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Phenotypic Abnormality (PA): Abnormality of the nervous system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the nervous system [HP:0000707] <4>(142|168) (156|103|45)
- 1:   Abnormality of nervous system physiology [HP:0012638] <26>(101|119) (112|81|39)
- 1:   Abnormality of nervous system morphology [HP:0012639] <5>(69|97) (79|52|16)
- 1:   Abnormality of the peripheral nervous system [HP:0410008] <3>(2|1) (2|2|0)
- 1:   Abnormality of ganglion [HP:0410014] <2>(0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
EF-G C-terminal domain-like0Direct
Notch domain0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Cyclin-like0Direct
SNARE fusion complex0Direct
PP2C-like0Direct
Subtilisin-like0Direct
LuxS/MPP-like metallohydrolase0Direct
S15/NS1 RNA-binding domain0Direct
CoA-dependent acyltransferases0Direct
Smc hinge domain0Direct
GroEL equatorial domain-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
SNF-like0Direct
GAF domain-like0Direct
Hook domain0Direct
CCCH zinc finger0Direct
CRAL/TRIO domain0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
Pseudouridine synthase0Direct
ValRS/IleRS/LeuRS editing domain0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
Apolipoprotein A-I0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Alkaline phosphatase-like0Direct
Ribonuclease PH domain 2-like0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
beta-sandwich domain of Sec23/240Direct
Calcium-dependent phosphotriesterase0Direct
Lamin A/C globular tail domain0Direct
L27 domain0Direct
Nicotinic receptor ligand binding domain-like0Direct
GroEL apical domain-like0Direct
FKBP-like0Direct
Methylglyoxal synthase-like0Direct
BRK domain-like0Direct
HIT-like0Direct
NTF2-like0Direct
Hect, E3 ligase catalytic domain0Direct
GroEL-intermediate domain like0Direct
L-aspartase-like0Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
Restriction endonuclease-like0Direct
TB module/8-cys domain0Direct
Helical domain of Sec23/240Direct
Zn-finger domain of Sec23/240Direct
Rhodanese/Cell cycle control phosphatase0Direct
Actin depolymerizing proteins0Direct
Arginase/deacetylase0Direct
Proton glutamate symport protein0Direct
DNA/RNA polymerases0Direct
SAND domain-like0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
Fibrinogen coiled-coil and central regions0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
STAT0Direct
4Fe-4S ferredoxins0Direct
CalX-like0Direct
Multidrug resistance efflux transporter EmrE0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
GroES-like0Direct
Tricorn protease domain 20Direct
Transcription factor STAT-4 N-domain0Direct
Thiolase-like0Direct
Translation proteins0Direct
JAB1/MPN domain0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Adenine nucleotide alpha hydrolases-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Putative DNA-binding domain0Direct
ADC-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
RuvA domain 2-like0Direct
UBA-like0Direct
DHS-like NAD/FAD-binding domain0Direct
Nucleotidylyl transferase0.01587Inherited
Voltage-gated potassium channels0.03402Inherited
Ribosomal protein S5 domain 2-like0.03559Inherited
Actin-like ATPase domain0.0524Inherited
Bromodomain0.0524Inherited
cAMP-binding domain-like0.07668Inherited
Ribonuclease H-like0.09262Inherited
Nucleotide-diphospho-sugar transferases0.09825Inherited
ARM repeat0.118Inherited
(Trans)glycosidases0.1493Inherited
Periplasmic binding protein-like II0.1626Inherited
WD40 repeat-like0.169Inherited
PreATP-grasp domain0.1947Inherited
Glycosyl hydrolase domain0.1947Inherited
Single hybrid motif0.1947Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.2512Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2518Inherited
Chaperone J-domain0.2727Inherited
GLA-domain0.2811Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.2811Inherited
MIR domain0.2811Inherited
GST C-terminal domain-like0.2811Inherited
SET domain0.2844Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.3138Inherited
Cysteine proteinases0.3144Inherited
Class II aaRS and biotin synthetases0.3194Inherited
RNI-like0.3209Inherited
HSP20-like chaperones0.3378Inherited
ARID-like0.3378Inherited
Kelch motif0.4047Inherited
Periplasmic binding protein-like I0.4047Inherited
Ypt/Rab-GAP domain of gyp1p0.4052Inherited
Sema domain0.4714Inherited
Mitochondrial carrier0.4775Inherited
Anaphylotoxins (complement system)0.4863Inherited
Cap-Gly domain0.4863Inherited
Rudiment single hybrid motif0.4863Inherited
DNA repair protein MutS, domain III0.4863Inherited
p53-like transcription factors0.5191Inherited
Alpha-macroglobulin receptor domain0.5353Inherited
Thioredoxin-like0.5368Inherited
RNA-binding domain, RBD0.5658Inherited
SH2 domain0.5949Inherited
NagB/RpiA/CoA transferase-like0.6038Inherited
MHC antigen-recognition domain0.6132Inherited
Tubulin nucleotide-binding domain-like0.6189Inherited
Nuclear receptor ligand-binding domain0.665Inherited
Tubulin C-terminal domain-like0.6688Inherited
Fibrinogen C-terminal domain-like0.6721Inherited
Terpenoid cyclases/Protein prenyltransferases0.6721Inherited
Myosin rod fragments0.6721Inherited
