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Phenotypic Abnormality (PA): Abnormality of the respiratory system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the respiratory system [HP:0002086] <3>(30|30) (33|19|17)
- 1:   Functional respiratory abnormality [HP:0002795] <27>(12|12) (13|7|2)
- 1:   Abnormal respiratory system morphology [HP:0012252] <5>(21|21) (23|14|14)
- 1:   Neoplasm of the respiratory system [HP:0100606] <4>(2|0) (2|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Saposin0Direct
Tricorn protease domain 20Direct
Notch domain0Direct
Plakin repeat0Direct
SH2 domain0.00008519Direct
Growth factor receptor domain0.006595Inherited
4-helical cytokines0.016Inherited
DEATH domain0.02614Inherited
TB module/8-cys domain0.03194Inherited
Adenine nucleotide alpha hydrolases-like0.04611Inherited
RuvA domain 2-like0.06585Inherited
Calcium-dependent phosphotriesterase0.06585Inherited
Protein kinase-like (PK-like)0.06864Inherited
Nicotinic receptor ligand binding domain-like0.08105Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.08105Inherited
MIR domain0.08553Inherited
MHC antigen-recognition domain0.1512Inherited
GLA-domain0.1552Inherited
Immunoglobulin0.1816Inherited
TNF receptor-like0.2024Inherited
EGF/Laminin0.2758Inherited
Cystine-knot cytokines0.2799Inherited
Snake toxin-like0.3672Inherited
Ubiquitin-like0.5209Inherited
RNA-binding domain, RBD0.5907Inherited
Intermediate filament protein, coiled coil region0.5981Inherited
ABC transporter transmembrane region0.7023Inherited
WD40 repeat-like0.7362Inherited
vWA-like0.861Inherited
Voltage-gated potassium channels0.8728Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
beta-glycanases0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Filamin repeat (rod domain)0Direct
Rel/Dorsal transcription factors, DNA-binding domain0Direct
Plakin repeat0Direct
SH2 domain0.00005053Direct
Growth factor receptor domain0.00005081Direct
Ras-binding domain, RBD0.01049Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.01049Inherited
TB module/8-cys domain0.02338Inherited
C1 set domains (antibody constant domain-like)0.02444Inherited
DEATH domain, DD0.02584Inherited
VWC domain0.0351Inherited
ZZ domain0.05168Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.0664Inherited
Nicotinic receptor ligand binding domain-like0.0664Inherited
MIR domain0.06923Inherited
Laminin-type module0.1152Inherited
RecA protein-like (ATPase-domain)0.1281Inherited
MHC antigen-recognition domain0.1281Inherited
GLA-domain0.1313Inherited
Arylsulfatase0.1904Inherited
TNF receptor-like0.3732Inherited
V set domains (antibody variable domain-like)0.411Inherited
Canonical RBD0.4205Inherited
ABC transporter ATPase domain-like0.5049Inherited
Intermediate filament protein, coiled coil region0.5725Inherited
ABC transporter transmembrane region0.6754Inherited
Integrin A (or I) domain0.7336Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Notch domain0Direct
Plakin repeat0Direct
Tricorn protease domain 20Direct
Saposin0Direct
SH2 domain0.00004067Direct
p53-like transcription factors0.0007896Direct
Growth factor receptor domain0.004205Inherited
4-helical cytokines0.01081Inherited
RCC1/BLIP-II0.01698Inherited
DEATH domain0.01841Inherited
TB module/8-cys domain0.02293Inherited
Adenine nucleotide alpha hydrolases-like0.03406Inherited
RuvA domain 2-like0.05025Inherited
Calcium-dependent phosphotriesterase0.05025Inherited
Protein kinase-like (PK-like)0.05256Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.06312Inherited
Nicotinic receptor ligand binding domain-like0.06312Inherited
MIR domain0.0669Inherited
MHC antigen-recognition domain0.1242Inherited
GLA-domain0.1276Inherited
Immunoglobulin0.151Inherited
TNF receptor-like0.1702Inherited
EGF/Laminin0.2387Inherited
Cystine-knot cytokines0.2427Inherited
Snake toxin-like0.3264Inherited
Ubiquitin-like0.4779Inherited
RNA-binding domain, RBD0.5489Inherited
Intermediate filament protein, coiled coil region0.5565Inherited
ABC transporter transmembrane region0.664Inherited
WD40 repeat-like0.6992Inherited
vWA-like0.8299Inherited
Voltage-gated potassium channels0.8424Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.9594Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.01081Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.02293Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.02293Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.06312Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.06981Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1242Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.1256Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1851Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.2006Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.4027Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.664Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02293Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.02293Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.03406Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.04253Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.05025Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2672Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.4274Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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