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Phenotypic Abnormality (PA): Neoplasm

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Neoplasm [HP:0002664] <2>(20|21) (23|8|3)
- 1:   Neoplasm by anatomical site [HP:0011793] <24>(18|19) (20|7|2)
- 1:   Neoplasm by histology [HP:0011792] <7>(5|7) (6|3|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DNA-glycosylase0Direct
SH2 domain0.00002755Direct
Protein kinase-like (PK-like)0.00009517Direct
TNF receptor-like0.01094Inherited
DNA repair protein MutS, domain III0.01366Inherited
DEATH domain0.01864Inherited
Sema domain0.02136Inherited
Snake toxin-like0.02522Inherited
Ribosomal protein S5 domain 2-like0.0264Inherited
DNA/RNA polymerases0.02914Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.03562Inherited
Ribonuclease H-like0.0377Inherited
BRCT domain0.07651Inherited
Plexin repeat0.101Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1371Inherited
Ubiquitin-like0.1404Inherited
Nuclear receptor ligand-binding domain0.2615Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2708Inherited
Intermediate filament protein, coiled coil region0.2781Inherited
(Phosphotyrosine protein) phosphatases II0.3424Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
DNA gyrase/MutL, N-terminal domain0Direct
DIX domain0Direct
DNA gyrase/MutL, second domain0Direct
SH2 domain0.0000223Direct
Protein kinases, catalytic subunit0.0001357Direct
RecA protein-like (ATPase-domain)0.006395Inherited
DNA repair protein MutS, domain III0.01015Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.01015Inherited
Sema domain0.01706Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.042Inherited
Ras-binding domain, RBD0.05953Inherited
POU-specific domain0.05953Inherited
Plexin repeat0.08991Inherited
FHA domain0.09513Inherited
RING finger domain, C3HC40.1165Inherited
DEATH domain, DD0.1171Inherited
Ran binding protein zinc finger-like0.1379Inherited
Laminin-type module0.2044Inherited
ABC transporter ATPase domain-like0.2198Inherited
Nuclear receptor ligand-binding domain0.2504Inherited
Intermediate filament protein, coiled coil region0.2701Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
DNA-glycosylase0Direct
SH2 domain0.00001208Direct
Protein kinase-like (PK-like)0.00004389Direct
TNF receptor-like0.007073Inherited
DNA repair protein MutS, domain III0.009024Inherited
DEATH domain0.01258Inherited
Sema domain0.01462Inherited
Snake toxin-like0.01748Inherited
RING/U-box0.01788Inherited
Ribosomal protein S5 domain 2-like0.01833Inherited
DNA/RNA polymerases0.02041Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.02547Inherited
Ribonuclease H-like0.02704Inherited
BRCT domain0.05877Inherited
Plexin repeat0.0794Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.111Inherited
Ubiquitin-like0.114Inherited
Ran binding protein zinc finger-like0.1268Inherited
lambda repressor-like DNA-binding domains0.1699Inherited
Nuclear receptor ligand-binding domain0.224Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2328Inherited
Intermediate filament protein, coiled coil region0.2396Inherited
(Phosphotyrosine protein) phosphatases II0.301Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.000738Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.005323Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.009024Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.009024Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.009024Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.01462Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3557Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0005895Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1967Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2159Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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