Integrin domains0.7328Inherited
ClpP/crotonase0.7711Inherited
PH domain-like0.8198Inherited
vWA-like0.8202Inherited
KRAB domain (Kruppel-associated box)0.9059Inherited
TIMP-like0.9088Inherited
Snake toxin-like0.9151Inherited
DEATH domain0.9569Inherited
Intermediate filament protein, coiled coil region0.9731Inherited
Homeodomain-like0.9825Inherited
Cytochrome P4501Inherited
Immunoglobulin1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Transcription factor STAT-4 N-domain0Direct
L27 domain0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Translational machinery components0Direct
DEP domain0Direct
p120GAP domain-like0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
Single strand DNA-binding domain, SSB0Direct
JAB1/MPN domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Prefoldin0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Hect, E3 ligase catalytic domain0Direct
Choline/Carnitine O-acyltransferase0Direct
Putative glucosidase YicI, domain 30Direct
Filamin repeat (rod domain)0Direct
Elongation factors0Direct
Protein serine/threonine phosphatase0Direct
DNA gyrase/MutL, N-terminal domain0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
GAF domain0Direct
Anticodon-binding domain0Direct
Cytoplasmic domain of inward rectifier potassium channel0Direct
a tRNA synthase domain0Direct
Notch domain0Direct
PWWP domain0Direct
DNA polymerase I0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Ribonuclease PH domain 1-like0Direct
IF2B-like0Direct
Exostosin0Direct
DNA gyrase/MutL, second domain0Direct
Cytochrome b50Direct
Helical domain of Sec23/240Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0Direct
TBP-associated factors, TAFs0Direct
Cyclin0Direct
Long-chain cytokines0Direct
UBA domain0Direct
FKBP immunophilin/proline isomerase0Direct
MPP-like0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Histone lysine methyltransferases0Direct
XPF/Rad1/Mus81 nuclease0Direct
FAD/NAD-linked reductases, N-terminal and central domains0Direct
Trunk domain of Sec23/240Direct
CUT domain0Direct
STAT0Direct
Myotubularin-like phosphatases0Direct
Fibrinogen coiled-coil and central regions0Direct
N-acetyl transferase, NAT0Direct
Ferredoxin domains from multidomain proteins0Direct
TB module/8-cys domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Histone deacetylase, HDAC0Direct
Ribonuclease PH domain 2-like0Direct
PP2C-like0Direct
SPRY domain0Direct
SNARE fusion complex0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
Smc hinge domain0Direct
Nicotinic receptor ligand binding domain-like0Direct
Proton glutamate symport protein0Direct
Arylsulfatase0Direct
Zn-finger domain of Sec23/240Direct
beta-sandwich domain of Sec23/240Direct
Subtilases0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Pyridoxal-dependent decarboxylase0Direct
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A0Direct
SWIRM domain0Direct
RhoGDI-like0Direct
Caspase recruitment domain, CARD0Direct
SNF-like0Direct
BRK domain-like0Direct
EF-G/eEF-2 domains III and V0Direct
Clathrin adaptor core protein0Direct
Amylase, catalytic domain0Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
Lamin A/C globular tail domain0Direct
beta-glycanases0Direct
STAT DNA-binding domain0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Phosphate binding protein-like0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
CAT-like0Direct
L-aspartase/fumarase0Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0Direct
Glycosyl transferases group 10Direct
ValRS/IleRS/LeuRS editing domain0Direct
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0Direct
CalX-beta domain0Direct
Apolipoprotein A-I0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
CCCH zinc finger0Direct
Cold shock DNA-binding domain-like0Direct
G proteins0.02376Inherited
Bromodomain0.03824Inherited
Voltage-gated potassium channels0.07035Inherited
Tyrosine-dependent oxidoreductases0.08608Inherited
Extended AAA-ATPase domain0.08608Inherited
cAMP-binding domain0.08808Inherited
PHD domain0.1024Inherited
FHA domain0.1321Inherited
HMG-box0.1592Inherited
Biotinyl/lipoyl-carrier proteins and domains0.1614Inherited
Actin/HSP700.1614Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1975Inherited
Chaperone J-domain0.2316Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2316Inherited
GLA-domain0.242Inherited
MIR domain0.242Inherited
Transforming growth factor (TGF)-beta0.2424Inherited
Tetramerization domain of potassium channels0.2712Inherited
Clathrin coat assembly domain0.2955Inherited
BC ATP-binding domain-like0.2955Inherited
BC N-terminal domain-like0.2955Inherited
ARID domain0.2955Inherited
Kelch motif0.359Inherited
Pyrin domain, PYD0.3622Inherited
28-residue LRR0.3682Inherited
Transducin (alpha subunit), insertion domain0.3682Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.3875Inherited
Sema domain0.4272Inherited
Mitochondrial carrier0.4305Inherited
BC C-terminal domain-like0.4433Inherited
Ypt/Rab-GAP domain of gyp1p0.4433Inherited
Glutathione S-transferase (GST), C-terminal domain0.4433Inherited
Cap-Gly domain0.4433Inherited
ZZ domain0.4433Inherited
Netrin-like domain (NTR/C345C module)0.4433Inherited
