SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Abnormality of the endocrine system

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the endocrine system [HP:0000818] <16>(28|35) (35|13|5)
- 1:   Abnormal circulating hormone level [HP:0003117] <28>(4|9) (6|4|1)
- 1:   Puberty and gonadal disorders [HP:0008373] <13>(15|18) (20|3|1)
- 1:   Diabetes mellitus [HP:0000819] <6>(3|3) (4|2|3)
- 1:   Neoplasm of the endocrine system [HP:0100568] <6>(6|5) (6|3|0)
- 1:   Abnormal urine hormone level [HP:0012029] <5>(0|0) (0|0|0)
- 1:   Abnormality of the thymus [HP:0000777] <5>(0|1) (0|0|0)
- 1:   Abnormal endocrine physiology [HP:0031072] <4>(0|0) (0|0|0)
- 1:   Abnormality of renin-angiotensin system [HP:0000847] <3>(3|3) (3|1|0)
- 1:   Abnormality of the adrenal glands [HP:0000834] <2>(4|5) (5|1|0)
- 1:   Abnormality of the hypothalamus-pituitary axis [HP:0000864] <2>(6|7) (7|2|0)
- 1:   Abnormality of the parathyroid gland [HP:0000828] <2>(0|0) (1|0|0)
- 1:   Abnormality of the pineal gland [HP:0012680] <2>(0|0) (0|0|0)
- 1:   Abnormality of the thyroid gland [HP:0000820] <2>(8|7) (8|3|0)
- 1:   Diabetes insipidus [HP:0000873] <2>(2|2) (2|1|0)
- 1:   Abnormality of endocrine pancreas physiology [HP:0012093] <1>(0|0) (0|0|0)
- 1:   Abnormal endocrine morphology [HP:0031071](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Smc hinge domain0Direct
Restriction endonuclease-like0Direct
SAND domain-like0Direct
Fibrinogen coiled-coil and central regions0Direct
DNA repair protein MutS, domain III0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Ribonuclease H-like0.0004589Direct
Nuclear receptor ligand-binding domain0.002767Inherited
Plexin repeat0.01415Inherited
HD-domain/PDEase-like0.01666Inherited
Sema domain0.01666Inherited
GAF domain-like0.03222Inherited
RuvA domain 2-like0.03222Inherited
MHC antigen-recognition domain0.0538Inherited
NagB/RpiA/CoA transferase-like0.07257Inherited
Fibrinogen C-terminal domain-like0.09795Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.09795Inherited
HMG-box0.1085Inherited
Trypsin-like serine proteases0.1831Inherited
p53-like transcription factors0.1928Inherited
SET domain0.1966Inherited
Homeodomain-like0.2531Inherited
Cytochrome P4500.3563Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.496Inherited
Ribosomal protein S5 domain 2-like0.5036Inherited
E set domains0.543Inherited
Immunoglobulin0.6776Inherited
Voltage-gated potassium channels0.8303Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
DNA polymerase I0Direct
IF2B-like0Direct
Long-chain cytokines0Direct
XPF/Rad1/Mus81 nuclease0Direct
DNA repair protein MutS, domain III0Direct
Fibrinogen coiled-coil and central regions0Direct
Smc hinge domain0Direct
Gonadodropin/Follitropin0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Nuclear receptor ligand-binding domain0.002168Inherited
Nuclear receptor0.002566Inherited
DNA gyrase/MutL, N-terminal domain0.009214Inherited
DNA gyrase/MutL, second domain0.009214Inherited
Acetylcholinesterase-like0.009214Inherited
Plexin repeat0.01118Inherited
Sema domain0.01291Inherited
Tyrosine-dependent oxidoreductases0.02225Inherited
GAF domain0.02494Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.02494Inherited
PDEase0.02887Inherited
Rhodopsin-like0.03878Inherited
G proteins0.04094Inherited
MHC antigen-recognition domain0.04569Inherited
Cytoplasmic domain of inward rectifier potassium channel0.05354Inherited
Fibrinogen C-terminal domain-like0.08564Inherited
Histone lysine methyltransferases0.08564Inherited
HMG-box0.09848Inherited
Tetratricopeptide repeat (TPR)0.103Inherited
C1 set domains (antibody constant domain-like)0.1373Inherited
PLC-like (P variant)0.1454Inherited
Ngr ectodomain-like0.153Inherited
Homeodomain0.1699Inherited
Eukaryotic proteases0.209Inherited
Cytochrome P4500.447Inherited
Voltage-gated potassium channels0.7082Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Smc hinge domain0Direct
DNA repair protein MutS, domain III0Direct
SAND domain-like0Direct
Restriction endonuclease-like0Direct
Ribonuclease H-like0.0002311Direct
DNA/RNA polymerases0.0008924Direct
Nuclear receptor ligand-binding domain0.001595Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.006575Inherited
Plexin repeat0.009372Inherited
Sema domain0.01116Inherited
HD-domain/PDEase-like0.01116Inherited
Cystine-knot cytokines0.01186Inherited
GAF domain-like0.02277Inherited
RuvA domain 2-like0.02277Inherited
MHC antigen-recognition domain0.03992Inherited
Family A G protein-coupled receptor-like0.0451Inherited
NagB/RpiA/CoA transferase-like0.05547Inherited
RING/U-box0.07413Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.07677Inherited
Fibrinogen C-terminal domain-like0.07677Inherited
HMG-box0.08553Inherited
NAD(P)-binding Rossmann-fold domains0.1032Inherited
Trypsin-like serine proteases0.1517Inherited
p53-like transcription factors0.1607Inherited
SET domain0.1643Inherited
Homeodomain-like0.216Inherited
Cytochrome P4500.3143Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.3394Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4517Inherited
Ribosomal protein S5 domain 2-like0.4594Inherited
E set domains0.4991Inherited
Immunoglobulin0.6379Inherited
Voltage-gated potassium channels0.7969Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.008198Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.01116Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.02273Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.02277Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.02277Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.02277Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.03992Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.04769Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1992Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.02277Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1765Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2441Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)