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Phenotypic Abnormality (PA): Abnormality of the cerebrum

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   Phenotypic abnormality [HP:0000118] <25>
+ + + + + 5:   Abnormality of the nervous system [HP:0000707] <4>(140|161) (154|97|43)
+ + + + 4:   Abnormality of nervous system morphology [HP:0012639] <5>(70|93) (79|45|15)
+ + + 3:   Morphological abnormality of the central nervous system [HP:0002011] <17>(62|82) (71|38|15)
+ + 2:   Abnormality of brain morphology [HP:0012443] <13>(45|61) (53|29|13)
+ 1:   Abnormality of forebrain morphology [HP:0100547] <5>(24|26) (29|13|4)
0:   Abnormality of the cerebrum [HP:0002060] <16>(23|25) (28|13|4)
- 1:   Cerebral calcification [HP:0002514] <12>(0|1) (1|1|0)
- 1:   Abnormality of the cerebral cortex [HP:0002538] <9>(4|3) (4|2|0)
- 1:   Cerebral inclusion bodies [HP:0100314] <8>(0|0) (1|1|0)
- 1:   Aplasia/Hypoplasia of the cerebrum [HP:0007364] <5>(11|13) (13|4|1)
- 1:   Atrophy/Degeneration affecting the cerebrum [HP:0007369] <5>(1|4) (1|2|0)
- 1:   Leukoencephalopathy [HP:0002352] <5>(1|1) (1|0|0)
- 1:   Abnormality of the cerebral subcortex [HP:0010993] <3>(4|6) (5|1|0)
- 1:   Abnormality of the septum pellucidum [HP:0007375] <3>(0|2) (1|1|1)
- 1:   Megalencephaly [HP:0001355] <1>(0|0) (1|0|0)
- 1:   Cerebral edema [HP:0002181](0|0) (0|0|0)
- 1:   Cerebral granulomatosis [HP:0100313](0|0) (0|0|0)
- 1:   Diffuse cerebral sclerosis [HP:0006918](0|0) (0|0|0)
- 1:   Encephalomalacia [HP:0040197](0|0) (0|0|0)
- 1:   Granulovacuolar degeneration [HP:0002528](0|0) (0|0|0)
- 1:   Porencephalic cyst [HP:0002132](0|0) (0|0|0)
- 1:   Schizencephaly [HP:0010636](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Pseudouridine synthase0Direct
4Fe-4S ferredoxins0Direct
Restriction endonuclease-like0Direct
ThrRS/AlaRS common domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
SAND domain-like0Direct
BRK domain-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
ADC-like0Direct
ARM repeat0.000449Direct
WD40 repeat-like0.0006669Direct
ARID-like0.01425Inherited
Nucleotide-diphospho-sugar transferases0.04191Inherited
NagB/RpiA/CoA transferase-like0.04399Inherited
Adenine nucleotide alpha hydrolases-like0.04399Inherited
Tubulin nucleotide-binding domain-like0.05307Inherited
Tubulin C-terminal domain-like0.08443Inherited
Actin-like ATPase domain0.1219Inherited
Ribonuclease H-like0.1944Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
XPF/Rad1/Mus81 nuclease0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
BRK domain-like0Direct
Ferredoxin domains from multidomain proteins0Direct
L-aspartase/fumarase0Direct
IF2B-like0Direct
Clathrin adaptor core protein0Direct
N-acetyl transferase, NAT0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
SWIRM domain0Direct
G proteins0.0001996Direct
Histone lysine methyltransferases0.0002111Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.000527Direct
Elongation factors0.001423Inherited
ARID domain0.008591Inherited
Bromodomain0.01996Inherited
Tubulin, GTPase domain0.03455Inherited
Tubulin, C-terminal domain0.05943Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.06453Inherited
Clathrin coat assembly domain0.1158Inherited
Transducin (alpha subunit), insertion domain0.3392Inherited
PDZ domain0.3511Inherited
I set domains0.6657Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Pseudouridine synthase0Direct
4Fe-4S ferredoxins0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
ADC-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
ThrRS/AlaRS common domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
SAND domain-like0Direct
Restriction endonuclease-like0Direct
BRK domain-like0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
ARM repeat0.0002332Direct
WD40 repeat-like0.0003549Direct
Nucleotidylyl transferase0.004123Inherited
ARID-like0.009538Inherited
SET domain0.01322Inherited
Bromodomain0.02333Inherited
Nucleotide-diphospho-sugar transferases0.03073Inherited
NagB/RpiA/CoA transferase-like0.03236Inherited
Adenine nucleotide alpha hydrolases-like0.03236Inherited
Tubulin nucleotide-binding domain-like0.03976Inherited
Tubulin C-terminal domain-like0.06592Inherited
Actin-like ATPase domain0.09806Inherited
Ribonuclease H-like0.1628Inherited
Protein kinase-like (PK-like)0.2361Inherited
Transducin (alpha subunit), insertion domain0.3554Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.003393Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.06592Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.06938Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.1056Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3554Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.5717Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.515Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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