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Phenotypic Abnormality (PA): Abnormality of the immune system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the immune system [HP:0002715] <3>(38|52) (40|29|16)
- 1:   Abnormality of immune system physiology [HP:0010978] <14>(29|37) (31|22|11)
- 1:   Abnormality of the lymphatic system [HP:0100763] <7>(9|19) (15|8|5)
- 1:   Abnormal immune system morphology [HP:0032251] <3>(11|11) (11|6|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Anaphylotoxins (complement system)0Direct
Lipoxigenase0Direct
Restriction endonuclease-like0Direct
SAND domain-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Tricorn protease domain 20Direct
DEATH domain0.000005254Direct
Immunoglobulin0.0002894Direct
MHC antigen-recognition domain0.0003855Direct
SH2 domain0.003404Inherited
Complement control module/SCR domain0.00379Inherited
TNF-like0.008675Inherited
ABC transporter transmembrane region0.008675Inherited
p53-like transcription factors0.00902Inherited
DNA/RNA polymerases0.009527Inherited
RNI-like0.01034Inherited
4-helical cytokines0.0126Inherited
(Trans)glycosidases0.01326Inherited
Globin-like0.01967Inherited
TNF receptor-like0.02704Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.05795Inherited
Caspase-like0.07723Inherited
STAT0.1022Inherited
Transcription factor STAT-4 N-domain0.1022Inherited
Alpha-macroglobulin receptor domain0.1129Inherited
Fibrinogen C-terminal domain-like0.1171Inherited
Terpenoid cyclases/Protein prenyltransferases0.1171Inherited
Trypsin-like serine proteases0.1397Inherited
TIMP-like0.1807Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2706Inherited
Cysteine-rich domain0.361Inherited
TSP-1 type 1 repeat0.3716Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4003Inherited
FYVE/PHD zinc finger0.4682Inherited
SH3-domain0.4855Inherited
LDL receptor-like module0.6867Inherited
Spermadhesin, CUB domain0.7051Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Animal lipoxigenases0Direct
Notch domain0Direct
ets domain0Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0Direct
Netrin-like domain (NTR/C345C module)0Direct
Long-chain cytokines0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
XPF/Rad1/Mus81 nuclease0Direct
Fibrinogen coiled-coil and central regions0Direct
Formate/glycerate dehydrogenases, substrate-binding domain0Direct
Anaphylotoxins (complement system)0Direct
beta-glycanases0Direct
Proteasome subunits0Direct
C1 set domains (antibody constant domain-like)0.00001615Direct
MHC antigen-recognition domain0.000244Direct
DEATH domain, DD0.002421Inherited
SH2 domain0.002559Inherited
Complement control module/SCR domain0.002753Inherited
ABC transporter ATPase domain-like0.004106Inherited
TNF-like0.006423Inherited
ABC transporter transmembrane region0.009364Inherited
Ras-binding domain, RBD0.01467Inherited
Globins0.01467Inherited
Pyrin domain, PYD0.03073Inherited
28-residue LRR0.0319Inherited
PX domain0.04723Inherited
TNF receptor-like0.0619Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.06344Inherited
Tandem AAA-ATPase domain0.07106Inherited
Transcription factor STAT-4 N-domain0.08601Inherited
STAT0.08601Inherited
STAT DNA-binding domain0.08601Inherited
Nitrogenase iron protein-like0.08601Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.08601Inherited
Alpha-macroglobulin receptor domain0.09655Inherited
Complement components0.09655Inherited
Fibrinogen C-terminal domain-like0.1006Inherited
Arylsulfatase0.1006Inherited
Caspase recruitment domain, CARD0.1526Inherited
Eukaryotic proteases0.1857Inherited
PLC-like (P variant)0.2526Inherited
Tetratricopeptide repeat (TPR)0.2546Inherited
PHD domain0.2546Inherited
Noncollagenous (NC1) domain of collagen IV0.2572Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.291Inherited
TSP-1 type 1 repeat0.3507Inherited
V set domains (antibody variable domain-like)0.3652Inherited
RecA protein-like (ATPase-domain)0.4318Inherited
SH3-domain0.5387Inherited
LDL receptor-like module0.6745Inherited
Spermadhesin, CUB domain0.69Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Notch domain0Direct
SAND domain-like0Direct
Tricorn protease domain 20Direct
Anaphylotoxins (complement system)0Direct
Restriction endonuclease-like0Direct
Lipoxigenase0Direct
DEATH domain0.000002179Direct
Immunoglobulin0.0001424Direct
MHC antigen-recognition domain0.0001923Direct
SH2 domain0.002003Inherited
Complement control module/SCR domain0.002243Inherited
TNF-like0.005537Inherited
ABC transporter transmembrane region0.005537Inherited
p53-like transcription factors0.005771Inherited
DNA/RNA polymerases0.00612Inherited
RNI-like0.006679Inherited
4-helical cytokines0.008261Inherited
(Trans)glycosidases0.008741Inherited
Globin-like0.01336Inherited
TNF receptor-like0.01882Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.04339Inherited
PX domain0.04339Inherited
Caspase-like0.05933Inherited
STAT0.0804Inherited
Transcription factor STAT-4 N-domain0.0804Inherited
Alpha-macroglobulin receptor domain0.08942Inherited
Fibrinogen C-terminal domain-like0.09314Inherited
Terpenoid cyclases/Protein prenyltransferases0.09314Inherited
Trypsin-like serine proteases0.1133Inherited
TIMP-like0.1496Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2326Inherited
Cysteine-rich domain0.3188Inherited
TSP-1 type 1 repeat0.3289Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.357Inherited
Snake toxin-like0.377Inherited
FYVE/PHD zinc finger0.4245Inherited
SH3-domain0.4418Inherited
LDL receptor-like module0.6475Inherited
Spermadhesin, CUB domain0.6662Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    82895,57424
  • 82895 - TSP-1 type 1 repeat
  • 57424 - LDL receptor-like module
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.00009007Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0001923Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.005537Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.005629Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01147Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0285Inherited
    57535,50494
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.05933Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.05933Inherited
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.05933Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.05933Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0804Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0804Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0804Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.1453Inherited
    49854,57196
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0.1453Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.1453Inherited
    57196,49854
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 0.2464Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.4562Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.000478Direct
    57196,49854,57535
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.05933Inherited
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.05933Inherited
    57535,57535,50494
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.05933Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.05933Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0804Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0804Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0804Inherited
    49854,57196,49854
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 0.1453Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.234Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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