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Phenotypic Abnormality (PA): Abnormality of the eye

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the eye [HP:0000478] <2>(64|78) (69|38|28)
- 1:   Abnormal eye physiology [HP:0012373] <17>(34|47) (37|22|20)
- 1:   Abnormal eye morphology [HP:0012372] <12>(39|48) (41|29|22)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
gamma-Crystallin-like0Direct
Notch domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Smc hinge domain0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Pseudouridine synthase0Direct
Ribonuclease PH domain 2-like0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
BPTI-like0Direct
FKBP-like0Direct
NTF2-like0Direct
Hect, E3 ligase catalytic domain0Direct
Restriction endonuclease-like0Direct
Connexin430Direct
Helical domain of Sec23/240Direct
Zn-finger domain of Sec23/240Direct
Cyclophilin-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
Actin depolymerizing proteins0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
4Fe-4S ferredoxins0Direct
Tricorn protease domain 20Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Putative DNA-binding domain0Direct
ADC-like0Direct
RUN domain-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
TPR-like0.0005456Direct
Homeodomain-like0.03115Inherited
Concanavalin A-like lectins/glucanases0.04644Inherited
Ribosomal protein S5 domain 2-like0.08929Inherited
SCOP hierarchy in SUPERFAMILY0.1009Inherited
ARID-like0.126Inherited
Nicotinic receptor ligand binding domain-like0.1493Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1493Inherited
RING/U-box0.1513Inherited
Voltage-gated potassium channels0.1755Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1787Inherited
GroEL equatorial domain-like0.1787Inherited
GroEL apical domain-like0.1787Inherited
TB module/8-cys domain0.1787Inherited
CalX-like0.1787Inherited
Nucleotide-diphospho-sugar transferases0.2116Inherited
cAMP-binding domain-like0.2285Inherited
GAF domain-like0.2527Inherited
RuvA domain 2-like0.2527Inherited
HMG-box0.3068Inherited
Intermediate filament protein, coiled coil region0.3964Inherited
MHC antigen-recognition domain0.4207Inherited
vWA-like0.4376Inherited
(Trans)glycosidases0.4868Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.5036Inherited
Growth factor receptor domain0.5058Inherited
C-type lectin-like0.5166Inherited
RNI-like0.5492Inherited
Glycosyl hydrolase domain0.5939Inherited
FnI-like domain0.6892Inherited
Immunoglobulin0.7376Inherited
EGF/Laminin0.751Inherited
TNF receptor-like0.8273Inherited
SMAD/FHA domain0.8648Inherited
DEATH domain0.9026Inherited
Complement control module/SCR domain0.9879Inherited
Family A G protein-coupled receptor-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Neurotrophin0Direct
p120GAP domain-like0Direct
Prefoldin0Direct
Hect, E3 ligase catalytic domain0Direct
Protein serine/threonine phosphatase0Direct
Crystallins/Ca-binding development proteins0Direct
Small Kunitz-type inhibitors & BPTI-like toxins0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Notch domain0Direct
PWWP domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Ribonuclease PH domain 1-like0Direct
IF2B-like0Direct
Cytochrome b50Direct
Helical domain of Sec23/240Direct
FKBP immunophilin/proline isomerase0Direct
VWC domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
XPF/Rad1/Mus81 nuclease0Direct
Trunk domain of Sec23/240Direct
Ferredoxin domains from multidomain proteins0Direct
Histone deacetylase, HDAC0Direct
Ribonuclease PH domain 2-like0Direct
RUN domain0Direct
Smc hinge domain0Direct
Zn-finger domain of Sec23/240Direct
beta-sandwich domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A0Direct
RhoGDI-like0Direct
Clathrin adaptor core protein0Direct
Connexin430Direct
beta-glycanases0Direct
Glycosyl transferases group 10Direct
Proteasome subunits0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Tetratricopeptide repeat (TPR)0.00002895Direct
Laminin G-like module0.002271Inherited
G proteins0.02058Inherited
Homeodomain0.02241Inherited
PHD domain0.03195Inherited
Extended AAA-ATPase domain0.05106Inherited
Fibroblast growth factors (FGF)0.06872Inherited
Histone lysine methyltransferases0.095Inherited
ARID domain0.1003Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1187Inherited
Nicotinic receptor ligand binding domain-like0.1187Inherited
Phosphate binding protein-like0.1306Inherited
cAMP-binding domain0.1435Inherited
DNA gyrase/MutL, N-terminal domain0.1469Inherited
DNA gyrase/MutL, second domain0.1469Inherited
TB module/8-cys domain0.1469Inherited
Caspase recruitment domain, CARD0.1469Inherited
CalX-beta domain0.1469Inherited
Transglutaminase core0.1786Inherited
C1 set domains (antibody constant domain-like)0.1904Inherited
GAF domain0.2152Inherited
Arylsulfatase0.2448Inherited
FHA domain0.2448Inherited
RecA protein-like (ATPase-domain)0.2448Inherited
HMG-box0.261Inherited
Noncollagenous (NC1) domain of collagen IV0.3234Inherited
Intermediate filament protein, coiled coil region0.3443Inherited
MHC antigen-recognition domain0.3743Inherited
