SUPERFAMILY 1.75 HMM library and genome assignments server

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Phenotypic Abnormality (PA): Abnormal cellular phenotype

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormal cellular phenotype [HP:0025354] <3>(10|11) (15|3|0)
- 1:   Abnormal cellular physiology [HP:0011017] <16>(10|10) (15|3|0)
- 1:   Abnormal cell morphology [HP:0025461] <6>(0|0) (0|0|0)
- 1:   Abnormal flow cytometry test rest [HP:0031550] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
TNF receptor-like0.000006686Direct
DEATH domain0.0008221Direct
4Fe-4S ferredoxins0.0018Inherited
SH2 domain0.001816Inherited
Acyl-CoA dehydrogenase NM domain-like0.004353Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.004353Inherited
TNF-like0.01465Inherited
Adenine nucleotide alpha hydrolases-like0.02233Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.02233Inherited
CoA-dependent acyltransferases0.03395Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
TNF receptor-like0.0001226Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.0006925Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0006925Direct
SH2 domain0.0009299Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0009951Direct
RecA protein-like (ATPase-domain)0.006161Inherited
DEATH domain, DD0.009213Inherited
TNF-like0.009213Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.02326Inherited
Mitochondrial carrier0.0471Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
TNF receptor-like0.000002901Direct
DEATH domain0.0004439Direct
4Fe-4S ferredoxins0.001027Inherited
Restriction endonuclease-like0.001027Inherited
SH2 domain0.001037Inherited
Acyl-CoA dehydrogenase NM domain-like0.002677Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.002677Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.006128Inherited
BRCT domain0.006574Inherited
TNF-like0.009834Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.01551Inherited
Adenine nucleotide alpha hydrolases-like0.01551Inherited
CoA-dependent acyltransferases0.0245Inherited
Mitochondrial carrier0.04924Inherited
Thioredoxin-like0.05467Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000006256Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.002677Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.006574Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)