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Phenotypic Abnormality (PA): Abnormal anterior eye segment morphology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Phenotypic abnormality [HP:0000118] <25>
+ + 2:   Abnormality of the eye [HP:0000478] <2>(58|72) (64|38|25)
+ 1:   Abnormal eye morphology [HP:0012372] <12>(36|45) (40|29|21)
0:   Abnormal anterior eye segment morphology [HP:0004328] <8>(15|21) (17|14|13)
- 1:   Abnormal cornea morphology [HP:0000481] <18>(7|10) (8|4|0)
- 1:   Abnormality iris morphology [HP:0000525] <14>(2|4) (3|2|0)
- 1:   Abnormal anterior chamber morphology [HP:0000593] <12>(1|1) (1|1|2)
- 1:   Ocular anterior segment dysgenesis [HP:0007700] <7>(1|2) (1|0|1)
- 1:   Abnormality of the lens [HP:0000517] <6>(6|9) (6|7|9)
- 1:   Abnormal suspensory ligament of lens morphology [HP:0012628](0|0) (0|0|0)
- 1:   Limbal stem cell deficiency [HP:0032107](0|0) (0|0|0)
- 1:   Pseudoexfoliation [HP:0012627](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Zn-finger domain of Sec23/240Direct
Smc hinge domain0Direct
Tricorn protease domain 20Direct
Notch domain0Direct
gamma-Crystallin-like0Direct
C-type lectin-like0.01464Inherited
Intermediate filament protein, coiled coil region0.02849Inherited
Multidrug efflux transporter AcrB transmembrane domain0.06337Inherited
FnI-like domain0.06415Inherited
Glycosyl hydrolase domain0.1338Inherited
TB module/8-cys domain0.1962Inherited
EGF/Laminin0.2036Inherited
(Trans)glycosidases0.4168Inherited
Nucleotide-diphospho-sugar transferases0.4848Inherited
Homeodomain-like0.6452Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Notch domain0Direct
Crystallins/Ca-binding development proteins0Direct
XPF/Rad1/Mus81 nuclease0Direct
Zn-finger domain of Sec23/240Direct
Smc hinge domain0Direct
RecA protein-like (ATPase-domain)0.006935Inherited
Multidrug efflux transporter AcrB transmembrane domain0.01707Inherited
Noncollagenous (NC1) domain of collagen IV0.0191Inherited
Intermediate filament protein, coiled coil region0.02028Inherited
EGF-type module0.02257Inherited
VWC domain0.04327Inherited
Pyrin domain, PYD0.0486Inherited
Transglutaminase core0.07226Inherited
TB module/8-cys domain0.1688Inherited
beta-glycanases0.1688Inherited
Arylsulfatase0.177Inherited
I set domains0.2955Inherited
TSP-1 type 1 repeat0.3075Inherited
BCR-homology GTPase activation domain (BH-domain)0.4071Inherited
C1 set domains (antibody constant domain-like)0.4439Inherited
PDZ domain0.5714Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Notch domain0Direct
Zn-finger domain of Sec23/240Direct
Smc hinge domain0Direct
Tricorn protease domain 20Direct
gamma-Crystallin-like0Direct
C-type lectin-like0.009826Inherited
Intermediate filament protein, coiled coil region0.02025Inherited
Multidrug efflux transporter AcrB transmembrane domain0.04822Inherited
FnI-like domain0.04882Inherited
beta-beta-alpha zinc fingers0.07097Inherited
Glycosyl hydrolase domain0.1087Inherited
TB module/8-cys domain0.1645Inherited
EGF/Laminin0.1713Inherited
(Trans)glycosidases0.3748Inherited
Nucleotide-diphospho-sugar transferases0.4418Inherited
RING/U-box0.5813Inherited
Homeodomain-like0.6053Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.005595Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.01706Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.01742Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.08257Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.1056Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1087Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.1199Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.1645Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.1645Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.29Inherited
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.3011Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00007006Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0004946Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0004946Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1645Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.1645Inherited
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.3011Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3429Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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