SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Phenotypic Abnormality (PA): Abnormality of the musculature

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <25>
0:   Abnormality of the musculature [HP:0003011] <22>(62|75) (67|30|6)
- 1:   Abnormal muscle morphology [HP:0011805] <22>(19|22) (19|10|2)
- 1:   Abnormality of facial musculature [HP:0000301] <12>(4|3) (4|3|0)
- 1:   Abnormal muscle physiology [HP:0011804] <11>(44|56) (52|21|4)
- 1:   Abnormality of the musculature of the limbs [HP:0009127] <10>(10|7) (11|2|0)
- 1:   Abnormality of the extraocular muscles [HP:0008049] <8>(0|0) (0|0|0)
- 1:   Abnormality of the diaphragm [HP:0000775] <6>(3|3) (3|2|0)
- 1:   Abnormality of the musculature of the neck [HP:0011006] <6>(4|4) (4|2|0)
- 1:   Abnormality of musculature of soft palate [HP:0430014] <5>(0|0) (0|0|0)
- 1:   Abnormality of skeletal muscles [HP:0040290] <4>(4|4) (4|2|0)
- 1:   Muscle abnormality related to mitochondrial dysfunction [HP:0003800] <4>(0|0) (0|0|0)
- 1:   Abnormality of axial muscles [HP:0040286] <3>(1|1) (1|0|0)
- 1:   Abnormality of the abdominal musculature [HP:0010991] <3>(1|1) (1|0|0)
- 1:   Abnormality of the musculature of the pelvis [HP:0001469] <3>(2|2) (2|1|0)
- 1:   Abnormality of the musculature of the thorax [HP:0009131] <3>(0|0) (0|0|0)
- 1:   Abnormality of the tongue muscle [HP:0040173] <2>(0|0) (0|0|0)
- 1:   Neoplasm of striated muscle [HP:0009728] <2>(0|0) (0|0|0)
- 1:   Abnormality of musculature of pharynx [HP:0430015] <1>(0|0) (0|0|0)
- 1:   Abnormality of occipitofrontalis muscle [HP:0040172] <1>(0|0) (0|0|0)
- 1:   Abnormality of hyoglossus muscle [HP:3000051](0|0) (0|0|0)
- 1:   Abnormality of the back musculature [HP:0410168](0|0) (0|0|0)
- 1:   Abnormality of the chest musculature [HP:0410167](0|0) (0|0|0)
- 1:   Abnormality of the shoulder musculature [HP:0410169](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Actin depolymerizing proteins0Direct
TK C-terminal domain-like0Direct
Pseudouridine synthase0Direct
Hect, E3 ligase catalytic domain0Direct
Putative DNA-binding domain0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Lamin A/C globular tail domain0Direct
CCCH zinc finger0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
Smc hinge domain0Direct
4Fe-4S ferredoxins0Direct
GroEL equatorial domain-like0Direct
CoA-dependent acyltransferases0Direct
Folate-binding domain0Direct
SNARE fusion complex0Direct
Rudiment single hybrid motif0Direct
ThrRS/AlaRS common domain0Direct
Aminomethyltransferase beta-barrel domain0Direct
PP2C-like0Direct
Single hybrid motif0Direct
FKBP-like0Direct
Rhodanese/Cell cycle control phosphatase0Direct
Hook domain0Direct
S15/NS1 RNA-binding domain0Direct
2Fe-2S ferredoxin-like0Direct
Methylglyoxal synthase-like0Direct
Ribonuclease PH domain 2-like0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Troponin coil-coiled subunits0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
ADC-like0Direct
Nucleotide-diphospho-sugar transferases0.0001405Direct
Class II aaRS and biotin synthetases0.001587Inherited
ARM repeat0.0141Inherited
Nicotinic receptor ligand binding domain-like0.01786Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.01786Inherited
Voltage-gated potassium channels0.03584Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.04237Inherited
Tropomyosin0.04329Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.08593Inherited
HMG-box0.09498Inherited
Spectrin repeat0.09595Inherited
RNA-binding domain, RBD0.1165Inherited
Actin-like ATPase domain0.1271Inherited
Calponin-homology domain, CH-domain0.1498Inherited
Kelch motif0.1654Inherited
Translation proteins0.2121Inherited
Calcium-dependent phosphotriesterase0.214Inherited
Myosin rod fragments0.2227Inherited
POZ domain0.2805Inherited
HSP20-like chaperones0.3086Inherited
ARID-like0.3086Inherited
MIR domain0.3086Inherited
GLA-domain0.7274Inherited
FnI-like domain0.7583Inherited
RING/U-box0.767Inherited
vWA-like0.7922Inherited
Intermediate filament protein, coiled coil region1Inherited
Trypsin-like serine proteases1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Protein serine/threonine phosphatase0Direct
CCCH zinc finger0Direct
PP2C-like0Direct
SNARE fusion complex0Direct
Anticodon-binding domain0Direct
Glycosyl transferases group 10Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Double-stranded RNA-binding domain (dsRBD)0Direct
Histone lysine methyltransferases0Direct
BC C-terminal domain-like0Direct
Lamin A/C globular tail domain0Direct
Troponin T0Direct
GABA-aminotransferase-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
a tRNA synthase domain0Direct
Myotubularin-like phosphatases0Direct
Hect, E3 ligase catalytic domain0Direct
Ferredoxin domains from multidomain proteins0Direct
beta-glycanases0Direct
Smc hinge domain0Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
Amylase, catalytic domain0Direct
Biotin dependent carboxylase carboxyltransferase domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Ribonuclease PH domain 1-like0Direct
IF2B-like0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0Direct
Filamin repeat (rod domain)0Direct
Ribonuclease PH domain 2-like0Direct
Proteasome subunits0Direct
Clathrin coat assembly domain0Direct
BC N-terminal domain-like0Direct
