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Phenotypic Abnormality (PA): Abnormality of the mouth

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of head or neck [HP:0000152] <2>(84|104) (94|53|33)
+ + 2:   Abnormality of the head [HP:0000234] <6>(83|101) (93|52|33)
+ 1:   Abnormality of the face [HP:0000271] <14>(69|85) (80|44|29)
0:   Abnormality of the mouth [HP:0000153] <2>(35|51) (43|29|22)
- 1:   Abnormal oral physiology [HP:0031815] <7>(2|2) (2|1|0)
- 1:   Abnormal oral morphology [HP:0031816] <5>(33|49) (41|27|22)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Zn-finger domain of Sec23/240Direct
Helical domain of Sec23/240Direct
Toll/Interleukin receptor TIR domain0Direct
Smc hinge domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Tricorn protease domain 20Direct
BRK domain-like0Direct
CalX-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Fibrinogen coiled-coil and central regions0Direct
TB module/8-cys domain0Direct
Plakin repeat0Direct
Integrin beta tail domain0Direct
PX domain0.01578Inherited
ARID-like0.02983Inherited
RNA-binding domain, RBD0.06075Inherited
Homeodomain-like0.07254Inherited
Tudor/PWWP/MBT0.08559Inherited
Calcium-dependent phosphotriesterase0.1003Inherited
Notch domain0.1003Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.1003Inherited
Glycosyl hydrolase domain0.2429Inherited
Bromodomain0.2562Inherited
SET domain0.2562Inherited
EGF/Laminin0.2777Inherited
Ubiquitin-like0.321Inherited
Fibrinogen C-terminal domain-like0.3352Inherited
SMAD/FHA domain0.3655Inherited
Hect, E3 ligase catalytic domain0.3956Inherited
RNI-like0.3956Inherited
MIR domain0.4738Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4796Inherited
Immunoglobulin0.5163Inherited
Intermediate filament protein, coiled coil region0.7879Inherited
DEATH domain0.8577Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
TB module/8-cys domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Protein serine/threonine phosphatase0Direct
Helical domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
BRK domain-like0Direct
Toll/Interleukin receptor TIR domain0Direct
Zn-finger domain of Sec23/240Direct
Smc hinge domain0Direct
Integrin beta EGF-like domains0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Fibrinogen coiled-coil and central regions0Direct
Integrin beta tail domain0Direct
Clathrin adaptor core protein0Direct
beta-sandwich domain of Sec23/240Direct
CalX-beta domain0Direct
Plakin repeat0Direct
Trunk domain of Sec23/240Direct
Histone deacetylase, HDAC0Direct
PX domain0.01166Inherited
HMG-box0.02103Inherited
ARID domain0.02284Inherited
Laminin-type module0.03936Inherited
Pyrin domain, PYD0.04446Inherited
VWC domain0.07061Inherited
Homeodomain0.08385Inherited
Notch domain0.08448Inherited
DIX domain0.08448Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.0872Inherited
RecA protein-like (ATPase-domain)0.0872Inherited
Canonical RBD0.09055Inherited
Fibroblast growth factors (FGF)0.1657Inherited
T-box0.1657Inherited
PHD domain0.1909Inherited
GLA-domain0.2127Inherited
Protein kinases, catalytic subunit0.2372Inherited
Bromodomain0.2387Inherited
28-residue LRR0.2461Inherited
PDZ domain0.2793Inherited
Fibrinogen C-terminal domain-like0.3108Inherited
Histone lysine methyltransferases0.3751Inherited
Hect, E3 ligase catalytic domain0.3751Inherited
Transcription factor STAT-4 N-domain0.4473Inherited
STAT DNA-binding domain0.4473Inherited
beta-glycanases0.4473Inherited
STAT0.4473Inherited
Clathrin coat assembly domain0.4473Inherited
MIR domain0.4473Inherited
Intermediate filament protein, coiled coil region0.7875Inherited
PLC-like (P variant)0.7973Inherited
Eukaryotic proteases0.938Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Zn-finger domain of Sec23/240Direct
Integrin beta tail domain0Direct
Helical domain of Sec23/240Direct
CalX-like0Direct
TB module/8-cys domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Plakin repeat0Direct
Smc hinge domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Toll/Interleukin receptor TIR domain0Direct
Tricorn protease domain 20Direct
BRK domain-like0Direct
PX domain0.01065Inherited
HMG-box0.01845Inherited
ARID-like0.02129Inherited
RNA-binding domain, RBD0.04603Inherited
Homeodomain-like0.05587Inherited
Tudor/PWWP/MBT0.067Inherited
Notch domain0.07937Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.07937Inherited
Calcium-dependent phosphotriesterase0.07937Inherited
Cytokine0.102Inherited
DPP6 N-terminal domain-like0.187Inherited
GLA-domain0.2022Inherited
Glycosyl hydrolase domain0.2077Inherited
SET domain0.2201Inherited
Bromodomain0.2201Inherited
EGF/Laminin0.2405Inherited
Ubiquitin-like0.282Inherited
Fibrinogen C-terminal domain-like0.2956Inherited
SMAD/FHA domain0.3247Inherited
Hect, E3 ligase catalytic domain0.3542Inherited
RNI-like0.3542Inherited
STAT0.4312Inherited
MIR domain0.4312Inherited
Transcription factor STAT-4 N-domain0.4312Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4367Inherited
Immunoglobulin0.4732Inherited
p53-like transcription factors0.7279Inherited
Intermediate filament protein, coiled coil region0.7536Inherited
DEATH domain0.8265Inherited
Trypsin-like serine proteases0.9491Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.07937Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.0801Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1189Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.129Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.2077Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.2847Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.2847Inherited
    55486,82895
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 82895 - TSP-1 type 1 repeat
  • 0.4312Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.4312Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.4312Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.4312Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.4312Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.5572Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.8085Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.07937Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.08975Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.4312Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.4312Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.4312Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.4563Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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