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Phenotypic Abnormality (PA): Abnormality of the genital system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the genitourinary system [HP:0000119] <5>(72|74) (80|28|7)
0:   Abnormality of the genital system [HP:0000078] <3>(33|36) (37|10|1)
- 1:   Abnormal reproductive system morphology [HP:0012243] <10>(26|28) (28|4|0)
- 1:   Genital neoplasm [HP:0010787] <6>(6|6) (7|2|0)
- 1:   Abnormality of reproductive system physiology [HP:0000080] <5>(9|10) (12|3|1)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Zn-finger domain of Sec23/240Direct
Smc hinge domain0Direct
Restriction endonuclease-like0Direct
ARID-like0Direct
BRK domain-like0Direct
DNA repair protein MutS, domain III0Direct
Fibrinogen coiled-coil and central regions0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Ribonuclease H-like0.00001537Direct
SET domain0.001627Inherited
HMG-box0.01816Inherited
CalX-like0.01883Inherited
Bromodomain0.02558Inherited
HD-domain/PDEase-like0.02808Inherited
GAF domain-like0.04383Inherited
RuvA domain 2-like0.04383Inherited
WD40 repeat-like0.05404Inherited
Chromo domain-like0.05461Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.06804Inherited
Nuclear receptor ligand-binding domain0.07268Inherited
BRCT domain0.1238Inherited
"Winged helix" DNA-binding domain0.1505Inherited
Family A G protein-coupled receptor-like0.2497Inherited
RING/U-box0.2677Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2818Inherited
Fibrinogen C-terminal domain-like0.2965Inherited
GroEL equatorial domain-like0.3036Inherited
RNA-binding domain, RBD0.3385Inherited
NagB/RpiA/CoA transferase-like0.4439Inherited
Ribosomal protein S5 domain 2-like0.5596Inherited
Trypsin-like serine proteases0.8599Inherited
DEATH domain0.9435Inherited
Cytochrome P4500.9436Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
XPF/Rad1/Mus81 nuclease0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
ARID domain0Direct
DNA repair protein MutS, domain III0Direct
DnaQ-like 3'-5' exonuclease0Direct
DIX domain0Direct
BRK domain-like0Direct
Zn-finger domain of Sec23/240Direct
Smc hinge domain0Direct
Fibrinogen coiled-coil and central regions0Direct
IF2B-like0Direct
DNA polymerase I0Direct
Histone lysine methyltransferases0.00138Inherited
PHD domain0.009481Inherited
HMG-box0.01207Inherited
RING finger domain, C3HC40.01207Inherited
Tandem AAA-ATPase domain0.01322Inherited
CalX-beta domain0.01351Inherited
Bromodomain0.01743Inherited
GAF domain0.03329Inherited
PDEase0.04309Inherited
Chromo domain0.04309Inherited
Nuclear receptor ligand-binding domain0.06058Inherited
Nuclear receptor0.06994Inherited
RecA protein-like (ATPase-domain)0.07117Inherited
MIR domain0.1582Inherited
Rhodopsin-like0.17Inherited
DNA gyrase/MutL, second domain0.1913Inherited
DNA gyrase/MutL, N-terminal domain0.1913Inherited
Extended AAA-ATPase domain0.2151Inherited
Extracellular domain of cell surface receptors0.2655Inherited
Fibrinogen C-terminal domain-like0.2677Inherited
Canonical RBD0.2901Inherited
ABC transporter ATPase domain-like0.5265Inherited
Ngr ectodomain-like0.5752Inherited
Eukaryotic proteases0.8144Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Zn-finger domain of Sec23/240Direct
Smc hinge domain0Direct
DNA repair protein MutS, domain III0Direct
ARID-like0Direct
Restriction endonuclease-like0Direct
BRK domain-like0Direct
Ribonuclease H-like0.000006888Direct
SET domain0.0009253Direct
DNA/RNA polymerases0.00179Inherited
HMG-box0.01242Inherited
CalX-like0.0129Inherited
Bromodomain0.01798Inherited
HD-domain/PDEase-like0.01992Inherited
GAF domain-like0.03223Inherited
RuvA domain 2-like0.03223Inherited
WD40 repeat-like0.04056Inherited
Chromo domain-like0.04108Inherited
FYVE/PHD zinc finger0.04963Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.05206Inherited
Nuclear receptor ligand-binding domain0.056Inherited
BRCT domain0.09975Inherited
"Winged helix" DNA-binding domain0.1235Inherited
MIR domain0.1528Inherited
Family A G protein-coupled receptor-like0.214Inherited
RING/U-box0.2313Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2446Inherited
Fibrinogen C-terminal domain-like0.2589Inherited
GroEL equatorial domain-like0.2657Inherited
RNA-binding domain, RBD0.2988Inherited
NagB/RpiA/CoA transferase-like0.4016Inherited
Immunoglobulin0.4169Inherited
Ribosomal protein S5 domain 2-like0.5168Inherited
Trypsin-like serine proteases0.8288Inherited
DEATH domain0.9173Inherited
Cytochrome P4500.9174Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    -7,56112
  • -7 - CATH
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.03223Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.03223Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.1918Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.03223Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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