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Phenotypic Abnormality (PA): Behavioral abnormality

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the nervous system [HP:0000707] <4>(142|168) (156|103|45)
+ 1:   Abnormality of nervous system physiology [HP:0012638] <26>(101|119) (112|81|39)
0:   Behavioral abnormality [HP:0000708] <38>(17|24) (19|15|5)
- 1:   Sleep disturbance [HP:0002360] <13>(1|1) (2|0|0)
- 1:   Impairment in personality functioning [HP:0031466] <12>(6|9) (9|3|0)
- 1:   Abnormal emotion/affect behavior [HP:0100851] <11>(4|4) (4|3|0)
- 1:   Abnormal social behavior [HP:0012433] <5>(1|1) (1|0|0)
- 1:   Autistic behavior [HP:0000729] <5>(0|2) (1|2|2)
- 1:   Hallucinations [HP:0000738] <5>(1|2) (1|3|0)
- 1:   Sound sensitivity [HP:0025112] <3>(1|1) (1|0|0)
- 1:   Abnormal consumption behavior [HP:0040202] <2>(0|1) (0|1|0)
- 1:   Abnormal temper tantrums [HP:0025160] <2>(0|0) (0|0|0)
- 1:   Obsessive-compulsive behavior [HP:0000722] <2>(1|0) (1|0|0)
- 1:   Perseveration [HP:0030223] <2>(1|1) (1|0|0)
- 1:   Psychosis [HP:0000709] <2>(0|0) (0|0|0)
- 1:   Restlessness [HP:0000711] <2>(2|2) (2|2|0)
- 1:   Addictive behavior [HP:0030858] <1>(0|0) (0|0|0)
- 1:   Delusions [HP:0000746] <1>(1|1) (1|0|0)
- 1:   Mania [HP:0100754] <1>(0|0) (0|0|0)
- 1:   Short attention span [HP:0000736] <1>(0|3) (1|1|0)
- 1:   Diminished ability to concentrate [HP:0031987](0|0) (0|0|0)
- 1:   Drooling [HP:0002307](0|0) (0|0|0)
- 1:   Echolalia [HP:0010529](0|0) (0|0|0)
- 1:   Hydrophobia [HP:0032505](0|0) (0|0|0)
- 1:   Hyperorality [HP:0000710](0|0) (0|0|0)
- 1:   Inflexible adherence to routines or rituals [HP:0000732](0|0) (0|0|0)
- 1:   Lack of insight [HP:0000757](0|0) (0|0|0)
- 1:   Lack of spontaneous play [HP:0000721](0|0) (0|0|0)
- 1:   Low frustration tolerance [HP:0000744](0|0) (0|1|0)
- 1:   Mutism [HP:0002300](1|1) (1|1|0)
- 1:   Negativism [HP:0410291](0|0) (0|0|0)
- 1:   Onychotillomania [HP:0032509](0|0) (0|0|0)
- 1:   Oppositional defiant disorder [HP:0010865](0|0) (0|0|0)
- 1:   Personality changes [HP:0000751](1|1) (1|0|0)
- 1:   Photophobia [HP:0000613](1|3) (1|0|0)
- 1:   Polyembolokoilamania [HP:0032508](0|0) (0|0|0)
- 1:   Pseudobulbar behavioral symptoms [HP:0002193](0|0) (0|0|0)
- 1:   Psychomotor retardation [HP:0025356](2|4) (2|1|1)
- 1:   Schizophrenia [HP:0100753](0|0) (0|2|0)
- 1:   Self hugging [HP:0032521](0|0) (0|0|0)
- 1:   Self-neglect [HP:0025479](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
L-aspartase-like0Direct
GAF domain-like0Direct
Single hybrid motif0.02004Inherited
Voltage-gated potassium channels0.03345Inherited
SET domain0.05326Inherited
Cap-Gly domain0.05829Inherited
Rudiment single hybrid motif0.05829Inherited
cAMP-binding domain-like0.0592Inherited
Bromodomain0.07636Inherited
Acyl-CoA N-acyltransferases (Nat)0.09225Inherited
NagB/RpiA/CoA transferase-like0.1372Inherited
4Fe-4S ferredoxins0.1501Inherited
Calcium-dependent phosphotriesterase0.1501Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.1794Inherited
RNA-binding domain, RBD0.2721Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4123Inherited
Nicotinic receptor ligand binding domain-like0.4123Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
IF2B-like0Direct
Clathrin adaptor core protein0Direct
Ferredoxin domains from multidomain proteins0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
L-aspartase/fumarase0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
GAF domain0Direct
Biotinyl/lipoyl-carrier proteins and domains0.0143Inherited
DNA gyrase/MutL, N-terminal domain0.0196Inherited
DNA gyrase/MutL, second domain0.0196Inherited
cAMP-binding domain0.03039Inherited
ZZ domain0.04463Inherited
BC C-terminal domain-like0.04463Inherited
Cap-Gly domain0.04463Inherited
Bromodomain0.06174Inherited
BC ATP-binding domain-like0.07473Inherited
BC N-terminal domain-like0.07473Inherited
PWWP domain0.1201Inherited
Pyrin domain, PYD0.1257Inherited
Cytoplasmic domain of inward rectifier potassium channel0.1526Inherited
28-residue LRR0.2197Inherited
Canonical RBD0.2239Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3795Inherited
Nicotinic receptor ligand binding domain-like0.3795Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
GAF domain-like0Direct
L-aspartase-like0Direct
Single hybrid motif0.01365Inherited
Voltage-gated potassium channels0.02376Inherited
SET domain0.03954Inherited
Cap-Gly domain0.04363Inherited
Rudiment single hybrid motif0.04363Inherited
cAMP-binding domain-like0.04436Inherited
Bromodomain0.05865Inherited
Acyl-CoA N-acyltransferases (Nat)0.07193Inherited
NagB/RpiA/CoA transferase-like0.1111Inherited
4Fe-4S ferredoxins0.1226Inherited
Calcium-dependent phosphotriesterase0.1226Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.1483Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.1557Inherited
RNA-binding domain, RBD0.234Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.3689Inherited
Nicotinic receptor ligand binding domain-like0.3689Inherited
Immunoglobulin0.8881Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.01931Inherited
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.04363Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.1226Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.1483Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.1483Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.1483Inherited
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1786Inherited
    54160,54160
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 0.1786Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.3041Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.3689Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.04363Inherited
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1786Inherited
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1786Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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