BC ATP-binding domain-like0Direct
UBA domain0Direct
FKBP immunophilin/proline isomerase0Direct
N-acetyl transferase, NAT0Direct
Biotinyl/lipoyl-carrier proteins and domains0Direct
Choline/Carnitine O-acyltransferase0Direct
Aminomethyltransferase folate-binding domain0Direct
Pyridoxal-dependent decarboxylase0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Aminomethyltransferase beta-barrel domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
Exostosin0Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.000326Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.003353Inherited
Extended AAA-ATPase domain0.007423Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.01106Inherited
Nicotinic receptor ligand binding domain-like0.01106Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.01907Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.01907Inherited
Laminin-type module0.01942Inherited
Tropomyosin0.03008Inherited
HMG-box0.07103Inherited
Spectrin repeat0.07209Inherited
Anticodon-binding domain of Class II aaRS0.07494Inherited
DNA gyrase/MutL, second domain0.1159Inherited
Clathrin adaptor core protein0.1159Inherited
DNA gyrase/MutL, N-terminal domain0.1159Inherited
Calponin-homology domain, CH-domain0.1161Inherited
Kelch motif0.1307Inherited
Canonical RBD0.1625Inherited
Myosin rod fragments0.1838Inherited
FHA domain0.1838Inherited
VWC domain0.1896Inherited
ARID domain0.2655Inherited
MIR domain0.2655Inherited
GLA-domain0.6879Inherited
Integrin A (or I) domain0.7975Inherited
Intermediate filament protein, coiled coil region1Inherited
Eukaryotic proteases1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Pseudouridine synthase0Direct
Methylglyoxal synthase-like0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
4Fe-4S ferredoxins0Direct
CoA-dependent acyltransferases0Direct
S15/NS1 RNA-binding domain0Direct
Hook domain0Direct
Hect, E3 ligase catalytic domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
2Fe-2S ferredoxin-like0Direct
SNARE fusion complex0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Aminomethyltransferase beta-barrel domain0Direct
ADC-like0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
GroEL equatorial domain-like0Direct
Putative DNA-binding domain0Direct
TK C-terminal domain-like0Direct
Ribonuclease PH domain 2-like0Direct
Folate-binding domain0Direct
Rudiment single hybrid motif0Direct
Troponin coil-coiled subunits0Direct
PP2C-like0Direct
Smc hinge domain0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
Single hybrid motif0Direct
ThrRS/AlaRS common domain0Direct
Actin depolymerizing proteins0Direct
FKBP-like0Direct
Lamin A/C globular tail domain0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Rhodanese/Cell cycle control phosphatase0Direct
CCCH zinc finger0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
Nucleotide-diphospho-sugar transferases0.0000689Direct
Nucleotidylyl transferase0.0005538Direct
Class II aaRS and biotin synthetases0.0009008Direct
ARM repeat0.009427Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.01219Inherited
Nicotinic receptor ligand binding domain-like0.01219Inherited
Voltage-gated potassium channels0.02595Inherited
Ribonuclease H-like0.0311Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.0311Inherited
Tropomyosin0.03182Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.06727Inherited
HMG-box0.07495Inherited
Spectrin repeat0.07575Inherited
Class II aaRS ABD-related0.07672Inherited
RNA-binding domain, RBD0.09334Inherited
Actin-like ATPase domain0.1026Inherited
Calponin-homology domain, CH-domain0.1229Inherited
Kelch motif0.1368Inherited
Translation proteins0.1795Inherited
Calcium-dependent phosphotriesterase0.1811Inherited
Myosin rod fragments0.1892Inherited
NagB/RpiA/CoA transferase-like0.1943Inherited
POZ domain0.2433Inherited
HSP20-like chaperones0.2704Inherited
MIR domain0.2704Inherited
ARID-like0.2704Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.54Inherited
GLA-domain0.6898Inherited
FnI-like domain0.7226Inherited
RING/U-box0.7317Inherited
vWA-like0.7581Inherited
Intermediate filament protein, coiled coil region0.9932Inherited
Trypsin-like serine proteases1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47060,55681
  • 47060 - S15/NS1 RNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    117281,117281
  • 117281 - Kelch motif
  • 117281 - Kelch motif
  • 0Direct
    54928,90209
  • 54928 - RNA-binding domain, RBD
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    103025,101790
  • 103025 - Folate-binding domain
  • 101790 - Aminomethyltransferase beta-barrel domain
  • 0Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.01219Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.04984Inherited
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.04984Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.05298Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.1189Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1189Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.1385Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.1892Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2533Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.3733Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.02089Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)