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Phenotypic Abnormality (PA): Neoplasm

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Neoplasm [HP:0002664] <2>(20|22) (24|7|4)
- 1:   Neoplasm by anatomical site [HP:0011793] <24>(19|19) (22|6|3)
- 1:   Neoplasm by histology [HP:0011792] <7>(4|7) (5|3|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DNA-glycosylase0Direct
SH2 domain0.00003019Direct
Protein kinase-like (PK-like)0.0005822Direct
TNF receptor-like0.005362Inherited
DEATH domain0.0124Inherited
DNA repair protein MutS, domain III0.01265Inherited
Ribosomal protein S5 domain 2-like0.01644Inherited
Ribonuclease H-like0.02304Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.03285Inherited
Sema domain0.04692Inherited
Snake toxin-like0.0711Inherited
BRCT domain0.07254Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.09847Inherited
Ubiquitin-like0.1126Inherited
Plexin repeat0.1729Inherited
Ankyrin repeat0.1757Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.2082Inherited
Nuclear receptor ligand-binding domain0.2191Inherited
Intermediate filament protein, coiled coil region0.2613Inherited
(Phosphotyrosine protein) phosphatases II0.2903Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
DIX domain0Direct
DNA gyrase/MutL, second domain0Direct
DNA gyrase/MutL, N-terminal domain0Direct
SH2 domain0.0000251Direct
Protein kinases, catalytic subunit0.0006343Direct
DNA repair protein MutS, domain III0.009408Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.009408Inherited
Tandem AAA-ATPase domain0.01549Inherited
RecA protein-like (ATPase-domain)0.01551Inherited
Sema domain0.03906Inherited
Ras-binding domain, RBD0.0566Inherited
POU-specific domain0.0566Inherited
RING finger domain, C3HC40.08885Inherited
DEATH domain, DD0.111Inherited
Ran binding protein zinc finger-like0.1323Inherited
Ankyrin repeat0.1395Inherited
PLC-like (P variant)0.14Inherited
Plexin repeat0.1579Inherited
Laminin-type module0.1958Inherited
Nuclear receptor ligand-binding domain0.2087Inherited
Intermediate filament protein, coiled coil region0.2548Inherited
ABC transporter ATPase domain-like0.2976Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
DNA-glycosylase0Direct
SH2 domain0.00001382Direct
Protein kinase-like (PK-like)0.0003062Direct
TNF receptor-like0.00336Inherited
DEATH domain0.008263Inherited
DNA repair protein MutS, domain III0.008424Inherited
Ribosomal protein S5 domain 2-like0.01111Inherited
Ribonuclease H-like0.01604Inherited
RING/U-box0.01734Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.02366Inherited
Sema domain0.03474Inherited
Snake toxin-like0.05466Inherited
BRCT domain0.05586Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.0779Inherited
p53-like transcription factors0.08633Inherited
Ubiquitin-like0.08995Inherited
Ran binding protein zinc finger-like0.1216Inherited
Plexin repeat0.1434Inherited
Ankyrin repeat0.1459Inherited
lambda repressor-like DNA-binding domains0.163Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1757Inherited
Nuclear receptor ligand-binding domain0.1856Inherited
Intermediate filament protein, coiled coil region0.225Inherited
(Phosphotyrosine protein) phosphatases II0.2525Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0001166Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.004795Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.008424Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.008424Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.008424Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.03474Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0005274Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0215Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1867Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2085Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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