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Phenotypic Abnormality (PA): Growth abnormality

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Growth abnormality [HP:0001507] <6>(29|47) (34|27|21)
- 1:   Growth delay [HP:0001510] <5>(10|14) (13|8|3)
- 1:   Abnormality of body weight [HP:0004323] <4>(9|22) (13|12|3)
- 1:   Asymmetric growth [HP:0100555] <4>(0|0) (0|0|0)
- 1:   Abnormality of body height [HP:0000002] <3>(9|13) (9|7|8)
- 1:   Heterotaxy [HP:0030853] <2>(0|0) (0|0|0)
- 1:   Increased body fat percentage [HP:0025521](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Plakin repeat0Direct
CCCH zinc finger0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Ribonuclease PH domain 2-like0Direct
BRK domain-like0Direct
TB module/8-cys domain0Direct
Helical domain of Sec23/240Direct
Zn-finger domain of Sec23/240Direct
Arginase/deacetylase0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
Tricorn protease domain 20Direct
JAB1/MPN domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
ADC-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
RuvA domain 2-like0Direct
STAT0.06348Inherited
Transcription factor STAT-4 N-domain0.06348Inherited
Bromodomain0.1103Inherited
Insulin-like0.1626Inherited
"Winged helix" DNA-binding domain0.2089Inherited
Homeodomain-like0.3951Inherited
Family A G protein-coupled receptor-like0.4033Inherited
MHC antigen-recognition domain0.4166Inherited
FnI-like domain0.442Inherited
vWA-like0.6068Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
JAB1/MPN domain0Direct
Notch domain0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Ribonuclease PH domain 1-like0Direct
Plakin repeat0Direct
HCDH C-domain-like0Direct
Exostosin0Direct
Helical domain of Sec23/240Direct
Long-chain cytokines0Direct
XPF/Rad1/Mus81 nuclease0Direct
Trunk domain of Sec23/240Direct
N-acetyl transferase, NAT0Direct
Ferredoxin domains from multidomain proteins0Direct
TB module/8-cys domain0Direct
Histone deacetylase, HDAC0Direct
Ribonuclease PH domain 2-like0Direct
P4 origin-binding domain-like0Direct
Zn-finger domain of Sec23/240Direct
beta-sandwich domain of Sec23/240Direct
Biotin dependent carboxylase carboxyltransferase domain0Direct
Erythroid transcription factor GATA-10Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
SWIRM domain0Direct
BRK domain-like0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
L-aspartase/fumarase0Direct
Proteasome subunits0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
CCCH zinc finger0Direct
Histone lysine methyltransferases0.006035Inherited
Hect, E3 ligase catalytic domain0.03848Inherited
Transcription factor STAT-4 N-domain0.05149Inherited
STAT0.05149Inherited
STAT DNA-binding domain0.05149Inherited
DNA gyrase/MutL, N-terminal domain0.08532Inherited
DNA gyrase/MutL, second domain0.08532Inherited
Bromodomain0.09574Inherited
GAF domain0.1396Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.1396Inherited
ZZ domain0.1396Inherited
Insulin-like0.1396Inherited
C1 set domains (antibody constant domain-like)0.3229Inherited
Rhodopsin-like0.3365Inherited
Integrin A (or I) domain0.3518Inherited
MHC antigen-recognition domain0.3916Inherited
Homeodomain0.4983Inherited
Phosphotyrosine-binding domain (PTB)0.8113Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
TB module/8-cys domain0Direct
Plakin repeat0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Arginase/deacetylase0Direct
RuvA domain 2-like0Direct
Helical domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Notch domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Zn-finger domain of Sec23/240Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Ribonuclease PH domain 2-like0Direct
Tricorn protease domain 20Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
JAB1/MPN domain0Direct
CCCH zinc finger0Direct
ADC-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
BRK domain-like0Direct
Hect, E3 ligase catalytic domain0.03504Inherited
STAT0.04797Inherited
Transcription factor STAT-4 N-domain0.04797Inherited
Bromodomain0.08704Inherited
Concanavalin A-like lectins/glucanases0.099Inherited
GAF domain-like0.1333Inherited
Insulin-like0.1333Inherited
Restriction endonuclease-like0.1333Inherited
"Winged helix" DNA-binding domain0.1756Inherited
SET domain0.1978Inherited
Homeodomain-like0.3518Inherited
Family A G protein-coupled receptor-like0.36Inherited
MHC antigen-recognition domain0.3731Inherited
FnI-like domain0.3982Inherited
vWA-like0.5646Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    -7,56112
  • -7 - CATH
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    47095,47095
  • 47095 - HMG-box
  • 47095 - HMG-box
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.04797Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.04797Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.04797Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.08031Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1333Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.1333Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.1333Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.2896Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.3731Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.04797Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.04797Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.1333Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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