DNA repair protein MutS, domain III0.4433Inherited
Anaphylotoxins (complement system)0.4433Inherited
L-arabinose binding protein-like0.4573Inherited
Alpha-macroglobulin receptor domain0.4908Inherited
Complement components0.4908Inherited
Nuclear receptor0.5391Inherited
SH2 domain0.547Inherited
VWC domain0.5618Inherited
MHC antigen-recognition domain0.5699Inherited
Tubulin, GTPase domain0.575Inherited
PDZ domain0.5783Inherited
Canonical RBD0.6187Inherited
Nuclear receptor ligand-binding domain0.6216Inherited
C1 set domains (antibody constant domain-like)0.6284Inherited
Tubulin, C-terminal domain0.6284Inherited
Fibrinogen C-terminal domain-like0.6328Inherited
Myosin rod fragments0.6328Inherited
RecA protein-like (ATPase-domain)0.6328Inherited
Ras-binding domain, RBD0.6407Inherited
Integrin domains0.6972Inherited
T-box0.7681Inherited
ABC transporter ATPase domain-like0.7884Inherited
Integrin A (or I) domain0.7931Inherited
Crotonase-like0.8858Inherited
KRAB domain (Kruppel-associated box)0.8858Inherited
Intermediate filament protein, coiled coil region0.9599Inherited
Complement control module/SCR domain0.9758Inherited
Cytochrome P4500.9769Inherited
Nucleotide and nucleoside kinases0.9884Inherited
Homeodomain0.9939Inherited
Second domain of FERM0.9981Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
TB module/8-cys domain0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
EF-G C-terminal domain-like0Direct
L27 domain0Direct
CoA-dependent acyltransferases0Direct
Fibrinogen coiled-coil and central regions0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
GAF domain-like0Direct
4Fe-4S ferredoxins0Direct
GroEL apical domain-like0Direct
GroES-like0Direct
Proton glutamate symport protein0Direct
Subtilisin-like0Direct
Nicotinic receptor ligand binding domain-like0Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
Actin depolymerizing proteins0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
S15/NS1 RNA-binding domain0Direct
beta-sandwich domain of Sec23/240Direct
Apolipoprotein A-I0Direct
PP2C-like0Direct
Arginase/deacetylase0Direct
Calcium-dependent phosphotriesterase0Direct
Pseudouridine synthase0Direct
CRAL/TRIO domain0Direct
Smc hinge domain0Direct
CalX-like0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
DHS-like NAD/FAD-binding domain0Direct
Multidrug resistance efflux transporter EmrE0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
RuvA domain 2-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
STAT0Direct
Lamin A/C globular tail domain0Direct
SNARE fusion complex0Direct
Cyclin-like0Direct
FKBP-like0Direct
HIT-like0Direct
UBA-like0Direct
Helical domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Notch domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Zn-finger domain of Sec23/240Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
L-aspartase-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Ribonuclease PH domain 2-like0Direct
Putative DNA-binding domain0Direct
GroEL equatorial domain-like0Direct
SAND domain-like0Direct
Tricorn protease domain 20Direct
Hook domain0Direct
Translation proteins0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
JAB1/MPN domain0Direct
Thiolase-like0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
GroEL-intermediate domain like0Direct
Alkaline phosphatase-like0Direct
CCCH zinc finger0Direct
NTF2-like0Direct
Methylglyoxal synthase-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Transcription factor STAT-4 N-domain0Direct
Restriction endonuclease-like0Direct
DNA/RNA polymerases0Direct
ADC-like0Direct
LuxS/MPP-like metallohydrolase0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Adenine nucleotide alpha hydrolases-like0Direct
SNF-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Hect, E3 ligase catalytic domain0Direct
BRK domain-like0Direct
Nucleotidylyl transferase0.0106Inherited
Voltage-gated potassium channels0.02419Inherited
Ribosomal protein S5 domain 2-like0.02544Inherited
Actin-like ATPase domain0.03882Inherited
Bromodomain0.03882Inherited
cAMP-binding domain-like0.05891Inherited
Ribonuclease H-like0.07222Inherited
Nucleotide-diphospho-sugar transferases0.07702Inherited
ARM repeat0.09389Inherited
(Trans)glycosidases0.122Inherited
Periplasmic binding protein-like II0.1333Inherited
WD40 repeat-like0.1391Inherited
HMG-box0.1621Inherited
BRCT domain0.1624Inherited
Single hybrid motif0.1624Inherited
PreATP-grasp domain0.1624Inherited
Glycosyl hydrolase domain0.1624Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.2146Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2151Inherited
Chaperone J-domain0.2345Inherited
GLA-domain0.2427Inherited
MIR domain0.2427Inherited
GST C-terminal domain-like0.2427Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.2427Inherited
SET domain0.2457Inherited
Cystine-knot cytokines0.2463Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.2732Inherited
Cysteine proteinases0.2739Inherited
Class II aaRS and biotin synthetases0.2788Inherited
RNI-like0.2802Inherited
ARID-like0.2964Inherited
HSP20-like chaperones0.2964Inherited
POZ domain0.3576Inherited
Kelch motif0.3614Inherited
Periplasmic binding protein-like I0.3614Inherited
