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Phenotypic Abnormality (PA): Abnormality of the immune system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the immune system [HP:0002715] <3>(35|48) (38|27|14)
- 1:   Abnormality of immune system physiology [HP:0010978] <14>(26|35) (29|19|8)
- 1:   Abnormality of the lymphatic system [HP:0100763] <7>(10|13) (12|4|1)
- 1:   Abnormal immune system morphology [HP:0032251] <3>(9|11) (9|6|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Restriction endonuclease-like0Direct
SAND domain-like0Direct
Tricorn protease domain 20Direct
BRK domain-like0Direct
Anaphylotoxins (complement system)0Direct
Notch domain0Direct
Fibrinogen coiled-coil and central regions0Direct
DEATH domain0.000007153Direct
SH2 domain0.0007379Direct
Immunoglobulin0.0008883Direct
(Trans)glycosidases0.006118Inherited
DNA/RNA polymerases0.008464Inherited
Complement control module/SCR domain0.009774Inherited
TNF receptor-like0.01093Inherited
RNI-like0.01343Inherited
ABC transporter transmembrane region0.01343Inherited
TNF-like0.01343Inherited
MHC antigen-recognition domain0.01522Inherited
Globin-like0.01788Inherited
4-helical cytokines0.02022Inherited
Transcription factor STAT-4 N-domain0.03651Inherited
STAT0.03651Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.05368Inherited
Alpha-macroglobulin receptor domain0.05368Inherited
Terpenoid cyclases/Protein prenyltransferases0.06288Inherited
Caspase-like0.07339Inherited
TIMP-like0.1056Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.186Inherited
Trypsin-like serine proteases0.1884Inherited
Fibrinogen C-terminal domain-like0.2442Inherited
TSP-1 type 1 repeat0.293Inherited
SH3-domain0.3244Inherited
Cysteine-rich domain0.3703Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.3945Inherited
LDL receptor-like module0.7509Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Long-chain cytokines0Direct
XPF/Rad1/Mus81 nuclease0Direct
Formate/glycerate dehydrogenases, substrate-binding domain0Direct
BRK domain-like0Direct
beta-glycanases0Direct
Fibrinogen coiled-coil and central regions0Direct
Proteasome subunits0Direct
Anaphylotoxins (complement system)0Direct
ets domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Netrin-like domain (NTR/C345C module)0Direct
SH2 domain0.0005792Direct
C1 set domains (antibody constant domain-like)0.001269Inherited
DEATH domain, DD0.002111Inherited
ABC transporter ATPase domain-like0.005846Inherited
Complement control module/SCR domain0.007773Inherited
TNF-like0.01055Inherited
MHC antigen-recognition domain0.01164Inherited
Ras-binding domain, RBD0.01359Inherited
Globins0.01359Inherited
ABC transporter transmembrane region0.01598Inherited
Laminin-type module0.01918Inherited
Transcription factor STAT-4 N-domain0.02882Inherited
STAT DNA-binding domain0.02882Inherited
STAT0.02882Inherited
Pyrin domain, PYD0.02882Inherited
28-residue LRR0.02929Inherited
TNF receptor-like0.02929Inherited
Alpha-macroglobulin receptor domain0.04426Inherited
Complement components0.04426Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.06106Inherited
Nitrogenase iron protein-like0.08254Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.08254Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.09216Inherited
Arylsulfatase0.09572Inherited
PLC-like (P variant)0.1375Inherited
Caspase recruitment domain, CARD0.148Inherited
PHD domain0.1958Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2111Inherited
Fibrinogen C-terminal domain-like0.2241Inherited
Noncollagenous (NC1) domain of collagen IV0.2499Inherited
Eukaryotic proteases0.2596Inherited
TSP-1 type 1 repeat0.2785Inherited
V set domains (antibody variable domain-like)0.2795Inherited
RecA protein-like (ATPase-domain)0.3279Inherited
SH3-domain0.3816Inherited
LDL receptor-like module0.7477Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Notch domain0Direct
SAND domain-like0Direct
Tricorn protease domain 20Direct
Anaphylotoxins (complement system)0Direct
Restriction endonuclease-like0Direct
BRK domain-like0Direct
DEATH domain0.000003113Direct
SH2 domain0.0003952Direct
Immunoglobulin0.0004824Direct
Actin-like ATPase domain0.0008Direct
(Trans)glycosidases0.00387Inherited
DNA/RNA polymerases0.005507Inherited
Complement control module/SCR domain0.006404Inherited
TNF receptor-like0.007209Inherited
TNF-like0.008948Inherited
ABC transporter transmembrane region0.008948Inherited
RNI-like0.008948Inherited
MHC antigen-recognition domain0.01024Inherited
Globin-like0.01221Inherited
4-helical cytokines0.01395Inherited
STAT0.0265Inherited
Transcription factor STAT-4 N-domain0.0265Inherited
Alpha-macroglobulin receptor domain0.04026Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.04026Inherited
Terpenoid cyclases/Protein prenyltransferases0.04783Inherited
Caspase-like0.05656Inherited
TIMP-like0.08394Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1552Inherited
Trypsin-like serine proteases0.1575Inherited
Fibrinogen C-terminal domain-like0.209Inherited
TSP-1 type 1 repeat0.2552Inherited
SH3-domain0.2852Inherited
Cysteine-rich domain0.3295Inherited
C-type lectin-like0.3367Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.3532Inherited
Snake toxin-like0.3614Inherited
LDL receptor-like module0.715Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    82895,57424
  • 82895 - TSP-1 type 1 repeat
  • 57424 - LDL receptor-like module
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0003645Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.004938Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.008948Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01024Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.01024Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0265Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0265Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0265Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0265Inherited
    57535,50494
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.05656Inherited
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.05656Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.05656Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.1395Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.1395Inherited
    49854,57196
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 0.1395Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1438Inherited
    57196,49854
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 0.2364Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.4415Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.00233Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0265Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0265Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.05656Inherited
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.05656Inherited
    57196,49854,57535
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.05656Inherited
    57535,57535,50494
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 50494 - Trypsin-like serine proteases
  • 0.05656Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.07583Inherited
    49854,57196,49854
  • 49854 - Spermadhesin, CUB domain
  • 57196 - EGF/Laminin
  • 49854 - Spermadhesin, CUB domain
  • 0.1395Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)