SUPERFAMILY 1.75 HMM library and genome assignments server

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Phenotypic Abnormality (PA): Abnormality of the cardiovascular system

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the cardiovascular system [HP:0001626] <5>(60|88) (73|43|30)
- 1:   Abnormal cardiovascular system physiology [HP:0011025] <16>(21|34) (29|18|16)
- 1:   Abnormality of the vasculature [HP:0002597] <13>(35|56) (45|27|18)
- 1:   Abnormal cardiac test [HP:0500015] <7>(1|3) (1|1|0)
- 1:   Abnormality of the fetal cardiovascular system [HP:0010948] <7>(0|0) (0|0|0)
- 1:   Abnormality of cardiovascular system morphology [HP:0030680] <3>(29|42) (31|19|20)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
GAF domain-like0Direct
Tricorn protease domain 20Direct
DPP6 N-terminal domain-like0Direct
RmlC-like cupins0Direct
TB module/8-cys domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Plakin repeat0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Smc hinge domain0Direct
GLA-domain0Direct
Creatinase/aminopeptidase0Direct
SAND domain-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Saposin0Direct
Apolipoprotein A-I0Direct
Zn-finger domain of Sec23/240Direct
Creatinase/prolidase N-terminal domain0Direct
Growth factor receptor domain0.01487Inherited
TNF receptor-like0.01635Inherited
Glycosyl hydrolase domain0.01774Inherited
Actin-like ATPase domain0.01905Inherited
Tropomyosin0.02893Inherited
(Trans)glycosidases0.03685Inherited
cAMP-binding domain-like0.04138Inherited
DEATH domain0.04405Inherited
DNA/RNA polymerases0.04585Inherited
Spectrin repeat0.05773Inherited
Globin-like0.07223Inherited
Protein kinase-like (PK-like)0.1053Inherited
SMAD MH1 domain0.1136Inherited
p53-like transcription factors0.159Inherited
Myosin rod fragments0.1647Inherited
Trypsin-like serine proteases0.1699Inherited
Caspase-like0.1769Inherited
MIR domain0.1782Inherited
4-helical cytokines0.1982Inherited
Snake toxin-like0.1982Inherited
Integrin domains0.2248Inherited
HMG-box0.2358Inherited
ARID-like0.253Inherited
MHC antigen-recognition domain0.2607Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3038Inherited
TNF-like0.3139Inherited
FnI-like domain0.3139Inherited
Fibrinogen C-terminal domain-like0.3387Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.3387Inherited
SMAD/FHA domain0.3667Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.4012Inherited
Hemopexin-like domain0.4321Inherited
RNI-like0.4973Inherited
PGBD-like0.5401Inherited
Cadherin-like0.5888Inherited
Voltage-gated potassium channels0.6739Inherited
L domain-like0.7182Inherited
(Phosphotyrosine protein) phosphatases II0.8552Inherited
Ribosomal protein S5 domain 2-like0.8628Inherited
FAD/NAD(P)-binding domain0.8977Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9712Inherited
Nicotinic receptor ligand binding domain-like0.9712Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Zn-finger domain of Sec23/240Direct
Proteasome subunits0Direct
Creatinase/aminopeptidase0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
ZZ domain0Direct
GLA-domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Apolipoprotein A-I0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
beta-glycanases0Direct
ets domain0Direct
Notch domain0Direct
Smc hinge domain0Direct
GAF domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Erythroid transcription factor GATA-10Direct
Plakin repeat0Direct
Putative glucosidase YicI, domain 30Direct
Sec1/munc18-like (SM) proteins0Direct
TB module/8-cys domain0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Multidomain cupredoxins0Direct
Fibrinogen coiled-coil and central regions0Direct
EGF-type module0.005675Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.01305Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.01305Inherited
Actin/HSP700.01305Inherited
Growth factor receptor domain0.02114Inherited
Tropomyosin0.02184Inherited
TNF receptor-like0.03001Inherited
PX domain0.03604Inherited
Spectrin repeat0.04766Inherited
Globins0.05913Inherited
Amylase, catalytic domain0.0952Inherited
DNA gyrase/MutL, second domain0.0952Inherited
SMAD MH1 domain0.0952Inherited
SMAD domain0.0952Inherited
DNA gyrase/MutL, N-terminal domain0.0952Inherited
Pyrin domain, PYD0.0952Inherited
ABC transporter ATPase domain-like0.1033Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.105Inherited
Protein kinases, catalytic subunit0.1086Inherited
Calponin-homology domain, CH-domain0.1191Inherited
Myosin rod fragments0.1431Inherited
Histone lysine methyltransferases0.1431Inherited
RecA protein-like (ATPase-domain)0.1431Inherited
Double-stranded RNA-binding domain (dsRBD)0.1519Inherited
NADPH-cytochrome p450 reductase-like0.1519Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.1519Inherited
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0.1543Inherited
MIR domain0.1543Inherited
Tetratricopeptide repeat (TPR)0.1868Inherited
PHD domain0.1868Inherited
Cytoplasmic domain of inward rectifier potassium channel0.1997Inherited
Integrin domains0.1997Inherited
DEATH domain, DD0.2029Inherited
C1 set domains (antibody constant domain-like)0.2029Inherited
HMG-box0.2144Inherited
ARID domain0.225Inherited
Transcription factor STAT-4 N-domain0.225Inherited
Ras-binding domain, RBD0.225Inherited
STAT DNA-binding domain0.225Inherited
DnaQ-like 3'-5' exonuclease0.225Inherited
Extracellular domain of cell surface receptors0.225Inherited
STAT0.225Inherited
MHC antigen-recognition domain0.2349Inherited
Transforming growth factor (TGF)-beta0.2477Inherited
Eukaryotic proteases0.2504Inherited
TNF-like0.2883Inherited
T-box0.2883Inherited
Fibrinogen C-terminal domain-like0.31Inherited
