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Phenotypic Abnormality (PA): Abnormality of the cardiovascular system

(show info)

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the cardiovascular system [HP:0001626] <5>(58|73) (67|39|27)
- 1:   Abnormal cardiovascular system physiology [HP:0011025] <16>(25|32) (29|21|16)
- 1:   Abnormality of the vasculature [HP:0002597] <13>(32|47) (40|24|15)
- 1:   Abnormal cardiac test [HP:0500015] <7>(1|3) (1|1|0)
- 1:   Abnormality of the fetal cardiovascular system [HP:0010948] <7>(0|0) (0|0|0)
- 1:   Abnormality of cardiovascular system morphology [HP:0030680] <3>(26|40) (32|17|20)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Zn-finger domain of Sec23/240Direct
GLA-domain0Direct
GAF domain-like0Direct
Saposin0Direct
Smc hinge domain0Direct
SMAD MH1 domain0Direct
SAND domain-like0Direct
Tricorn protease domain 20Direct
BRK domain-like0Direct
Cap-Gly domain0Direct
RmlC-like cupins0Direct
Notch domain0Direct
Fibrinogen coiled-coil and central regions0Direct
TB module/8-cys domain0Direct
Plakin repeat0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
TNF receptor-like0.003358Inherited
Actin-like ATPase domain0.02604Inherited
cAMP-binding domain-like0.03794Inherited
(Trans)glycosidases0.04581Inherited
Growth factor receptor domain0.04694Inherited
Globin-like0.06949Inherited
MIR domain0.06949Inherited
Glycosyl hydrolase domain0.08055Inherited
MHC antigen-recognition domain0.08055Inherited
DEATH domain0.09442Inherited
4-helical cytokines0.1128Inherited
Tropomyosin0.1185Inherited
Spectrin repeat0.1258Inherited
Caspase-like0.1718Inherited
DNA/RNA polymerases0.1718Inherited
Snake toxin-like0.1899Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.202Inherited
Integrin domains0.2165Inherited
ARID-like0.2455Inherited
Acyl-CoA dehydrogenase NM domain-like0.2509Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.2509Inherited
Immunoglobulin0.2648Inherited
Protein kinase-like (PK-like)0.2772Inherited
FnI-like domain0.3009Inherited
Trypsin-like serine proteases0.3225Inherited
Myosin rod fragments0.3269Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.3269Inherited
RNI-like0.3749Inherited
TNF-like0.3749Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3916Inherited
L domain-like0.4853Inherited
SMAD/FHA domain0.4904Inherited
Complement control module/SCR domain0.4904Inherited
Fibrinogen C-terminal domain-like0.5409Inherited
TPR-like0.5418Inherited
Cadherin-like0.5728Inherited
Voltage-gated potassium channels0.6893Inherited
(Phosphotyrosine protein) phosphatases II0.7881Inherited
Ribosomal protein S5 domain 2-like0.7952Inherited
FAD/NAD(P)-binding domain0.8436Inherited
Nicotinic receptor ligand binding domain-like0.9421Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9421Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
GLA-domain0Direct
TB module/8-cys domain0Direct
SMAD domain0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
BRK domain-like0Direct
Cap-Gly domain0Direct
Zn-finger domain of Sec23/240Direct
beta-glycanases0Direct
Smc hinge domain0Direct
Multidomain cupredoxins0Direct
Fibrinogen coiled-coil and central regions0Direct
ZZ domain0Direct
Proteasome subunits0Direct
SMAD MH1 domain0Direct
ets domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Plakin repeat0Direct
GAF domain0Direct
Erythroid transcription factor GATA-10Direct
TNF receptor-like0.007006Inherited
Actin/HSP700.02023Inherited
EGF-type module0.02504Inherited
Growth factor receptor domain0.02643Inherited
Globins0.05634Inherited
MIR domain0.05634Inherited
ABC transporter ATPase domain-like0.06529Inherited
C1 set domains (antibody constant domain-like)0.06685Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.06687Inherited
RecA protein-like (ATPase-domain)0.06687Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.06687Inherited
MHC antigen-recognition domain0.06687Inherited
T-box0.08858Inherited
DNA gyrase/MutL, second domain0.09165Inherited
Amylase, catalytic domain0.09165Inherited
Pyrin domain, PYD0.09165Inherited
DNA gyrase/MutL, N-terminal domain0.09165Inherited
Tropomyosin0.1005Inherited
Spectrin repeat0.1091Inherited
PHD domain0.1256Inherited
Histone lysine methyltransferases0.1373Inherited
Calponin-homology domain, CH-domain0.1448Inherited
Double-stranded RNA-binding domain (dsRBD)0.1479Inherited
Tetratricopeptide repeat (TPR)0.1752Inherited
Integrin domains0.1919Inherited
Cytoplasmic domain of inward rectifier potassium channel0.1919Inherited
DEATH domain, DD0.1934Inherited
Ras-binding domain, RBD0.2179Inherited
ARID domain0.2179Inherited
Extracellular domain of cell surface receptors0.2179Inherited
LIM domain0.2255Inherited
Transforming growth factor (TGF)-beta0.236Inherited
Protein kinases, catalytic subunit0.2574Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2654Inherited
28-residue LRR0.2996Inherited
Myosin rod fragments0.2996Inherited
DnaQ-like 3'-5' exonuclease0.3153Inherited
Caspase recruitment domain, CARD0.3153Inherited