Ypt/Rab-GAP domain of gyp1p0.3618Inherited
Transducin (alpha subunit), insertion domain0.3695Inherited
Sema domain0.4277Inherited
Mitochondrial carrier0.4337Inherited
Rudiment single hybrid motif0.4424Inherited
DNA repair protein MutS, domain III0.4424Inherited
Cap-Gly domain0.4424Inherited
Anaphylotoxins (complement system)0.4424Inherited
p53-like transcription factors0.4747Inherited
Alpha-macroglobulin receptor domain0.4913Inherited
Thioredoxin-like0.4927Inherited
SMAD/FHA domain0.4927Inherited
RNA-binding domain, RBD0.5226Inherited
SH2 domain0.5522Inherited
NagB/RpiA/CoA transferase-like0.5614Inherited
MHC antigen-recognition domain0.5712Inherited
Tubulin nucleotide-binding domain-like0.5771Inherited
Nuclear receptor ligand-binding domain0.6246Inherited
Tubulin C-terminal domain-like0.6288Inherited
Fibrinogen C-terminal domain-like0.6322Inherited
Myosin rod fragments0.6322Inherited
Terpenoid cyclases/Protein prenyltransferases0.6322Inherited
PDZ domain-like0.6564Inherited
Integrin domains0.6949Inherited
ClpP/crotonase0.7343Inherited
HAD-like0.7643Inherited
PH domain-like0.7857Inherited
vWA-like0.7862Inherited
(Phosphotyrosine protein) phosphatases II0.8438Inherited
TNF receptor-like0.8498Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.8498Inherited
Calcium ATPase, transmembrane domain M0.8623Inherited
KRAB domain (Kruppel-associated box)0.8773Inherited
TIMP-like0.8802Inherited
Snake toxin-like0.8868Inherited
Calcium ATPase, transduction domain A0.8942Inherited
DEATH domain0.9322Inherited
Intermediate filament protein, coiled coil region0.9498Inherited
Homeodomain-like0.9602Inherited
Cytochrome P4500.9829Inherited
Second domain of FERM0.9896Inherited
Immunoglobulin0.998Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    81296,48239
  • 81296 - E set domains
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 0Direct
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    54211,54980
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    54980,54211
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    -7,56112
  • -7 - CATH
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    50447,-8
  • 50447 - Translation proteins
  • -8 - ECOD
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    50447,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    49265,49899
  • 49265 - Fibronectin type III
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    47060,55681
  • 47060 - S15/NS1 RNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    -8,54980
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    81383,52047
  • 81383 - F-box domain
  • 52047 - RNI-like
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.05489Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.05891Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1624Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.1984Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1999Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.3187Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.3618Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3618Inherited
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0.3618Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3695Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.4277Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.4277Inherited
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.4424Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4424Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.4424Inherited
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0.4424Inherited
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0.5614Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.5712Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.6256Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.6288Inherited
    50044,52540
  • 50044 - SH3-domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.6388Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.7343Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.8498Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.865Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.963Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    52540,50447,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    49854,57424,57424
  • 49854 - Spermadhesin, CUB domain
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,49899,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    54980,54211,54980
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    50447,-8,54980
  • 50447 - Translation proteins
  • -8 - ECOD
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1093Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1984Inherited
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.4424Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.4588Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.8354Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8433Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.8498Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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