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Phenotypic Abnormality (PA): Abnormality of the skin

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the integument [HP:0001574] <4>(48|69) (59|37|15)
0:   Abnormality of the skin [HP:0000951] <4>(34|55) (45|36|12)
- 1:   Neoplasm of the skin [HP:0008069] <29>(4|5) (4|3|1)
- 1:   Abnormality of skin morphology [HP:0011121] <22>(29|49) (40|31|11)
- 1:   Abnormality of skin physiology [HP:0011122] <6>(3|6) (5|3|0)
- 1:   Abnormal perifollicular morphology [HP:0031285] <3>(1|1) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Tricorn protease domain 20Direct
Plakin repeat0Direct
DHS-like NAD/FAD-binding domain0Direct
SAND domain-like0Direct
Notch domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Apolipoprotein A-I0Direct
Integrin beta tail domain0Direct
Zn-finger domain of Sec23/240Direct
RuvA domain 2-like0Direct
ABC transporter transmembrane region0.005187Inherited
MHC antigen-recognition domain0.0103Inherited
DNA/RNA polymerases0.01737Inherited
Integrin domains0.03197Inherited
Globin-like0.03251Inherited
DNA repair protein MutS, domain III0.1054Inherited
ARID-like0.1447Inherited
EGF/Laminin0.1576Inherited
Prefoldin0.1655Inherited
Complement control module/SCR domain0.2116Inherited
Spectrin repeat0.2386Inherited
Nicotinic receptor ligand binding domain-like0.2695Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2695Inherited
DEATH domain0.3035Inherited
Ribosomal protein S5 domain 2-like0.3165Inherited
Intermediate filament protein, coiled coil region0.3279Inherited
alpha/beta-Hydrolases0.3951Inherited
RNI-like0.3992Inherited
SH2 domain0.4121Inherited
FnI-like domain0.4131Inherited
HMG-box0.4481Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.5638Inherited
Immunoglobulin0.5667Inherited
(Trans)glycosidases0.8467Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Histone deacetylase, HDAC0Direct
Integrin beta EGF-like domains0Direct
ets domain0Direct
Exostosin0Direct
Proteasome subunits0Direct
Zn-finger domain of Sec23/240Direct
Integrin beta tail domain0Direct
Notch domain0Direct
Apolipoprotein A-I0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
Erythroid transcription factor GATA-10Direct
Plakin repeat0Direct
Caspase catalytic domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Integrin A (or I) domain0.0006327Direct
C1 set domains (antibody constant domain-like)0.001149Inherited
MHC antigen-recognition domain0.007968Inherited
GLA-domain0.01343Inherited
Globins0.02579Inherited
DnaQ-like 3'-5' exonuclease0.02579Inherited
Integrin domains0.02586Inherited
Pyrin domain, PYD0.04891Inherited
DNA gyrase/MutL, second domain0.04891Inherited
DNA gyrase/MutL, N-terminal domain0.04891Inherited
EGF-type module0.07896Inherited
beta-sandwich domain of Sec23/240.09024Inherited
Trunk domain of Sec23/240.09024Inherited
C-terminal, gelsolin-like domain of Sec23/240.09024Inherited
DNA repair protein MutS, domain III0.09024Inherited
Helical domain of Sec23/240.09024Inherited
Ras-binding domain, RBD0.1279Inherited
ARID domain0.1279Inherited
Tyrosine-dependent oxidoreductases0.1999Inherited
Complement control module/SCR domain0.1999Inherited
Spectrin repeat0.2256Inherited
Bromodomain0.2552Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2552Inherited
Nicotinic receptor ligand binding domain-like0.2552Inherited
DEATH domain, DD0.3268Inherited
Intermediate filament protein, coiled coil region0.3279Inherited
RecA protein-like (ATPase-domain)0.3311Inherited
Laminin-type module0.3707Inherited
TNF receptor-like0.3707Inherited
SH2 domain0.4135Inherited
HMG-box0.441Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.5372Inherited
VWC domain0.5372Inherited
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0.6086Inherited
PHD domain0.6199Inherited
Histone lysine methyltransferases0.7161Inherited
G proteins0.752Inherited
Ngr ectodomain-like0.8156Inherited
V set domains (antibody variable domain-like)0.9491Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SAND domain-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Apolipoprotein A-I0Direct
DHS-like NAD/FAD-binding domain0Direct
RuvA domain 2-like0Direct
Plakin repeat0Direct
Integrin beta tail domain0Direct
Tricorn protease domain 20Direct
Zn-finger domain of Sec23/240Direct
Notch domain0Direct
ABC transporter transmembrane region0.00316Inherited
MHC antigen-recognition domain0.006648Inherited
DNA/RNA polymerases0.01167Inherited
GLA-domain0.01167Inherited
Integrin domains0.02255Inherited
Globin-like0.02296Inherited
C-terminal, gelsolin-like domain of Sec23/240.08302Inherited
Helical domain of Sec23/240.08302Inherited
DNA repair protein MutS, domain III0.08302Inherited
P-loop containing nucleoside triphosphate hydrolases0.09813Inherited
ARID-like0.1178Inherited
EGF/Laminin0.129Inherited
Prefoldin0.1359Inherited
Complement control module/SCR domain0.178Inherited
Spectrin repeat0.2028Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2107Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.2315Inherited
Nicotinic receptor ligand binding domain-like0.2315Inherited
Bromodomain0.2315Inherited
DEATH domain0.2635Inherited
Ribosomal protein S5 domain 2-like0.276Inherited
Intermediate filament protein, coiled coil region0.2869Inherited
alpha/beta-Hydrolases0.3517Inherited
RNI-like0.3558Inherited
Nucleotide-diphospho-sugar transferases0.3667Inherited
SH2 domain0.3687Inherited
FnI-like domain0.3696Inherited
4-helical cytokines0.392Inherited
HMG-box0.4042Inherited
Protein kinase-like (PK-like)0.4906Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.5203Inherited
Immunoglobulin0.5235Inherited
Adenine nucleotide alpha hydrolases-like0.5823Inherited
(Trans)glycosidases0.814Inherited
L domain-like0.9081Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    53300,49265
  • 53300 - vWA-like
  • 49265 - Fibronectin type III
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    49265,53300
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    103473,100895
  • 103473 - MFS general substrate transporter
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00316Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.006648Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.01228Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.01517Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04394Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.04394Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.04394Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.06927Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.07813Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08302Inherited
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.08302Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1457Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.1525Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.2315Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2869Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.3011Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.5101Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    49265,49265,53300
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.006648Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.05249Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1359Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2063Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.5101Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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