SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Abnormal heart morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the cardiovascular system [HP:0001626] <5>(58|73) (67|39|27)
+ 1:   Abnormality of cardiovascular system morphology [HP:0030680] <3>(26|40) (32|17|20)
0:   Abnormal heart morphology [HP:0001627] <16>(19|32) (22|14|20)
- 1:   Abnormal myocardium morphology [HP:0001637] <11>(4|9) (5|1|2)
- 1:   Abnormal cardiac ventricle morphology [HP:0001713] <9>(3|11) (5|3|9)
- 1:   Abnormal cardiomyocyte morphology [HP:0031331] <9>(0|0) (0|0|0)
- 1:   Abnormal cardiac atrium morphology [HP:0005120] <8>(2|3) (3|0|1)
- 1:   Abnormal spatial orientation of the cardiac segments [HP:0011534] <7>(1|1) (1|1|1)
- 1:   Abnormal pericardium morphology [HP:0001697] <6>(3|2) (3|1|0)
- 1:   Neoplasm of the heart [HP:0100544] <6>(0|0) (0|0|0)
- 1:   Abnormal anatomic location of the heart [HP:0004307] <4>(1|1) (1|1|1)
- 1:   Abnormal heart valve morphology [HP:0001654] <4>(3|8) (3|8|11)
- 1:   Abnormal cardiac septum morphology [HP:0001671] <3>(1|9) (2|3|9)
- 1:   Abnormal endocardium morphology [HP:0004306] <3>(1|0) (1|1|0)
- 1:   Congenital malformation of the right heart [HP:0011723] <3>(0|1) (0|0|0)
- 1:   Abnormal connection of the cardiac segments [HP:0011545] <2>(0|1) (0|1|2)
- 1:   Hypoplastic heart [HP:0001961] <2>(2|3) (4|2|0)
- 1:   Congenital malformation of the left heart [HP:0045017] <1>(0|1) (2|1|0)
- 1:   Cardiomegaly [HP:0001640](1|0) (1|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
TB module/8-cys domain0Direct
SMAD MH1 domain0.02626Inherited
Tropomyosin0.02737Inherited
MIR domain0.02923Inherited
MHC antigen-recognition domain0.04933Inherited
FnI-like domain0.07129Inherited
TPR-like0.2521Inherited
Spectrin repeat0.3065Inherited
(Trans)glycosidases0.3373Inherited
Ribosomal protein S5 domain 2-like0.3565Inherited
FAD/NAD(P)-binding domain0.3677Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.4144Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.5056Inherited
4-helical cytokines0.5567Inherited
Nicotinic receptor ligand binding domain-like0.6237Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6237Inherited
Protein kinase-like (PK-like)0.7608Inherited
DEATH domain0.9831Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
TB module/8-cys domain0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
ZZ domain0Direct
DNA gyrase/MutL, second domain0.005939Inherited
Amylase, catalytic domain0.005939Inherited
DNA gyrase/MutL, N-terminal domain0.005939Inherited
SMAD domain0.01789Inherited
beta-glycanases0.01789Inherited
SMAD MH1 domain0.01789Inherited
Tropomyosin0.01857Inherited
Extracellular domain of cell surface receptors0.02012Inherited
MIR domain0.02012Inherited
Tetratricopeptide repeat (TPR)0.0262Inherited
LIM domain0.02837Inherited
MHC antigen-recognition domain0.03537Inherited
VWC domain0.04337Inherited
C1 set domains (antibody constant domain-like)0.1224Inherited
EGF-type module0.1227Inherited
PHD domain0.1529Inherited
Transforming growth factor (TGF)-beta0.2144Inherited
Spectrin repeat0.2542Inherited
T-box0.2542Inherited
Growth factor receptor domain0.2762Inherited
Histone lysine methyltransferases0.3011Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.3574Inherited
RecA protein-like (ATPase-domain)0.3574Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.3574Inherited
Erythroid transcription factor GATA-10.3574Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.5793Inherited
Nicotinic receptor ligand binding domain-like0.5793Inherited
Protein kinases, catalytic subunit0.6904Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Notch domain0Direct
TB module/8-cys domain0Direct
SMAD MH1 domain0.01845Inherited
Restriction endonuclease-like0.01845Inherited
Tropomyosin0.01934Inherited
MIR domain0.02082Inherited
MHC antigen-recognition domain0.03668Inherited
FnI-like domain0.05481Inherited
TPR-like0.2162Inherited
Spectrin repeat0.2685Inherited
(Trans)glycosidases0.2976Inherited
Ribosomal protein S5 domain 2-like0.3162Inherited
FAD/NAD(P)-binding domain0.3269Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.3725Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.4625Inherited
4-helical cytokines0.5138Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.5828Inherited
Nicotinic receptor ligand binding domain-like0.5828Inherited
p53-like transcription factors0.6234Inherited
EF-hand0.661Inherited
Protein kinase-like (PK-like)0.7252Inherited
DEATH domain0.9612Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.00622Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.02082Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.03668Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.0426Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1252Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1411Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.2285Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2285Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.5828Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0005776Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.002795Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.04453Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.07002Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.07655Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2685Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4368Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)