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Phenotypic Abnormality (PA): Abnormality of the vasculature

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the cardiovascular system [HP:0001626] <5>(60|88) (73|43|30)
0:   Abnormality of the vasculature [HP:0002597] <13>(35|56) (45|27|18)
- 1:   Abnormal vascular morphology [HP:0025015] <12>(15|18) (16|11|10)
- 1:   Vascular skin abnormality [HP:0011276] <10>(6|10) (9|2|1)
- 1:   Abnormality of head blood vessel [HP:3000036] <7>(1|0) (1|0|0)
- 1:   Abnormality of the cerebral vasculature [HP:0100659] <7>(7|10) (10|4|1)
- 1:   Abnormality of the lymphatic system [HP:0100763] <7>(9|19) (15|8|5)
- 1:   Abnormality of the pulmonary vasculature [HP:0004930] <6>(1|0) (3|2|3)
- 1:   Abnormal vascular physiology [HP:0030163] <5>(1|1) (1|0|1)
- 1:   Abnormality of the hepatic vasculature [HP:0006707] <5>(0|0) (0|0|0)
- 1:   Abnormality of the vasculature of the eye [HP:0008047] <4>(6|5) (6|4|1)
- 1:   Abnormality of gastrointestinal vasculature [HP:0004296] <3>(0|0) (0|0|0)
- 1:   Abnormality of neck blood vessel [HP:3000037] <2>(0|0) (0|0|0)
- 1:   Vascular neoplasm [HP:0100742] <2>(2|1) (2|0|0)
- 1:   Abnormality of infraorbital artery [HP:3000060](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Smc hinge domain0Direct
GAF domain-like0Direct
Apolipoprotein A-I0Direct
Saposin0Direct
Zn-finger domain of Sec23/240Direct
Fibrinogen coiled-coil and central regions0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
DEATH domain0.0143Inherited
Globin-like0.01449Inherited
SMAD MH1 domain0.03118Inherited
Snake toxin-like0.03133Inherited
FnI-like domain0.05333Inherited
MHC antigen-recognition domain0.0536Inherited
(Trans)glycosidases0.0596Inherited
Caspase-like0.06391Inherited
Fibrinogen C-terminal domain-like0.08994Inherited
Growth factor receptor domain0.1414Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.1507Inherited
GLA-domain0.1787Inherited
TNF receptor-like0.2127Inherited
p53-like transcription factors0.2257Inherited
DNA/RNA polymerases0.2289Inherited
TNF-like0.3143Inherited
Protein kinase-like (PK-like)0.326Inherited
RNI-like0.3547Inherited
ARID-like0.3754Inherited
Myosin rod fragments0.4553Inherited
HMG-box0.523Inherited
Integrin domains0.5406Inherited
SMAD/FHA domain0.5872Inherited
TB module/8-cys domain0.6359Inherited
(Phosphotyrosine protein) phosphatases II0.6933Inherited
Tropomyosin0.7291Inherited
Actin-like ATPase domain0.8741Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
alpha-Amylases, C-terminal beta-sheet domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Putative glucosidase YicI, domain 30Direct
GAF domain0Direct
Notch domain0Direct
ets domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Smc hinge domain0Direct
Zn-finger domain of Sec23/240Direct
beta-glycanases0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Proteasome subunits0Direct
Apolipoprotein A-I0Direct
Globins0.01047Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.01745Inherited
Tetratricopeptide repeat (TPR)0.02336Inherited
Pyrin domain, PYD0.02347Inherited
SMAD domain0.02347Inherited
SMAD MH1 domain0.02347Inherited
C1 set domains (antibody constant domain-like)0.02551Inherited
MHC antigen-recognition domain0.04366Inherited
Double-stranded RNA-binding domain (dsRBD)0.05134Inherited
Transcription factor STAT-4 N-domain0.06844Inherited
Extracellular domain of cell surface receptors0.06844Inherited
Ras-binding domain, RBD0.06844Inherited
STAT0.06844Inherited
STAT DNA-binding domain0.06844Inherited
DnaQ-like 3'-5' exonuclease0.06844Inherited
Fibrinogen C-terminal domain-like0.07559Inherited
DEATH domain, DD0.0894Inherited
Growth factor receptor domain0.1106Inherited
Caspase recruitment domain, CARD0.1277Inherited
VWC domain0.1295Inherited
GLA-domain0.1524Inherited
RecA protein-like (ATPase-domain)0.1524Inherited
Transforming growth factor (TGF)-beta0.186Inherited
28-residue LRR0.1994Inherited
PX domain0.1994Inherited
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0.26Inherited
TNF receptor-like0.2821Inherited
TNF-like0.2821Inherited
ARID domain0.3405Inherited
Protein kinases, catalytic subunit0.3798Inherited
Erythroid transcription factor GATA-10.4211Inherited
Myosin rod fragments0.4211Inherited
HMG-box0.4908Inherited
Integrin domains0.5064Inherited
TB module/8-cys domain0.606Inherited
Second domain of FERM0.6147Inherited
Intermediate filament protein, coiled coil region0.6869Inherited
ABC transporter ATPase domain-like0.6972Inherited
Tropomyosin0.7038Inherited
Actin/HSP700.8397Inherited
Ngr ectodomain-like0.9136Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.9638Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.9638Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
GAF domain-like0Direct
Apolipoprotein A-I0Direct
Smc hinge domain0Direct
Notch domain0Direct
Zn-finger domain of Sec23/240Direct
Saposin0Direct
Glycosyl hydrolase domain0.000657Direct
DEATH domain0.00948Inherited
Globin-like0.009602Inherited
SMAD MH1 domain0.02197Inherited
Snake toxin-like0.02208Inherited
FnI-like domain0.03959Inherited
MHC antigen-recognition domain0.0398Inherited
(Trans)glycosidases0.04469Inherited
Caspase-like0.0483Inherited
STAT0.06369Inherited
Transcription factor STAT-4 N-domain0.06369Inherited
Fibrinogen C-terminal domain-like0.07001Inherited
Growth factor receptor domain0.1148Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.1232Inherited
GLA-domain0.1477Inherited
TNF receptor-like0.179Inherited
p53-like transcription factors0.191Inherited
PX domain0.1938Inherited
DNA/RNA polymerases0.1938Inherited
Cystine-knot cytokines0.2289Inherited
TNF-like0.2738Inherited
Protein kinase-like (PK-like)0.285Inherited
RNI-like0.3128Inherited
ARID-like0.3326Inherited
Myosin rod fragments0.4116Inherited
HMG-box0.4785Inherited
Integrin domains0.4968Inherited
Second domain of FERM0.5408Inherited
SMAD/FHA domain0.5444Inherited
TB module/8-cys domain0.5947Inherited
(Phosphotyrosine protein) phosphatases II0.6545Inherited
Intermediate filament protein, coiled coil region0.6591Inherited
Tropomyosin0.6909Inherited
SH3-domain0.6971Inherited
Actin-like ATPase domain0.8429Inherited
L domain-like0.8493Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.9044Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.000657Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02197Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.02767Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0398Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.0483Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.04896Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.06369Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.06369Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.06369Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.08539Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.2217Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.2738Inherited
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.3326Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.3326Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.3326Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.5947Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.5947Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.8053Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00405Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0483Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.06369Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.06369Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0648Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.08539Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.1938Inherited
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.3326Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.3326Inherited
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.3326Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.5947Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.5947Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.5947Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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