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Phenotypic Abnormality (PA): Abnormality of the genitourinary system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the genitourinary system [HP:0000119] <5>(72|74) (80|28|7)
- 1:   Urogenital fistula [HP:0100589] <5>(1|0) (1|0|0)
- 1:   Abnormality of the urinary system [HP:0000079] <4>(36|39) (42|14|6)
- 1:   Neoplasm of the genitourinary tract [HP:0007379] <4>(6|7) (8|2|1)
- 1:   Abnormality of the genital system [HP:0000078] <3>(33|36) (37|10|1)
- 1:   Cloacal abnormality [HP:0012620] <2>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
NAD kinase/diacylglycerol kinase-like0Direct
Zn-finger domain of Sec23/240Direct
Putative DNA-binding domain0Direct
Lamin A/C globular tail domain0Direct
PRTase-like0Direct
DNA-glycosylase0Direct
Smc hinge domain0Direct
Restriction endonuclease-like0Direct
Sec63 N-terminal domain-like0Direct
ARID-like0Direct
Histone-fold0Direct
Insulin-like0Direct
SAND domain-like0Direct
Tricorn protease domain 20Direct
BRK domain-like0Direct
DNA repair protein MutS, domain III0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Methylglyoxal synthase-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Ribonuclease H-like0.002155Inherited
ClpP/crotonase0.01644Inherited
Alkaline phosphatase-like0.0176Inherited
WD40 repeat-like0.02511Inherited
"Winged helix" DNA-binding domain0.02659Inherited
(Trans)glycosidases0.03005Inherited
RING/U-box0.03365Inherited
NagB/RpiA/CoA transferase-like0.03444Inherited
Bromodomain0.03778Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.04126Inherited
Actin-like ATPase domain0.05526Inherited
BRCT domain0.06405Inherited
SET domain0.06888Inherited
HMG-box0.08133Inherited
Transcription factor STAT-4 N-domain0.09329Inherited
GroEL equatorial domain-like0.09329Inherited
STAT0.09329Inherited
CalX-like0.09329Inherited
PreATP-grasp domain0.09699Inherited
RNA-binding domain, RBD0.1098Inherited
Glutathione synthetase ATP-binding domain-like0.1295Inherited
Adenine nucleotide alpha hydrolases-like0.1464Inherited
GAF domain-like0.1519Inherited
RuvA domain 2-like0.1519Inherited
L-aspartase-like0.1519Inherited
FYVE/PHD zinc finger0.1578Inherited
C-type lectin-like0.1611Inherited
E set domains0.1693Inherited
HD-domain/PDEase-like0.1832Inherited
Homeodomain-like0.2062Inherited
Acyl-CoA dehydrogenase NM domain-like0.2109Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.2109Inherited
Chromo domain-like0.2546Inherited
Nuclear receptor ligand-binding domain0.3008Inherited
Acyl-CoA N-acyltransferases (Nat)0.3117Inherited
Cysteine-rich domain0.3175Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3455Inherited
MHC antigen-recognition domain0.373Inherited
Family A G protein-coupled receptor-like0.3868Inherited
Cytochrome P4500.4286Inherited
TPR-like0.439Inherited
Ribosomal protein S5 domain 2-like0.582Inherited
Clc chloride channel0.6044Inherited
Fibrinogen C-terminal domain-like0.7005Inherited
Mitochondrial carrier0.7517Inherited
Cytokine0.7661Inherited
ARM repeat0.7899Inherited
L domain-like0.7985Inherited
TNF-like0.9402Inherited
Trypsin-like serine proteases0.9596Inherited
DEATH domain0.9915Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Cytochrome b50Direct
XPF/Rad1/Mus81 nuclease0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Formate/glycerate dehydrogenases, substrate-binding domain0Direct
ARID domain0Direct
DNA repair protein MutS, domain III0Direct
DnaQ-like 3'-5' exonuclease0Direct
Lamin A/C globular tail domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
DIX domain0Direct
BRK domain-like0Direct
DNA gyrase/MutL, second domain0Direct
Zn-finger domain of Sec23/240Direct
beta-glycanases0Direct
Smc hinge domain0Direct
Phosphoribosyltransferases (PRTases)0Direct
Integrin alpha N-terminal domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Diacylglycerol kinase-like0Direct
IF2B-like0Direct
TBP-associated factors, TAFs0Direct
Insulin-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
Sec63 N-terminal domain0Direct
DNA polymerase I0Direct
HCDH C-domain-like0Direct
DNA gyrase/MutL, N-terminal domain0Direct
Cystathionine synthase-like0Direct
PHD domain0.001267Inherited
RecA protein-like (ATPase-domain)0.008815Inherited
Bromodomain0.03082Inherited
Histone lysine methyltransferases0.03297Inherited
Arylsulfatase0.03297Inherited
Crotonase-like0.04629Inherited
BC N-terminal domain-like0.04629Inherited
BC ATP-binding domain-like0.04629Inherited
POU-specific domain0.04629Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.05295Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.05295Inherited
HMG-box0.07091Inherited
Transcription factor STAT-4 N-domain0.07848Inherited
STAT DNA-binding domain0.07848Inherited
STAT0.07848Inherited
CalX-beta domain0.07848Inherited
Actin/HSP700.08283Inherited
RING finger domain, C3HC40.1101Inherited
GAF domain0.1309Inherited
Extended AAA-ATPase domain0.1454Inherited
Tandem AAA-ATPase domain0.1584Inherited
Cytoplasmic domain of inward rectifier potassium channel0.1624Inherited
Homeodomain0.165Inherited
WD40-repeat0.1814Inherited
Noncollagenous (NC1) domain of collagen IV0.1915Inherited
Extracellular domain of cell surface receptors0.1915Inherited
Canonical RBD0.196Inherited
PDEase0.231Inherited
