SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Abnormal lung morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the respiratory system [HP:0002086] <3>(30|35) (38|24|21)
+ 1:   Abnormal respiratory system morphology [HP:0012252] <5>(20|25) (26|18|17)
0:   Abnormal lung morphology [HP:0002088] <28>(11|18) (18|11|7)
- 1:   Interstitial pulmonary abnormality [HP:0006530] <10>(0|0) (0|0|0)
- 1:   Neoplasm of the lung [HP:0100526] <9>(1|0) (1|0|0)
- 1:   Abnormal pulmonary thoracic imaging finding [HP:0031983] <7>(0|0) (0|0|0)
- 1:   Abnormality of the pleura [HP:0002103] <7>(2|3) (3|1|0)
- 1:   Abnormality of the pulmonary vasculature [HP:0004930] <6>(1|0) (3|2|3)
- 1:   Pulmonary cyst [HP:0032445] <5>(0|0) (0|0|0)
- 1:   Aplasia/Hypoplasia of the lungs [HP:0006703] <3>(1|1) (1|0|0)
- 1:   Pneumothorax [HP:0002107] <3>(0|1) (0|0|0)
- 1:   Respiratory tract infection [HP:0011947] <3>(2|7) (3|3|1)
- 1:   Abnormal lung lobation [HP:0002101] <2>(0|0) (0|0|0)
- 1:   Abnormal subpleural morphology [HP:0031630] <2>(0|0) (0|0|0)
- 1:   Bronchopulmonary sequestration [HP:0010960] <2>(0|0) (0|0|0)
- 1:   Pulmonary hemorrhage [HP:0040223] <2>(0|0) (1|0|0)
- 1:   Pulmonary infiltrates [HP:0002113] <2>(2|2) (2|1|0)
- 1:   Abnormal pulmonary lymphatics [HP:0006529] <1>(0|0) (0|0|0)
- 1:   Pulmonary fibrosis [HP:0002206] <1>(0|1) (1|1|0)
- 1:   Pulmonary opacity [HP:0031457] <1>(0|0) (0|0|0)
- 1:   Alveolar proteinosis [HP:0006517](0|0) (0|0|0)
- 1:   Atelectasis [HP:0100750](0|0) (0|0|1)
- 1:   Chronic lung disease [HP:0006528](0|0) (0|0|0)
- 1:   Emphysema [HP:0002097](1|1) (1|1|0)
- 1:   Hypersensitivity pneumonitis [HP:0006516](0|0) (0|0|0)
- 1:   Intraalveolar nodular calcifications [HP:0006514](0|0) (0|0|0)
- 1:   Lung abscess [HP:0025044](0|0) (0|0|0)
- 1:   Pulmonary edema [HP:0100598](0|0) (0|0|0)
- 1:   Pulmonary eosinophilic infiltration [HP:0032071](0|0) (0|0|0)
- 1:   Pulmonary granulomatosis [HP:0030250](0|0) (0|0|0)
- 1:   Unilateral primary pulmonary dysgenesis [HP:0006549](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Saposin0Direct
Tricorn protease domain 20Direct
DEATH domain0.00005129Direct
4-helical cytokines0.0254Inherited
TNF receptor-like0.03794Inherited
MHC antigen-recognition domain0.05382Inherited
Tropomyosin0.1556Inherited
ABC transporter transmembrane region0.5064Inherited
Ubiquitin-like0.5881Inherited
Growth factor receptor domain0.8034Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
beta-glycanases0Direct
Rel/Dorsal transcription factors, DNA-binding domain0Direct
DEATH domain, DD0.0004902Direct
Ras-binding domain, RBD0.0006682Direct
STAT0.0006682Direct
STAT DNA-binding domain0.0006682Direct
Transcription factor STAT-4 N-domain0.0006682Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0006682Direct
VWC domain0.002911Inherited
C1 set domains (antibody constant domain-like)0.002945Inherited
Tetratricopeptide repeat (TPR)0.01831Inherited
MHC antigen-recognition domain0.04284Inherited
Eukaryotic proteases0.07858Inherited
Tropomyosin0.1321Inherited
ABC transporter transmembrane region0.3254Inherited
Arylsulfatase0.5647Inherited
ABC transporter ATPase domain-like0.7971Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Saposin0Direct
Tricorn protease domain 20Direct
Notch domain0Direct
DEATH domain0.00002305Direct
STAT0.0005941Direct
Transcription factor STAT-4 N-domain0.0005941Direct
RCC1/BLIP-II0.0007448Direct
4-helical cytokines0.0176Inherited
TNF receptor-like0.02723Inherited
MHC antigen-recognition domain0.03995Inherited
Trypsin-like serine proteases0.08632Inherited
Tropomyosin0.1273Inherited
Snake toxin-like0.1502Inherited
Immunoglobulin0.2898Inherited
ABC transporter transmembrane region0.4622Inherited
Ubiquitin-like0.5452Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.7017Inherited
Growth factor receptor domain0.7686Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0005941Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0005941Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0005941Direct
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.02712Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.03995Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.3871Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.4358Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4622Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0005941Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0005941Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001784Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00721Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.009062Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.5501Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)