SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Aplasia/Hypoplasia involving the central nervous system

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   Phenotypic abnormality [HP:0000118] <25>
+ + + 3:   Abnormality of the nervous system [HP:0000707] <4>(140|161) (154|97|43)
+ + 2:   Abnormality of nervous system morphology [HP:0012639] <5>(70|93) (79|45|15)
+ 1:   Morphological abnormality of the central nervous system [HP:0002011] <17>(62|82) (71|38|15)
0:   Aplasia/Hypoplasia involving the central nervous system [HP:0002977] <13>(19|22) (22|9|2)
- 1:   Aplasia/Hypoplasia of the cerebrum [HP:0007364] <5>(11|13) (13|4|1)
- 1:   Atrophy/Degeneration affecting the cerebrum [HP:0007369] <5>(1|4) (1|2|0)
- 1:   Aplasia/Hypoplasia of the cerebellum [HP:0007360] <2>(1|1) (1|1|0)
- 1:   Aplasia/Hypoplasia of the optic tract [HP:0011000] <2>(0|0) (0|0|0)
- 1:   Aplasia/Hypoplasia of the pyramidal tract [HP:0007363] <2>(0|0) (0|0|0)
- 1:   Aplasia/Hypoplasia involving the corticospinal tracts [HP:0007365] <1>(0|0) (0|0|0)
- 1:   Aplasia/Hypoplasia of the brainstem [HP:0007362] <1>(2|2) (3|1|0)
- 1:   Optic nerve hypoplasia [HP:0000609] <1>(1|1) (1|0|0)
- 1:   Agenesis of pineal gland [HP:0012687](0|0) (0|0|0)
- 1:   Global brain atrophy [HP:0002283](0|0) (0|0|0)
- 1:   Hypoplasia of olfactory tract [HP:0007036](0|0) (0|0|0)
- 1:   Hypoplasia of the olfactory bulb [HP:0040326](0|0) (0|0|0)
- 1:   Hypoplastic olfactory lobes [HP:0006894](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Pseudouridine synthase0Direct
Smc hinge domain0Direct
Restriction endonuclease-like0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
BRK domain-like0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
ADC-like0Direct
WD40 repeat-like0.000134Direct
ARID-like0.009135Inherited
Tubulin nucleotide-binding domain-like0.04103Inherited
Tubulin C-terminal domain-like0.05746Inherited
MIR domain0.1984Inherited
Actin-like ATPase domain0.2005Inherited
NagB/RpiA/CoA transferase-like0.209Inherited
Homeodomain-like0.4125Inherited
Ribonuclease H-like0.4193Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
XPF/Rad1/Mus81 nuclease0Direct
Protein serine/threonine phosphatase0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
BRK domain-like0Direct
Smc hinge domain0Direct
IF2B-like0Direct
Clathrin adaptor core protein0Direct
N-acetyl transferase, NAT0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
SWIRM domain0Direct
Histone deacetylase, HDAC0Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.004578Inherited
ARID domain0.005015Inherited
Bromodomain0.01592Inherited
Tubulin, GTPase domain0.02352Inherited
Tubulin, C-terminal domain0.03501Inherited
Elongation factors0.05197Inherited
Clathrin coat assembly domain0.08696Inherited
MIR domain0.1551Inherited
Homeodomain0.3947Inherited
PDZ domain0.4047Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Pseudouridine synthase0Direct
ADC-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Smc hinge domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Restriction endonuclease-like0Direct
BRK domain-like0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
WD40 repeat-like0.0000655Direct
ARID-like0.005967Inherited
Bromodomain0.02082Inherited
Tubulin nucleotide-binding domain-like0.03005Inherited
Tubulin C-terminal domain-like0.04343Inherited
Nucleotidylyl transferase0.0526Inherited
Nucleotide-diphospho-sugar transferases0.1044Inherited
MIR domain0.1666Inherited
Actin-like ATPase domain0.1684Inherited
NagB/RpiA/CoA transferase-like0.1764Inherited
Homeodomain-like0.3707Inherited
Ribonuclease H-like0.3772Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.0212Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.04343Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.1764Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.2212Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)