Trypsin-like serine proteases0.6051Inherited
Cytochrome P4500.6139Inherited
Ribosomal protein S5 domain 2-like0.696Inherited
Complement control module/SCR domain0.7565Inherited
L domain-like0.8315Inherited
Family A G protein-coupled receptor-like0.8459Inherited
Cytokine0.8575Inherited
DEATH domain0.9542Inherited
TNF-like0.9763Inherited
Immunoglobulin1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Dual specificity phosphatase-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
DNA gyrase/MutL, N-terminal domain0Direct
DNA polymerase I0Direct
DIX domain0Direct
HCDH C-domain-like0Direct
IF2B-like0Direct
DNA gyrase/MutL, second domain0Direct
Cytochrome b50Direct
Integrin alpha N-terminal domain0Direct
TBP-associated factors, TAFs0Direct
XPF/Rad1/Mus81 nuclease0Direct
DNA repair protein MutS, domain III0Direct
Fibrinogen coiled-coil and central regions0Direct
Phosphoribosyltransferases (PRTases)0Direct
Smc hinge domain0Direct
Zn-finger domain of Sec23/240Direct
Cystathionine synthase-like0Direct
Formate/glycerate dehydrogenases, substrate-binding domain0Direct
Lamin A/C globular tail domain0Direct
beta-glycanases0Direct
Insulin-like0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
ARID domain0Direct
Diacylglycerol kinase-like0Direct
Sec63 N-terminal domain0Direct
PHD domain0.001074Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.01038Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.01038Inherited
Bromodomain0.03691Inherited
Histone lysine methyltransferases0.0381Inherited
Arylsulfatase0.0381Inherited
RecA protein-like (ATPase-domain)0.0381Inherited
Transcription factor STAT-4 N-domain0.05116Inherited
Crotonase-like0.05116Inherited
STAT0.05116Inherited
BC ATP-binding domain-like0.05116Inherited
BC N-terminal domain-like0.05116Inherited
POU-specific domain0.05116Inherited
STAT DNA-binding domain0.05116Inherited
CalX-beta domain0.08471Inherited
HMG-box0.0948Inherited
RING finger domain, C3HC40.0948Inherited
GAF domain0.1388Inherited
Extended AAA-ATPase domain0.1632Inherited
Cytoplasmic domain of inward rectifier potassium channel0.1764Inherited
Actin/HSP700.1764Inherited
Extracellular domain of cell surface receptors0.2041Inherited
Noncollagenous (NC1) domain of collagen IV0.2041Inherited
Homeodomain0.2052Inherited
MHC antigen-recognition domain0.2062Inherited
PDEase0.2472Inherited
WD40-repeat0.3024Inherited
C1 set domains (antibody constant domain-like)0.3205Inherited
ABC transporter ATPase domain-like0.332Inherited
Clc chloride channel0.3412Inherited
Chromo domain0.3688Inherited
Nuclear receptor0.3778Inherited
Nuclear receptor ligand-binding domain0.3854Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.4044Inherited
Canonical RBD0.4074Inherited
Fibrinogen C-terminal domain-like0.4885Inherited
Mitochondrial carrier0.5111Inherited
Fibroblast growth factors (FGF)0.5989Inherited
Eukaryotic proteases0.6465Inherited
Cytochrome P4500.6617Inherited
Complement control module/SCR domain0.7377Inherited
Rhodopsin-like0.8113Inherited
TNF-like0.97Inherited
Ngr ectodomain-like0.9798Inherited
Voltage-gated potassium channels0.9869Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Cytochrome b5-like heme/steroid binding domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
ARID-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Smc hinge domain0Direct
NAD kinase/diacylglycerol kinase-like0Direct
Sec63 N-terminal domain-like0Direct
Lamin A/C globular tail domain0Direct
Insulin-like0Direct
Zn-finger domain of Sec23/240Direct
DNA repair protein MutS, domain III0Direct
PRTase-like0Direct
Putative DNA-binding domain0Direct
SAND domain-like0Direct
Tricorn protease domain 20Direct
Methylglyoxal synthase-like0Direct
Restriction endonuclease-like0Direct
DNA-glycosylase0Direct
Ribonuclease H-like0.008443Inherited
Integrin domains0.009643Inherited
ClpP/crotonase0.01379Inherited
Alkaline phosphatase-like0.0153Inherited
RING/U-box0.01688Inherited
NagB/RpiA/CoA transferase-like0.02865Inherited
DNA/RNA polymerases0.02865Inherited
Bromodomain0.03401Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.03554Inherited
SET domain0.04471Inherited
(Trans)glycosidases0.04781Inherited
STAT0.04842Inherited
Transcription factor STAT-4 N-domain0.04842Inherited
"Winged helix" DNA-binding domain0.05156Inherited
Clavaminate synthase-like0.05438Inherited
BRCT domain0.05573Inherited
WD40 repeat-like0.06156Inherited
Acyl-CoA dehydrogenase NM domain-like0.08067Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.08067Inherited
CalX-like0.08096Inherited
GroEL equatorial domain-like0.08096Inherited
HMG-box0.08793Inherited
Actin-like ATPase domain0.08838Inherited
C-type lectin-like0.1182Inherited
FYVE/PHD zinc finger0.1315Inherited
Adenine nucleotide alpha hydrolases-like0.1319Inherited
GAF domain-like0.134Inherited
4Fe-4S ferredoxins0.134Inherited
RuvA domain 2-like0.134Inherited
L-aspartase-like0.134Inherited
Homeodomain-like0.1381Inherited
Protein kinase-like (PK-like)0.1475Inherited
HD-domain/PDEase-like0.1693Inherited
lambda repressor-like DNA-binding domains0.1693Inherited
PreATP-grasp domain0.1693Inherited
MHC antigen-recognition domain0.1978Inherited
RNA-binding domain, RBD0.2407Inherited
Glutathione synthetase ATP-binding domain-like0.2909Inherited
Acyl-CoA N-acyltransferases (Nat)0.2914Inherited
TPR-like0.3003Inherited
E set domains0.3046Inherited
Clc chloride channel0.3307Inherited
Chromo domain-like0.3573Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3654Inherited
Nuclear receptor ligand-binding domain0.3678Inherited
CBS-domain pair0.3758Inherited
ARM repeat0.3973Inherited
Fibrinogen C-terminal domain-like0.4752Inherited
Cysteine-rich domain0.4921Inherited
Mitochondrial carrier0.4956Inherited
Trypsin-like serine proteases0.5628Inherited
Cytochrome P4500.5721Inherited
Ribosomal protein S5 domain 2-like0.6571Inherited
Complement control module/SCR domain0.7197Inherited
L domain-like0.7981Inherited
Family A G protein-coupled receptor-like0.8131Inherited
Cytokine0.8255Inherited
DEATH domain0.9292Inherited
TNF-like0.9532Inherited
Voltage-gated potassium channels0.9643Inherited
Immunoglobulin0.9873Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
-7,56112
  • -7 - CATH
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.0225Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.04842Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.04842Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.04842Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.05573Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.07212Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.08067Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.134Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.134Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.134Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.1693Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.1971Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1978Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.4645Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.4956Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0Direct
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.04842Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.04842Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.08067Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0862Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1184Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.134Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.4752Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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