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Phenotypic Abnormality (PA): Abnormality of the vasculature

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormality of the cardiovascular system [HP:0001626] <5>(58|73) (67|39|27)
0:   Abnormality of the vasculature [HP:0002597] <13>(32|47) (40|24|15)
- 1:   Abnormal vascular morphology [HP:0025015] <12>(11|17) (17|11|10)
- 1:   Vascular skin abnormality [HP:0011276] <10>(5|9) (8|1|1)
- 1:   Abnormality of head blood vessel [HP:3000036] <7>(1|0) (1|0|0)
- 1:   Abnormality of the cerebral vasculature [HP:0100659] <7>(8|11) (11|4|1)
- 1:   Abnormality of the lymphatic system [HP:0100763] <7>(10|13) (12|4|1)
- 1:   Abnormality of the pulmonary vasculature [HP:0004930] <6>(1|0) (3|2|3)
- 1:   Abnormal vascular physiology [HP:0030163] <5>(1|1) (1|1|1)
- 1:   Abnormality of the hepatic vasculature [HP:0006707] <5>(0|0) (0|0|0)
- 1:   Abnormality of the vasculature of the eye [HP:0008047] <4>(4|4) (4|3|1)
- 1:   Abnormality of gastrointestinal vasculature [HP:0004296] <3>(0|0) (0|0|0)
- 1:   Abnormality of neck blood vessel [HP:3000037] <2>(0|0) (0|0|0)
- 1:   Vascular neoplasm [HP:0100742] <2>(2|1) (2|0|0)
- 1:   Abnormality of infraorbital artery [HP:3000060](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Zn-finger domain of Sec23/240Direct
GAF domain-like0Direct
Saposin0Direct
Smc hinge domain0Direct
SMAD MH1 domain0Direct
Notch domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
MHC antigen-recognition domain0.009759Inherited
Globin-like0.01261Inherited
DEATH domain0.01826Inherited
Snake toxin-like0.02674Inherited
Caspase-like0.05906Inherited
(Trans)glycosidases0.0631Inherited
Complement control module/SCR domain0.09176Inherited
FnI-like domain0.1082Inherited
Growth factor receptor domain0.116Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.1394Inherited
GLA-domain0.1644Inherited
TNF receptor-like0.1926Inherited
Fibrinogen C-terminal domain-like0.195Inherited
Protein kinase-like (PK-like)0.2742Inherited
DNA/RNA polymerases0.2751Inherited
SMAD/FHA domain0.2943Inherited
RNI-like0.3543Inherited
TNF-like0.3543Inherited
ARID-like0.3569Inherited
Integrin domains0.516Inherited
(Phosphotyrosine protein) phosphatases II0.6109Inherited
TB module/8-cys domain0.6141Inherited
Actin-like ATPase domain0.8984Inherited
L domain-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
SMAD domain0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Zn-finger domain of Sec23/240Direct
beta-glycanases0Direct
Smc hinge domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Proteasome subunits0Direct
SMAD MH1 domain0Direct
ets domain0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
GAF domain0Direct
C1 set domains (antibody constant domain-like)0.004832Inherited
MHC antigen-recognition domain0.007467Inherited
Globins0.009503Inherited
Pyrin domain, PYD0.02171Inherited
Double-stranded RNA-binding domain (dsRBD)0.0486Inherited
Ras-binding domain, RBD0.06465Inherited
Extracellular domain of cell surface receptors0.06465Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.07006Inherited
Complement control module/SCR domain0.0841Inherited
DEATH domain, DD0.08561Inherited
DnaQ-like 3'-5' exonuclease0.1225Inherited
Caspase recruitment domain, CARD0.1225Inherited
VWC domain0.1238Inherited
GLA-domain0.148Inherited
RecA protein-like (ATPase-domain)0.148Inherited
Fibrinogen C-terminal domain-like0.1788Inherited
28-residue LRR0.1935Inherited
Growth factor receptor domain0.2637Inherited
TNF receptor-like0.2736Inherited
Protein kinases, catalytic subunit0.3297Inherited
ARID domain0.3337Inherited
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0.3337Inherited
TNF-like0.3362Inherited
Transforming growth factor (TGF)-beta0.3846Inherited
Erythroid transcription factor GATA-10.412Inherited
Integrin domains0.4972Inherited
Myosin rod fragments0.4972Inherited
TB module/8-cys domain0.598Inherited
Intermediate filament protein, coiled coil region0.6634Inherited
ABC transporter ATPase domain-like0.6834Inherited
Ngr ectodomain-like0.8449Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.8977Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.8977Inherited
Actin/HSP700.8977Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SMAD MH1 domain0Direct
Fibrinogen coiled-coil and central regions0Direct
Notch domain0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Zn-finger domain of Sec23/240Direct
GAF domain-like0Direct
Smc hinge domain0Direct
Saposin0Direct
MHC antigen-recognition domain0.006393Inherited
Globin-like0.008393Inherited
DEATH domain0.01249Inherited
Snake toxin-like0.01882Inherited
Acyl-CoA N-acyltransferases (Nat)0.01974Inherited
Caspase-like0.04457Inherited
(Trans)glycosidases0.048Inherited
Complement control module/SCR domain0.07217Inherited
FnI-like domain0.08612Inherited
Growth factor receptor domain0.09288Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.1136Inherited
GLA-domain0.1358Inherited
TNF receptor-like0.1613Inherited
Fibrinogen C-terminal domain-like0.1634Inherited
Protein kinase-like (PK-like)0.2374Inherited
DNA/RNA polymerases0.2381Inherited
SMAD/FHA domain0.2566Inherited
p53-like transcription factors0.2624Inherited
Cystine-knot cytokines0.3098Inherited
TNF-like0.3139Inherited
4-helical cytokines0.3139Inherited
RNI-like0.3139Inherited
ARID-like0.3165Inherited
Integrin domains0.473Inherited
Myosin rod fragments0.473Inherited
SH3-domain0.5475Inherited
(Phosphotyrosine protein) phosphatases II0.5698Inherited
TB module/8-cys domain0.5731Inherited
Intermediate filament protein, coiled coil region0.6207Inherited
Actin-like ATPase domain0.8696Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.8779Inherited
L domain-like0.9875Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.006393Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.01946Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01974Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.04244Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.04457Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.07607Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1021Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2304Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.2524Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.3165Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.3165Inherited
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.3165Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.5731Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.5731Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.8417Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.003437Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0138Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.04457Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.05699Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.18Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.3165Inherited
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.3165Inherited
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.3165Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.5731Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.5731Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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