SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Abnormal heart morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the cardiovascular system [HP:0001626] <5>(60|88) (73|43|30)
+ 1:   Abnormality of cardiovascular system morphology [HP:0030680] <3>(29|42) (31|19|20)
0:   Abnormal heart morphology [HP:0001627] <16>(20|35) (24|16|20)
- 1:   Abnormal myocardium morphology [HP:0001637] <11>(3|9) (4|1|2)
- 1:   Abnormal cardiac ventricle morphology [HP:0001713] <9>(5|9) (5|5|10)
- 1:   Abnormal cardiomyocyte morphology [HP:0031331] <9>(0|0) (0|0|0)
- 1:   Abnormal cardiac atrium morphology [HP:0005120] <8>(2|3) (2|0|1)
- 1:   Abnormal spatial orientation of the cardiac segments [HP:0011534] <7>(0|1) (1|0|1)
- 1:   Abnormal pericardium morphology [HP:0001697] <6>(3|2) (3|1|0)
- 1:   Neoplasm of the heart [HP:0100544] <6>(0|0) (0|0|0)
- 1:   Abnormal anatomic location of the heart [HP:0004307] <4>(0|1) (1|0|1)
- 1:   Abnormal heart valve morphology [HP:0001654] <4>(5|11) (6|10|11)
- 1:   Abnormal cardiac septum morphology [HP:0001671] <3>(2|8) (2|4|10)
- 1:   Abnormal endocardium morphology [HP:0004306] <3>(1|0) (1|1|0)
- 1:   Congenital malformation of the right heart [HP:0011723] <3>(0|1) (0|0|0)
- 1:   Abnormal connection of the cardiac segments [HP:0011545] <2>(0|1) (0|2|2)
- 1:   Hypoplastic heart [HP:0001961] <2>(2|3) (4|2|0)
- 1:   Congenital malformation of the left heart [HP:0045017] <1>(0|1) (2|1|0)
- 1:   Cardiomegaly [HP:0001640](1|0) (1|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
TB module/8-cys domain0Direct
Tropomyosin0.005193Inherited
Myosin rod fragments0.02676Inherited
Hemopexin-like domain0.05374Inherited
MIR domain0.06338Inherited
FnI-like domain0.078Inherited
PGBD-like0.104Inherited
MHC antigen-recognition domain0.1214Inherited
Spectrin repeat0.2794Inherited
(Trans)glycosidases0.3578Inherited
Ribosomal protein S5 domain 2-like0.3718Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.4291Inherited
FAD/NAD(P)-binding domain0.4353Inherited
4-helical cytokines0.4945Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.5334Inherited
Protein kinase-like (PK-like)0.6432Inherited
Nicotinic receptor ligand binding domain-like0.6867Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6867Inherited
DEATH domain0.9733Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
TB module/8-cys domain0Direct
Notch domain0Direct
ZZ domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Tropomyosin0.003069Inherited
DNA gyrase/MutL, second domain0.006633Inherited
Amylase, catalytic domain0.006633Inherited
DNA gyrase/MutL, N-terminal domain0.006633Inherited
Myosin rod fragments0.01799Inherited
beta-glycanases0.0195Inherited
Extracellular domain of cell surface receptors0.02213Inherited
Tetratricopeptide repeat (TPR)0.03062Inherited
Hemopexin-like domain0.03912Inherited
MIR domain0.04731Inherited
VWC domain0.04731Inherited
LIM domain0.0508Inherited
SMAD domain0.0542Inherited
SMAD MH1 domain0.0542Inherited
MMP N-terminal domain0.081Inherited
Matrix metalloproteases, catalytic domain0.081Inherited
MHC antigen-recognition domain0.09501Inherited
EGF-type module0.1199Inherited
PHD domain0.1653Inherited
C1 set domains (antibody constant domain-like)0.2157Inherited
Spectrin repeat0.2285Inherited
Growth factor receptor domain0.2617Inherited
T-box0.269Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.3169Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.3169Inherited
Histone lysine methyltransferases0.3169Inherited
RecA protein-like (ATPase-domain)0.3741Inherited
Erythroid transcription factor GATA-10.3741Inherited
Protein kinases, catalytic subunit0.5764Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6447Inherited
Nicotinic receptor ligand binding domain-like0.6447Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
TB module/8-cys domain0Direct
Notch domain0Direct
Tropomyosin0.003165Inherited
Myosin rod fragments0.01859Inherited
Restriction endonuclease-like0.01976Inherited
Hemopexin-like domain0.03985Inherited
MIR domain0.04786Inherited
SMAD MH1 domain0.05459Inherited
FnI-like domain0.05994Inherited
PGBD-like0.08199Inherited
MHC antigen-recognition domain0.09687Inherited
Spectrin repeat0.2409Inherited
TPR-like0.2656Inherited
(Trans)glycosidases0.3157Inherited
Ribosomal protein S5 domain 2-like0.3291Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.3852Inherited
FAD/NAD(P)-binding domain0.3913Inherited
4-helical cytokines0.4501Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.4892Inherited
Protein kinase-like (PK-like)0.6022Inherited
p53-like transcription factors0.6469Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6475Inherited
Nicotinic receptor ligand binding domain-like0.6475Inherited
DEATH domain0.95Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    48726,56112
  • 48726 - Immunoglobulin
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.006818Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.02123Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02549Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.08199Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.09687Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1337Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1502Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.2058Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2409Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.6475Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0006702Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.003165Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.04786Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.07605Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.08199Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2812Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4501Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)