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Phenotypic Abnormality (PA): Abnormality of the ear

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the ear [HP:0000598] <2>(18|32) (22|13|10)
- 1:   Abnormal ear morphology [HP:0031703] <5>(15|26) (18|11|10)
- 1:   Abnormal ear physiology [HP:0031704] <2>(8|10) (10|4|6)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
ADC-like0Direct
JAB1/MPN domain0Direct
FabD/lysophospholipase-like0Direct
Smc hinge domain0Direct
Ribonuclease PH domain 2-like0Direct
L27 domain0Direct
Lamin A/C globular tail domain0Direct
RuvA domain 2-like0Direct
4Fe-4S ferredoxins0Direct
GroEL equatorial domain-like0.0565Inherited
SET domain0.06168Inherited
MIR domain0.0859Inherited
Bromodomain0.0902Inherited
Integrin domains0.1036Inherited
Acyl-CoA N-acyltransferases (Nat)0.2239Inherited
Transcription factor STAT-4 N-domain0.352Inherited
STAT0.352Inherited
Family A G protein-coupled receptor-like0.975Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Histone deacetylase, HDAC0Direct
Ribonuclease PH domain 1-like0Direct
Lipoxigenase N-terminal domain0Direct
RhoGDI-like0Direct
Ribonuclease PH domain 2-like0Direct
XPF/Rad1/Mus81 nuclease0Direct
L27 domain0Direct
Smc hinge domain0Direct
JAB1/MPN domain0Direct
Enabled/VASP homology 1 domain (EVH1 domain)0Direct
Ferredoxin domains from multidomain proteins0Direct
beta-glycanases0Direct
VWC domain0.01061Inherited
Arylsulfatase0.01093Inherited
Extended AAA-ATPase domain0.0179Inherited
ARID domain0.02121Inherited
PHD domain0.02186Inherited
Histone lysine methyltransferases0.04831Inherited
MIR domain0.0652Inherited
Bromodomain0.06749Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.07983Inherited
Integrin domains0.07986Inherited
G proteins0.1136Inherited
I set domains0.1542Inherited
C1 set domains (antibody constant domain-like)0.2751Inherited
Transcription factor STAT-4 N-domain0.3062Inherited
STAT0.3062Inherited
STAT DNA-binding domain0.3062Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.3671Inherited
Pleckstrin-homology domain (PH domain)0.7864Inherited
Rhodopsin-like0.9649Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Smc hinge domain0Direct
Lamin A/C globular tail domain0Direct
ADC-like0Direct
L27 domain0Direct
FabD/lysophospholipase-like0Direct
4Fe-4S ferredoxins0Direct
RuvA domain 2-like0Direct
Ribonuclease PH domain 2-like0Direct
JAB1/MPN domain0Direct
ARID-like0.02207Inherited
GroEL equatorial domain-like0.04252Inherited
SET domain0.0468Inherited
PDZ domain-like0.05858Inherited
MIR domain0.06687Inherited
Bromodomain0.07056Inherited
Integrin domains0.08188Inherited
Acyl-CoA N-acyltransferases (Nat)0.1897Inherited
Cysteine-rich domain0.2742Inherited
STAT0.3113Inherited
Transcription factor STAT-4 N-domain0.3113Inherited
Family A G protein-coupled receptor-like0.9517Inherited
Cysteine proteinases0.9703Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    52799,52799
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.04252Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.08053Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.1145Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.3113Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.3113Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.3113Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.06687Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0926Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1318Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3073Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.3113Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.3113Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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