Chromo domain0.231Inherited
ABC transporter ATPase domain-like0.2406Inherited
Nuclear receptor0.2763Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2799Inherited
Nuclear receptor ligand-binding domain0.2843Inherited
MHC antigen-recognition domain0.3475Inherited
Rhodopsin-like0.3714Inherited
MIR domain0.4415Inherited
C1 set domains (antibody constant domain-like)0.4705Inherited
Cytochrome P4500.4821Inherited
Fibroblast growth factors (FGF)0.5747Inherited
Clc chloride channel0.5821Inherited
Fibrinogen C-terminal domain-like0.6836Inherited
Mitochondrial carrier0.7402Inherited
Ngr ectodomain-like0.9249Inherited
TNF-like0.9334Inherited
Eukaryotic proteases0.9859Inherited
Voltage-gated potassium channels0.9912Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Methylglyoxal synthase-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Sec63 N-terminal domain-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Zn-finger domain of Sec23/240Direct
Cytochrome b5-like heme/steroid binding domain0Direct
Insulin-like0Direct
Putative DNA-binding domain0Direct
DNA-glycosylase0Direct
Smc hinge domain0Direct
PRTase-like0Direct
DNA repair protein MutS, domain III0Direct
Lamin A/C globular tail domain0Direct
Histone-fold0Direct
SAND domain-like0Direct
Tricorn protease domain 20Direct
ARID-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Restriction endonuclease-like0Direct
BRK domain-like0Direct
NAD kinase/diacylglycerol kinase-like0Direct
Ribonuclease H-like0.001248Inherited
Integrin domains0.00795Inherited
ClpP/crotonase0.01111Inherited
Alkaline phosphatase-like0.01201Inherited
WD40 repeat-like0.01761Inherited
"Winged helix" DNA-binding domain0.01871Inherited
(Trans)glycosidases0.02146Inherited
RING/U-box0.02428Inherited
NagB/RpiA/CoA transferase-like0.02487Inherited
DNA/RNA polymerases0.02487Inherited
Bromodomain0.02751Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.03023Inherited
Actin-like ATPase domain0.0416Inherited
BRCT domain0.04872Inherited
SET domain0.05277Inherited
HMG-box0.06335Inherited
GroEL equatorial domain-like0.07352Inherited
CalX-like0.07352Inherited
STAT0.07352Inherited
Transcription factor STAT-4 N-domain0.07352Inherited
PreATP-grasp domain0.07661Inherited
RNA-binding domain, RBD0.08755Inherited
Glutathione synthetase ATP-binding domain-like0.1048Inherited
Adenine nucleotide alpha hydrolases-like0.1199Inherited
GAF domain-like0.1247Inherited
RuvA domain 2-like0.1247Inherited
L-aspartase-like0.1247Inherited
FYVE/PHD zinc finger0.1298Inherited
C-type lectin-like0.1328Inherited
E set domains0.1402Inherited
lambda repressor-like DNA-binding domains0.1526Inherited
HD-domain/PDEase-like0.1526Inherited
Homeodomain-like0.1738Inherited
Acyl-CoA dehydrogenase NM domain-like0.1781Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.1781Inherited
Chromo domain-like0.2186Inherited
Nuclear receptor ligand-binding domain0.263Inherited
Acyl-CoA N-acyltransferases (Nat)0.2733Inherited
Cysteine-rich domain0.2788Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3053Inherited
MHC antigen-recognition domain0.332Inherited
Family A G protein-coupled receptor-like0.3456Inherited
Cytochrome P4500.3863Inherited
TPR-like0.3967Inherited
MIR domain0.4271Inherited
Ribosomal protein S5 domain 2-like0.54Inherited
CBS-domain pair0.5525Inherited
Clc chloride channel0.5632Inherited
Fibrinogen C-terminal domain-like0.6621Inherited
Mitochondrial carrier0.7157Inherited
Cytokine0.7307Inherited
ARM repeat0.7556Inherited
L domain-like0.7646Inherited
PDZ domain-like0.8803Inherited
TNF-like0.9137Inherited
Trypsin-like serine proteases0.9348Inherited
DEATH domain0.9706Inherited
Voltage-gated potassium channels0.9889Inherited
Immunoglobulin0.9968Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
117281,117281
  • 117281 - Kelch motif
  • 117281 - Kelch motif
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0Direct
    52540,46785
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    -7,56112
  • -7 - CATH
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.02995Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.04872Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.07352Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.07352Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.07352Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.1247Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.1247Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.1247Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.1526Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.1781Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.1825Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.2448Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.332Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.4378Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0Direct
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.07007Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.07352Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.07352Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.1247Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.445Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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