28-residue LRR0.31Inherited
Caspase recruitment domain, CARD0.3233Inherited
LIM domain0.3385Inherited
VWC domain0.3712Inherited
G proteins0.3889Inherited
Hemopexin-like domain0.4041Inherited
Voltage-gated potassium channels0.4858Inherited
Matrix metalloproteases, catalytic domain0.511Inherited
MMP N-terminal domain0.511Inherited
Cadherin0.6429Inherited
V set domains (antibody variable domain-like)0.7283Inherited
Calmodulin-like0.795Inherited
Second domain of FERM0.8609Inherited
Ngr ectodomain-like0.9522Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9658Inherited
Nicotinic receptor ligand binding domain-like0.9658Inherited
Intermediate filament protein, coiled coil region0.9661Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Creatinase/prolidase N-terminal domain0Direct
Smc hinge domain0Direct
GLA-domain0Direct
Sec1/munc18-like (SM) proteins0Direct
Fibrinogen coiled-coil and central regions0Direct
Saposin0Direct
Notch domain0Direct
Plakin repeat0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Tricorn protease domain 20Direct
SAND domain-like0Direct
Apolipoprotein A-I0Direct
GAF domain-like0Direct
TB module/8-cys domain0Direct
RmlC-like cupins0Direct
Creatinase/aminopeptidase0Direct
DPP6 N-terminal domain-like0Direct
Zn-finger domain of Sec23/240Direct
Growth factor receptor domain0.009874Inherited
TNF receptor-like0.01094Inherited
Glycosyl hydrolase domain0.01191Inherited
Actin-like ATPase domain0.01286Inherited
Tropomyosin0.02023Inherited
(Trans)glycosidases0.02639Inherited
cAMP-binding domain-like0.02983Inherited
DEATH domain0.03197Inherited
DNA/RNA polymerases0.03346Inherited
PX domain0.03346Inherited
Spectrin repeat0.04315Inherited
Globin-like0.05517Inherited
Immunoglobulin0.07718Inherited
Protein kinase-like (PK-like)0.08302Inherited
SMAD MH1 domain0.08995Inherited
Acyl-CoA dehydrogenase NM domain-like0.09466Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.09466Inherited
Calponin-homology domain, CH-domain0.1098Inherited
p53-like transcription factors0.1302Inherited
Myosin rod fragments0.1351Inherited
Trypsin-like serine proteases0.1398Inherited
Restriction endonuclease-like0.146Inherited
Caspase-like0.146Inherited
MIR domain0.1472Inherited
4-helical cytokines0.1656Inherited
Snake toxin-like0.1656Inherited
Integrin domains0.19Inherited
HMG-box0.2001Inherited
ARID-like0.2158Inherited
Transcription factor STAT-4 N-domain0.2158Inherited
STAT0.2158Inherited
MHC antigen-recognition domain0.2231Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2637Inherited
TNF-like0.2734Inherited
FnI-like domain0.2734Inherited
Fibrinogen C-terminal domain-like0.2973Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.2973Inherited
SMAD/FHA domain0.3242Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3578Inherited
Hemopexin-like domain0.3882Inherited
RNI-like0.453Inherited
PGBD-like0.4962Inherited
Cadherin-like0.5458Inherited
Cystine-knot cytokines0.56Inherited
TPR-like0.5764Inherited
Voltage-gated potassium channels0.634Inherited
SH3-domain0.6771Inherited
L domain-like0.6797Inherited
(Phosphotyrosine protein) phosphatases II0.8231Inherited
Ribosomal protein S5 domain 2-like0.8312Inherited
Second domain of FERM0.8312Inherited
FAD/NAD(P)-binding domain0.8683Inherited
Intermediate filament protein, coiled coil region0.9463Inherited
Nicotinic receptor ligand binding domain-like0.9476Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9476Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    48726,56112
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.007014Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.01191Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.01759Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.02983Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.02983Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.04717Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.05642Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.06536Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.08657Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.08995Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.08995Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08995Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.09466Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.09903Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.146Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.158Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.19Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2158Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2158Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.2158Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.2231Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.2231Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.4962Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.9476Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003994Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.007014Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02023Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.03346Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.03346Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.09903Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1213Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.146Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2158Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2158Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.263Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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