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Phenotypic Abnormality (PA): Growth abnormality

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Growth abnormality [HP:0001507] <6>(29|43) (34|25|15)
- 1:   Growth delay [HP:0001510] <5>(11|13) (13|8|3)
- 1:   Abnormality of body weight [HP:0004323] <4>(8|17) (12|11|3)
- 1:   Asymmetric growth [HP:0100555] <4>(0|1) (0|0|0)
- 1:   Abnormality of body height [HP:0000002] <3>(9|13) (9|7|8)
- 1:   Heterotaxy [HP:0030853] <2>(0|0) (0|0|0)
- 1:   Increased body fat percentage [HP:0025521](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Zn-finger domain of Sec23/240Direct
Helical domain of Sec23/240Direct
CCCH zinc finger0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
Arginase/deacetylase0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
RuvA domain 2-like0Direct
FabD/lysophospholipase-like0Direct
Tricorn protease domain 20Direct
BRK domain-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Notch domain0Direct
JAB1/MPN domain0Direct
Ribonuclease PH domain 2-like0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Plakin repeat0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
ADC-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Hect, E3 ligase catalytic domain0.1347Inherited
SET domain0.1543Inherited
GAF domain-like0.1556Inherited
Insulin-like0.1556Inherited
"Winged helix" DNA-binding domain0.1797Inherited
Family A G protein-coupled receptor-like0.3068Inherited
MHC antigen-recognition domain0.3826Inherited
Homeodomain-like0.4189Inherited
FnI-like domain0.4217Inherited
vWA-like0.4503Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
CCCH zinc finger0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Helical domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
JAB1/MPN domain0Direct
BRK domain-like0Direct
Ferredoxin domains from multidomain proteins0Direct
Zn-finger domain of Sec23/240Direct
Biotin dependent carboxylase carboxyltransferase domain0Direct
L-aspartase/fumarase0Direct
Ribonuclease PH domain 1-like0Direct
Ribonuclease PH domain 2-like0Direct
Proteasome subunits0Direct
N-acetyl transferase, NAT0Direct
beta-sandwich domain of Sec23/240Direct
P4 origin-binding domain-like0Direct
HCDH C-domain-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Exostosin0Direct
Plakin repeat0Direct
Erythroid transcription factor GATA-10Direct
SWIRM domain0Direct
Trunk domain of Sec23/240Direct
Histone deacetylase, HDAC0Direct
Histone lysine methyltransferases0.005391Inherited
Transcription factor STAT-4 N-domain0.0816Inherited
STAT DNA-binding domain0.0816Inherited
DNA gyrase/MutL, second domain0.0816Inherited
STAT0.0816Inherited
DNA gyrase/MutL, N-terminal domain0.0816Inherited
Hect, E3 ligase catalytic domain0.1183Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.135Inherited
Insulin-like0.135Inherited
GAF domain0.135Inherited
G proteins0.1432Inherited
Rhodopsin-like0.2894Inherited
C1 set domains (antibody constant domain-like)0.291Inherited
Integrin A (or I) domain0.3355Inherited
MHC antigen-recognition domain0.3584Inherited
Homeodomain0.5439Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Arginase/deacetylase0Direct
Notch domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Zn-finger domain of Sec23/240Direct
Helical domain of Sec23/240Direct
ADC-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
JAB1/MPN domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Ribonuclease PH domain 2-like0Direct
Plakin repeat0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
FabD/lysophospholipase-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Tricorn protease domain 20Direct
RuvA domain 2-like0Direct
BRK domain-like0Direct
CCCH zinc finger0Direct
STAT0.07607Inherited
Transcription factor STAT-4 N-domain0.07607Inherited
Bromodomain0.07961Inherited
Hect, E3 ligase catalytic domain0.1095Inherited
SET domain0.1268Inherited
Insulin-like0.1279Inherited
GAF domain-like0.1279Inherited
Restriction endonuclease-like0.1279Inherited
"Winged helix" DNA-binding domain0.1493Inherited
Family A G protein-coupled receptor-like0.2687Inherited
Concanavalin A-like lectins/glucanases0.2751Inherited
MHC antigen-recognition domain0.3414Inherited
Homeodomain-like0.3768Inherited
FnI-like domain0.3797Inherited
vWA-like0.408Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
117281,117281
  • 117281 - Kelch motif
  • 117281 - Kelch motif
  • 0Direct
    47095,47095
  • 47095 - HMG-box
  • 47095 - HMG-box
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    -7,56112
  • -7 - CATH
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.07607Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.07607Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.07607Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.07607Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1279Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.1279Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.1279Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.2793Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.3414Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.07607Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.07607Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.1279Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)