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Phenotypic Abnormality (PA): Abnormal cellular physiology

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   Phenotypic abnormality [HP:0000118] <25>
+ 1:   Abnormal cellular phenotype [HP:0025354] <3>(10|11) (14|3|0)
+ 1:   Abnormality of metabolism/homeostasis [HP:0001939] <15>(73|82) (82|38|18)
0:   Abnormal cellular physiology [HP:0011017] <16>(10|10) (14|3|0)
- 1:   Abnormal lymphocyte physiology [HP:0031409] <5>(5|6) (5|2|0)
- 1:   Abnormality of DNA repair [HP:0003254] <5>(0|0) (0|0|0)
- 1:   Abnormality of lysosomal metabolism [HP:0004356] <4>(0|0) (0|0|0)
- 1:   Intracellular accumulation of autofluorescent lipopigment storage material [HP:0003204] <3>(0|0) (0|0|0)
- 1:   Abnormality of chromosome segregation [HP:0002916] <2>(0|0) (0|0|0)
- 1:   Abnormality of chromosome stability [HP:0003220] <2>(0|1) (1|0|0)
- 1:   Abnormality of redox activity [HP:0025463] <2>(0|0) (0|0|0)
- 1:   Abnormality of the mitochondrion [HP:0012103] <2>(5|3) (7|1|0)
- 1:   Abnormal cell proliferation [HP:0031377] <1>(0|0) (0|0|0)
- 1:   Abnormality of chromosome condensation [HP:0011019] <1>(0|0) (0|0|0)
- 1:   Abnormality of glycosaminoglycan metabolism [HP:0004371] <1>(0|0) (0|0|0)
- 1:   Abnormality of the cell cycle [HP:0011018] <1>(0|0) (0|0|0)
- 1:   Elevated intracellular cystine [HP:0003358](0|0) (0|0|0)
- 1:   Increased cellular sensitivity to UV light [HP:0003224](0|0) (0|0|0)
- 1:   Increased intracellular sodium [HP:0003575](0|0) (0|0|0)
- 1:   Increased sensitivity to ionizing radiation [HP:0011133](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
TNF receptor-like0.0001516Direct
DEATH domain0.006179Inherited
4Fe-4S ferredoxins0.01602Inherited
SH2 domain0.01833Inherited
TNF-like0.0268Inherited
Adenine nucleotide alpha hydrolases-like0.04374Inherited
CoA-dependent acyltransferases0.04374Inherited
Acyl-CoA dehydrogenase NM domain-like0.06574Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.06574Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.08109Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
TNF receptor-like0.0009285Direct
SH2 domain0.01057Inherited
TNF-like0.01691Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.01691Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.01691Inherited
DEATH domain, DD0.01691Inherited
RecA protein-like (ATPase-domain)0.02288Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.02985Inherited
Mitochondrial carrier0.09564Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
TNF receptor-like0.00007457Direct
Restriction endonuclease-like0.000942Direct
DEATH domain0.003913Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.005415Inherited
BRCT domain0.006021Inherited
4Fe-4S ferredoxins0.01083Inherited
SH2 domain0.01255Inherited
TNF-like0.01889Inherited
Adenine nucleotide alpha hydrolases-like0.03216Inherited
CoA-dependent acyltransferases0.03216Inherited
Acyl-CoA dehydrogenase NM domain-like0.05018Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.05018Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.06315Inherited
Mitochondrial carrier0.1024Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.00004544Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0251Inherited
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.05018Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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