SUPERFAMILY 1.75 HMM library and genome assignments server

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Mode of Inheritance (MI): Autosomal recessive inheritance

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Mode of inheritance [HP:0000005] <12>
0:   Autosomal recessive inheritance [HP:0000007] <1>(65|67) (65|40|16)
- 1:   Sex-limited autosomal recessive inheritance [HP:0031362](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Hairpin loop containing domain-like0Direct
NAD kinase/diacylglycerol kinase-like0Direct
Carbohydrate phosphatase0Direct
ValRS/IleRS/LeuRS editing domain0Direct
TK C-terminal domain-like0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
Cytidine deaminase-like0Direct
HIT-like0Direct
Helical domain of Sec23/240Direct
FAD-linked oxidases, C-terminal domain0Direct
NagB/RpiA/CoA transferase-like0Direct
Metallo-dependent hydrolases0Direct
Saposin0Direct
Phoshotransferase/anion transport protein0Direct
4Fe-4S ferredoxins0Direct
GroEL equatorial domain-like0Direct
Restriction endonuclease-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Aldolase0Direct
Folate-binding domain0Direct
Rudiment single hybrid motif0Direct
LuxS/MPP-like metallohydrolase0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Heme-dependent peroxidases0Direct
ThrRS/AlaRS common domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
RUN domain-like0Direct
PX domain0Direct
FabD/lysophospholipase-like0Direct
Tricorn protease domain 20Direct
Single hybrid motif0Direct
Phosphoglycerate mutase-like0Direct
Anaphylotoxins (complement system)0Direct
FKBP-like0Direct
Thyroglobulin type-1 domain0Direct
Rhodanese/Cell cycle control phosphatase0Direct
Serum albumin-like0Direct
CalX-like0Direct
RmlC-like cupins0Direct
FAD-binding/transporter-associated domain-like0Direct
Class I glutamine amidotransferase-like0Direct
DNA repair protein MutS, domain III0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Adenine nucleotide alpha hydrolases-like0Direct
Methylglyoxal synthase-like0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Ribonuclease PH domain 2-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Pentein0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Serine protease inhibitors0Direct
Kazal-type serine protease inhibitors0Direct
CAD & PB1 domains0Direct
Plakin repeat0Direct
L-aspartase-like0Direct
Integrin beta tail domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Sema domain0Direct
Trefoil0Direct
Plexin repeat0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Cation efflux protein transmembrane domain-like0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
Nucleotide-diphospho-sugar transferases0.0001219Direct
Nucleotidylyl transferase0.000626Direct


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Class I glutamine amidotransferases (GAT)0Direct
RUN domain0Direct
Plexin repeat0Direct
Cytochrome b50Direct
XPF/Rad1/Mus81 nuclease0Direct
Myeloperoxidase-like0Direct
Tudor domain0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
Glutathione S-transferase (GST), C-terminal domain0Direct
Anticodon-binding domain0Direct
Glutathione peroxidase-like0Direct
Trefoil0Direct
DNA repair protein MutS, domain III0Direct
MPP-like0Direct
Helical domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Nitrogenase iron protein-like0Direct
BC C-terminal domain-like0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Pancreatic carboxypeptidases0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Ovomucoid domain III-like0Direct
Ferredoxin domains from multidomain proteins0Direct
beta-glycanases0Direct
Osteonectin0Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
Integrin beta EGF-like domains0Direct
Biotin dependent carboxylase carboxyltransferase domain0Direct
Inositol monophosphatase/fructose-1,6-bisphosphatase-like0Direct
Fibrinogen coiled-coil and central regions0Direct
PX domain0Direct
L-aspartase/fumarase0Direct
Lipoxigenase N-terminal domain0Direct
Diacylglycerol kinase-like0Direct
Ribonuclease PH domain 1-like0Direct
Gonadodropin/Follitropin0Direct
Integrin beta tail domain0Direct
IF2B-like0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
Ribonuclease PH domain 2-like0Direct
Proteasome subunits0Direct
Sema domain0Direct
Class I aldolase0Direct
Clathrin adaptor core protein0Direct
Serum albumin-like0Direct
BC N-terminal domain-like0Direct
BC ATP-binding domain-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
FKBP immunophilin/proline isomerase0Direct
Anaphylotoxins (complement system)0Direct
Cation efflux protein transmembrane domain-like0Direct
Biotinyl/lipoyl-carrier proteins and domains0Direct
beta-sandwich domain of Sec23/240Direct
CalX-beta domain0Direct
Thyroglobulin type-1 domain0Direct
Aminomethyltransferase folate-binding domain0Direct
Pyridoxal-dependent decarboxylase0Direct
C1 set domains (antibody constant domain-like)0Direct
Cystathionine synthase-like0Direct
Adenosine/AMP deaminase0Direct
Exostosin0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Plakin repeat0Direct
Trunk domain of Sec23/240Direct
Netrin-like domain (NTR/C345C module)0Direct
Reprolysin-like0Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
FAD-binding/transporter-associated domain-like0Direct
Pentein0Direct
Methylglyoxal synthase-like0Direct
Thyroglobulin type-1 domain0Direct
Fibrinogen coiled-coil and central regions0Direct
ValRS/IleRS/LeuRS editing domain0Direct
4Fe-4S ferredoxins0Direct
Quinoprotein alcohol dehydrogenase-like0Direct
Cation efflux protein transmembrane domain-like0Direct
Phoshotransferase/anion transport protein0Direct
Trefoil0Direct
HIT-like0Direct
Cytidine deaminase-like0Direct
Metallo-dependent hydrolases0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Hairpin loop containing domain-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Integrin beta tail domain0Direct
Helical domain of Sec23/240Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Heme-dependent peroxidases0Direct
GroEL equatorial domain-like0Direct
Serum albumin-like0Direct
NagB/RpiA/CoA transferase-like0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Serine protease inhibitors0Direct
TK C-terminal domain-like0Direct
CalX-like0Direct
RUN domain-like0Direct
Sema domain0Direct
Ribonuclease PH domain 2-like0Direct
CAD & PB1 domains0Direct
PX domain0Direct
Folate-binding domain0Direct
Plakin repeat0Direct
Plexin repeat0Direct
Rudiment single hybrid motif0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
Adenine nucleotide alpha hydrolases-like0Direct
Class I glutamine amidotransferase-like0Direct
Single hybrid motif0Direct
FabD/lysophospholipase-like0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
ThrRS/AlaRS common domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
FKBP-like0Direct
DNA repair protein MutS, domain III0Direct
LuxS/MPP-like metallohydrolase0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Tricorn protease domain 20Direct
L-aspartase-like0Direct
Anaphylotoxins (complement system)0Direct
Restriction endonuclease-like0Direct
Saposin0Direct
FAD-linked oxidases, C-terminal domain0Direct
Carbohydrate phosphatase0Direct
Rhodanese/Cell cycle control phosphatase0Direct
NAD kinase/diacylglycerol kinase-like0Direct
Kazal-type serine protease inhibitors0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Aldolase0Direct
RmlC-like cupins0Direct
Phosphoglycerate mutase-like0Direct
Nucleotide-diphospho-sugar transferases0.00009296Direct
Nucleotidylyl transferase0.000501Direct

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55486,82895
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0Direct
    63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    52799,52799
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0Direct
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    49854,57424
  • 49854 - Spermadhesin, CUB domain
  • 57424 - LDL receptor-like module
  • 0Direct
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    56176,55103
  • 56176 - FAD-binding/transporter-associated domain-like
  • 55103 - FAD-linked oxidases, C-terminal domain
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,49899,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    47473,51695,49562
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct


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