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Phenotypic Abnormality (PA): Abnormality of the mouth

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of head or neck [HP:0000152] <2>(86|104) (97|58|38)
+ + 2:   Abnormality of the head [HP:0000234] <6>(85|102) (96|57|38)
+ 1:   Abnormality of the face [HP:0000271] <14>(70|85) (82|46|31)
0:   Abnormality of the mouth [HP:0000153] <2>(37|57) (46|32|22)
- 1:   Abnormal oral physiology [HP:0031815] <7>(2|3) (2|1|1)
- 1:   Abnormal oral morphology [HP:0031816] <6>(35|53) (44|30|21)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
C-terminal, gelsolin-like domain of Sec23/240Direct
Tricorn protease domain 20Direct
TB module/8-cys domain0Direct
CalX-like0Direct
Plakin repeat0Direct
Helical domain of Sec23/240Direct
Integrin beta tail domain0Direct
Smc hinge domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Zn-finger domain of Sec23/240Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Actin depolymerizing proteins0Direct
Tudor/PWWP/MBT0.0004561Direct
HMG-box0.01356Inherited
ARID-like0.03392Inherited
RNA-binding domain, RBD0.08952Inherited
Notch domain0.1083Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.1083Inherited
Calcium-dependent phosphotriesterase0.1083Inherited
Homeodomain-like0.1421Inherited
Hect, E3 ligase catalytic domain0.1623Inherited
MHC antigen-recognition domain0.2655Inherited
Bromodomain0.2724Inherited
RNI-like0.3136Inherited
Ubiquitin-like0.3191Inherited
Fibrinogen C-terminal domain-like0.3601Inherited
SMAD/FHA domain0.3864Inherited
BRK domain-like0.4863Inherited
MIR domain0.4935Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5077Inherited
Immunoglobulin0.7307Inherited
Transcription factor STAT-4 N-domain0.7578Inherited
STAT0.7578Inherited
4-helical cytokines0.7934Inherited
Intermediate filament protein, coiled coil region0.8097Inherited
DEATH domain0.9122Inherited
Trypsin-like serine proteases0.9839Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Zn-finger domain of Sec23/240Direct
CalX-beta domain0Direct
Armadillo repeat0Direct
Protein serine/threonine phosphatase0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Helical domain of Sec23/240Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Interleukin-1 (IL-1)0Direct
Clathrin adaptor core protein0Direct
Glycosyl transferases group 10Direct
Integrin beta EGF-like domains0Direct
Smc hinge domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Histone deacetylase, HDAC0Direct
Plakin repeat0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
TB module/8-cys domain0Direct
beta-sandwich domain of Sec23/240Direct
Trunk domain of Sec23/240Direct
Fibrinogen coiled-coil and central regions0Direct
PWWP domain0Direct
Integrin beta tail domain0Direct
HMG-box0.009842Inherited
PX domain0.01314Inherited
ARID domain0.02536Inherited
Laminin-type module0.04461Inherited
SPRY domain0.04825Inherited
Pyrin domain, PYD0.04825Inherited
VWC domain0.07598Inherited
Notch domain0.08929Inherited
DIX domain0.08929Inherited
Hect, E3 ligase catalytic domain0.142Inherited
RecA protein-like (ATPase-domain)0.1591Inherited
Canonical RBD0.1617Inherited
Homeodomain0.1617Inherited
C1 set domains (antibody constant domain-like)0.1726Inherited
Fibroblast growth factors (FGF)0.1726Inherited
GLA-domain0.2241Inherited
PDZ domain0.2304Inherited
T-box0.236Inherited
MHC antigen-recognition domain0.2365Inherited
Bromodomain0.2492Inherited
28-residue LRR0.2542Inherited
Fibrinogen C-terminal domain-like0.3272Inherited
PHD domain0.335Inherited
Histone lysine methyltransferases0.3885Inherited
Clathrin coat assembly domain0.4568Inherited
BRK domain-like0.4568Inherited
beta-glycanases0.4568Inherited
MIR domain0.4608Inherited
Tetratricopeptide repeat (TPR)0.5506Inherited
Transcription factor STAT-4 N-domain0.7386Inherited
STAT DNA-binding domain0.7386Inherited
STAT0.7386Inherited
Intermediate filament protein, coiled coil region0.8025Inherited
PLC-like (P variant)0.8081Inherited
Eukaryotic proteases0.9505Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Smc hinge domain0Direct
CalX-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Plakin repeat0Direct
Tricorn protease domain 20Direct
TB module/8-cys domain0Direct
Helical domain of Sec23/240Direct
Actin depolymerizing proteins0Direct
Zn-finger domain of Sec23/240Direct
Integrin beta tail domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Tudor/PWWP/MBT0.0002293Direct
HMG-box0.008947Inherited
PX domain0.01233Inherited
ARID-like0.02408Inherited
Multidrug efflux transporter AcrB transmembrane domain0.04569Inherited
Actin-like ATPase domain0.0588Inherited
RNA-binding domain, RBD0.06959Inherited
Notch domain0.08537Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.08537Inherited
Calcium-dependent phosphotriesterase0.08537Inherited
Cytokine0.08835Inherited
Homeodomain-like0.1155Inherited
Hect, E3 ligase catalytic domain0.1332Inherited
EGF/Laminin0.1736Inherited
DPP6 N-terminal domain-like0.1991Inherited
GLA-domain0.2165Inherited
Glycosyl hydrolase domain0.2244Inherited
MHC antigen-recognition domain0.2276Inherited
Bromodomain0.2343Inherited
RNI-like0.273Inherited
Ubiquitin-like0.2785Inherited
Fibrinogen C-terminal domain-like0.3178Inherited
SMAD/FHA domain0.3432Inherited
SET domain0.4089Inherited
BRK domain-like0.4424Inherited
MIR domain0.4491Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4634Inherited
Immunoglobulin0.6926Inherited
Transcription factor STAT-4 N-domain0.7209Inherited
STAT0.7209Inherited
4-helical cytokines0.7579Inherited
Intermediate filament protein, coiled coil region0.775Inherited
DEATH domain0.8838Inherited
Trypsin-like serine proteases0.9618Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    57889,48350
  • 57889 - Cysteine-rich domain
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.08537Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.08908Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1317Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.2244Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.2244Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.2276Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.2964Inherited
    55486,82895
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 82895 - TSP-1 type 1 repeat
  • 0.4424Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4424Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.6857Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.7209Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.7209Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.7209Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.8196Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.08537Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1668Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2426Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.4925Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.7209Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.7209Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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