TNF-like0.3484Inherited
VWC domain0.3606Inherited
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0.3606Inherited
Eukaryotic proteases0.4524Inherited
Complement control module/SCR domain0.4673Inherited
Fibrinogen C-terminal domain-like0.514Inherited
Voltage-gated potassium channels0.5191Inherited
Calmodulin-like0.628Inherited
Cadherin0.6288Inherited
Ngr ectodomain-like0.8802Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9343Inherited
Nicotinic receptor ligand binding domain-like0.9343Inherited
Intermediate filament protein, coiled coil region0.9599Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SMAD MH1 domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Cap-Gly domain0Direct
Notch domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Zn-finger domain of Sec23/240Direct
TB module/8-cys domain0Direct
Plakin repeat0Direct
GAF domain-like0Direct
Smc hinge domain0Direct
SAND domain-like0Direct
Tricorn protease domain 20Direct
Saposin0Direct
BRK domain-like0Direct
GLA-domain0Direct
RmlC-like cupins0Direct
TNF receptor-like0.002028Inherited
Actin-like ATPase domain0.01834Inherited
p53-like transcription factors0.027Inherited
cAMP-binding domain-like0.02762Inherited
(Trans)glycosidases0.03382Inherited
Growth factor receptor domain0.03476Inherited
MIR domain0.05329Inherited
Globin-like0.05329Inherited
Glycosyl hydrolase domain0.06271Inherited
MHC antigen-recognition domain0.06271Inherited
DEATH domain0.07449Inherited
Acyl-CoA N-acyltransferases (Nat)0.08708Inherited
4-helical cytokines0.09017Inherited
Tropomyosin0.09501Inherited
Spectrin repeat0.1015Inherited
Calponin-homology domain, CH-domain0.1351Inherited
Caspase-like0.1424Inherited
Restriction endonuclease-like0.1424Inherited
DNA/RNA polymerases0.1425Inherited
Snake toxin-like0.1589Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1698Inherited
Integrin domains0.1833Inherited
ARID-like0.2101Inherited
Acyl-CoA dehydrogenase NM domain-like0.2153Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.2153Inherited
Immunoglobulin0.2286Inherited
Protein kinase-like (PK-like)0.2401Inherited
FnI-like domain0.263Inherited
Trypsin-like serine proteases0.2834Inherited
Myosin rod fragments0.2876Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2876Inherited
GroEL equatorial domain-like0.3063Inherited
TNF-like0.3339Inherited
RNI-like0.3339Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3502Inherited
L domain-like0.4423Inherited
Complement control module/SCR domain0.4475Inherited
SMAD/FHA domain0.4475Inherited
Fibrinogen C-terminal domain-like0.4981Inherited
TPR-like0.4991Inherited
Cadherin-like0.5303Inherited
Cystine-knot cytokines0.5421Inherited
SH3-domain0.5578Inherited
Voltage-gated potassium channels0.6508Inherited
EF-hand0.6957Inherited
(Phosphotyrosine protein) phosphatases II0.7537Inherited
Ribosomal protein S5 domain 2-like0.7612Inherited
FAD/NAD(P)-binding domain0.8116Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9157Inherited
Nicotinic receptor ligand binding domain-like0.9157Inherited
Intermediate filament protein, coiled coil region0.9396Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.006471Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.02568Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.02762Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.04183Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.06271Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.06271Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.07317Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.08708Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.08708Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08708Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.103Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.1424Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1589Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.1833Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1833Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.2049Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.2101Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.2153Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.2807Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.4981Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.9157Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003654Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.03193Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.03193Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.09501Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.09501Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.09501Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1156Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1424Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2552Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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