Bromodomain0.3958Inherited
BCR-homology GTPase activation domain (BH-domain)0.4244Inherited
Pyrin domain, PYD0.4298Inherited
28-residue LRR0.4574Inherited
EGF-type module0.5057Inherited
LDL receptor-like module0.5257Inherited
PDZ domain0.5332Inherited
DEATH domain, DD0.7253Inherited
I set domains0.7466Inherited
Integrin A (or I) domain0.7577Inherited
TSP-1 type 1 repeat0.8359Inherited
Complement control module/SCR domain0.9783Inherited
Rhodopsin-like1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Cytochrome b5-like heme/steroid binding domain0Direct
4Fe-4S ferredoxins0Direct
gamma-Crystallin-like0Direct
Actin depolymerizing proteins0Direct
RUN domain-like0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Pseudouridine synthase0Direct
Smc hinge domain0Direct
Connexin430Direct
Cyclophilin-like0Direct
FKBP-like0Direct
BPTI-like0Direct
Helical domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Notch domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Zn-finger domain of Sec23/240Direct
Ribonuclease PH domain 2-like0Direct
Putative DNA-binding domain0Direct
Tricorn protease domain 20Direct
NTF2-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
Restriction endonuclease-like0Direct
ADC-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Hect, E3 ligase catalytic domain0Direct
TPR-like0.0002778Direct
Homeodomain-like0.02194Inherited
Concanavalin A-like lectins/glucanases0.03394Inherited
Ribosomal protein S5 domain 2-like0.06944Inherited
ARID-like0.1011Inherited
Tudor/PWWP/MBT0.1185Inherited
Nicotinic receptor ligand binding domain-like0.1219Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1219Inherited
RING/U-box0.1236Inherited
Voltage-gated potassium channels0.1448Inherited
TB module/8-cys domain0.1477Inherited
GroEL apical domain-like0.1477Inherited
CalX-like0.1477Inherited
GroEL equatorial domain-like0.1477Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1477Inherited
Nucleotide-diphospho-sugar transferases0.1781Inherited
cAMP-binding domain-like0.1935Inherited
GAF domain-like0.2156Inherited
RuvA domain 2-like0.2156Inherited
PDZ domain-like0.222Inherited
Periplasmic binding protein-like II0.2477Inherited
HMG-box0.2668Inherited
Intermediate filament protein, coiled coil region0.3531Inherited
MHC antigen-recognition domain0.3769Inherited
vWA-like0.3938Inherited
Bromodomain0.3996Inherited
(Trans)glycosidases0.4429Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.4594Inherited
Growth factor receptor domain0.4615Inherited
C-type lectin-like0.4722Inherited
RNI-like0.5054Inherited
LDL receptor-like module0.5311Inherited
Glycosyl hydrolase domain0.5512Inherited
FnI-like domain0.6502Inherited
Immunoglobulin0.7Inherited
EGF/Laminin0.7138Inherited
TNF receptor-like0.7936Inherited
SMAD/FHA domain0.8332Inherited
TSP-1 type 1 repeat0.8332Inherited
DEATH domain0.8736Inherited
Complement control module/SCR domain0.9662Inherited
Family A G protein-coupled receptor-like0.9947Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.005845Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0829Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.1219Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.1477Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.1477Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.1477Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.1477Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.2156Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.2156Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.2156Inherited
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.2443Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.3051Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.3176Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.3769Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.3769Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.4022Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.4302Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4302Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.5058Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.5512Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.6545Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.6796Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.9457Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04629Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.06866Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.06866Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.06953Inherited
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.1459Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1477Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.1477Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.18Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.2156Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.4116Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.8529Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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