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Phenotypic Abnormality (PA): Abnormality of blood and blood-forming tissues

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of blood and blood-forming tissues [HP:0001871] <11>(23|36) (27|16|5)
- 1:   Abnormal erythrocyte morphology [HP:0001877] <20>(2|4) (2|0|0)
- 1:   Abnormal bleeding [HP:0001892] <16>(10|16) (12|3|1)
- 1:   Hematological neoplasm [HP:0004377] <7>(2|3) (3|1|0)
- 1:   Abnormal thrombosis [HP:0001977] <5>(5|4) (5|1|0)
- 1:   Abnormality of bone marrow cell morphology [HP:0005561] <5>(3|4) (3|1|0)
- 1:   Abnormality of coagulation [HP:0001928] <5>(6|7) (8|4|2)
- 1:   Abnormal leukocyte morphology [HP:0001881] <4>(5|10) (7|5|2)
- 1:   Abnormal thrombocyte morphology [HP:0001872] <4>(5|10) (9|6|4)
- 1:   Abnormal erythrocyte physiology [HP:0020054] <3>(0|0) (0|0|0)
- 1:   Abnormal myeloid cell morphology [HP:0020047] <1>(0|0) (0|0|0)
- 1:   Extramedullary hematopoiesis [HP:0001978](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Globin-like0Direct
Fibrinogen coiled-coil and central regions0Direct
SH2 domain0.000006253Direct
Trypsin-like serine proteases0.00004485Direct
DEATH domain0.0006332Direct
TNF receptor-like0.001424Inherited
GLA-domain0.001794Inherited
Transcription factor STAT-4 N-domain0.01339Inherited
STAT0.01339Inherited
Ras GEF0.01339Inherited
RNI-like0.02759Inherited
Snake toxin-like0.03154Inherited
Hairpin loop containing domain-like0.03378Inherited
4-helical cytokines0.05911Inherited
Complement control module/SCR domain0.07174Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.07819Inherited
BEACH domain0.08545Inherited
Fibrinogen C-terminal domain-like0.1056Inherited
Cysteine-rich domain0.1645Inherited
MHC antigen-recognition domain0.1812Inherited
Integrin domains0.1812Inherited
Immunoglobulin0.2072Inherited
L domain-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Multidomain cupredoxins0Direct
Fibrinogen coiled-coil and central regions0Direct
Proteasome subunits0Direct
Globins0Direct
SH2 domain0.000005438Direct
Eukaryotic proteases0.0001203Direct
GLA-domain0.001268Inherited
Transcription factor STAT-4 N-domain0.01016Inherited
STAT DNA-binding domain0.01016Inherited
DNA gyrase/MutL, second domain0.01016Inherited
Ras GEF0.01016Inherited
STAT0.01016Inherited
Pyrin domain, PYD0.01016Inherited
DNA gyrase/MutL, N-terminal domain0.01016Inherited
ABC transporter ATPase domain-like0.01894Inherited
DEATH domain, DD0.02301Inherited
Nitrogenase iron protein-like0.0324Inherited
Kringle modules0.0514Inherited
Complement control module/SCR domain0.06552Inherited
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0.06792Inherited
BEACH domain0.07342Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.07942Inherited
C1 set domains (antibody constant domain-like)0.07942Inherited
28-residue LRR0.09463Inherited
Fibrinogen C-terminal domain-like0.09463Inherited
Tandem AAA-ATPase domain0.1269Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.1332Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.1655Inherited
RecA protein-like (ATPase-domain)0.1655Inherited
Integrin domains0.1655Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.1655Inherited
MHC antigen-recognition domain0.1655Inherited
VWC domain0.2018Inherited
V set domains (antibody variable domain-like)0.2359Inherited
Transforming growth factor (TGF)-beta0.5165Inherited
Ngr ectodomain-like0.9275Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Globin-like0Direct
SH2 domain0.000002704Direct
Trypsin-like serine proteases0.00002092Direct
DEATH domain0.0003354Direct
TNF receptor-like0.0008021Direct
GLA-domain0.001023Inherited
Ras GEF0.008925Inherited
STAT0.008925Inherited
Transcription factor STAT-4 N-domain0.008925Inherited
RNI-like0.01952Inherited
Snake toxin-like0.02264Inherited
Hairpin loop containing domain-like0.02437Inherited
4-helical cytokines0.04461Inherited
Complement control module/SCR domain0.05516Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0606Inherited
BEACH domain0.06683Inherited
Kringle-like0.08143Inherited
Fibrinogen C-terminal domain-like0.08394Inherited
p53-like transcription factors0.1279Inherited
Cysteine-rich domain0.1359Inherited
MHC antigen-recognition domain0.1507Inherited
Integrin domains0.1507Inherited
Immunoglobulin0.1747Inherited
FnI-like domain0.1753Inherited
Cystine-knot cytokines0.75Inherited
L domain-like0.9967Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00009744Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0006187Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.008925Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.008925Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.008925Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.008925Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.008925Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.01206Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.01663Inherited
    50729,81837
  • 50729 - PH domain-like
  • 81837 - BEACH domain
  • 0.02437Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.02821Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1507Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.004733Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.008925Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.008925Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.008925Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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